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Conserved domains on  [gi|1370513954|ref|XP_024303203|]
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extracellular matrix protein 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-673 1.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 316 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 395
Cdd:COG4886    45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 396 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 473
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 474 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 551
Cdd:COG4886   192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 552 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 629
Cdd:COG4886   245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1370513954 630 MKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIK 673
Cdd:COG4886   321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 7.24e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 69.38  E-value: 7.24e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370513954 103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
Amnionless super family cl28792
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 116-211 1.09e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


The actual alignment was detected with superfamily member pfam14828:

Pssm-ID: 464340  Cd Length: 449  Bit Score: 45.07  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 116 WSPEPC---TTCLCSDGRVLcdETMCH--PQRCPQT-----VIPEGECCPVCSATVSysllsgiaLNDRNEFSGDSSEQR 185
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENL--ERICAnvLQRCPPPhclspLRPEGHCCDVCGAIVS--------LDYSSCFDLQTYRAR 255

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1370513954 186 eptnLLHKQLPPP-----QVGMDRIVRKEAL 211
Cdd:pfam14828 256 ----LRHLFLALPkykgvQLAVSKVGKDQRL 282
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-673 1.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 316 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 395
Cdd:COG4886    45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 396 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 473
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 474 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 551
Cdd:COG4886   192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 552 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 629
Cdd:COG4886   245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1370513954 630 MKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIK 673
Cdd:COG4886   321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
320-572 1.16e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 320 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITSSgigPKAfkLLKKLMRL 398
Cdd:PRK15370  175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSI---PAT--LPDTIQEM 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 399 NMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDlnQLVTLELEGNNLS-----------EANV--NPLAFKPLK- 464
Cdd:PRK15370  247 ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPETl 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 465 --SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESIDL 542
Cdd:PRK15370  324 ppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLDV 374

                         250       260       270
                  ....*....|....*....|....*....|
gi 1370513954 543 SYNKLYHVPSYLPKSLLHLVLLGNQIERIP 572
Cdd:PRK15370  375 SRNALTNLPENLPAALQIMQASRNNLVRLP 404
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 7.24e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 69.38  E-value: 7.24e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370513954 103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
LRR_8 pfam13855
Leucine rich repeat;
343-405 1.05e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.05e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370513954 343 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMDGNNL 405
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 2.08e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 62.53  E-value: 2.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370513954  103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 334-504 3.59e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 3.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 334 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSsgigpkafklLKKLMRLNMdgnnliqipsql 412
Cdd:cd21340    36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 413 pstLEELKVNENNLQ-----AIDEESLSDL-NQLVTLELEGNNLSEanvnplafkpLKSLAYLRlgknkfriipqglpgS 486
Cdd:cd21340    92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                         170
                  ....*....|....*...
gi 1370513954 487 IEELYLENNQIEEITEIC 504
Cdd:cd21340   144 LEQLDASNNQISDLEELL 161
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 116-211 1.09e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 45.07  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 116 WSPEPC---TTCLCSDGRVLcdETMCH--PQRCPQT-----VIPEGECCPVCSATVSysllsgiaLNDRNEFSGDSSEQR 185
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENL--ERICAnvLQRCPPPhclspLRPEGHCCDVCGAIVS--------LDYSSCFDLQTYRAR 255

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1370513954 186 eptnLLHKQLPPP-----QVGMDRIVRKEAL 211
Cdd:pfam14828 256 ----LRHLFLALPkykgvQLAVSKVGKDQRL 282
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-673 1.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 316 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 395
Cdd:COG4886    45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 396 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 473
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 474 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 551
Cdd:COG4886   192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 552 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 629
Cdd:COG4886   245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1370513954 630 MKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIK 673
Cdd:COG4886   321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
337-674 1.02e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 337 IPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTL 416
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 417 EELKvNENNLQAIDEESLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGKNKFRIIPQGLPG--SIEELYLEN 494
Cdd:COG4886    93 GDLT-NLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 495 NQIEEITEICFNHTrKINVIVLRYNKIEEnriAPLAWINQENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQIERIP 572
Cdd:COG4886   169 NQLTDLPEELGNLT-NLKELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 573 GyvFGHMePGLEYLYLSFNKLADdgmdrVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEIC 652
Cdd:COG4886   245 E--LGNL-TNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                         330       340
                  ....*....|....*....|..
gi 1370513954 653 NAEEDDDSNLEHLHLENNYIKI 674
Cdd:COG4886   317 LLLLTTLLLLLLLLKGLLVTLT 338
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
325-624 8.44e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 8.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 325 RTISCINAMLTQIPPLTA--PQITSLELTGNSIASIPDEaFNGLPNLERLDLSKNNITSsgIgPKAFKLLKKLMRLNMDG 402
Cdd:COG4886   116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTD--L-PEELGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 403 NNLIQIPSQL--PSTLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEANvnplAFKPLKSLAYLRLGKNKFRIIP 480
Cdd:COG4886   192 NQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLP 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 481 QGLP-GSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLL 559
Cdd:COG4886   267 PLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370513954 560 HLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIP 624
Cdd:COG4886   347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
372-679 2.31e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 2.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 372 LDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 451
Cdd:COG4886     4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 452 EANVNPLAFKPLKSLAYLRLGKNKfriiPQGLPGSIEELYLENNQIEEITEicfnhtrkinvivlrynkieenRIAPLaw 531
Cdd:COG4886    84 LLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPE----------------------ELANL-- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 532 inqENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQIERIPGyVFGHMePGLEYLYLSFNKLADDGMdrvSFYGAyHS 609
Cdd:COG4886   136 ---TNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNL-TNLKELDLSNNQITDLPE---PLGNL-TN 206

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 610 LRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNIlpEEICNAeedddSNLEHLHLENNyiKIREIPS 679
Cdd:COG4886   207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL--PELGNL-----TNLEELDLSNN--QLTDLPP 267
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
320-572 1.16e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 320 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITSSgigPKAfkLLKKLMRL 398
Cdd:PRK15370  175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSI---PAT--LPDTIQEM 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 399 NMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDlnQLVTLELEGNNLS-----------EANV--NPLAFKPLK- 464
Cdd:PRK15370  247 ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPETl 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 465 --SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESIDL 542
Cdd:PRK15370  324 ppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLDV 374

                         250       260       270
                  ....*....|....*....|....*....|
gi 1370513954 543 SYNKLYHVPSYLPKSLLHLVLLGNQIERIP 572
Cdd:PRK15370  375 SRNALTNLPENLPAALQIMQASRNNLVRLP 404
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 7.24e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 69.38  E-value: 7.24e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370513954 103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
314-571 8.63e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.20  E-value: 8.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 314 LRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEafngLPN-LERLDLSKNNITSSgigPKafKLL 392
Cdd:PRK15370  212 KSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPER----LPSaLQSLDLFHNKISCL---PE--NLP 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 393 KKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNqlvTLELEGNNLSEAnvnPLAFKPlkSLAYLRLG 472
Cdd:PRK15370  283 EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENALTSL---PASLPP--ELQVLDVS 354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 473 KNKFRIIPQGLPGSIEELYLENNQIEEITEicfnhtrkiNVivlrynkieenriaPLAwinqenLESIDLSYNKLyhvpS 552
Cdd:PRK15370  355 KNQITVLPETLPPTITTLDVSRNALTNLPE---------NL--------------PAA------LQIMQASRNNL----V 401

                         250
                  ....*....|....*....
gi 1370513954 553 YLPKSLLHLVLLGNQIERI 571
Cdd:PRK15370  402 RLPESLPHFRGEGPQPTRI 420
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
393-633 2.43e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 76.66  E-value: 2.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 393 KKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDLNQLvtLELEGNNLSEANVN-PLAFKPL-------- 463
Cdd:PRK15370  199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPDTIQE--MELSINRITELPERlPSALQSLdlfhnkis 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 464 -------KSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEicfnhTRKINVIVLrynKIEENRIAPLAWINQEN 536
Cdd:PRK15370  276 clpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE-----TLPPGLKTL---EAGENALTSLPASLPPE 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 537 LESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPgyvfGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLD 616
Cdd:PRK15370  348 LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLP----ENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVE 423

                         250
                  ....*....|....*..
gi 1370513954 617 HNDLKSipPGIQEMKAL 633
Cdd:PRK15370  424 YNPFSE--RTIQNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
343-405 1.05e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.05e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370513954 343 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMDGNNL 405
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 2.08e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 62.53  E-value: 2.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370513954  103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
391-651 9.76e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.10  E-value: 9.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 391 LLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEeslsdlnqlvtlELEGNnlseanvnplafkpLKSLaYLR 470
Cdd:PRK15370  176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPE------------NLQGN--------------IKTL-YAN 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 471 lgKNKFRIIPQGLPGSIEELYLENNQIEEITEicfNHTRKINVIVLRYNKieenrIAPLAWINQENLESIDLSYNKLYHV 550
Cdd:PRK15370  229 --SNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNK-----ISCLPENLPEELRYLSVYDNSIRTL 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 551 PSYLPKSLLHLVLLGNQIERIPGYvfghMEPGLEYLYLSFNKLA-------------DDGMDRVSFYGAY--HSLRELFL 615
Cdd:PRK15370  299 PAHLPSGITHLNVQSNSLTALPET----LPPGLKTLEAGENALTslpaslppelqvlDVSKNQITVLPETlpPTITTLDV 374

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1370513954 616 DHNDLKSIPPGIQemKALHFLRLNNNKIRNiLPEEI 651
Cdd:PRK15370  375 SRNALTNLPENLP--AALQIMQASRNNLVR-LPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 331-667 1.57e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 1.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 331 NAMLTQIPP--LTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITssGIGPKAFKLLKKLMRLNMDGNNLI-Q 407
Cdd:PLN00113  270 NKLSGPIPPsiFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--GKIPVALTSLPRLQVLQLWSNKFSgE 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 408 IPSQL--PSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLsEANVnPLAFKPLKSLAYLRLGKNKFRiipQGLPG 485
Cdd:PLN00113  348 IPKNLgkHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL-EGEI-PKSLGACRSLRRVRLQDNSFS---GELPS 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 486 SIEELYLennqieeiteicfnhtrkINVIVLRYNKIEeNRIAPLAWiNQENLESIDLSYNKLY-HVP-SYLPKSLLHLVL 563
Cdd:PLN00113  423 EFTKLPL------------------VYFLDISNNNLQ-GRINSRKW-DMPSLQMLSLARNKFFgGLPdSFGSKRLENLDL 482

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 564 LGNQIERIPGYVFGHMePGLEYLYLSFNKLADDGMDRVSfygAYHSLRELFLDHNDLK-SIPPGIQEMKALHFLRLNNNK 642
Cdd:PLN00113  483 SRNQFSGAVPRKLGSL-SELMQLKLSENKLSGEIPDELS---SCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQ 558

                         330       340
                  ....*....|....*....|....*
gi 1370513954 643 IRNILPEEICNAEEDDDSNLEHLHL 667
Cdd:PLN00113  559 LSGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 344-670 2.29e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNItSSGIGPKAFKLLKKLMRLNMDGNNLI-QIPSQLPSTLEELKVN 422
Cdd:PLN00113   70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLS 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 423 ENNLQAIDEESLSDLNQLVTLELEGNNLSeaNVNPLAFKPLKSLAYLRLGKNKFriiPQGLPGSIEELylennqieeite 502
Cdd:PLN00113  149 NNMLSGEIPNDIGSFSSLKVLDLGGNVLV--GKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQM------------ 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 503 icfnhtRKINVIVLRYNKIE---ENRIAPLAWINQenlesIDLSYNKLyhvPSYLPKSLLHLvllgnqieripgyvfghm 579
Cdd:PLN00113  212 ------KSLKWIYLGYNNLSgeiPYEIGGLTSLNH-----LDLVYNNL---TGPIPSSLGNL------------------ 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 580 ePGLEYLYLSFNKLADdgmdrvsfygayhslrelfldhndlkSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEeddd 659
Cdd:PLN00113  260 -KNLQYLFLYQNKLSG--------------------------PIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQ---- 308

                         330
                  ....*....|.
gi 1370513954 660 sNLEHLHLENN 670
Cdd:PLN00113  309 -NLEILHLFSN 318
LRR_8 pfam13855
Leucine rich repeat;
367-450 2.69e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 367 PNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMdgnnliqipsqlpstleelkvNENNLQAIDEESLSDLNQLVTLELE 446
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDL---------------------SNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 1370513954 447 GNNL 450
Cdd:pfam13855  58 GNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
312-572 2.85e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.56  E-value: 2.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 312 GTLRLPSGCSLSYRTISCINAMLTQIPPLtAPQITSLELTGNSIASIPDEAfnglPNLERLDLSKNNITSSGIGPKAfkl 391
Cdd:PRK15387  212 GLTTLPDCLPAHITTLVIPDNNLTSLPAL-PPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPALPSG--- 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 392 lkkLMRLNMDGNNLIQIPSqLPSTLEELKVNENNLQaideeSLSDL-NQLVTLELEGNNLSEANVNPlafkplKSLAYLR 470
Cdd:PRK15387  284 ---LCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLA-----SLPALpSELCKLWAYNNQLTSLPTLP------SGLQELS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 471 LGKNKFRIIPQgLPGSIEELYLENNQIEEITEICFNHTRKInvivlrynkIEENRIAPLAWINQEnLESIDLSYNKLYHV 550
Cdd:PRK15387  349 VSDNQLASLPT-LPSELYKLWAYNNRLTSLPALPSGLKELI---------VSGNRLTSLPVLPSE-LKELMVSGNRLTSL 417

                         250       260
                  ....*....|....*....|..
gi 1370513954 551 PsYLPKSLLHLVLLGNQIERIP 572
Cdd:PRK15387  418 P-MLPSGLLSLSVYRNQLTRLP 438
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 334-504 3.59e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 3.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 334 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSsgigpkafklLKKLMRLNMdgnnliqipsql 412
Cdd:cd21340    36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 413 pstLEELKVNENNLQ-----AIDEESLSDL-NQLVTLELEGNNLSEanvnplafkpLKSLAYLRlgknkfriipqglpgS 486
Cdd:cd21340    92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                         170
                  ....*....|....*...
gi 1370513954 487 IEELYLENNQIEEITEIC 504
Cdd:cd21340   144 LEQLDASNNQISDLEELL 161
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 343-547 8.48e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 8.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 343 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSSGIGP--KAFKLLKKLMRLNMDGNNL-----IQIPSQ 411
Cdd:COG5238   208 TTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGNQIgaegaIALAKA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 412 L--PSTLEELKVNENNLQaiDE------ESLSDLNQLVTLELEGNNLSEANVNPL--AFKPLKSLAYLRLGKNKfrIIPQ 481
Cdd:COG5238   288 LqgNTTLTSLDLSVNRIG--DEgaialaEGLQGNKTLHTLNLAYNGIGAQGAIALakALQENTTLHSLDLSDNQ--IGDE 363

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370513954 482 GLPGSIEelYLENNQieeiteicfnHTRKINvivLRYNKI-EENRIAPLAWINQENLESIDLSYNKL 547
Cdd:COG5238   364 GAIALAK--YLEGNT----------TLRELN---LGKNNIgKQGAEALIDALQTNRLHTLILDGNLI 415
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
398-679 4.94e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.32  E-value: 4.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 398 LNMDGNNLIQIPSQLPSTLEELKVNENNLQaideeSLSDL-NQLVTLELEGNNLSEANV------------NPLAFKPL- 463
Cdd:PRK15387  206 LNVGESGLTTLPDCLPAHITTLVIPDNNLT-----SLPALpPELRTLEVSGNQLTSLPVlppgllelsifsNPLTHLPAl 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 464 -KSLAYLRLGKNKFRIIPQgLPGSIEELYLENNQIEEI----TEICfnhtrkinvIVLRYNkieeNRIAPLAWInQENLE 538
Cdd:PRK15387  281 pSGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASLpalpSELC---------KLWAYN----NQLTSLPTL-PSGLQ 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 539 SIDLSYNKLYHVPSyLPKSLLHLVLLGNQIERIPGyvfghMEPGLEYLYLSFNKLaddgmdrVSFYGAYHSLRELFLDHN 618
Cdd:PRK15387  346 ELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPA-----LPSGLKELIVSGNRL-------TSLPVLPSELKELMVSGN 412

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370513954 619 DLKSIPPGIQEMKALHFLRlnNNKIRniLPEEICNAEEDDDSNLEHLHLENNYIK-IREIPS 679
Cdd:PRK15387  413 RLTSLPMLPSGLLSLSVYR--NQLTR--LPESLIHLSSETTVNLEGNPLSERTLQaLREITS 470
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
316-455 1.63e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 316 LPSGCSlsyrTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAfngLPNLERLDLSKNNITssgIGPKAfkLLKKL 395
Cdd:PRK15370  302 LPSGIT----HLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQIT---VLPET--LPPTI 369

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370513954 396 MRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDE---ESLSDLNQLVTLELEGNNLSEANV 455
Cdd:PRK15370  370 TTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPEslpHFRGEGPQPTRIIVEYNPFSERTI 432
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 334-673 2.01e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.03  E-value: 2.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 334 LTQIPPLTAPQITSLEltGNSIASIPDEAFNGLPNLERldlSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQlp 413
Cdd:COG5238    15 LLSANPATTEQSELTK--RATIVNLRSYHLHGGAILLA---RYLQSRSSITQYLRFEGQGDPGLNPVALEKAAEAFPT-- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 414 stlEELKVNENNLQAIDEESLSDLNQLVT-----LELEGNNLSEANVNPLA-----------FKPLKSLAYLRLGKNKFR 477
Cdd:COG5238    88 ---QLLVVDWEGAEEVSPVALAETATAVAtpppdLRRIMAKTLEDSLILYLalprrinliqvLKDPLGGNAVHLLGLAAR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 478 I--------IPQGLPGSIEELYLENNQIEE--ITEICfNHTRK---INVIVLRYNKIEENRIAPLAWINQEN--LESIDL 542
Cdd:COG5238   165 LgllaaismAKALQNNSVETVYLGCNQIGDegIEELA-EALTQnttVTTLWLKRNPIGDEGAEILAEALKGNksLTTLDL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 543 SYNK-----LYHVPSYL--PKSLLHLVLLGNQIEripgyvfghmEPGLEYL--YLSFNKladdgmdrvsfygayhSLREL 613
Cdd:COG5238   244 SNNQigdegVIALAEALknNTTVETLYLSGNQIG----------AEGAIALakALQGNT----------------TLTSL 297

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370513954 614 FLDHNDL-----KSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEdDDSNLEHLHLENNYIK 673
Cdd:COG5238   298 DLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQ-ENTTLHSLDLSDNQIG 361
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 490-672 8.84e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 8.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 490 LYLENNQIEEITEicFNHTRKINVIVLRYNKIEenRIaplawinqENLESIdlsynklyhvpsylpKSLLHLVLLGNQIE 569
Cdd:cd21340     7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT--KI--------ENLEFL---------------TNLTHLYLQNNQIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 570 RIPGyvFGHMePGLEYLYLSFNKLAddgmdRVSFYGAYHSLRELFLDHNDLksiPPGiQEM-----------KALHFLRL 638
Cdd:cd21340    60 KIEN--LENL-VNLKKLYLGGNRIS-----VVEGLENLTNLEELHIENQRL---PPG-EKLtfdprslaalsNSLRVLNI 127

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1370513954 639 NNNKIRNILPEEICnaeedddSNLEHLHLENNYI 672
Cdd:cd21340   128 SGNNIDSLEPLAPL-------RNLEQLDASNNQI 154
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
316-458 3.28e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.55  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 316 LPSGcslsYRTISCINAMLTQIPPLTApQITSLELTGNSIASIPdeafnGLPN-LERLDLSKNNITSSGIGPKAfklLKK 394
Cdd:PRK15387  340 LPSG----LQELSVSDNQLASLPTLPS-ELYKLWAYNNRLTSLP-----ALPSgLKELIVSGNRLTSLPVLPSE---LKE 406

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370513954 395 LMrlnMDGNNLIQIPsQLPSTLEELKVNENNLQAIdEESLSDLNQLVTLELEGNNLSEANVNPL 458
Cdd:PRK15387  407 LM---VSGNRLTSLP-MLPSGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPLSERTLQAL 465
LRR_8 pfam13855
Leucine rich repeat;
536-593 4.71e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370513954 536 NLESIDLSYNKLYHVPSYLPKSLLHLVLL---GNQIERIPGYVFGHMePGLEYLYLSFNKL 593
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLdlsNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
414-476 5.90e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370513954 414 STLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEanVNPLAFKPLKSLAYLRLGKNKF 476
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
557-620 7.54e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 7.54e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370513954 557 SLLHLVLLGNQIERIPGYVFGHMePGLEYLYLSFNKLadDGMDRVSFYGaYHSLRELFLDHNDL 620
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLL--TTLSPGAFSG-LPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 318-547 7.68e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 7.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 318 SGCSLSYRTISCINAMLTQIPPLTapqitSLELTGNSIASIPD------EAFNGLPNLERLDLSKNNITSSGIGPkaFKL 391
Cdd:cd00116    31 EGNTLGEEAAKALASALRPQPSLK-----ELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGV--LES 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 392 LkklmrlnmdgnnliqipsQLPSTLEELKVNENNLQ----AIDEESLSDLN-QLVTLELEGNNLSEANVNPLA--FKPLK 464
Cdd:cd00116   104 L------------------LRSSSLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAkaLRANR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 465 SLAYLRLGKNK-----FRIIPQGLPGS--IEELYLENNQIEE----ITEICFNHTRKINVIVLRYNKIEENRIAPLAWIN 533
Cdd:cd00116   166 DLKELNLANNGigdagIRALAEGLKANcnLEVLDLNNNGLTDegasALAETLASLKSLEVLNLGDNNLTDAGAAALASAL 245

                         250
                  ....*....|....*..
gi 1370513954 534 QEN---LESIDLSYNKL 547
Cdd:cd00116   246 LSPnisLLTLSLSCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 492-694 7.88e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 7.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 492 LENNQIEEITEICFNHTRKINVIVlrynkieenRIAPLAWINQENLESIDLSYNKLYH-----VPSYLPKSLL-HLVL-- 563
Cdd:cd00116    47 LRPQPSLKELCLSLNETGRIPRGL---------QSLLQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLqELKLnn 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 564 --LGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVS-FYGAYHSLRELFLDHNDLKsiPPGI----QEMKA---L 633
Cdd:cd00116   118 ngLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAkALRANRDLKELNLANNGIG--DAGIralaEGLKAncnL 195

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370513954 634 HFLRLNNNKIRNILPEEICNAEEDDDSnLEHLHLENNyiKIREIPSYTFSCIRSYSSIVLK 694
Cdd:cd00116   196 EVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDN--NLTDAGAAALASALLSPNISLL 253
LRR_8 pfam13855
Leucine rich repeat;
581-643 2.81e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.81e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370513954 581 PGLEYLYLSFNKLadDGMDRVSFYGAyHSLRELFLDHNDLKSIPPG-IQEMKALHFLRLNNNKI 643
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 342-645 4.61e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 342 APQITSLELTGNSI-----ASIPDEAFNGLPNLERLDLSKNNITSSGIgpkafKLLKKLMRLNmdgnnliqipsqlpSTL 416
Cdd:COG5238   150 PLGGNAVHLLGLAArlgllAAISMAKALQNNSVETVYLGCNQIGDEGI-----EELAEALTQN--------------TTV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 417 EELKVNENNlqaIDEES-------LSDLNQLVTLELEGNNLSEANVNPLAfkplkslAYLRLGKNkfriipqglpgsIEE 489
Cdd:COG5238   211 TTLWLKRNP---IGDEGaeilaeaLKGNKSLTTLDLSNNQIGDEGVIALA-------EALKNNTT------------VET 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 490 LYLENNQIEEITEICFNHTRKINvIVLRYNKIEENRIAPLAWIN-----QEN--LESIDLSYNKLyhvpsylpksllhlv 562
Cdd:COG5238   269 LYLSGNQIGAEGAIALAKALQGN-TTLTSLDLSVNRIGDEGAIAlaeglQGNktLHTLNLAYNGI--------------- 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 563 llGNQ-IERIPGYVFGHmePGLEYLYLSFNKLADDGMDRVSFYGAYH-SLRELFLDHNDL-----KSIPPGIQEMKaLHF 635
Cdd:COG5238   333 --GAQgAIALAKALQEN--TTLHSLDLSDNQIGDEGAIALAKYLEGNtTLRELNLGKNNIgkqgaEALIDALQTNR-LHT 407

                         330
                  ....*....|
gi 1370513954 636 LRLNNNKIRN 645
Cdd:COG5238   408 LILDGNLIGA 417
LRR_8 pfam13855
Leucine rich repeat;
486-547 4.78e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370513954 486 SIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIeeNRIAPLAWINQENLESIDLSYNKL 547
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 116-211 1.09e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 45.07  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 116 WSPEPC---TTCLCSDGRVLcdETMCH--PQRCPQT-----VIPEGECCPVCSATVSysllsgiaLNDRNEFSGDSSEQR 185
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENL--ERICAnvLQRCPPPhclspLRPEGHCCDVCGAIVS--------LDYSSCFDLQTYRAR 255

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1370513954 186 eptnLLHKQLPPP-----QVGMDRIVRKEAL 211
Cdd:pfam14828 256 ----LRHLFLALPkykgvQLAVSKVGKDQRL 282
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 342-476 1.92e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 342 APQITSLELTGNSIASIPDE----AFNGLPNLERLDLSKNNITSSGIGP--KAFKLLKKLMRLNMDGNN--------LIQ 407
Cdd:cd00116   136 PPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEVLDLNNNGltdegasaLAE 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370513954 408 IPSQLPStLEELKVNENNL-----QAIDEESLSDLNQLVTLELEGNNLSEANVNPLA--FKPLKSLAYLRLGKNKF 476
Cdd:cd00116   216 TLASLKS-LEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAevLAEKESLLELDLRGNKF 290
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
103-143 2.16e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 39.85  E-value: 2.16e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1370513954  103 CLVKGITMYNKAVWSpEPCTTCLCSDGRVLCDETMCHPQRC 143
Cdd:smart00215   1 CWNNGSYYPPGAKWD-DDCNRCTCLNGRVSCTKVWCGPKPC 40
LRR_8 pfam13855
Leucine rich repeat;
609-672 4.07e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370513954 609 SLRELFLDHNDLKSIPPGI-QEMKALHFLRLNNNKIRNILPEEIcnaeeDDDSNLEHLHLENNYI 672
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAF-----SGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 463-676 1.35e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 463 LKSLAYLRL-GKNKFRIIPQGLPGSIEELYLENNQIEEITEicFNHTRKINVIVLRYNKIEenRIaplawinqENLESId 541
Cdd:cd21340     1 LKRITHLYLnDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIE--KI--------ENLENL- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 542 lsynklyhvpsylpKSLLHLVLLGNQIERIPGyvfghME--PGLEYLYLSFNKLADDGM---DRVSFYGAYHSLRELFLD 616
Cdd:cd21340    68 --------------VNLKKLYLGGNRISVVEG-----LEnlTNLEELHIENQRLPPGEKltfDPRSLAALSNSLRVLNIS 128

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370513954 617 HNDLKSIPPgIQEMKALHFLRLNNNKIRNIlpEEICNAEEdDDSNLEHLHLENNYI----KIRE 676
Cdd:cd21340   129 GNNIDSLEP-LAPLRNLEQLDASNNQISDL--EELLDLLS-SWPSLRELDLTGNPVckkpKYRD 188
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 416-643 1.60e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 416 LEELKVNENNLqaiDEESLSDL-------NQLVTLELEGNNLSEANVN----PLAFKPLKSLAYLRLGKNKFRIIPQGL- 483
Cdd:cd00116    25 LQVLRLEGNTL---GEEAAKALasalrpqPSLKELCLSLNETGRIPRGlqslLQGLTKGCGLQELDLSDNALGPDGCGVl 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 484 -----PGSIEELYLENNQIEE-----ITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQEN--LESIDLSYNKLYH-- 549
Cdd:cd00116   102 esllrSSSLQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANrdLKELNLANNGIGDag 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 550 VPSYLP-----KSLLHLVLLGNQIERIPGYVFGHM---EPGLEYLYLSFNKLADDGMDRV--SFYGAYHSLRELFLDHND 619
Cdd:cd00116   182 IRALAEglkanCNLEVLDLNNNGLTDEGASALAETlasLKSLEVLNLGDNNLTDAGAAALasALLSPNISLLTLSLSCND 261

                         250       260
                  ....*....|....*....|....*....
gi 1370513954 620 L-----KSIPPGIQEMKALHFLRLNNNKI 643
Cdd:cd00116   262 ItddgaKDLAEVLAEKESLLELDLRGNKF 290
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 343-420 1.82e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 343 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSSGigpkAFKLLK-----KLMRLNMDGNNL-IQIPSQL 412
Cdd:COG5238   348 TTLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQG----AEALIDalqtnRLHTLILDGNLIgAEAQQRL 423


                  ....*...
gi 1370513954 413 PSTLEELK 420
Cdd:COG5238   424 EQLLERIK 431
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 343-382 1.91e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1370513954 343 PQITSLELTGNSIASIPdeAFNGLPNLERLDLSKNNITSS 382
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 361-453 2.81e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 361 EAFNGLPNLERLDLSKNNITSSGIG--PKAFKLLKKLMRLNMDGNNLIQIP-----SQLPS---TLEELKVNENNLQAID 430
Cdd:cd00116   187 EGLKANCNLEVLDLNNNGLTDEGASalAETLASLKSLEVLNLGDNNLTDAGaaalaSALLSpniSLLTLSLSCNDITDDG 266

                          90       100
                  ....*....|....*....|....*..
gi 1370513954 431 EESL----SDLNQLVTLELEGNNLSEA 453
Cdd:cd00116   267 AKDLaevlAEKESLLELDLRGNKFGEE 293
PLN03150 PLN03150
hypothetical protein; Provisional
 347-416 3.81e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513954 347 SLELTGNSIASIPDEAFNGLPNLERLDLSKNNItsSGIGPKAFKLLKKLMRLNMDGNNLiqiPSQLPSTL 416
Cdd:PLN03150  446 SINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF--NGSIPESLGQLTSLRILNLNGNSL---SGRVPAAL 510
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 367-414 6.24e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 6.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1370513954 367 PNLERLDLSKNNITSSGigpkAFKLLKKLMRLNMDGNNLIQIPSQLPS 414
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP----PLAKLPNLETLDLSGNNKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 609-646 9.54e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 9.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1370513954 609 SLRELFLDHNDLKSIPPgIQEMKALHFLRL-NNNKIRNI 646
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP-LAKLPNLETLDLsGNNKITDL 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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