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Conserved domains on  [gi|1370464145|ref|XP_024305183|]
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intraflagellar transport protein 88 homolog isoform X21 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
208-350 2.23e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 72.35  E-value: 2.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTYQVIVKnkMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVnkqmrIKIMQNI 287
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYEKALE--LDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD-----AEALNNL 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370464145 288 GVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMKKAFQKLitvpLEIDED 350
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDPdDAEALYNLGLALLELGRYDEAIEAYERA----LELDPD 142
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
208-350 2.23e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 72.35  E-value: 2.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTYQVIVKnkMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVnkqmrIKIMQNI 287
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYEKALE--LDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD-----AEALNNL 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370464145 288 GVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMKKAFQKLitvpLEIDED 350
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDPdDAEALYNLGLALLELGRYDEAIEAYERA----LELDPD 142
TPR_12 pfam13424
Tetratricopeptide repeat;
243-313 2.30e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 45.07  E-value: 2.30e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370464145 243 ILKMNMGNIYLKQRNYSKAIKFYRMALD---QVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPN 313
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEiarRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
SNAP cd15832
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 238-339 2.77e-05

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


Pssm-ID: 276937 [Multi-domain]  Cd Length: 278  Bit Score: 45.26  E-value: 2.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 238 FSNAGILKMNMGNIYLKQR-NYSKAIKFYRMA-----LDQVPSVNKQMRIKIMQnigvTFIQAGQYSDAINSYEHI--MS 309
Cdd:cd15832   107 FRQAAKHLKEIAELYENELgDLDKAIEAYEQAadyyeGEGANSLANKCYLKVAD----LAAQLEDYDKAIEIYEQVarSS 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1370464145 310 MAPNL----------KAGynltICYFAIGDREKMKKAFQK 339
Cdd:cd15832   183 LENNLlkysakdyflKAG----LCHLAAGDVVAAQRALEK 218
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 247-274 3.81e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.51  E-value: 3.81e-05
                           10        20
                   ....*....|....*....|....*...
gi 1370464145  247 NMGNIYLKQRNYSKAIKFYRMALDQVPS 274
Cdd:smart00028   6 NLGNAYLKLGDYDEALEYYEKALELDPN 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 208-342 2.57e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTYQVIVKnKMFSNAGILKmNMGNIYLKQRNySKAIKFYRMALDQVPSVNKqmrikIMQNI 287
Cdd:TIGR02917 772 LRTALAELYLAQKDYDKAIKHYQTVVK-KAPDNAVVLN-NLAWLYLELKD-PRALEYAERALKLAPNIPA-----ILDTL 843

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370464145 288 GVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMKKAFQKLIT 342
Cdd:TIGR02917 844 GWLLVEKGEADRALPLLRKAVNIAPeAAAIRYHLALALLATGRKAEARKELDKLLN 899
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
208-350 2.23e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 72.35  E-value: 2.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTYQVIVKnkMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVnkqmrIKIMQNI 287
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYEKALE--LDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD-----AEALNNL 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370464145 288 GVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMKKAFQKLitvpLEIDED 350
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDPdDAEALYNLGLALLELGRYDEAIEAYERA----LELDPD 142
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 207-341 1.80e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.44  E-value: 1.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 207 SVLFNLASQYSVNEMYAEALNTYQVIVKNKMfSNAGILKMnMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQN 286
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELDP-DNPEAFAL-LGEILLQLGDLDEAIVLLHEALELDPD-----EPEARLN 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370464145 287 IGVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMKKAFQKLI 341
Cdd:COG4783    78 LGLALLKAGDYDEALALLEKALKLDPeHPEAYLRLARAYRALGRPDEAIAALEKAL 133
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
208-341 2.69e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.18  E-value: 2.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTY-QVIVKNkmFSNAGILkMNMGNIYLKQRNYSKAIKFYRMALDQVPSVnkqmrIKIMQN 286
Cdd:COG0457    44 ALYNLGLAYLRLGRYEEALADYeQALELD--PDDAEAL-NNLGLALQALGRYEEALEDYDKALELDPDD-----AEALYN 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370464145 287 IGVTFIQAGQYSDAINSYEHIMSMAPNL-KAGYNLTICYFAIGDREKMKKAFQKLI 341
Cdd:COG0457   116 LGLALLELGRYDEAIEAYERALELDPDDaDALYNLGIALEKLGRYEEALELLEKLE 171
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 156-340 8.63e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.56  E-value: 8.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 156 ELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVT-TPENinldltYSVLFNLASQYSVNEMYAEALNTYQVIVK 234
Cdd:COG3914    67 AAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAlNPDN------AEALFNLGNLLLALGRLEEALAALRRALA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 235 NKMfSNAGILkMNMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAP-N 313
Cdd:COG3914   141 LNP-DFAEAY-LNLGEALRRLGRLEEAIAALRRALELDPD-----NAEALNNLGNALQDLGRLEEAIAAYRRALELDPdN 213

                         170       180
                  ....*....|....*....|....*..
gi 1370464145 314 LKAGYNLTICYFAIGDREKMKKAFQKL 340
Cdd:COG3914   214 ADAHSNLLFALRQACDWEVYDRFEELL 240
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 246-341 8.86e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.17  E-value: 8.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 246 MNMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICY 324
Cdd:COG4235    21 LLLGRAYLRLGRYDEALAAYEKALRLDPD-----NADALLDLAEALLAAGDTEEAEELLERALALDPdNPEALYLLGLAA 95

                          90
                  ....*....|....*..
gi 1370464145 325 FAIGDREKMKKAFQKLI 341
Cdd:COG4235    96 FQQGDYAEAIAAWQKLL 112
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 210-343 1.26e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.59  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 210 FNLASQYSVNEMYAEALNTYQVIVKNKmfSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNIGV 289
Cdd:COG2956    12 YFKGLNYLLNGQPDKAIDLLEEALELD--PETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD-----RAEALLELAQ 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370464145 290 TFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMKKAFQKLITV 343
Cdd:COG2956    85 DYLKAGLLDRAEELLEKLLELDPdDAEALRLLAEIYEQEGDWEKAIEVLERLLKL 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 205-343 3.22e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.43  E-value: 3.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 205 TYSVLFNLASQYSVNEMYAEALNTYQVIVKNKmfSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIM 284
Cdd:COG2956    41 TVEAHLALGNLYRRRGEYDRAIRIHQKLLERD--PDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPD-----DAEAL 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 285 QNIGVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMKKAFQKLITV 343
Cdd:COG2956   114 RLLAEIYEQEGDWEKAIEVLERLLKLGPeNAHAYCELAELYLEQGDYDEAIEALEKALKL 173
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 208-341 1.04e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.89  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTY-QVIVKNKMFSNAgilKMNMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQN 286
Cdd:COG2956   146 AYCELAELYLEQGDYDEAIEALeKALKLDPDCARA---LLLLAELYLEQGDYEEAIAALERALEQDPD-----YLPALPR 217

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370464145 287 IGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLI 341
Cdd:COG2956   218 LAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQL 272
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 208-341 1.18e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAgiLKMNMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNI 287
Cdd:COG2956    78 ALLELAQDYLKAGLLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPE-----NAHAYCEL 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370464145 288 GVTFIQAGQYSDAINSYEHIMSMAPN-LKAGYNLTICYFAIGDREKMKKAFQKLI 341
Cdd:COG2956   151 AELYLEQGDYDEAIEALEKALKLDPDcARALLLLAELYLEQGDYEEAIAALERAL 205
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 252-341 1.84e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 51.92  E-value: 1.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 252 YLKQRNYSKAIKFYRMALDQVPsvNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPN----LKAGYNLTICYFAI 327
Cdd:COG1729     3 LLKAGDYDEAIAAFKAFLKRYP--NSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDspkaPDALLKLGLSYLEL 80

                          90
                  ....*....|....
gi 1370464145 328 GDREKMKKAFQKLI 341
Cdd:COG1729    81 GDYDKARATLEELI 94
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 250-341 4.63e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.27  E-value: 4.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 250 NIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIG 328
Cdd:COG5010    62 NLYNKLGDFEESLALLEQALQLDPN-----NPELYYNLALLYSRSGDKDEAKEYYEKALALSPdNPNAYSNLAALLLSLG 136

                          90
                  ....*....|...
gi 1370464145 329 DREKMKKAFQKLI 341
Cdd:COG5010   137 QDDEAKAALQRAL 149
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
251-341 8.11e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 8.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 251 IYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNIGVTFIQAGQYSDAInSYEHIMSMAP-NLKAGYNLTICYFAIGD 329
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPD-----NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPnNAEALLNLAELLLELGD 74

                          90
                  ....*....|..
gi 1370464145 330 REKMKKAFQKLI 341
Cdd:COG3063    75 YDEALAYLERAL 86
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 208-313 8.36e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 8.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTYQVIVKnkMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNI 287
Cdd:COG4783    40 AFALLGEILLQLGDLDEAIVLLHEALE--LDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPE-----HPEAYLRL 112

                          90       100
                  ....*....|....*....|....*.
gi 1370464145 288 GVTFIQAGQYSDAINSYEHIMSMAPN 313
Cdd:COG4783   113 ARAYRALGRPDEAIAALEKALELDPD 138
TPR_12 pfam13424
Tetratricopeptide repeat;
243-313 2.30e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 45.07  E-value: 2.30e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370464145 243 ILKMNMGNIYLKQRNYSKAIKFYRMALD---QVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPN 313
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEiarRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 249-341 2.83e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.22  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 249 GNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAI 327
Cdd:COG3914    85 ALLLQALGRYEEALALYRRALALNPD-----NAEALFNLGNLLLALGRLEEALAALRRALALNPdFAEAYLNLGEALRRL 159

                          90
                  ....*....|....
gi 1370464145 328 GDREKMKKAFQKLI 341
Cdd:COG3914   160 GRLEEAIAALRRAL 173
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 169-312 5.51e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.11  E-value: 5.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 169 DLKLALEKAKDAGRKERVLVRQREQVTTPENINLDLTYSVLFNLAsqYSVNEMYAEALNTYQVIVKnkMFSNAGILKMNM 248
Cdd:COG5010    19 KLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNL--YNKLGDFEESLALLEQALQ--LDPNNPELYYNL 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370464145 249 GNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAP 312
Cdd:COG5010    95 ALLYSRSGDKDEAKEYYEKALALSPD-----NPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
SNAP pfam14938
Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are ...
 238-329 2.42e-05

Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.


Pssm-ID: 405606 [Multi-domain]  Cd Length: 273  Bit Score: 45.64  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 238 FSNAGILKMNMGNIYLKQR-NYSKAIKFYRMALD-----QVPSVNKQMRIKIMQnigvTFIQAGQYSDAINSYEHI--MS 309
Cdd:pfam14938 102 FRRAAKHKKEIAELYEQELgDLEKAIEAYEQAADwyegeGASALANKCYLKVAD----LSAELEDYPKAIEIYEKVakNS 177

                          90       100       110
                  ....*....|....*....|....*....|
gi 1370464145 310 MAPNL----------KAGynltICYFAIGD 329
Cdd:pfam14938 178 LENNLlkysvkeyflKAG----LCHLAAGD 203
SNAP cd15832
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 238-339 2.77e-05

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


Pssm-ID: 276937 [Multi-domain]  Cd Length: 278  Bit Score: 45.26  E-value: 2.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 238 FSNAGILKMNMGNIYLKQR-NYSKAIKFYRMA-----LDQVPSVNKQMRIKIMQnigvTFIQAGQYSDAINSYEHI--MS 309
Cdd:cd15832   107 FRQAAKHLKEIAELYENELgDLDKAIEAYEQAadyyeGEGANSLANKCYLKVAD----LAAQLEDYDKAIEIYEQVarSS 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1370464145 310 MAPNL----------KAGynltICYFAIGDREKMKKAFQK 339
Cdd:cd15832   183 LENNLlkysakdyflKAG----LCHLAAGDVVAAQRALEK 218
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 247-274 3.81e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.51  E-value: 3.81e-05
                           10        20
                   ....*....|....*....|....*...
gi 1370464145  247 NMGNIYLKQRNYSKAIKFYRMALDQVPS 274
Cdd:smart00028   6 NLGNAYLKLGDYDEALEYYEKALELDPN 33
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 209-313 5.93e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.30  E-value: 5.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 209 LFNLASQYSVNEMYAEALNTYQVIVKNKmFSNAGILkMNMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNIG 288
Cdd:COG4235    20 WLLLGRAYLRLGRYDEALAAYEKALRLD-PDNADAL-LDLAEALLAAGDTEEAEELLERALALDPD-----NPEALYLLG 92

                          90       100
                  ....*....|....*....|....*
gi 1370464145 289 VTFIQAGQYSDAINSYEHIMSMAPN 313
Cdd:COG4235    93 LAAFQQGDYAEAIAAWQKLLALLPA 117
TPR_1 pfam00515
Tetratricopeptide repeat;
246-274 6.85e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.71  E-value: 6.85e-05
                          10        20
                  ....*....|....*....|....*....
gi 1370464145 246 MNMGNIYLKQRNYSKAIKFYRMALDQVPS 274
Cdd:pfam00515   5 YNLGNAYFKLGKYDEALEYYEKALELNPN 33
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 222-313 1.53e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 40.75  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 222 YAEALNTYQVIVKN----KMFSNAgilKMNMGNIYLKQRNYSKAIKFYRMALDQVPsvNKQMRIKIMQNIGVTFIQAGQY 297
Cdd:COG1729     9 YDEAIAAFKAFLKRypnsPLAPDA---LYWLGEAYYALGDYDEAAEAFEKLLKRYP--DSPKAPDALLKLGLSYLELGDY 83

                          90
                  ....*....|....*.
gi 1370464145 298 SDAINSYEHIMSMAPN 313
Cdd:COG1729    84 DKARATLEELIKKYPD 99
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 208-339 1.88e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.44  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTYQVIVKnkMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSvnkqmRIKIMQNI 287
Cdd:COG3914   148 AYLNLGEALRRLGRLEEAIAALRRALE--LDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPD-----NADAHSNL 220

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370464145 288 GVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQK 339
Cdd:COG3914   221 LFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAELLALARA 272
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 208-342 2.57e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464145 208 VLFNLASQYSVNEMYAEALNTYQVIVKnKMFSNAGILKmNMGNIYLKQRNySKAIKFYRMALDQVPSVNKqmrikIMQNI 287
Cdd:TIGR02917 772 LRTALAELYLAQKDYDKAIKHYQTVVK-KAPDNAVVLN-NLAWLYLELKD-PRALEYAERALKLAPNIPA-----ILDTL 843

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370464145 288 GVTFIQAGQYSDAINSYEHIMSMAP-NLKAGYNLTICYFAIGDREKMKKAFQKLIT 342
Cdd:TIGR02917 844 GWLLVEKGEADRALPLLRKAVNIAPeAAAIRYHLALALLATGRKAEARKELDKLLN 899
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 203-274 3.07e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 3.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370464145 203 DLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSN-AGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPS 274
Cdd:COG1729    27 PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkAPDALLKLGLSYLELGDYDKARATLEELIKKYPD 99
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 246-273 3.29e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 34.81  E-value: 3.29e-03
                          10        20
                  ....*....|....*....|....*...
gi 1370464145 246 MNMGNIYLKQRNYSKAIKFYRMALDQVP 273
Cdd:pfam07719   5 YNLGLAYYKLGDYEEALEAYEKALELDP 32
TPR_7 pfam13176
Tetratricopeptide repeat;
247-270 5.59e-03

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 34.44  E-value: 5.59e-03
                          10        20
                  ....*....|....*....|....
gi 1370464145 247 NMGNIYLKQRNYSKAIKFYRMALD 270
Cdd:pfam13176   4 NLGRIYRKLGDYDEAISLYEQALA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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