Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277  295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157      1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80

                   ....*.
gi 1370459277  375 GEGFSP 380
Cdd:cd17157     81 GEGFSP 86

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277 1032 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 1111
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277 1112 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 1191
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64

                          170       180
                   ....*....|....*....|....*
gi 1370459277 1192 RSGMEVVLVEKKSDGSHQRWIHQED 1216
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED 89

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370459277  730 AAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 774
Cdd:cd23454     60 IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277  295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157      1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80

                   ....*.
gi 1370459277  375 GEGFSP 380
Cdd:cd17157     81 GEGFSP 86

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277 1032 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 1111
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277 1112 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 1191
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64

                          170       180
                   ....*....|....*....|....*
gi 1370459277 1192 RSGMEVVLVEKKSDGSHQRWIHQED 1216
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED 89

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1370459277  547 GLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYG 580
Cdd:cd17072     38 NLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370459277  730 AAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 774
Cdd:cd23454     60 IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277  295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157      1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80

                   ....*.
gi 1370459277  375 GEGFSP 380
Cdd:cd17157     81 GEGFSP 86

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459277  936 VRLRVLQNGEKNKNRSVTILGPDIS-PGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCG 1005
Cdd:cd17072      1 VRLRVLKNGERDLERAVYVVGPDLElQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459277  174 IKVTAYKNGSR--TVFARVTVP--TITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTG 240
Cdd:cd17072      1 VRLRVLKNGERdlERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459277  174 IKVTAYKNGSRTVFARVTVPTIT-LLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLNP 246
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVGEFqLFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRDQLVYVSCGEAWIDP 74

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459277  174 IKVTAYKNGSRTVFARVTV--PTITLLLEECTEKLNLNMAARRVFLADGKEALePEDIPHEADVYVSTGEPFL 244
Cdd:cd17158      1 VKILAYKNGEGRLRDGVLIigSTFPGLLDQCTHRLGLARAARRLYTADGTLIL-TLILRYPIEVWVSCGEPFI 72

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459277  936 VRLRVLQNGEKNKNRSVTILGPDIsPGRKTQCTEILNLPSAARRLYNEKGKEIFALkDLQRDELVYVSCGELWI 1009
Cdd:cd17158      1 VKILAYKNGEGRLRDGVLIIGSTF-PGLLDQCTHRLGLARAARRLYTADGTLILTL-ILRYPIEVWVSCGEPFI 72

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277  295 VRILFFKNGMG--QDGHEITVGkeTMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDIskvpllekCLQNSITplrglLWV 372
Cdd:cd17158      1 VKILAYKNGEGrlRDGVLIIGS--TFPGLLDQCTHRLGLARAARRLYTADGTLILTL--------ILRYPIE-----VWV 65

                   ....*...
gi 1370459277  373 SKGEGFSP 380
Cdd:cd17158     66 SCGEPFIP 73

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277  937 RLRVLQNGEkNKNRSVTILGPDISPGRKTqCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGE 1006
Cdd:cd17159      2 RVLVYPNGG-SPERAVYAWGKSIEELLDS-CTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGE 69

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459277  174 IKVTAYKNGSR----TVFA--RVTVPTITLLLEECTEKLNLNM-AARRVFLADGKEALEPEDIPHEADVYVS 238
Cdd:cd01617      1 KRITVFRNGDKnfkgVKVLvkPRRFRTFDQLLDELTEKLGLPTgGVRKLYTPSGKLVKSLSDLEDGESYVVC 72

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459277   170 QPRVIKVTAYKNG------SRTVFARVTVPTITLLLEECTE--KLNLNMAARRVFLADGKEALEPEDIpHEADVYVSTGE 241
Cdd:smart00537    2 LVKPKRIRFYRNGdrffkgVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTSLDEL-EDGGSYVASGT 80

                            90
                    ....*....|.
gi 1370459277   242 pflNPFKKIKD 252
Cdd:smart00537   81 ---EAFKKVDY 88

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370459277  730 AAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 774
Cdd:cd23454     60 IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106