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Conserved domains on  [gi|1207190477|ref|XP_021328253|]
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ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X2 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 548-634 1.89e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190477  548 PEAPLMVRLSVTGSTTLTVSFQEPASMNSAVvTKYKVEWSclKDFSLLAGELILENLQSLKCTITGLTMGRQYYVQVSAY 627
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYR--EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77


                   ....*..
gi 1207190477  628 NMKGWGP 634
Cdd:cd00063     78 NGGGESP 84
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
411-474 1.04e-07

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.35  E-value: 1.04e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190477  411 NIQSSE---ALFEAVEQQDLDAVQILLfQYTADeldLNTPNSEGLTPLDISIMTNNVPIAKLLLKAG 474
Cdd:COG0666    147 NAQDNDgntPLHLAAANGNLEIVKLLL-EAGAD---VNARDNDGETPLHLAAENGHLEIVKLLLEAG 209
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 548-634 1.89e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190477  548 PEAPLMVRLSVTGSTTLTVSFQEPASMNSAVvTKYKVEWSclKDFSLLAGELILENLQSLKCTITGLTMGRQYYVQVSAY 627
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYR--EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77


                   ....*..
gi 1207190477  628 NMKGWGP 634
Cdd:cd00063     78 NGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 548-633 9.38e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 9.38e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190477   548 PEAPLMVRLSVTGSTTLTVSFQEPASMNSavvTKYKVEWSCLKDFSLLAGELILENLQSLKCTITGLTMGRQYYVQVSAY 627
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI---TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1207190477   628 NMKGWG 633
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
550-634 2.48e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 2.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190477  550 APLMVRLSVTGSTTLTVSFQEPASMNSaVVTKYKVEWSCLKDFSLLAGELILENLQSlkCTITGLTMGRQYYVQVSAYNM 629
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWNEITVPGTTTS--VTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 1207190477  630 KGWGP 634
Cdd:pfam00041   79 GGEGP 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
411-474 1.04e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.35  E-value: 1.04e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190477  411 NIQSSE---ALFEAVEQQDLDAVQILLfQYTADeldLNTPNSEGLTPLDISIMTNNVPIAKLLLKAG 474
Cdd:COG0666    147 NAQDNDgntPLHLAAANGNLEIVKLLL-EAGAD---VNARDNDGETPLHLAAENGHLEIVKLLLEAG 209
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
547-628 1.27e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.62  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190477  547 PPEAPLMVRLSVTGSTTLTVSFQEPASmnsAVVTKYKVEWSCLKDFSLlagELILENLQSLKCTITGLTMGRQYYVQVSA 626
Cdd:COG3401    326 PPAAPSGLTATAVGSSSITLSWTASSD---ADVTGYNVYRSTSGGGTY---TKIAETVTTTSYTDTGLTPGTTYYYKVTA 399


                   ..
gi 1207190477  627 YN 628
Cdd:COG3401    400 VD 401
Ank_2 pfam12796
Ankyrin repeats (3 copies);
417-474 5.03e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 5.03e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190477  417 ALFEAVEQQDLDAVQILLfqytaDELDLNtPNSEGLTPLDISIMTNNVPIAKLLLKAG 474
Cdd:pfam12796   33 ALHLAAKNGHLEIVKLLL-----EHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKG 84
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 548-634 1.89e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190477  548 PEAPLMVRLSVTGSTTLTVSFQEPASMNSAVvTKYKVEWSclKDFSLLAGELILENLQSLKCTITGLTMGRQYYVQVSAY 627
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYR--EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77


                   ....*..
gi 1207190477  628 NMKGWGP 634
Cdd:cd00063     78 NGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 548-633 9.38e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 9.38e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190477   548 PEAPLMVRLSVTGSTTLTVSFQEPASMNSavvTKYKVEWSCLKDFSLLAGELILENLQSLKCTITGLTMGRQYYVQVSAY 627
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI---TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1207190477   628 NMKGWG 633
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
550-634 2.48e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 2.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190477  550 APLMVRLSVTGSTTLTVSFQEPASMNSaVVTKYKVEWSCLKDFSLLAGELILENLQSlkCTITGLTMGRQYYVQVSAYNM 629
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWNEITVPGTTTS--VTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 1207190477  630 KGWGP 634
Cdd:pfam00041   79 GGEGP 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
411-474 1.04e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.35  E-value: 1.04e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190477  411 NIQSSE---ALFEAVEQQDLDAVQILLfQYTADeldLNTPNSEGLTPLDISIMTNNVPIAKLLLKAG 474
Cdd:COG0666    147 NAQDNDgntPLHLAAANGNLEIVKLLL-EAGAD---VNARDNDGETPLHLAAENGHLEIVKLLLEAG 209
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
411-474 5.31e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.03  E-value: 5.31e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190477  411 NIQSSEALFEAVEQQDLDAVQILLfqytADELDLNTPNSEGLTPLDISIMTNNVPIAKLLLKAG 474
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLL----EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG 143
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
417-474 2.65e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.72  E-value: 2.65e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190477  417 ALFEAVEQQDLDAVQILLfqytADELDLNTPNSEGLTPLDISIMTNNVPIAKLLLKAG 474
Cdd:COG0666    123 PLHLAAYNGNLEIVKLLL----EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG 176
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
547-628 1.27e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.62  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190477  547 PPEAPLMVRLSVTGSTTLTVSFQEPASmnsAVVTKYKVEWSCLKDFSLlagELILENLQSLKCTITGLTMGRQYYVQVSA 626
Cdd:COG3401    326 PPAAPSGLTATAVGSSSITLSWTASSD---ADVTGYNVYRSTSGGGTY---TKIAETVTTTSYTDTGLTPGTTYYYKVTA 399


                   ..
gi 1207190477  627 YN 628
Cdd:COG3401    400 VD 401
Ank_2 pfam12796
Ankyrin repeats (3 copies);
417-474 5.03e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 5.03e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190477  417 ALFEAVEQQDLDAVQILLfqytaDELDLNtPNSEGLTPLDISIMTNNVPIAKLLLKAG 474
Cdd:pfam12796   33 ALHLAAKNGHLEIVKLLL-----EHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKG 84
Ank_4 pfam13637
Ankyrin repeats (many copies);
415-471 7.50e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 7.50e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190477  415 SEALFEAVEQQDLDAVQILLfqytADELDLNTPNSEGLTPLDISIMTNNVPIAKLLL 471
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLL----EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
418-494 9.04e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.80  E-value: 9.04e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190477  418 LFEAVEQQDLDAVQILLFQytadELDLNTPNSEGLTPLDISIMTNNVPIAKLLLKaggkesphFVSLESRDAHLSAL 494
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLEN----GADANLQDKNGRTALHLAAKNGHLEIVKLLLE--------HADVNLKDNGRTAL 65
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
417-477 1.15e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 45.72  E-value: 1.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190477  417 ALFEAVEQQDLDAVQILLfQYTADeldLNTPNSEGLTPLDISIMTNNVPIAKLLLKAGGKE 477
Cdd:COG0666    189 PLHLAAENGHLEIVKLLL-EAGAD---VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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