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Conserved domains on  [gi|1207165261|ref|XP_021325713|]
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ensconsin isoform X6 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 476-622 3.62e-13

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


:

Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 67.76  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261 476 RPSAGTTDPEEASRLLAEKRRQAREQREREEEEKRQQEEAERRSREEMARR----KAEERAKREEEAQRQAEEKRRKEEE 551
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRaeeeRARREEEARRLEEERRREEEERQRK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207165261 552 EMRLEEERAQREREEAERLQKQKEEEEARQKEEAERLRLEREKHFQKEEAERMERKKRLEEIMKRTRRSDQ 622
Cdd:pfam05672  81 AEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKRIEEIMKRTRKSDQ 151
ARGLU super family cl38471
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 65-156 6.40e-07

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


The actual alignment was detected with superfamily member pfam15346:

Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 49.66  E-value: 6.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQNAVRGSKWQEREERARQFH---ERQLEERKKRLEEQRMKE-DKRRAAVEEKRRQKleEEKVRYE 140
Cdd:pfam15346  46 ARKIMEKQVLEELEREREAELEEERRKEEEERKKReelERILEENNRKIEEAQRKEaEERLAMLEEQRRMK--EERQRRE 123

                          90       100
                  ....*....|....*....|...
gi 1207165261 141 AVIRRTMERSQ-------RARPK 156
Cdd:pfam15346 124 KEEEEREKREQqkilnkkNSRPK 146
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 352-479 8.03e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261 352 NLSYPTPSLSLFTPKRAPSPVGH---RSRVTNPSPNRSS-TAKPFQKTPNPKKSRSPPPPASIPLSHSNPSLSPGNLRPS 427
Cdd:pfam05109 519 NATSPTPAVTTPTPNATSPTLGKtspTSAVTTPTPNATSpTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGET 598

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207165261 428 RPTSESLRVTAEREAAKKEDVEPPKTEPEAPLTTTEPSSEASGSSPGGRPSA 479
Cdd:pfam05109 599 SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSS 650
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 476-622 3.62e-13

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 67.76  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261 476 RPSAGTTDPEEASRLLAEKRRQAREQREREEEEKRQQEEAERRSREEMARR----KAEERAKREEEAQRQAEEKRRKEEE 551
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRaeeeRARREEEARRLEEERRREEEERQRK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207165261 552 EMRLEEERAQREREEAERLQKQKEEEEARQKEEAERLRLEREKHFQKEEAERMERKKRLEEIMKRTRRSDQ 622
Cdd:pfam05672  81 AEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKRIEEIMKRTRKSDQ 151
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 65-156 6.40e-07

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 49.66  E-value: 6.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQNAVRGSKWQEREERARQFH---ERQLEERKKRLEEQRMKE-DKRRAAVEEKRRQKleEEKVRYE 140
Cdd:pfam15346  46 ARKIMEKQVLEELEREREAELEEERRKEEEERKKReelERILEENNRKIEEAQRKEaEERLAMLEEQRRMK--EERQRRE 123

                          90       100
                  ....*....|....*....|...
gi 1207165261 141 AVIRRTMERSQ-------RARPK 156
Cdd:pfam15346 124 KEEEEREKREQqkilnkkNSRPK 146
PTZ00121 PTZ00121
MAEBL; Provisional
 55-156 9.67e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 9.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261   55 KPEPLMLKNDERQRLARE-RREELDKQNAVRGSKWQEREERARQFHERQLEERKKRLEEQRMKEDKRRAAVEEKRRqKLE 133
Cdd:PTZ00121  1662 KAAEEAKKAEEDKKKAEEaKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKK-EAE 1740

                           90       100
                   ....*....|....*....|...
gi 1207165261  134 EEKVRYEAVIRRTMERSQRARPK 156
Cdd:PTZ00121  1741 EDKKKAEEAKKDEEEKKKIAHLK 1763
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 61-154 2.25e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  61 LKNDERQRLARE---RREELDKQNAVRGSKWQEREERARQFhERQLEERKKRLEEQRMKEDKRRAAVEEKR--RQKLEEE 135
Cdd:COG1196   218 LKEELKELEAELlllKLRELEAELEELEAELEELEAELEEL-EAELAELEAELEELRLELEELELELEEAQaeEYELLAE 296

                          90
                  ....*....|....*....
gi 1207165261 136 KVRYEAVIRRTMERSQRAR 154
Cdd:COG1196   297 LARLEQDIARLEERRRELE 315
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 67-153 1.35e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 41.75  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  67 QRLARERREELD--KQNAVRGSKWQEREERARQfhERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRYEAVIR 144
Cdd:TIGR02794  50 QQANRIQQQKKPaaKKEQERQKKLEQQAEEAEK--QRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAK 127


                  ....*....
gi 1207165261 145 RTMERSQRA 153
Cdd:TIGR02794 128 QAAEAKAKA 136
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 65-152 2.88e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 40.25  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQnavrgsKWQEREERARQfHERQLEERKKRLEE------QRMKEDKRRAAVEEKR--RQKLEEEK 136
Cdd:cd16269   197 EKEIEAERAKAEAAEQ------ERKLLEEQQRE-LEQKLEDQERSYEEhlrqlkEKMEEERENLLKEQERalESKLKEQE 269

                          90
                  ....*....|....*.
gi 1207165261 137 VRYEAVIRRTMERSQR 152
Cdd:cd16269   270 ALLEEGFKEQAELLQE 285
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 352-479 8.03e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261 352 NLSYPTPSLSLFTPKRAPSPVGH---RSRVTNPSPNRSS-TAKPFQKTPNPKKSRSPPPPASIPLSHSNPSLSPGNLRPS 427
Cdd:pfam05109 519 NATSPTPAVTTPTPNATSPTLGKtspTSAVTTPTPNATSpTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGET 598

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207165261 428 RPTSESLRVTAEREAAKKEDVEPPKTEPEAPLTTTEPSSEASGSSPGGRPSA 479
Cdd:pfam05109 599 SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSS 650
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 476-622 3.62e-13

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 67.76  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261 476 RPSAGTTDPEEASRLLAEKRRQAREQREREEEEKRQQEEAERRSREEMARR----KAEERAKREEEAQRQAEEKRRKEEE 551
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRaeeeRARREEEARRLEEERRREEEERQRK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207165261 552 EMRLEEERAQREREEAERLQKQKEEEEARQKEEAERLRLEREKHFQKEEAERMERKKRLEEIMKRTRRSDQ 622
Cdd:pfam05672  81 AEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKRIEEIMKRTRKSDQ 151
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 65-156 6.40e-07

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 49.66  E-value: 6.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQNAVRGSKWQEREERARQFH---ERQLEERKKRLEEQRMKE-DKRRAAVEEKRRQKleEEKVRYE 140
Cdd:pfam15346  46 ARKIMEKQVLEELEREREAELEEERRKEEEERKKReelERILEENNRKIEEAQRKEaEERLAMLEEQRRMK--EERQRRE 123

                          90       100
                  ....*....|....*....|...
gi 1207165261 141 AVIRRTMERSQ-------RARPK 156
Cdd:pfam15346 124 KEEEEREKREQqkilnkkNSRPK 146
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 84-153 5.86e-06

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 46.96  E-value: 5.86e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  84 RGSKWQEREERARqfheRQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRYEAVIRRTMERSQRA 153
Cdd:pfam05672   1 KPSAGTTDAEEAA----RILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRAEEERARREEEARRL 66
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 65-152 3.82e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.04  E-value: 3.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQNAVRGSKWQErEERARQFHERQLEERKKRLEEqrmkEDKRRAAVEEKRRQKLEEEKVRYEAVIR 144
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIE-EERKRKLLEKEMEERQKAIYE----EERRREAEEERRKQQEMEERRRIQEQMR 559


                  ....*...
gi 1207165261 145 RTMERSQR 152
Cdd:pfam17380 560 KATEERSR 567
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 65-148 8.64e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 45.29  E-value: 8.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQNAVRGSKWQEREERARqfhERQLEERKKRlEEQRMKEDkRRAAVEEKRRQK---LEEEKVRYEA 141
Cdd:pfam13868 191 AQQEKAQDEKAERDELRAKLYQEEQERKERQK---EREEAEKKAR-QRQELQQA-REEQIELKERRLaeeAEREEEEFER 265


                  ....*..
gi 1207165261 142 VIRRTME 148
Cdd:pfam13868 266 MLRKQAE 272
PTZ00121 PTZ00121
MAEBL; Provisional
 55-156 9.67e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 9.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261   55 KPEPLMLKNDERQRLARE-RREELDKQNAVRGSKWQEREERARQFHERQLEERKKRLEEQRMKEDKRRAAVEEKRRqKLE 133
Cdd:PTZ00121  1662 KAAEEAKKAEEDKKKAEEaKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKK-EAE 1740

                           90       100
                   ....*....|....*....|...
gi 1207165261  134 EEKVRYEAVIRRTMERSQRARPK 156
Cdd:PTZ00121  1741 EDKKKAEEAKKDEEEKKKIAHLK 1763
PRK12704 PRK12704
phosphodiesterase; Provisional
 72-152 1.31e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.15  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  72 ERREELDKQNAVRGSKWQEREERARQfHERQLEERKKRLEEQRMKEDKRRAAVeEKRRQKLEEEKVRYEAVIRRTMERSQ 151
Cdd:PRK12704   68 KLRNEFEKELRERRNELQKLEKRLLQ-KEENLDRKLELLEKREEELEKKEKEL-EQKQQELEKKEEELEELIEEQLQELE 145


                  .
gi 1207165261 152 R 152
Cdd:PRK12704  146 R 146
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 65-154 1.40e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 42.72  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQNavrgskwQEREERARQFHE----RQLEERKKRLEEQRMKEDKRRAAvEEKRRQKLEEEKVRYE 140
Cdd:pfam05672  18 EKRRQAREQREREEQER-------LEKEEEERLRKEelrrRAEEERARREEEARRLEEERRRE-EEERQRKAEEEAEERE 89

                          90
                  ....*....|....
gi 1207165261 141 AVIRRTMERSQRAR 154
Cdd:pfam05672  90 QREQEEQERLQKQK 103
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 65-160 1.57e-04

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 41.83  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERR-EELDKQNAVRGSKWQEREERARQFHE--RQLEERKKRLEEQR------MKEDKRRAAVEEKRRQKLEEE 135
Cdd:pfam20492   5 EREKQELEERlKQYEEETKKAQEELEESEETAEELEEerRQAEEEAERLEQKRqeaeeeKERLEESAEMEAEEKEQLEAE 84

                          90       100
                  ....*....|....*....|....*
gi 1207165261 136 KVRYEAVIRRTMERSQRARPKSNRW 160
Cdd:pfam20492  85 LAEAQEEIARLEEEVERKEEEARRL 109
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 64-152 1.96e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 44.73  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  64 DERQR-LARERREELDKQNAVRGSKWQErEERARQFHERQLEERKKRL-EEQRMK------EDKRRAAVEEKRRQKL--- 132
Cdd:pfam17380 442 EERAReMERVRLEEQERQQQVERLRQQE-EERKRKKLELEKEKRDRKRaEEQRRKilekelEERKQAMIEEERKRKLlek 520

                          90       100
                  ....*....|....*....|...
gi 1207165261 133 ---EEEKVRYEAVIRRTMERSQR 152
Cdd:pfam17380 521 emeERQKAIYEEERRREAEEERR 543
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 66-119 2.22e-04

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 42.72  E-value: 2.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1207165261  66 RQRLARER-REELDKQNAVRGSKWQEREERARQFHERQLEERKKRLEEQRMKEDK 119
Cdd:pfam09756  19 QQREAEEEeREEREKLEEKREEEYKEREEREEEAEKEKEEEERKQEEEQERKEQE 73
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 61-154 2.25e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  61 LKNDERQRLARE---RREELDKQNAVRGSKWQEREERARQFhERQLEERKKRLEEQRMKEDKRRAAVEEKR--RQKLEEE 135
Cdd:COG1196   218 LKEELKELEAELlllKLRELEAELEELEAELEELEAELEEL-EAELAELEAELEELRLELEELELELEEAQaeEYELLAE 296

                          90
                  ....*....|....*....
gi 1207165261 136 KVRYEAVIRRTMERSQRAR 154
Cdd:COG1196   297 LARLEQDIARLEERRRELE 315
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 70-149 2.43e-04

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 43.12  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  70 ARERREELDKQNAvrgskwqEREERARQfherQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEE-----EKVRYEAVIR 144
Cdd:pfam15927   1 ARLREEEEERLRA-------EEEEAERL----EEERREEEEEERLAAEQDRRAEELEELKHLLEErkealEKLRAEAREE 69


                  ....*
gi 1207165261 145 RTMER 149
Cdd:pfam15927  70 AEWER 74
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 63-159 2.82e-04

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 41.96  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  63 NDERQRLARERREELDKQnaVRGSKWQEREERARQFHERQLEERKKRLEEQRMKEDKRRAaVEEKRRQKLEEEKVRYEAV 142
Cdd:pfam15346  36 EAEVERRVEEARKIMEKQ--VLEELEREREAELEEERRKEEEERKKREELERILEENNRK-IEEAQRKEAEERLAMLEEQ 112

                          90
                  ....*....|....*..
gi 1207165261 143 IRRTMERSQRARPKSNR 159
Cdd:pfam15346 113 RRMKEERQRREKEEEER 129
PTZ00121 PTZ00121
MAEBL; Provisional
 55-153 3.06e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 3.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261   55 KPEPLMLKNDERQRLARERREElDKQNAVRGSKWQEREERARQFHE--RQLEERKKRLEEQRMKEDKRRAAVEEKRRqKL 132
Cdd:PTZ00121  1634 KVEQLKKKEAEEKKKAEELKKA-EEENKIKAAEEAKKAEEDKKKAEeaKKAEEDEKKAAEALKKEAEEAKKAEELKK-KE 1711

                           90       100
                   ....*....|....*....|.
gi 1207165261  133 EEEKVRYEAVIRRTMERSQRA 153
Cdd:PTZ00121  1712 AEEKKKAEELKKAEEENKIKA 1732
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 67-141 4.82e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.26  E-value: 4.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207165261  67 QRLARERREELDKQNAvrgskwQEREERARQFHERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRYEA 141
Cdd:PRK09510   74 AKRAEEQRKKKEQQQA------EELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAA 142
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 65-154 7.27e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 42.60  E-value: 7.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQNAVRgSKWQEREErarqfhERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRyeAVIR 144
Cdd:pfam13868 120 EKLEKQRQLREEIDEFNEEQ-AEWKELEK------EEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREI--ARLR 190

                          90
                  ....*....|
gi 1207165261 145 RTMERSQRAR 154
Cdd:pfam13868 191 AQQEKAQDEK 200
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 62-135 7.94e-04

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 41.18  E-value: 7.94e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207165261  62 KNDERQRLARERREELDKQNAVrgsKWQEREERARQFHER--QLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEE 135
Cdd:pfam09756   2 KLGAKKRAKLELKEAKRQQREA---EEEEREEREKLEEKReeEYKEREEREEEAEKEKEEEERKQEEEQERKEQEE 74
PTZ00121 PTZ00121
MAEBL; Provisional
 62-153 1.00e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 1.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261   62 KNDERQRLARERREELDKQNAVRgskwqeREERARQFHERQLEERKKRLEEQ-RMKEDKRRAAVEEKRR----QKLEEEK 136
Cdd:PTZ00121  1559 KAEEKKKAEEAKKAEEDKNMALR------KAEEAKKAEEARIEEVMKLYEEEkKMKAEEAKKAEEAKIKaeelKKAEEEK 1632

                           90
                   ....*....|....*..
gi 1207165261  137 VRYEAVIRRTMERSQRA 153
Cdd:PTZ00121  1633 KKVEQLKKKEAEEKKKA 1649
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 59-154 1.32e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  59 LMLKNDERQRLARERREELDKQNAVRGSKWQEREERAR-QFHERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKV 137
Cdd:COG1196   290 EYELLAELARLEQDIARLEERRRELEERLEELEEELAElEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLE 369

                          90
                  ....*....|....*..
gi 1207165261 138 RYEAVIRRTMERSQRAR 154
Cdd:COG1196   370 AEAELAEAEEELEELAE 386
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 67-153 1.35e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 41.75  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  67 QRLARERREELD--KQNAVRGSKWQEREERARQfhERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRYEAVIR 144
Cdd:TIGR02794  50 QQANRIQQQKKPaaKKEQERQKKLEQQAEEAEK--QRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAK 127


                  ....*....
gi 1207165261 145 RTMERSQRA 153
Cdd:TIGR02794 128 QAAEAKAKA 136
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 65-154 1.43e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQNAVRGSKWQEREERARQfHERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRYEAVIR 144
Cdd:COG1196   309 ERRRELEERLEELEEELAELEEELEELEEELEE-LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE 387

                          90
                  ....*....|
gi 1207165261 145 RTMERSQRAR 154
Cdd:COG1196   388 LLEALRAAAE 397
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 46-159 1.55e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 41.86  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  46 SPTEIHTVTK------------PEPLMLKNDERQRLARER-REELDKQNAVR-GSKWQEREERARQFHERQleERKKRLE 111
Cdd:pfam15709 298 SPTQTFVVTGnmeseeerseedPSKALLEKREQEKASRDRlRAERAEMRRLEvERKRREQEEQRRLQQEQL--ERAEKMR 375

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1207165261 112 EQRMKEDKRRAAVEEKRRQKLEEEKVRYEAVIRRTMERSQRARPKSNR 159
Cdd:pfam15709 376 EELELEQQRRFEEIRLRKQRLEEERQRQEEEERKQRLQLQAAQERARQ 423
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 65-152 2.88e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 40.25  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  65 ERQRLARERREELDKQnavrgsKWQEREERARQfHERQLEERKKRLEE------QRMKEDKRRAAVEEKR--RQKLEEEK 136
Cdd:cd16269   197 EKEIEAERAKAEAAEQ------ERKLLEEQQRE-LEQKLEDQERSYEEhlrqlkEKMEEERENLLKEQERalESKLKEQE 269

                          90
                  ....*....|....*.
gi 1207165261 137 VRYEAVIRRTMERSQR 152
Cdd:cd16269   270 ALLEEGFKEQAELLQE 285
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 60-154 3.38e-03

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 37.98  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  60 MLKNDERQRLARERREELDKQNAvrgskwQEREERARQFHERQ-LEERKKRLEEQRMKEDKRRAAVEEKRR------QKL 132
Cdd:pfam20492  22 TKKAQEELEESEETAEELEEERR------QAEEEAERLEQKRQeAEEEKERLEESAEMEAEEKEQLEAELAeaqeeiARL 95

                          90       100
                  ....*....|....*....|..
gi 1207165261 133 EEEKVRYEAVIRRTMERSQRAR 154
Cdd:pfam20492  96 EEEVERKEEEARRLQEELEEAR 117
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-154 3.50e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  62 KNDERQRLARERREELDKQNAVRGSkwQEREERARQFHERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRYEA 141
Cdd:COG1196   384 LAEELLEALRAAAELAAQLEELEEA--EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEAL 461

                          90
                  ....*....|...
gi 1207165261 142 VIRRTMERSQRAR 154
Cdd:COG1196   462 LELLAELLEEAAL 474
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 62-154 3.54e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.29  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  62 KNDERQRLARERREELDKQNAVRgskwQEREERARQFHERQLEERKKRLEEQRMKEDKRRAA-----------VEEKRRQ 130
Cdd:pfam13868 230 KARQRQELQQAREEQIELKERRL----AEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKrlehrrelekqIEEREEQ 305

                          90       100
                  ....*....|....*....|....
gi 1207165261 131 KLEEEKVRYEavIRRTMERSQRAR 154
Cdd:pfam13868 306 RAAEREEELE--EGERLREEEAER 327
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
64-135 3.78e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 40.79  E-value: 3.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207165261  64 DERQRLaRERREELDKQNAVRGSKWQEREERARQFHERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEE 135
Cdd:PRK02224  606 DEIERL-REKREALAELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREER 676
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 64-138 3.80e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.29  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  64 DERQRLARER-REELDKQNAVRGSKWQEREERA------------RQFHERQLEERKKRLEEQR---MKEDKRRAAVEEK 127
Cdd:pfam13868 247 LKERRLAEEAeREEEEFERMLRKQAEDEEIEQEeaekrrmkrlehRRELEKQIEEREEQRAAEReeeLEEGERLREEEAE 326

                          90
                  ....*....|.
gi 1207165261 128 RRQKLEEEKVR 138
Cdd:pfam13868 327 RRERIEEERQK 337
PTZ00121 PTZ00121
MAEBL; Provisional
 49-153 4.38e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 4.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261   49 EIHTVTKPEPLMLKNDERQRLARERREELDKQNAVRGSKWQEREERARQFHERQLEERKKRLEEQRMKEDKRRAAVEEKR 128
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAK 1681

                           90       100
                   ....*....|....*....|....*
gi 1207165261  129 RQklEEEKVRYEAVIRRTMERSQRA 153
Cdd:PTZ00121  1682 KA--EEDEKKAAEALKKEAEEAKKA 1704
PRK12704 PRK12704
phosphodiesterase; Provisional
 64-151 4.49e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.15  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  64 DERQRLARERREELDKqnavrgsKWQEREERarqfhERQLEERKKRLEEQRMKEDKR--RAA---VEEKRRQKLE--EEK 136
Cdd:PRK12704   99 DRKLELLEKREEELEK-------KEKELEQK-----QQELEKKEEELEELIEEQLQEleRISgltAEEAKEILLEkvEEE 166

                          90
                  ....*....|....*..
gi 1207165261 137 VRYEA--VIRRTMERSQ 151
Cdd:PRK12704  167 ARHEAavLIKEIEEEAK 183
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 62-141 4.69e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 40.17  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  62 KNDERQRLARERREELDKQNAVRGSKWQEREE---RARQFHERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVR 138
Cdd:PRK09510   77 AEEQRKKKEQQQAEELQQKQAAEQERLKQLEKerlAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRA 156


                  ...
gi 1207165261 139 YEA 141
Cdd:PRK09510  157 AAA 159
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 61-154 4.90e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 4.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  61 LKNDERQRLARERREELDKQNAVRGSKWQEREERARQFHERQL-EERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRY 139
Cdd:pfam17380 398 LEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLeEERAREMERVRLEEQERQQQVERLRQQEEERKRKKL 477

                          90
                  ....*....|....*
gi 1207165261 140 EavirrtMERSQRAR 154
Cdd:pfam17380 478 E------LEKEKRDR 486
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 62-145 5.41e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 39.83  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  62 KNDERQRLARERREELDKQNAvrgskwQEREERARQFHERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRYEA 141
Cdd:TIGR02794  65 KEQERQKKLEQQAEEAEKQRA------AEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEA 138


                  ....
gi 1207165261 142 VIRR 145
Cdd:TIGR02794 139 EAER 142
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 64-134 5.93e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 39.52  E-value: 5.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207165261  64 DERQRLARERREELDKQNAvRGSKWQeREERARQFHERQLEERKKRlEEQRMKEDKRRAAVEEKRRQKLEE 134
Cdd:pfam13868 274 EEIEQEEAEKRRMKRLEHR-RELEKQ-IEEREEQRAAEREEELEEG-ERLREEEAERRERIEEERQKKLKE 341
PTZ00121 PTZ00121
MAEBL; Provisional
 61-156 6.09e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 6.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261   61 LKNDERQRLARERR--EELDKQNAVRGSKWQEREERARQFHERQLEERKKrLEEQRMKEDKRRAAVEEKRR----QKLEE 134
Cdd:PTZ00121  1539 AKKAEEKKKADELKkaEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKK-AEEARIEEVMKLYEEEKKMKaeeaKKAEE 1617

                           90       100
                   ....*....|....*....|..
gi 1207165261  135 EKVRYEAVIRRTMERSQRARPK 156
Cdd:PTZ00121  1618 AKIKAEELKKAEEEKKKVEQLK 1639
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 64-154 6.56e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 6.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  64 DERQRLARERREELDKQNAVRGSKW----QEREERARQFHERQLEERKKRLEEQRMKEDKRRaavEEKRRQKLEEEKVRY 139
Cdd:COG1196   245 EAELEELEAELEELEAELAELEAELeelrLELEELELELEEAQAEEYELLAELARLEQDIAR---LEERRRELEERLEEL 321

                          90
                  ....*....|....*
gi 1207165261 140 EAVIRRTMERSQRAR 154
Cdd:COG1196   322 EEELAELEEELEELE 336
PTZ00121 PTZ00121
MAEBL; Provisional
 55-158 7.04e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 7.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261   55 KPEPLMLKNDERQRLARERREELDKQNAVRGSKWQEREERARQFHERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEE 134
Cdd:PTZ00121  1105 KTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKA 1184

                           90       100
                   ....*....|....*....|....*.
gi 1207165261  135 EKVRYEAVIRRTME--RSQRARPKSN 158
Cdd:PTZ00121  1185 EEVRKAEELRKAEDarKAEAARKAEE 1210
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 64-155 7.41e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 37.71  E-value: 7.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  64 DERQRLARERREELDKQNAVRgskwQEREERARQFHE-RQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRY-EA 141
Cdd:pfam05672  30 EEQERLEKEEEERLRKEELRR----RAEEERARREEEaRRLEEERRREEEERQRKAEEEAEEREQREQEEQERLQKQkEE 105

                          90
                  ....*....|....
gi 1207165261 142 VIRRTMERSQRARP 155
Cdd:pfam05672 106 AEAKAREEAERQRQ 119
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 89-154 7.97e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 39.13  E-value: 7.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207165261  89 QEREERARQfhERQLEERKKRLEEQRMKEDKRRAAVEEKRRQKLEEEKVRYEAVIRRTMERSQRAR 154
Cdd:pfam13868  26 AQIAEKKRI--KAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKR 89
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 352-479 8.03e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261 352 NLSYPTPSLSLFTPKRAPSPVGH---RSRVTNPSPNRSS-TAKPFQKTPNPKKSRSPPPPASIPLSHSNPSLSPGNLRPS 427
Cdd:pfam05109 519 NATSPTPAVTTPTPNATSPTLGKtspTSAVTTPTPNATSpTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGET 598

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207165261 428 RPTSESLRVTAEREAAKKEDVEPPKTEPEAPLTTTEPSSEASGSSPGGRPSA 479
Cdd:pfam05109 599 SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSS 650
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 71-158 8.88e-03

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 37.47  E-value: 8.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261  71 RERREELDKQNAVRgskwQEREERARQfheRQLEERKKRLEEQRmkedkrraaVEEKRRQKLEEEKVRYEAVIRRTMERS 150
Cdd:pfam15236  49 RKRQKALEHQNAIK----KQLEEKERQ---KKLEEERRRQEEQE---------EEERLRREREEEQKQFEEERRKQKEKE 112


                  ....*...
gi 1207165261 151 QRARPKSN 158
Cdd:pfam15236 113 EAMTRKTQ 120
PTZ00121 PTZ00121
MAEBL; Provisional
 62-148 9.39e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 9.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165261   62 KNDERQRLARE---RREELDKQNAVRGSKWQEREERARQFHERQLEE-------RKKRLEEQRMKEDKRRAavEEKRRQK 131
Cdd:PTZ00121  1654 KAEEENKIKAAeeaKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEakkaeelKKKEAEEKKKAEELKKA--EEENKIK 1731

                           90
                   ....*....|....*..
gi 1207165261  132 LEEEKVRYEAVIRRTME 148
Cdd:PTZ00121  1732 AEEAKKEAEEDKKKAEE 1748
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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