NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1370513079|ref|XP_024303083|]
View 

putative protein N-methyltransferase FAM86B1 isoform X10 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-174 9.35e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam10294:

Pssm-ID: 473071  Cd Length: 172  Bit Score: 69.67  E-value: 9.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513079  47 RTVLELGSGAGLTGLAICKMCRPRAYIFSDpHSRVLEQLRGNVLLNGLsleaditgnldSPRVTVAQLDWDVAMVHQLSA 126
Cdd:pfam10294  48 LNVLELGSGTGLVGIAVALLLPGASVTITD-LEEALELLKKNIELNAL-----------SSKVVVKVLDWGENLPPDLFD 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370513079 127 FQP-DVVIAADVLYCPEAIVSLVGVLQRLAAcrehkRAPEVYVAFTVRN 174
Cdd:pfam10294 116 GHPvDLILAADCVYNEDSFPLLEKTLKDLLG-----KESVILVAYKKRR 159
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 47-174 9.35e-15

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 69.67  E-value: 9.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513079  47 RTVLELGSGAGLTGLAICKMCRPRAYIFSDpHSRVLEQLRGNVLLNGLsleaditgnldSPRVTVAQLDWDVAMVHQLSA 126
Cdd:pfam10294  48 LNVLELGSGTGLVGIAVALLLPGASVTITD-LEEALELLKKNIELNAL-----------SSKVVVKVLDWGENLPPDLFD 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370513079 127 FQP-DVVIAADVLYCPEAIVSLVGVLQRLAAcrehkRAPEVYVAFTVRN 174
Cdd:pfam10294 116 GHPvDLILAADCVYNEDSFPLLEKTLKDLLG-----KESVILVAYKKRR 159
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 41-101 8.49e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 39.36  E-value: 8.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370513079  41 VPFPPARTVLELGSGAGLTGLAICKMCrPRAYIFS---DPhsRVLEQLRGNVLLNGLS-----LEADIT 101
Cdd:COG4123    33 APVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGveiQP--EAAELARRNVALNGLEdritvIHGDLK 98
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 47-174 9.35e-15

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 69.67  E-value: 9.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513079  47 RTVLELGSGAGLTGLAICKMCRPRAYIFSDpHSRVLEQLRGNVLLNGLsleaditgnldSPRVTVAQLDWDVAMVHQLSA 126
Cdd:pfam10294  48 LNVLELGSGTGLVGIAVALLLPGASVTITD-LEEALELLKKNIELNAL-----------SSKVVVKVLDWGENLPPDLFD 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370513079 127 FQP-DVVIAADVLYCPEAIVSLVGVLQRLAAcrehkRAPEVYVAFTVRN 174
Cdd:pfam10294 116 GHPvDLILAADCVYNEDSFPLLEKTLKDLLG-----KESVILVAYKKRR 159
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 50-156 1.10e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 40.04  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513079  50 LELGSGAGLTGLAICKMCRPRAYIFSDPHSRVLEQLRGNVllnglsleaditgnLDSPRVTVAQLDWDVAMVHQLSAFQP 129
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERL--------------AALGLLNAVRVELFQLDLGELDPGSF 66

                          90       100
                  ....*....|....*....|....*..
gi 1370513079 130 DVVIAADVLYCPEAIVSLVGVLQRLAA 156
Cdd:pfam08242  67 DVVVASNVLHHLADPRAVLRNIRRLLK 93
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 41-101 8.49e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 39.36  E-value: 8.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370513079  41 VPFPPARTVLELGSGAGLTGLAICKMCrPRAYIFS---DPhsRVLEQLRGNVLLNGLS-----LEADIT 101
Cdd:COG4123    33 APVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGveiQP--EAAELARRNVALNGLEdritvIHGDLK 98
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 40-124 9.60e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.02  E-value: 9.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513079  40 TVPFPPARTVLELGSGAGLTGLAICKMCRPRAYIFSDPHSRVLEQLRGNVLLNGLS----LEADITGNLDSPRVTV---- 111
Cdd:COG2813    44 HLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLEnvevLWSDGLSGVPDGSFDLilsn 123

                          90
                  ....*....|....*..
gi 1370513079 112 ----AQLDWDVAMVHQL 124
Cdd:COG2813   124 ppfhAGRAVDKEVAHAL 140
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 40-116 1.02e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.73  E-value: 1.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370513079  40 TVPFPPARTVLELGSGAGLTGLAICKMCrPRAYI-FSDPHSRVLEQLRGNVLLNGLSLEADITGNLDSPrVTVAQLDW 116
Cdd:pfam05175  26 HLPKDLSGKVLDLGCGAGVLGAALAKES-PDAELtMVDINARALESARENLAANGLENGEVVASDVYSG-VEDGKFDL 101
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
45-157 1.90e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 36.73  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513079  45 PARTVLELGSGAGLTGLAICKMCRPRAYIFSDPHSRVLEQLRGNVllnglsleaditgnldsPRVTVAQLDwdvamVHQL 124
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL-----------------PNVRFVVAD-----LRDL 58

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1370513079 125 SAFQP-DVVIAADVL-YCPEaivsLVGVLQRLAAC 157
Cdd:COG4106    59 DPPEPfDLVVSNAALhWLPD----HAALLARLAAA 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH