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Conserved domains on  [gi|1370464251|ref|XP_024305204|]
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zinc finger MYM-type protein 5 isoform X5 [Homo sapiens]

Protein Classification

heavy metal translocating P-type ATPase( domain architecture ID 10654490)

heavy metal translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRASH smart00746
metallochaperone-like domain;
271-307 9.95e-06

metallochaperone-like domain;


:

Pssm-ID: 214799  Cd Length: 39  Bit Score: 41.98  E-value: 9.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370464251  271 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKR 307
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
 
Name Accession Description Interval E-value
TRASH smart00746
metallochaperone-like domain;
271-307 9.95e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 41.98  E-value: 9.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370464251  271 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKR 307
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 268-303 2.42e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 40.82  E-value: 2.42e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1370464251 268 KITCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 303
Cdd:pfam06467   3 KATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
TRASH smart00746
metallochaperone-like domain;
271-307 9.95e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 41.98  E-value: 9.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370464251  271 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKR 307
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 268-303 2.42e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 40.82  E-value: 2.42e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1370464251 268 KITCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 303
Cdd:pfam06467   3 KATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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