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Conserved domains on  [gi|1207118875|ref|XP_021322219|]
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coiled-coil domain-containing protein 106-like [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC106 super family cl24381
Coiled-coil domain-containing protein 106; CCDC106, coiled-coil domain-containing protein 106, ...
 77-178 1.47e-28

Coiled-coil domain-containing protein 106; CCDC106, coiled-coil domain-containing protein 106, is a family of eukaryote proteins. Yeast two-hybrid screening has identified CCDC106 as a p53-interacting partner. CCDC106 is a negative regulator of p53 and may be involved in tumourigenesis in some cancers by promoting the degradation of p53 protein and inhibiting its transactivity.


The actual alignment was detected with superfamily member pfam15794:

Pssm-ID: 464874  Cd Length: 220  Bit Score: 105.29  E-value: 1.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207118875  77 RVTEPWQVVKRYKAVLEIFDRGSNMTYAFRKYGVDRNTIVQTAVIAELAIAAPEKYSEIQNNRV--EKLSTITQKCqdAI 154
Cdd:pfam15794 119 RVKDPEDVLCRYKKILTTFQRLKSMSRAFQKHGVDRNTVASTAPIAELLLAAPEKVQEVGEFDPskETLLEYARRC--AT 196

                          90       100
                  ....*....|....*....|....
gi 1207118875 155 MADKSIAHKIQAMKKEGKLLPIRK 178
Cdd:pfam15794 197 ALDEETLEKVQQLKASGLLLPISY 220
 
Name Accession Description Interval E-value
CCDC106 pfam15794
Coiled-coil domain-containing protein 106; CCDC106, coiled-coil domain-containing protein 106, ...
 77-178 1.47e-28

Coiled-coil domain-containing protein 106; CCDC106, coiled-coil domain-containing protein 106, is a family of eukaryote proteins. Yeast two-hybrid screening has identified CCDC106 as a p53-interacting partner. CCDC106 is a negative regulator of p53 and may be involved in tumourigenesis in some cancers by promoting the degradation of p53 protein and inhibiting its transactivity.


Pssm-ID: 464874  Cd Length: 220  Bit Score: 105.29  E-value: 1.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207118875  77 RVTEPWQVVKRYKAVLEIFDRGSNMTYAFRKYGVDRNTIVQTAVIAELAIAAPEKYSEIQNNRV--EKLSTITQKCqdAI 154
Cdd:pfam15794 119 RVKDPEDVLCRYKKILTTFQRLKSMSRAFQKHGVDRNTVASTAPIAELLLAAPEKVQEVGEFDPskETLLEYARRC--AT 196

                          90       100
                  ....*....|....*....|....
gi 1207118875 155 MADKSIAHKIQAMKKEGKLLPIRK 178
Cdd:pfam15794 197 ALDEETLEKVQQLKASGLLLPISY 220
 
Name Accession Description Interval E-value
CCDC106 pfam15794
Coiled-coil domain-containing protein 106; CCDC106, coiled-coil domain-containing protein 106, ...
 77-178 1.47e-28

Coiled-coil domain-containing protein 106; CCDC106, coiled-coil domain-containing protein 106, is a family of eukaryote proteins. Yeast two-hybrid screening has identified CCDC106 as a p53-interacting partner. CCDC106 is a negative regulator of p53 and may be involved in tumourigenesis in some cancers by promoting the degradation of p53 protein and inhibiting its transactivity.


Pssm-ID: 464874  Cd Length: 220  Bit Score: 105.29  E-value: 1.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207118875  77 RVTEPWQVVKRYKAVLEIFDRGSNMTYAFRKYGVDRNTIVQTAVIAELAIAAPEKYSEIQNNRV--EKLSTITQKCqdAI 154
Cdd:pfam15794 119 RVKDPEDVLCRYKKILTTFQRLKSMSRAFQKHGVDRNTVASTAPIAELLLAAPEKVQEVGEFDPskETLLEYARRC--AT 196

                          90       100
                  ....*....|....*....|....
gi 1207118875 155 MADKSIAHKIQAMKKEGKLLPIRK 178
Cdd:pfam15794 197 ALDEETLEKVQQLKASGLLLPISY 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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