NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1207166556|ref|XP_021326030|]
View 

netrin-G1 isoform X1 [Danio rerio]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11079789)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
50-296 2.60e-70

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 225.15  E-value: 2.60e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556  50 CQPEAADMTKYLKVTldpPNITCG-DPPETYCTLENP---YMCNnECDAATDELAHPPELMFDIVGRNPTTFWQSTSWkk 125
Cdd:pfam00055   1 CYPAFGNLAFGREVS---ATSTCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETG-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556 126 YPKPLAVNITLSWNKTIELTDdIVITFESGRPEQMVLEKSLDYGRSWQPYQFYATDCLDAFTMEPKTMKDITQHtllDII 205
Cdd:pfam00055  75 VIQYENVNLTLDLGKEFHFTY-LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556 206 CTEEYSrGYVWKNDKTVRFEirdrfaLFAGPKLHNMAslygqlDTTKNLRDFFTITDLRIRLLRPATGATMV--DENNLS 283
Cdd:pfam00055 151 CTSEYS-DISPLTGGEVIFS------TLEGRPSANIF------DYSPELQDWLTATNIRIRLLRLHTLGDELldDPSVLR 217

                         250
                  ....*....|...
gi 1207166556 284 RYYYAISDIKVHG 296
Cdd:pfam00055 218 KYYYAISDISVGG 230
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 421-468 1.05e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.50  E-value: 1.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1207166556 421 CNCNPFGSESDRCN-GTGYCRCKEGATGAMCHECLPGYlWDNGCKSRVC 468
Cdd:cd00055     2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGY-YGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 297-343 2.41e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.96  E-value: 2.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1207166556 297 RCKCNLHANSCIY-DKEKLTCECEHNTTGPDCGRCKRNFQARAWSAGS 343
Cdd:cd00055     1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 475-499 2.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*...
gi 1207166556 475 CQNGGVCVNYV---RCQCPPAYTGLLCE 499
Cdd:cd00054    11 CQNGGTCVNTVgsyRCSCPPGYTGRNCE 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 355-413 7.41e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 34.64  E-value: 7.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207166556 355 CMANYAGPVNCECYNHSNRCSyievlnavicvsCKHNTRGQHCHLCKLGYYRNATAKPD 413
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCE------------CKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
50-296 2.60e-70

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 225.15  E-value: 2.60e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556  50 CQPEAADMTKYLKVTldpPNITCG-DPPETYCTLENP---YMCNnECDAATDELAHPPELMFDIVGRNPTTFWQSTSWkk 125
Cdd:pfam00055   1 CYPAFGNLAFGREVS---ATSTCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETG-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556 126 YPKPLAVNITLSWNKTIELTDdIVITFESGRPEQMVLEKSLDYGRSWQPYQFYATDCLDAFTMEPKTMKDITQHtllDII 205
Cdd:pfam00055  75 VIQYENVNLTLDLGKEFHFTY-LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556 206 CTEEYSrGYVWKNDKTVRFEirdrfaLFAGPKLHNMAslygqlDTTKNLRDFFTITDLRIRLLRPATGATMV--DENNLS 283
Cdd:pfam00055 151 CTSEYS-DISPLTGGEVIFS------TLEGRPSANIF------DYSPELQDWLTATNIRIRLLRLHTLGDELldDPSVLR 217

                         250
                  ....*....|...
gi 1207166556 284 RYYYAISDIKVHG 296
Cdd:pfam00055 218 KYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 71-296 2.78e-39

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 143.27  E-value: 2.78e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556   71 TCGDP-PETYCTLEnPYMCNNE----CDAATDELAHPPELMFDIVGRNPTTFWQSTSWKKYPKplAVNITLSWNKTIELT 145
Cdd:smart00136  25 TCGEPgPERYCKLV-GHTEQGKkcdyCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGPQ--NVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556  146 DdIVITFESGRPEQMVLEKSlDYGRSWQPYQFYATDCLDAFTMEPKTMkdITQHTLLDIICTEEYSRgyvwkndktvrfE 225
Cdd:smart00136 102 Y-VILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGP--ITKGNEDEVICTSEYSD------------I 165

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207166556  226 IRDRFALFAGPKLHNMASLYgQLDTTKNLRDFFTITDLRIRLLRPAT--GATMVDE-NNLSRYYYAISDIKVHG 296
Cdd:smart00136 166 VPLEGGEIAFSLLEGRPSAT-DFDNSPVLQEWVTATNIRVRLTRLRTlgDELMDDRpEVTRRYYYAISDIAVGG 238
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 421-468 1.05e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.50  E-value: 1.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1207166556 421 CNCNPFGSESDRCN-GTGYCRCKEGATGAMCHECLPGYlWDNGCKSRVC 468
Cdd:cd00055     2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGY-YGLPSQGGGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 421-468 1.17e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.12  E-value: 1.17e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1207166556 421 CNCNPFGSESDRCN-GTGYCRCKEGATGAMCHECLPGYLWDNGCKSRVC 468
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
421-457 4.58e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.54  E-value: 4.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207166556  421 CNCNPFGSESDRCN-GTGYCRCKEGATGAMCHECLPGY 457
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 297-343 2.41e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.96  E-value: 2.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1207166556 297 RCKCNLHANSCIY-DKEKLTCECEHNTTGPDCGRCKRNFQARAWSAGS 343
Cdd:cd00055     1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 298-334 1.95e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 1.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207166556 298 CKCNLHA---NSCiyDKEKLTCECEHNTTGPDCGRCKRNF 334
Cdd:pfam00053   1 CDCNPHGslsDTC--DPETGQCLCKPGVTGRHCDRCKPGY 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 475-499 2.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*...
gi 1207166556 475 CQNGGVCVNYV---RCQCPPAYTGLLCE 499
Cdd:cd00054    11 CQNGGTCVNTVgsyRCSCPPGYTGRNCE 38
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
298-334 3.45e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 35.75  E-value: 3.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207166556  298 CKCNL---HANSCiyDKEKLTCECEHNTTGPDCGRCKRNF 334
Cdd:smart00180   1 CDCDPggsASGTC--DPDTGQCECKPNVTGRRCDRCAPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 355-413 7.41e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 34.64  E-value: 7.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207166556 355 CMANYAGPVNCECYNHSNRCSyievlnavicvsCKHNTRGQHCHLCKLGYYRNATAKPD 413
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCE------------CKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
50-296 2.60e-70

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 225.15  E-value: 2.60e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556  50 CQPEAADMTKYLKVTldpPNITCG-DPPETYCTLENP---YMCNnECDAATDELAHPPELMFDIVGRNPTTFWQSTSWkk 125
Cdd:pfam00055   1 CYPAFGNLAFGREVS---ATSTCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETG-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556 126 YPKPLAVNITLSWNKTIELTDdIVITFESGRPEQMVLEKSLDYGRSWQPYQFYATDCLDAFTMEPKTMKDITQHtllDII 205
Cdd:pfam00055  75 VIQYENVNLTLDLGKEFHFTY-LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556 206 CTEEYSrGYVWKNDKTVRFEirdrfaLFAGPKLHNMAslygqlDTTKNLRDFFTITDLRIRLLRPATGATMV--DENNLS 283
Cdd:pfam00055 151 CTSEYS-DISPLTGGEVIFS------TLEGRPSANIF------DYSPELQDWLTATNIRIRLLRLHTLGDELldDPSVLR 217

                         250
                  ....*....|...
gi 1207166556 284 RYYYAISDIKVHG 296
Cdd:pfam00055 218 KYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 71-296 2.78e-39

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 143.27  E-value: 2.78e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556   71 TCGDP-PETYCTLEnPYMCNNE----CDAATDELAHPPELMFDIVGRNPTTFWQSTSWKKYPKplAVNITLSWNKTIELT 145
Cdd:smart00136  25 TCGEPgPERYCKLV-GHTEQGKkcdyCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGPQ--NVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207166556  146 DdIVITFESGRPEQMVLEKSlDYGRSWQPYQFYATDCLDAFTMEPKTMkdITQHTLLDIICTEEYSRgyvwkndktvrfE 225
Cdd:smart00136 102 Y-VILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGP--ITKGNEDEVICTSEYSD------------I 165

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207166556  226 IRDRFALFAGPKLHNMASLYgQLDTTKNLRDFFTITDLRIRLLRPAT--GATMVDE-NNLSRYYYAISDIKVHG 296
Cdd:smart00136 166 VPLEGGEIAFSLLEGRPSAT-DFDNSPVLQEWVTATNIRVRLTRLRTlgDELMDDRpEVTRRYYYAISDIAVGG 238
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 421-468 1.05e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.50  E-value: 1.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1207166556 421 CNCNPFGSESDRCN-GTGYCRCKEGATGAMCHECLPGYlWDNGCKSRVC 468
Cdd:cd00055     2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGY-YGLPSQGGGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 421-468 1.17e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.12  E-value: 1.17e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1207166556 421 CNCNPFGSESDRCN-GTGYCRCKEGATGAMCHECLPGYLWDNGCKSRVC 468
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
421-457 4.58e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.54  E-value: 4.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207166556  421 CNCNPFGSESDRCN-GTGYCRCKEGATGAMCHECLPGY 457
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 297-343 2.41e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.96  E-value: 2.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1207166556 297 RCKCNLHANSCIY-DKEKLTCECEHNTTGPDCGRCKRNFQARAWSAGS 343
Cdd:cd00055     1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 298-334 1.95e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 1.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207166556 298 CKCNLHA---NSCiyDKEKLTCECEHNTTGPDCGRCKRNF 334
Cdd:pfam00053   1 CDCNPHGslsDTC--DPETGQCLCKPGVTGRHCDRCKPGY 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 475-499 2.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*...
gi 1207166556 475 CQNGGVCVNYV---RCQCPPAYTGLLCE 499
Cdd:cd00054    11 CQNGGTCVNTVgsyRCSCPPGYTGRNCE 38
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
298-334 3.45e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 35.75  E-value: 3.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207166556  298 CKCNL---HANSCiyDKEKLTCECEHNTTGPDCGRCKRNF 334
Cdd:smart00180   1 CDCDPggsASGTC--DPDTGQCECKPNVTGRRCDRCAPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 355-413 7.41e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 34.64  E-value: 7.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207166556 355 CMANYAGPVNCECYNHSNRCSyievlnavicvsCKHNTRGQHCHLCKLGYYRNATAKPD 413
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCE------------CKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH