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Conserved domains on  [gi|1370460446|ref|XP_024304495|]
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large neutral amino acids transporter small subunit 3 isoform X4 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 1905563)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FucP super family cl43255
Fucose permease [Carbohydrate transport and metabolism];
1-165 1.85e-04

Fucose permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0738:

Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.69  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   1 MLNLGFTIGSFVLSattLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFG-GICLTFTS 79
Cdd:COG0738    47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446  80 LTLPNMFGNLRSTLMALMIGSYASSAITFPGI--KLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYT 157
Cdd:COG0738   119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLggLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198


                  ....*...
gi 1370460446 158 KKIKLSGL 165
Cdd:COG0738   199 SAASLKSL 206
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-165 1.85e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.69  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   1 MLNLGFTIGSFVLSattLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFG-GICLTFTS 79
Cdd:COG0738    47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446  80 LTLPNMFGNLRSTLMALMIGSYASSAITFPGI--KLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYT 157
Cdd:COG0738   119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLggLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198


                  ....*...
gi 1370460446 158 KKIKLSGL 165
Cdd:COG0738   199 SAASLKSL 206
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 6-145 3.26e-04

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 43.01  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   6 FTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALA-SRDVEALS-PLIFLALSLNGFGGICLTFTSLTLP 83
Cdd:cd17354    43 LSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVvTGLISDLSfWLMCLCFFLIGNSTSSLYTAALVTC 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370460446  84 N-MFGNLRSTLMALMIGSYA-SSAITFPGIKLIYDAGVAFVVIMFTWsglacLIFLNCTLNWPI 145
Cdd:cd17354   123 AkNFPESRGLAIGIPKGCYGlSGAIGSQLYKALFFHDSARVFLFLAV-----LPAVVGLLAWFS 181
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-165 1.85e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.69  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   1 MLNLGFTIGSFVLSattLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFG-GICLTFTS 79
Cdd:COG0738    47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446  80 LTLPNMFGNLRSTLMALMIGSYASSAITFPGI--KLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYT 157
Cdd:COG0738   119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLggLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198


                  ....*...
gi 1370460446 158 KKIKLSGL 165
Cdd:COG0738   199 SAASLKSL 206
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
4-137 2.60e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   4 LGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASrdveALSPLIFLALsLNGFGGICLTFTSLTLP 83
Cdd:COG2223    44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV----SYWLLLLLGL-LLGIGGGGSFAVGIALV 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370460446  84 NMF--GNLRSTLMALMIGSY--ASSAITFPGIKLIYDAGVAFVviMFTWSGLACLIFL 137
Cdd:COG2223   119 SKWfpPDRRGLALGLAAGGGnlGAAVAAFLAPLLIAAFGWRNA--FLILGILLLVVAV 174
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 6-145 3.26e-04

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 43.01  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   6 FTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALA-SRDVEALS-PLIFLALSLNGFGGICLTFTSLTLP 83
Cdd:cd17354    43 LSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVvTGLISDLSfWLMCLCFFLIGNSTSSLYTAALVTC 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370460446  84 N-MFGNLRSTLMALMIGSYA-SSAITFPGIKLIYDAGVAFVVIMFTWsglacLIFLNCTLNWPI 145
Cdd:cd17354   123 AkNFPESRGLAIGIPKGCYGlSGAIGSQLYKALFFHDSARVFLFLAV-----LPAVVGLLAWFS 181
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 7-72 1.03e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.45  E-value: 1.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370460446   7 TIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFGG 72
Cdd:cd17475    38 SALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS-----YPVLLVLLFLVGAGY 98
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
4-128 1.09e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   4 LGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASrdvealSPLIFLAL-SLNGFG-GICLTFTSLT 81
Cdd:COG2271    49 LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT------SFWQLLLLrFLLGLGeAGFFPAALKL 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370460446  82 LPNMF-GNLRSTLMALMIGSYASSAITFPGIkliydagVAFVVIMFTW 128
Cdd:COG2271   123 IAEWFpPKERGRALGIFNAGGPLGGALAPPL-------LGWLLAAFGW 163
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 4-73 1.59e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 40.67  E-value: 1.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   4 LGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSlnGFGGI 73
Cdd:cd17353    42 LAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAIS-----LPLLFLGYG--VLGGI 104
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 4-109 1.68e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 40.72  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   4 LGFTIGsFVLSATTLPL-GILMDRFGPRPVRLVGSACFTASCTLMALASrdveALSPLIFLALSLNGFGGICLTF--TSL 80
Cdd:cd17355    42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT----SLWQLYLLWGLLGGGGAGTLAAvaFAT 116

                          90       100
                  ....*....|....*....|....*....
gi 1370460446  81 TLPNMFGNLRSTLMALMIGSYASSAITFP 109
Cdd:cd17355   117 VAAWWFERRRGLALGILTAGGGLGSLVFL 145
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 2-129 4.58e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.23  E-value: 4.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   2 LNLGFTIGSFvlsattlPLGILMDRFGPRPVRLVGSACFTASCTLMALASrdveaLSPLIFLALSLNGFG-GICLTFTSL 80
Cdd:cd17333    40 QNAGYLIGSL-------LAGFLMKRLGRRRTLILGLLLISLALALIFATP-----SIYLFVVLMFLAGLGaGILDTGANT 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370460446  81 TLPNMFGNLRSTLMALMIGSYASSAITFPGIkliydaGVAFVVIMFTWS 129
Cdd:cd17333   108 FVGALFEESSATRLNVLHGFFGLGALIGPLI------ATSLLTSELSWS 150
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-167 5.40e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.95  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   1 MLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALAsrdveALSPLIFLALSLNGFGGICLTFTSL 80
Cdd:cd06174    32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-----PSFWLLLLGRFLLGLGSGLIDPAVL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446  81 TL------PNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGV-AFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEE 153
Cdd:cd06174   107 ALiadlfpERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWrAVFLIAAALALLAAILLLLVVPDPPESARAKNEE 186

                         170
                  ....*....|....
gi 1370460446 154 VNYTKKIKLSGLAL 167
Cdd:cd06174   187 ASSKSVLKLLKRVL 200
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
4-101 6.88e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370460446   4 LGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLP 83
Cdd:COG2814   247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                          90
                  ....*....|....*...
gi 1370460446  84 nmfGNLRSTLMALMIGSY 101
Cdd:COG2814   327 ---PEARGRASGLYNSAF 341
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 4-71 9.84e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.31  E-value: 9.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370460446   4 LGFTIGSFVLSATTlplGILMDRFGPRPVRLVGSACFTASCTLMALASRDveALSPLIFLALSLNGFG 71
Cdd:cd17321   211 LPLALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLALLGAD--SSVWLLLPGLVLLGLG 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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