protein CC2D2B isoform X4 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| CC2D2AN-C2 | pfam15625 | CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ... |
427-594 | 3.84e-63 | ||||
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL). : Pssm-ID: 464780 Cd Length: 174 Bit Score: 212.64 E-value: 3.84e-63
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| DUF5523 super family | cl39200 | Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ... |
22-224 | 8.59e-46 | ||||
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families. The actual alignment was detected with superfamily member pfam17661: Pssm-ID: 465443 Cd Length: 255 Bit Score: 165.91 E-value: 8.59e-46
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| C2 super family | cl14603 | C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ... |
857-902 | 2.64e-04 | ||||
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. The actual alignment was detected with superfamily member cd04018: Pssm-ID: 472691 [Multi-domain] Cd Length: 151 Bit Score: 42.62 E-value: 2.64e-04
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| Name | Accession | Description | Interval | E-value | ||||
| CC2D2AN-C2 | pfam15625 | CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ... |
427-594 | 3.84e-63 | ||||
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL). Pssm-ID: 464780 Cd Length: 174 Bit Score: 212.64 E-value: 3.84e-63
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| DUF5523 | pfam17661 | Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ... |
22-224 | 8.59e-46 | ||||
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families. Pssm-ID: 465443 Cd Length: 255 Bit Score: 165.91 E-value: 8.59e-46
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| C2C_Ferlin | cd04018 | C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and ... |
857-902 | 2.64e-04 | ||||
C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and other proteins, such as Synaptotagmins, are implicated in facilitating the fusion process when cell membranes fuse together. There are six known human Ferlins: Dysferlin (Fer1L1), Otoferlin (Fer1L2), Myoferlin (Fer1L3), Fer1L4, Fer1L5, and Fer1L6. Defects in these genes can lead to a wide range of diseases including muscular dystrophy (dysferlin), deafness (otoferlin), and infertility (fer-1, fertilization factor-1). Structurally they have 6 tandem C2 domains, designated as (C2A-C2F) and a single C-terminal transmembrane domain, though there is a new study that disputes this and claims that there are actually 7 tandem C2 domains with another C2 domain inserted between C2D and C2E. In a subset of them (Dysferlin, Myoferlin, and Fer1) there is an additional conserved domain called DysF. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology. Pssm-ID: 175985 [Multi-domain] Cd Length: 151 Bit Score: 42.62 E-value: 2.64e-04
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| Name | Accession | Description | Interval | E-value | ||||
| CC2D2AN-C2 | pfam15625 | CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ... |
427-594 | 3.84e-63 | ||||
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL). Pssm-ID: 464780 Cd Length: 174 Bit Score: 212.64 E-value: 3.84e-63
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| DUF5523 | pfam17661 | Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ... |
22-224 | 8.59e-46 | ||||
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families. Pssm-ID: 465443 Cd Length: 255 Bit Score: 165.91 E-value: 8.59e-46
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| C2C_Ferlin | cd04018 | C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and ... |
857-902 | 2.64e-04 | ||||
C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and other proteins, such as Synaptotagmins, are implicated in facilitating the fusion process when cell membranes fuse together. There are six known human Ferlins: Dysferlin (Fer1L1), Otoferlin (Fer1L2), Myoferlin (Fer1L3), Fer1L4, Fer1L5, and Fer1L6. Defects in these genes can lead to a wide range of diseases including muscular dystrophy (dysferlin), deafness (otoferlin), and infertility (fer-1, fertilization factor-1). Structurally they have 6 tandem C2 domains, designated as (C2A-C2F) and a single C-terminal transmembrane domain, though there is a new study that disputes this and claims that there are actually 7 tandem C2 domains with another C2 domain inserted between C2D and C2E. In a subset of them (Dysferlin, Myoferlin, and Fer1) there is an additional conserved domain called DysF. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology. Pssm-ID: 175985 [Multi-domain] Cd Length: 151 Bit Score: 42.62 E-value: 2.64e-04
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