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Conserved domains on  [gi|1207162030|ref|XP_021324978|]
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ceramide synthase 5 isoform X1 [Danio rerio]

Protein Classification

ceramide synthase( domain architecture ID 10053302)

ceramide synthase catalyzes formation of ceramide from sphinganine and acyl-CoA substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TRAM_LAG1_CLN8 pfam03798
TLC domain;
132-325 2.52e-52

TLC domain;


:

Pssm-ID: 461055  Cd Length: 200  Bit Score: 172.46  E-value: 2.52e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 132 KFCESMWRFTFYLSIFTYGMRFLWQSPWMWDTRQCWYNYPYQVLTS---GLYYYYVTELAFY-WSLMFSQFTDIKRKDFL 207
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLGYtswLVKFYYLIQLGYFiWDLLVLLFYEKRRKDFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 208 IMFIHHLATIGLISFSYVNNMLRVGSLVMCVHDASDFLLEAAKLANYAKYQRVCDVVFVIFGIIFFGTRLIIFPFWILNT 287
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLFVLFLVSFFVTRLVLGPFWILLS 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1207162030 288 TLFESWQII--GPYPSWWLFNFLLLVLQVLHIFWSYLIAR 325
Cdd:pfam03798 161 ILDYAGLDVptGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
81-128 9.09e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 39.92  E-value: 9.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1207162030  81 NAVLEKVFtSITKSPDSRHSEGLSKQLDWDVRKVQRWFRHRRNQDKPS 128
Cdd:cd00086    12 LEELEKEF-EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
 
Name Accession Description Interval E-value
TRAM_LAG1_CLN8 pfam03798
TLC domain;
132-325 2.52e-52

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 172.46  E-value: 2.52e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 132 KFCESMWRFTFYLSIFTYGMRFLWQSPWMWDTRQCWYNYPYQVLTS---GLYYYYVTELAFY-WSLMFSQFTDIKRKDFL 207
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLGYtswLVKFYYLIQLGYFiWDLLVLLFYEKRRKDFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 208 IMFIHHLATIGLISFSYVNNMLRVGSLVMCVHDASDFLLEAAKLANYAKYQRVCDVVFVIFGIIFFGTRLIIFPFWILNT 287
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLFVLFLVSFFVTRLVLGPFWILLS 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1207162030 288 TLFESWQII--GPYPSWWLFNFLLLVLQVLHIFWSYLIAR 325
Cdd:pfam03798 161 ILDYAGLDVptGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
131-331 2.14e-49

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 164.77  E-value: 2.14e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030  131 TKFCESMWRFTFYLSIFTYGMRFLWQSPWMWDTRqcwYNYPYQVLTSGLYYYYVTELAFYWSLMFSQ--FTDIKRKDFLI 208
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPK---SLYPIQGMSPLAKFYYLFSLGYFIHDLVALllFQDLKRKDFKE 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030  209 MFIHHLATIGLISFSYVNNMLRVGSLVMCVHDASDFLLEAAKLANYAKYQ--RVCDVVFVIFGIIFFGTRLIIFPFWILN 286
Cdd:smart00724  78 MLVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKksLLYDVNFVLFAVVFFVFRLILFPFLILT 157
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1207162030  287 TTLFESWQIIG--PYPSWWLFNFLLLVLQVLHIFWSYLIARIAFKAI 331
Cdd:smart00724 158 VTVHYAQAESGlfPPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLL 204
LAG1 COG5058
Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, ...
132-334 5.38e-29

Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion];


Pssm-ID: 227391 [Multi-domain]  Cd Length: 395  Bit Score: 115.71  E-value: 5.38e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 132 KFCESMWRFTFYLSIFTYGMRFLWQSP-WMWDTRQCWYNYPYQVLTSGLYYYYVTELAFYW--SLMFSQFTDIKRKDFLI 208
Cdd:COG5058   156 RFCEQMYAIFYYGVSGPFGLYVMRSSPlWFFNTKALYETYPVFYNPFLFKAFYLIQAAFWAqqACILVLQLEKPRKDFKE 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 209 MFIHHLATIGLISFSYVNNMLRVGSLVMCVHDASDFLLEAAKLANYAKYqRVCDVVFVIFGIIFFGTRLIIFP--FWILN 286
Cdd:COG5058   236 LVFHHIVTLLLIWLSYVFHFTRMGLAIYITMDVSDFFLSLSKTLNYLNS-VLATFIFGIFVFIWIYSRHYLNLkiLWSVL 314
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207162030 287 TTL---------FESWQiIGPYPSWWLFNFLLLVLQVLHIFWSYLIARIAFKAIVRG 334
Cdd:COG5058   315 TAFrtignfvldVATQQ-YKCWISLPIVFILLQALQLVNIYWLFLIVRVAYRVIWEG 370
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
81-128 9.09e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 39.92  E-value: 9.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1207162030  81 NAVLEKVFtSITKSPDSRHSEGLSKQLDWDVRKVQRWFRHRRNQDKPS 128
Cdd:cd00086    12 LEELEKEF-EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
82-126 1.35e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 36.32  E-value: 1.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1207162030  82 AVLEKVFtSITKSPDSRHSEGLSKQLDWDVRKVQRWFRHRRNQDK 126
Cdd:pfam00046  13 EELEKEF-QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
 
Name Accession Description Interval E-value
TRAM_LAG1_CLN8 pfam03798
TLC domain;
132-325 2.52e-52

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 172.46  E-value: 2.52e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 132 KFCESMWRFTFYLSIFTYGMRFLWQSPWMWDTRQCWYNYPYQVLTS---GLYYYYVTELAFY-WSLMFSQFTDIKRKDFL 207
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLGYtswLVKFYYLIQLGYFiWDLLVLLFYEKRRKDFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 208 IMFIHHLATIGLISFSYVNNMLRVGSLVMCVHDASDFLLEAAKLANYAKYQRVCDVVFVIFGIIFFGTRLIIFPFWILNT 287
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLFVLFLVSFFVTRLVLGPFWILLS 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1207162030 288 TLFESWQII--GPYPSWWLFNFLLLVLQVLHIFWSYLIAR 325
Cdd:pfam03798 161 ILDYAGLDVptGPFLLYYIFLILLLVLQLLNIYWFYLIIR 200
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
131-331 2.14e-49

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 164.77  E-value: 2.14e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030  131 TKFCESMWRFTFYLSIFTYGMRFLWQSPWMWDTRqcwYNYPYQVLTSGLYYYYVTELAFYWSLMFSQ--FTDIKRKDFLI 208
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPK---SLYPIQGMSPLAKFYYLFSLGYFIHDLVALllFQDLKRKDFKE 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030  209 MFIHHLATIGLISFSYVNNMLRVGSLVMCVHDASDFLLEAAKLANYAKYQ--RVCDVVFVIFGIIFFGTRLIIFPFWILN 286
Cdd:smart00724  78 MLVHHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKksLLYDVNFVLFAVVFFVFRLILFPFLILT 157
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1207162030  287 TTLFESWQIIG--PYPSWWLFNFLLLVLQVLHIFWSYLIARIAFKAI 331
Cdd:smart00724 158 VTVHYAQAESGlfPPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLL 204
LAG1 COG5058
Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, ...
132-334 5.38e-29

Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion];


Pssm-ID: 227391 [Multi-domain]  Cd Length: 395  Bit Score: 115.71  E-value: 5.38e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 132 KFCESMWRFTFYLSIFTYGMRFLWQSP-WMWDTRQCWYNYPYQVLTSGLYYYYVTELAFYW--SLMFSQFTDIKRKDFLI 208
Cdd:COG5058   156 RFCEQMYAIFYYGVSGPFGLYVMRSSPlWFFNTKALYETYPVFYNPFLFKAFYLIQAAFWAqqACILVLQLEKPRKDFKE 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207162030 209 MFIHHLATIGLISFSYVNNMLRVGSLVMCVHDASDFLLEAAKLANYAKYqRVCDVVFVIFGIIFFGTRLIIFP--FWILN 286
Cdd:COG5058   236 LVFHHIVTLLLIWLSYVFHFTRMGLAIYITMDVSDFFLSLSKTLNYLNS-VLATFIFGIFVFIWIYSRHYLNLkiLWSVL 314
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207162030 287 TTL---------FESWQiIGPYPSWWLFNFLLLVLQVLHIFWSYLIARIAFKAIVRG 334
Cdd:COG5058   315 TAFrtignfvldVATQQ-YKCWISLPIVFILLQALQLVNIYWLFLIVRVAYRVIWEG 370
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
81-128 9.09e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 39.92  E-value: 9.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1207162030  81 NAVLEKVFtSITKSPDSRHSEGLSKQLDWDVRKVQRWFRHRRNQDKPS 128
Cdd:cd00086    12 LEELEKEF-EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
82-126 1.35e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 36.32  E-value: 1.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1207162030  82 AVLEKVFtSITKSPDSRHSEGLSKQLDWDVRKVQRWFRHRRNQDK 126
Cdd:pfam00046  13 EELEKEF-QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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