NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1370465484|ref|XP_024305464|]
View 

G-protein coupled receptor 135 isoform X1 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
120-398 9.80e-137

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15212:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 285  Bit Score: 395.68  E-value: 9.80e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15212    17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLFGDR-------LCLANGFFNACFGIVST 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSV 279
Cdd:cd15212    90 LTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGFYHCLYVLHSGPSRLGAAYSS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 280 GLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQa 359
Cdd:cd15212   170 VLIVLCYLLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAAAGG- 248
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 360 qtMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLL 398
Cdd:cd15212   249 --YQFPPLMDTVAIWMAWANGAINPLIYAIRNPNISMLL 285
 
Name Accession Description Interval E-value
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
120-398 9.80e-137

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 395.68  E-value: 9.80e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15212    17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLFGDR-------LCLANGFFNACFGIVST 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSV 279
Cdd:cd15212    90 LTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGFYHCLYVLHSGPSRLGAAYSS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 280 GLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQa 359
Cdd:cd15212   170 VLIVLCYLLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAAAGG- 248
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 360 qtMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLL 398
Cdd:cd15212   249 --YQFPPLMDTVAIWMAWANGAINPLIYAIRNPNISMLL 285
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
120-387 1.80e-33

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 127.03  E-value: 1.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLN----------HGDWpfgSALCKIVGALFVVNGY 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWeLLGAPRELAAAQSFHGCLYRTsPDPAQLG 274
Cdd:pfam00001  71 ASILLLTAISIDRYLAIVHPLRYKrrRTPRRAKVLILVIWVLALLLSLPP-LLFGWTLTVPEGNVTVCFIDF-PEDLSKP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:pfam00001 149 VSYTLLISVLGFLLPLLVILVCYTLIIRTLR------KSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLD 222
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1370465484 355 AARQAQTMQAP-SLLSVVAVWLTWANGAINPVIY 387
Cdd:pfam00001 223 SLALDCELSRLlDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
197-388 4.80e-03

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 38.99  E-value: 4.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRP----PREKIGRRRALQLLagAWLTALGFSLPWELlgapreLAAAQSFHGCLYRT---SPD 269
Cdd:PHA03087  124 NSMNFITVMSVDRYIAIVHPvksnKINTVKYGYIVSLV--IWIISIIETTPILF------VYTTKKDHETLICCmfyNNK 195
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLrffsevrtattvLIMIVFVIcCWGPYCF 349
Cdd:PHA03087  196 TMNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKSKKNKKAIKLVL------------IIVILFVI-FWLPFNV 262
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 350 LVLLAAARQAQ------TMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:PHA03087  263 SVFVYSLHILHfksgckAVKYIQYALHVTEIISLSHCCINPLIYA 307
 
Name Accession Description Interval E-value
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
120-398 9.80e-137

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 395.68  E-value: 9.80e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15212    17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLFGDR-------LCLANGFFNACFGIVST 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSV 279
Cdd:cd15212    90 LTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGFYHCLYVLHSGPSRLGAAYSS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 280 GLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQa 359
Cdd:cd15212   170 VLIVLCYLLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAAAGG- 248
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 360 qtMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLL 398
Cdd:cd15212   249 --YQFPPLMDTVAIWMAWANGAINPLIYAIRNPNISMLL 285
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
120-391 1.38e-46

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 163.23  E-value: 1.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSApaaaagpwRGFCAASRFFSSCFGIVST 199
Cdd:cd00637    15 GNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFG--------DALCKLLGFLQSVSLLASI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPWeLLGAPRElaaaQSFHGCLYRTSPDPAQLGAAF 277
Cdd:cd00637    87 LTLTAISVDRYLAIVHPlrYRRRFTRRRAKLLIALIWLLSLLLALPP-LLGWGVY----DYGGYCCCCLCWPDLTLSKAY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPV-NTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAA 356
Cdd:cd00637   162 TIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSsSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVF 241
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1370465484 357 RQAQTmQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd00637   242 GPDPS-PLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
120-387 1.80e-33

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 127.03  E-value: 1.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLN----------HGDWpfgSALCKIVGALFVVNGY 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWeLLGAPRELAAAQSFHGCLYRTsPDPAQLG 274
Cdd:pfam00001  71 ASILLLTAISIDRYLAIVHPLRYKrrRTPRRAKVLILVIWVLALLLSLPP-LLFGWTLTVPEGNVTVCFIDF-PEDLSKP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:pfam00001 149 VSYTLLISVLGFLLPLLVILVCYTLIIRTLR------KSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLD 222
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1370465484 355 AARQAQTMQAP-SLLSVVAVWLTWANGAINPVIY 387
Cdd:pfam00001 223 SLALDCELSRLlDKALSVTLWLAYVNSCLNPIIY 256
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
120-394 1.93e-31

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 121.52  E-value: 1.93e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPW---RGFCAASRFFSSCFGI 196
Cdd:cd14967    16 GNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLL-----------GYWpfgPVLCRFWIALDVLCCT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTALGFSLPWELLGAPRElaaAQSFHGCLYRTSPDPaqlg 274
Cdd:cd14967    85 ASILNLCAISLDRYLAITRPLryRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDET---QPSVVDCECEFTPNK---- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 aAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpvntyarvlrffSEVRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:cd14967   158 -IYVLVSSVISFFIPLLIMIVLYARIFRVAR-------------------RELKAAKTLAIIVGAFLLCWLPFFIIYLVS 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370465484 355 AARQAQTMqaPSLLSVVAVWLTWANGAINPVIYAIRNPNI 394
Cdd:cd14967   218 AFCPPDCV--PPILYAVFFWLGYLNSALNPIIYALFNRDF 255
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
120-391 1.27e-27

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 111.91  E-value: 1.27e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgfCAASRFFSSCFGIVST 199
Cdd:cd14969    17 LNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPG--------CVIYGFAVTFLGLVSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPR-EKIGRRRALQLLAGAWLTALGFSLPwELLG----APrELaaaqSFHGC---LYRTSPDpa 271
Cdd:cd14969    89 STLAALAFERYLVIVRPLKaFRLSKRRALILIAFIWLYGLFWALP-PLFGwssyVP-EG----GGTSCsvdWYSKDPN-- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 qlGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVR-VRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFL 350
Cdd:cd14969   161 --SLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRaARRKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVV 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1370465484 351 VLLAAARQAQT-----MQAPSLLS-VVAVWltwangaiNPVIYAIRN 391
Cdd:cd14969   239 SLYVSFGGESTippllATIPALFAkSSTIY--------NPIIYVFMN 277
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
120-393 7.46e-27

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 110.00  E-value: 7.46e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPWRG---FCAASRFFSSCFGI 196
Cdd:cd14993    17 GNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVY-----------RPWVFgevLCKAVPYLQGVSVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPW----ELLGAPRELAAAQSFHGClyRTSPDP 270
Cdd:cd14993    86 ASVLTLVAISIDRYLAICYPlkARRVSTKRRARIIIVAIWVIAIIIMLPLlvvyELEEIISSEPGTITIYIC--TEDWPS 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTV----RLSDVRVRPVNTYARVLRffSEVRTATTVLIMIVFVICCWGP 346
Cdd:cd14993   164 PELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLwrrkPPGDRGSANSTSSRRILR--SKKKVARMLIVVVVLFALSWLP 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 347 Y----CFLVLLAAARQAQTMQAPSLLSvVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd14993   242 YyvlsILLDFGPLSSEESDENFLLILP-FAQLLGYSNSAINPIIYCFMSKK 291
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
120-394 4.28e-24

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 101.91  E-value: 4.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPW---RGFCaasRFFSSCFGI 196
Cdd:cd15203    17 GNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLT-----------KNWpfgSILC---KLVPSLQGV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 ---VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPwellgapreLAAAQSFHGCLYRTSP----- 268
Cdd:cd15203    83 sifVSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLP---------LAIFQELSDVPIEILPycgyf 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 -----DPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTV--RLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFV- 340
Cdd:cd15203   154 cteswPSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLrkRVKKKRGKRTLSSRRRRSELRRKRRTNRLLIAMVVVf 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 341 ICCWGPYCFLVLLAA--ARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNI 394
Cdd:cd15203   234 AVCWLPLNLFNLLRDfePLPQIDGRHFYLIFLICHLIAMSSACVNPLLYGWLNDNF 289
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
120-390 3.33e-22

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 95.89  E-value: 3.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAaaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15213    17 GNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDI--------FCRISAMLYWFFVLEGV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRpPREKIGRRRALQLLAGAWLTALGFSLP----WELLGAPRElaAAQsfhgCLYRTSPDPAQLga 275
Cdd:cd15213    89 AILLIISVDRYLIIVQ-RQDKLNPHRAKILIAVSWVLSFCVSFPplvgWGKYEFPPR--APQ----CVLGYTESPADR-- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpvntyarvlRFfsEVRTATTVLIMIVFVICCWGPYCFLVLLAA 355
Cdd:cd15213   160 IYVVLLLVAVFFIPFLIMLYSYFCILNTVR----------------SF--KTRAFTTILILFIGFSVCWLPYTVYSLLSV 221
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1370465484 356 ARQAQTMQAPslLSVVAVWLTWANGAINPVIYAIR 390
Cdd:cd15213   222 FSRYSSSFYV--ISTCLLWLSYLKSAFNPVIYCWR 254
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
120-394 1.92e-21

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 94.23  E-value: 1.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLD-LFTppggsapaaaagPWR---GFCAASRFfsscfg 195
Cdd:cd15207    17 GNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDnILT------------GWPfgdVMCKLSPL------ 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 iVSTLSVAL-------ISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELL--GAPRELAAAQSFHGClyrT 266
Cdd:cd15207    79 -VQGVSVAAsvftlvaIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVleVKEYQFFRGQTVHIC---V 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 267 SPDPAQLG-AAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRV---RPVNTYARVLRFFSEVrtaTTVLIMIVFV-I 341
Cdd:cd15207   155 EFWPSDEYrKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGggsASREAQAAVSKKKVRV---IKMLIVVVVLfA 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 342 CCWGPYCFLVLLA-----AARQAQTMQA---PsllsvVAVWLTWANGAINPVIYAIRNPNI 394
Cdd:cd15207   232 LSWLPLHTVTMLDdfgnlSPNQREVLYVyiyP-----IAHWLAYFNSCVNPIVYGYFNRNF 287
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
120-393 4.17e-21

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 93.34  E-value: 4.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15202    17 GNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAV-----------NNTWifgLFMCHFSNFAQYCSVH 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTS-PDPAQLG- 274
Cdd:cd15202    86 VSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDwPERADLFw 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVrvrPVNtyARVLRFFSEVRTATTVLIMIVFVIC----CWGPYCFL 350
Cdd:cd15202   166 KYYDLALFILQYFLPLLVISFAYARVGIKLWASNM---PGD--ATTERYFALRRKKKKVIKMLMVVVVlfalCWLPFNIY 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 351 VLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15202   241 VLLLSSKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNER 283
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
120-392 1.47e-19

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 89.01  E-value: 1.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSC---FGI 196
Cdd:cd15336    17 GNALVIYAFCRSKKLRTPANYFIINLAV-----------SDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCgalFGI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPwELLG----APRELAAAQSFHgclYRTsPDP 270
Cdd:cd15336    86 TSMITLLAISLDRYLVITKPLAsiRWVSKKRAMIIILLVWLYSLAWSLP-PLFGwsayVPEGLLTSCTWD---YMT-FTP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQlgAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYAR------VLRFFSEVRTATTVLIMIVFVICCW 344
Cdd:cd15336   161 SV--RAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVQKLGSQDRkekakqYQRMKNEWKMAKIAFVVILLFVLSW 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1370465484 345 GPYCFLVLLAAARQAQTMqAPSLLSVVAVwLTWANGAINPVIYAIRNP 392
Cdd:cd15336   239 SPYACVALIAWAGYAHLL-TPYMKSVPAV-IAKASAIYNPIIYAITHP 284
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
120-392 7.64e-19

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 86.86  E-value: 7.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDLF--TPPGGSAPAAAAGPWRG---FCAASRFFSSCF 194
Cdd:cd15079    17 GNGLVIYIFSTTKSLRTPSNMLV--------------VNLAISDFLmmIKMPIFIYNSFYEGWALgplGCQIYAFLGSLS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 195 GIVSTLSVALISLDRYCAIVRP-PREKIGRRRALQLLAGAWLTALGFSLPWELLG----APRELAAAQSFHGcLYRTSPD 269
Cdd:cd15079    83 GIGSIWTNAAIAYDRYNVIVKPlNGNPLTRGKALLLILFIWLYALPWALLPLLFGwgryVPEGFLTSCSFDY-LTRDWNT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PAQLGAAFsvglvVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFS---------EVRTATTVLIMIVFV 340
Cdd:cd15079   162 RSFVATIF-----VFAYVIPLIIIIYCYSFIVKAVFAHEKALREQAKKMNVVSLRSnadankqsaEIRIAKVALTNVFLW 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370465484 341 ICCWGPYCFLVLLAAA--RQAQTmqaPsLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15079   237 FIAWTPYAVVALIGAFgnQSLLT---P-LVSMIPALFAKTAACYNPIVYAISHP 286
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
120-387 1.02e-18

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 86.19  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDL----FTPPGGSAPAAAAGPWRG--FCAASRFFSSC 193
Cdd:cd15390    17 GNLIVIWIVLAHKRMRTVTNYFL--------------VNLAVADLlisaFNTVFNFTYLLYNDWPFGlfYCKFSNFVAIT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPwELLGAPRELAAAQSFHG---CLYRTSPDP 270
Cdd:cd15390    83 TVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALP-QLLYSTTETYYYYTGSErtvCFIAWPDGP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 -AQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVR-------LSDVRVRPVNTYARVLRFFsevrtattVLIMIVFVIc 342
Cdd:cd15390   162 nSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWgsktigeNTPRQLESVRAKRKVVKMM--------IVVVVIFAI- 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 343 CWGPYCFLVLLAAARQAQTMQAPSLLSVVAV-WLTWANGAINPVIY 387
Cdd:cd15390   233 CWLPYHLYFILTYLYPDINSWKYIQQIYLAIyWLAMSNSMYNPIIY 278
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
189-392 1.12e-18

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 86.22  E-value: 1.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 189 FFSSCFGIVSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPwELLGAPRELaaAQSFH-GCLYR 265
Cdd:cd15337    79 FAGGIFGFMSITTLAAISIDRYLVIAKPLEamKKMTFKRAFIMIIIIWLWSLLWSIP-PFFGWGRYV--PEGFQtSCTFD 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 266 -TSPDPAQLgaAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSD-------VRVRPVNTYARVLRFFSEVRTATTVLIMI 337
Cdd:cd15337   156 yLSRDLNNR--LFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEkemtqtaKSGMGKDTEKNDARKKAEIRIAKVAIILI 233
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 338 VFVICCWGPYCFLVLLAAARQAQTMQapSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15337   234 SLFLLSWTPYAVVALLGQFGPAYWIT--PYVSELPVMFAKASAIYNPIIYALSHP 286
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
120-396 3.29e-18

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 85.02  E-value: 3.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAfLDLFTppggsapaAAAGPWR---GFCAASRFFSSCFGI 196
Cdd:cd15204    17 GNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFE-MDYYV--------VRQRSWThgdVLCAVVNYLRTVSLY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQS-FHGCLYrtSPDPAQLGA 275
Cdd:cd15204    88 VSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQGKiFCGQIW--PVDQQAYYK 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCH----YHICKtvrlsdvRVRPVNTYARVLRFFSEVRTATTVLIMIVFV-ICCWGPYcfl 350
Cdd:cd15204   166 AYYLFLFVLEFVLPVLIMTLCYlrivRKVWF-------RRVPGQQTEQIRRRLRRRRRKVRLLVVILTAfVLCWAPY--- 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 351 VLLAAARQ-AQTMQAPSLLSVVAVW----LTWANGAINPVIYAIRNPNISM 396
Cdd:cd15204   236 YGYAIVRDfFPTLLSKEKLNTTIFYiveaLAMSNSMINTVVYVAFNNNIRK 286
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
120-392 5.15e-18

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 84.31  E-value: 5.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15083    17 GNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSF-----------SGRWifgKTGCDMYGFSGGLFGI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPwELLG----APRELAAAQSFHgclYrTSPDP 270
Cdd:cd15083    86 MSINTLAAIAVDRYLVITRPmkASVRISHRRALIVIAVVWLYSLLWVLP-PLFGwsryVLEGLLTSCSFD---Y-LSRDD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQlgAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTY-------ARVLRFFSEVRTATTVLIMIVFVICC 343
Cdd:cd15083   161 AN--RSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRfskselsSPKARRQAEVKTAKIALLLVLLFCLA 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1370465484 344 WGPYCFLVLLAAARQAQTMqaPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15083   239 WTPYAVVALIGQFGYLEVL--TPLATAIPAAFAKTSAIYNPVIYAFSHP 285
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
120-388 7.31e-17

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 80.59  E-value: 7.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldlFTPPGGSAPAAAAGPWrgFCAASRFFSSCFGIVST 199
Cdd:cd14971    17 GNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVP------FTATIYPLPGWVFGDF--MCKFVHYFQQVSMHASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLGAPRELAAAQsfHGCLYRTSPDPAqLGAAF 277
Cdd:cd14971    89 FTLVAMSLDRFLAVVYPLRSLHIRtpRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGN--RTVCSEAWPSRA-HRRAF 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRffsevRTATTVLIMIVFVICCWGPYCFLVLLAAAR 357
Cdd:cd14971   166 ALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKR-----KVTRLVLVVVVLFAACWGPIHAILLLVALG 240
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1370465484 358 QAQTMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd14971   241 PFPLTYATYALRIWAHCLAYSNSAVNPVLYA 271
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
189-391 7.45e-17

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 80.55  E-value: 7.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 189 FFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGR-RRALQLLAGAWLTALGFSLPwELLGAPRELAAAQSFHGCLYRTS 267
Cdd:cd15086    78 FANSLFGIVSLISLAVLSYERYCTLLRPTEADVSDyRKAWLGVGGSWLYSLLWTLP-PLLGWSSYGPEGPGTTCSVQWTS 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 268 PDPAQLgaAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvRVRPVNTYARVLRffsEVRTATTVLIMIVFVICCWGPY 347
Cdd:cd15086   157 RSANSI--SYIICLFIFCLLLPFLVMVYCYGRLLYAIK----QVGKINKSTARKR---EQHVLLMVVTMVICYLLCWLPY 227
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1370465484 348 CFLVLLAaarqaqTMQAPSLL----SVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15086   228 GVMALLA------TFGKPGLVtpvaSIVPSILAKSSTVVNPIIYVFMN 269
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
193-395 2.20e-16

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 79.73  E-value: 2.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 193 CFGIV-STLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELaaAQSFHGClYRTSPDPA 271
Cdd:cd14986    81 VVGLFaSTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLVIFVEREL--GDGVHQC-WSSFYTPW 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAAFSVGLVVAcYLLPFLLMCFCHYHICKTV-------------------RLSDVRVRPVNTYARvlrffSEVRTATT 332
Cdd:cd14986   158 QRKVYITWLATYV-FVIPLIILSYCYGRILRTIwirsrqktdrpiaptamscRSVSCVSSRVSLISR-----AKIKTIKM 231
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370465484 333 VLIMIVFVICCWGPYcFLVLLAAARQAQTmQAPSLLSVVAVWLTWANGAINPVIYAIRNPNIS 395
Cdd:cd14986   232 TLVIILAFILCWTPY-FIVQLLDVYAGMQ-QLENDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
120-388 2.59e-16

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 79.40  E-value: 2.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLR-TVTNAFILSLSLSDLLTALLCLP-AAFLDLftppggsapaaaAGPWR--GFCAASRFFSSCFG 195
Cdd:cd15057    17 GNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPwAAVNEV------------AGYWPfgSFCDVWVSFDIMCS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 IVSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPWELLGAPRelAAAQSFHGCLYRTSPD-PAQ 272
Cdd:cd15057    85 TASILNLCVISVDRYWAISSPFRyeRRMTRRRAFIMIAVAWTLSALISFIPVQLGWHR--ADDTSEALALYADPCQcDSS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdVRVRPVNTYARVL------------RFFSEVRTATTV-LIMIVF 339
Cdd:cd15057   163 LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAR---RQIRRIAALERAAqestnpdsslrsSLRRETKALKTLsIIMGVF 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370465484 340 vICCWGPycFLVL-----LAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15057   240 -VCCWLP--FFILncvlpFCDLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIYA 290
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
120-388 8.96e-16

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 77.01  E-value: 8.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15067    16 GNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMT----------GGYWlfgRDWCDVWHSFDVLAST 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTALGFSLP----WELLGAPRELAaaqsfHGCLYRTSpdp 270
Cdd:cd15067    86 ASILNLCVISLDRYWAITDPIsyPSRMTKRRALIMIALVWICSALISFPaiawWRAVDPGPSPP-----NQCLFTDD--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 aQLGAAFSVglVVACYlLPFLLMCFchyhicktvrlsdvrvrpvnTYARVLRFFS-EVRTATTV-LIMIVFVIcCWGPYC 348
Cdd:cd15067   158 -SGYLIFSS--CVSFY-IPLVVMLF--------------------TYYRIYRAAAkEQKAAKTLgIVMGVFIL-CWLPFF 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370465484 349 FLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15067   213 VTNILIGFCPSNCVSNPDILFPLVTWLGYINSGMNPIIYA 252
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
120-391 1.33e-15

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 77.02  E-value: 1.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15392    17 GNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALL----------ILQYWpfgEFMCPVVNYLQAVSVF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWEL---LGAPRELAAAQSFhgCLYRTSPDpaQL 273
Cdd:cd15392    87 VSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAItsrLFEDSNASCGQYI--CTESWPSD--TN 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 GAAFSVGLVVACYLLPFLLMCFCHYHIckTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFV-ICCWGPYCFLVL 352
Cdd:cd15392   163 RYIYSLVLMILQYFVPLAVLVFTYTRI--GIVVWAKRTPGEAENNRDQRMAESKRKLVKMMITVVAIfALCWLPLNILNL 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370465484 353 LAAARQAQTMQAP-SLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15392   241 VGDHDESIYSWPYiPYLWLAAHWLAMSHCCYNPFIYCWMN 280
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
197-393 1.84e-15

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 76.20  E-value: 1.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTA-LGFSLP---WELLGAPRELAAAQsfhgCLYRTSPDP 270
Cdd:cd15049    86 ASVMNLLLISFDRYFSVTRPLtyRAKRTPKRAILMIALAWVISfVLWAPAilgWQYFVGERTVPDGQ----CYIQFLDDP 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AqlgaaFSVGLVVACYLLPFLLMCFCHYHICKTVrlsdVRVRpvntyaRVLRffsevrtaTTVLIMIVFVICcWGPYCFL 350
Cdd:cd15049   162 A-----ITFGTAIAAFYLPVLVMTILYWRIYRET----ARER------KAAR--------TLSAILLAFIIT-WTPYNIL 217
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 351 VLLAAARQAQTmqaPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15049   218 VLVSTFCAKCI---PDTLWSFGYWLCYINSTINPFCYALCNKT 257
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
120-387 3.24e-15

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 76.27  E-value: 3.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15208    17 GNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVT-----------ETWffgQVLCKIIPYLQTVSVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWEL---LGAPRELAAAQS-FHGCLYRTSPDPAQ 272
Cdd:cd15208    86 VSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIvmeCSRVVPLANKTIlLTVCDERWSDSIYQ 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 lgAAFSVGLVVACYLLPFLLMCFCHYHI-----CKTVRLSDVRVRPVNTYARVLRFFSEV------RTATTVLIMIVFVI 341
Cdd:cd15208   166 --KVYHICFFLVTYLLPLCLMILAYFQIfrklwCRQIPGTSSVVQRKWNKPRKSAVAAEEkqlrsrRKTAKMLIVVVIMF 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1370465484 342 C-CWGPYCFLVLLAAARQAQTMQAPS--LLSVVAVWLTWANGAINPVIY 387
Cdd:cd15208   244 AiCYLPVHLLNILRYVFGLFTVDRETiyAWFLFSHWLVYANSAINPIIY 292
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
120-388 1.72e-14

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 73.87  E-value: 1.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLD-LFTPPG-GSAPAAAAGPWRgF----CAASRFFSSC 193
Cdd:cd14970    17 GNSLVIYVILRYSKMKTVTNIYI--------------LNLAVADeLFLLGLpFLATSYLLGYWP-FgevmCKIVLSVDAY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGIVSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLGapRELAAAQSFHGCLYRTSPDPA 271
Cdd:cd14970    82 NMFTSIFCLTVMSVDRYLAVVHPVKSLRFRtpRKAKLVSLCVWALSLVLGLPVIIFA--RTLQEEGGTISCNLQWPDPPD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAAFSVGLVVACYLLPFLLMCFCHYHIckTVRLSDVRVRPVNTYARVLRffSEVRTATTVLIMIVFVICCWGPY--CF 349
Cdd:cd14970   160 YWGRVFTIYTFVLGFAVPLLVITVCYSLI--IRRLRSSRNLSTSGAREKRR--ARRKVTRLVLVVVAVFVVCWLPFhvFQ 235
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 350 LVLLAAARQAQTMQAPSLLSVVAvwLTWANGAINPVIYA 388
Cdd:cd14970   236 IVRLLIDPPETLTVVGVFLFCIA--LSYANSCLNPILYA 272
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
120-388 2.36e-14

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 73.22  E-value: 2.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHR--QLRTVTNAFILSLSLSDLLTALLC---------LPAAFLDLFtppggsapaaaagpwrgFCAASR 188
Cdd:cd15098    17 GNSLVITVLARVKpgKRRSTTNVFILNLSIADLFFLLFCvpfqatiysLPEWVFGAF-----------------MCKFVH 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 189 FFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGClYRT 266
Cdd:cd15098    80 YFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRtrRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASNQTFC-WEN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 267 SPDPAQlGAAFSVGLVVACYLLPFLLMCFCH----YHICKTVRlsdvrvrpvNTYARVLRffSEVRTATTVLIMIVFVIC 342
Cdd:cd15098   159 WPEKQQ-KPVYVVCTFVFGYLLPLLLITFCYakvlNHLHKKLK---------NMSKKSER--SKKKTAQTVLVVVVVFGI 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 343 CWGPYCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15098   227 SWLPHHIIHLWVEFGDFPLTQASFVLRITAHCLAYANSCVNPIIYA 272
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
120-392 2.75e-14

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 73.23  E-value: 2.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFtppggsapaaaaGPWR---GFCAASRFFSSCFG 195
Cdd:cd15073    17 SNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPfSAASDLH------------GSWKfgyAGCQWYAFLNIFFG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 IVSTLSVALISLDRYCAIVRPP-REKIGRRRALQLLAGAWLtalgFSLPWellgaprelaAAQSFHGcLYRTSPDPA--- 271
Cdd:cd15073    85 MASIGLLTVVAVDRYLTICRPDlGRKMTTNTYTVMILLAWT----NAFFW----------AAMPLVG-WASYALDPTgat 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 ---------QLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvRVRPVNTYARVLRFFSEVRTATTV-LIMIVFVI 341
Cdd:cd15073   150 ctinwrkndSSFVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVK----KVLASDCLESVNIDWTDQNDVTKMsVIMIVMFL 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 342 CCWGPYCFLVLLAAARQAQTMqaPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15073   226 VAWSPYSIVCLWASFGEPKKI--PPWMAIIPPLFAKSSTFYNPCIYVIANK 274
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
117-393 2.90e-14

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 73.08  E-value: 2.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 117 SSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaaAGPWRGFCAASRFFSSC--- 193
Cdd:cd15074    14 STLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAF-----------AHRWLFGDIGCVFYGFCgfl 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGIVSTLSVALISLDRYCAIVRPP-REKIGRRRALQLLAGAWLTALGFSLPwELLGAPRelAAAQSFHG--CL--YRTSP 268
Cdd:cd15074    83 FGCCSINTLTAISIYRYLKICHPPyGPKLSRRHVCIVIVAIWLYALFWAVA-PLVGWGS--YGPEPFGTscSIdwTGASA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAqlGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRV-RPVNTYARVLRFFSEVrTATTVLIMIVFVIcCWGPY 347
Cdd:cd15074   160 SVG--GMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVaGFDSRSKRQHKIERKV-TKVAVLICAGFLI-AWTPY 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 348 CFLVLLAAArqAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15074   236 AVVSMWSAF--GSPDSVPILASILPALFAKSSCMYNPIIYLLFSSK 279
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
120-393 4.07e-14

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 72.83  E-value: 4.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFldlftppggsaPAAAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15393    17 GNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQF-----------QAALLQRWvlpRFMCPFCPFVQVLSVN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAqsfHGCLYRTSPDP----AQ 272
Cdd:cd15393    86 VSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALALRVEELTDK---TNNGVKPFCLPvgpsDD 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDvrvRPVNtyARVLRFFSEVRTATTVLIMIVFVIC----CWGPYC 348
Cdd:cd15393   163 WWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTK---APGN--AQDVRDDEILKNKKKVIKMLIIVVAlfalCWLPLQ 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 349 FLVLLAAAR-QAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15393   238 TYNLLNEIKpEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEK 283
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
120-391 7.15e-14

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 71.76  E-value: 7.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFTPPGGSAPaaaagpwrgFCAASRFFSSCFGIVS 198
Cdd:cd15063    17 GNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPfSAVNEVLDVWIFGHT---------WCQIWLAVDVWMCTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 199 TLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPwELLGAPRELAAAQSFHGclyrTSPDPAQLGAA 276
Cdd:cd15063    88 ILNLCAISLDRYLAITRPIRYPslMSTKRAKCLIAGVWVLSFVICFP-PLVGWNDGKDGIMDYSG----SSSLPCTCELT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 277 FSVGLVV----ACYLLPFLLMCFCHYHICKTVRLsdvrvrpvntyarvlrffsEVRTATTVLIMIVFVICCWGPYcFLVL 352
Cdd:cd15063   163 NGRGYVIysalGSFYIPMLVMLFFYFRIYRAARM-------------------ETKAAKTVAIIVGCFIFCWLPF-FTVY 222
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 353 LAAARQAQTMqaPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15063   223 LVRAFCEDCI--PPLLFSVFFWLGYCNSALNPCIYALFS 259
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
120-391 1.00e-13

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 70.85  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPW---RGFCaasRFFSScFGI 196
Cdd:cd15061    16 GNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLL-----------GYWplgSHLC---DFWIS-LDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 V----STLSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTALGFSLPwELLGaPRELAAAQSFhGCLYRTSPdp 270
Cdd:cd15061    81 LlctaSILNLCCISLDRYFAITYPLkyRTKRSRRLAITMILAVWVISLLITSP-PLVG-PSWHGRRGLG-SCYYTYDK-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 aqlgaAFSVGLVVACYLLPFLLMCFchyhicktvrlsdvrvrpvnTYARVLRFF-SEVRTATTVLIMIVFVICCWGPYCF 349
Cdd:cd15061   156 -----GYRIYSSMGSFFLPLLLMLF--------------------VYLRIFRVIaKERKTAKTLAIVVGCFIVCWLPFFI 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370465484 350 LVLLAAARQAqtmQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15061   211 MYLIEPFCDC---QFSEALSTAFTWLGYFNSVINPFIYAFYN 249
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
183-392 1.05e-13

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 71.43  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPWELLGAPRE-LAAAQSF 259
Cdd:cd15055    72 FCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLypTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPgLIRYNSC 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 260 HG-CLYRTSpdpaqlgAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlSDVRV-----------RPVNTYARVlrffSEV 327
Cdd:cd15055   152 YGeCVVVVN-------FIWGVVDLVLTFILPCTVMIVLYMRIFVVAR-SQARAirshtaqvsleGSSKKVSKK----SER 219
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 328 RTATTV-LIMIVFVICcWGPYcFLVLLAAarqaQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15055   220 KAAKTLgIVVGVFLLC-WLPY-YIVSLVD----PYISTPSSVFDVLIWLGYFNSCLNPLIYALFYP 279
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
120-392 3.41e-13

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 70.03  E-value: 3.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15048    17 GNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLT-----------GKWpfgKVFCKAWLVVDYTLCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTALGFSLP----WELLGA----PRELAAAQsFHGCLYrt 266
Cdd:cd15048    86 ASALTIVLISLDRYLSVTKAVkyRAKQTKRRTVLLMALVWILAFLLYGPaiigWDLWTGysivPTGDCEVE-FFDHFY-- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 267 spdpaqlgaaFSVGLVVACYLLPFLLMCFCHYHI-CKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVL----------- 334
Cdd:cd15048   163 ----------FTFITSVLEFFIPFISVSFFNLLIyLNIRKRSRRRPLRSVPILPASQNPSRARSQREQVklrrdrkaaks 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 335 ---IMIVFVIcCWGPYCFLVLLAAArqAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15048   233 laiLVLVFLI-CWAPYTILTIIRSF--CSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHP 290
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
117-388 4.29e-13

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 69.55  E-value: 4.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 117 SSLGNCAVMGVIVKHRQLRTVTNAFILSlslsdlltallcLPAAFLdLFTPPGGSAPAAAAGPW---RGFCaasRFFSSC 193
Cdd:cd14984    14 GLVGNSLVLLVLLYYRKLRSMTDVYLLN------------LALADL-LFVLTLPFWAVYAADGWvfgSFLC---KLVSAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGI---VSTLSVALISLDRYCAIVRPPREKIGRRRALQLL--AGAWLTALGFSLPwELLGapRELAAAQSFHGCLYRTSP 268
Cdd:cd14984    78 YTInfySGILFLACISIDRYLAIVHAVSALRARTLLHGKLtcLGVWALALLLSLP-EFIF--SQVSEENGSSICSYDYPE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAQLG-AAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRpvntyARVLRFfsevrtatTVLIMIVFVIcCWGPY 347
Cdd:cd14984   155 DTATTWkTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKK-----HRALRV--------IFAVVVVFFL-CWLPY 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1370465484 348 CFLVLL-AAARQAQTMQAPSLLSVVAVWLTWANG------AINPVIYA 388
Cdd:cd14984   221 NIVLLLdTLQLLGIISRSCELSKSLDYALQVTESlafshcCLNPVLYA 268
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
198-391 4.78e-13

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 69.29  E-value: 4.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPwELLGAPRELAAAQSFHGCLYRTSPDPAQLGA 275
Cdd:cd15059    87 SIVNLCAISLDRYWSVTQAVEynLKRTPRRAKAMIAAVWIISAVISLP-PLFGWKDEQPWHGAEPQCELSDDPGYVLFSS 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSvglvvacYLLPFLLMcfchyhicktvrlsdvrvrpVNTYARVLRFF-SEVRTATTVL--IMIVFVICcWGPYCFLVL 352
Cdd:cd15059   166 IGS-------FYIPLLIM--------------------IIVYARIYRAAkRKERRFTLVLgvVMGAFVLC-WLPFFFTYP 217
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370465484 353 LAAArqAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15059   218 LVVV--CKTCGVPELLFKFFFWLGYCNSALNPVIYTIFN 254
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
184-389 6.55e-13

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 69.38  E-value: 6.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSfhGCl 263
Cdd:cd15197    73 CKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIPMLIIFEKTGLSNGEV--QC- 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 264 YRTSPDPAQLGAAFSVgLVVACYLLPFLLMCFCHYHICKTV-----------RLSDVRVRPVNTYARVLRFFSEVRTATT 332
Cdd:cd15197   150 WILWPEPWYWKVYMTI-VAFLVFFIPATIISICYIIIVRTIwkkskiqvtinKAGLHDGSSRRSSSRGIIPRAKIKTIKM 228
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370465484 333 VLIMIVFVICCWGPYCFLVLLAAARQ---AQTMQAPSLL--SVVAVwltwaNGAINPVIYAI 389
Cdd:cd15197   229 TFVIVTVFIICWSPYFVFDLLDVFGLlprSKTKIAAATFiqSLAPL-----NSAINPLIYCL 285
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
120-393 8.71e-13

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 69.04  E-value: 8.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPWRG---FCAASRFFSSCFGI 196
Cdd:cd15205    17 GNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNIS-----------SNWLGgafMCKMVPFVQSTAVV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLPW---ELLGAPRELAAAQSFHGCLYR-TSPDP 270
Cdd:cd15205    86 TSILTMTCIAVERHQGIVHPLKMKWqyTNRRAFTMLGLVWIVSVIVGSPMlfvQQLEVKYDFLYEKRHVCCLERwYSPTQ 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQLGAAFsvgLVVACYLLPFLLMCFCHYHIC------KTVRLSDV-RVRPVNTYARVLRffsEVRTATTVLIMIVFVIC- 342
Cdd:cd15205   166 QKIYTTF---ILVILFLLPLTTMLFLYSRIGyelwikKRVGDASVlQTIHGIEMSKISR---KKKRAVKMMVTVVLLFAv 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 343 CWGPYCFLVLLAAARQAQTMQ----APSLLSVVAVwLTWANGAINPVIYAIRNPN 393
Cdd:cd15205   240 CWAPFHVVHMMIEYSNLENKYdgvtIKLIFAIVQL-IGFSNSFNNPIVYAFMNEN 293
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
120-389 8.81e-13

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 68.86  E-value: 8.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd14997    17 GNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWA----------REPWllgEFMCKLVPFVELTVAH 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWELLGAPRELAA--AQSFHGCLyrtSPDPAQ 272
Cdd:cd14997    87 ASVLTILAISFERYYAICHPLQAKyvCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFndGTPVAVCR---TPADTF 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFSVGLVVACYLLPFLLMCFCHYHICKtvRLsdVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVIC----CWGPYC 348
Cdd:cd14997   164 WKVAYILSTIVVFFVVPLAILSGLYSVICR--RL--VGHPALESRRADAANRHTLRSRRQVVYMLITVVVlffvCLLPFR 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 349 FL---VLLAAARQAQTMQAPSLLSVVAV--WLTWANGAINPVIYAI 389
Cdd:cd14997   240 VVtlwIIFAPDEDLQALGLEGYLNLLVFcrVMVYLNSALNPILYNL 285
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
194-395 1.56e-12

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 68.19  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGI-VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELL-GAPRELAAAQSFHGCL-YRTSPDP 270
Cdd:cd15195    82 FGMyLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIfSVLRKMPEQPGFHQCVdFGSAPTK 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQLgAAFSVGLVVACYLLPFLLMCFCH----YHICKTVRlSDVRVRPVNTYARVLRFFSEVRTAT---TVLIMIVFVIcC 343
Cdd:cd15195   162 KQE-RLYYFFTMILSFVIPLIITVTCYllilFEISKMAK-RARDTPISNRRRSRTNSLERARMRTlrmTALIVLTFIV-C 238
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370465484 344 WGPYCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNIS 395
Cdd:cd15195   239 WGPYYVLGLWYWFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIR 290
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
120-389 2.45e-12

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 67.31  E-value: 2.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldlFTPPGGSAPAaaagpW---RGFCAASRFF------ 190
Cdd:cd15095    17 GNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVP------FTAALYATPS-----WvfgDFMCKFVNYMmqvtvq 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 191 SSCfgivstLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPwelLGAPRELAAAQSFHGCLYRTSP 268
Cdd:cd15095    86 ATC------LTLTALSVDRYYAIVHPIRSLRFRtpRVAVVVSACIWIVSFLLSIP---VAIYYRLEEGYWYGPQTYCREV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAQLG-AAFSVGLVVACYLLPFLLMCFCH----YHICKTVRLSDVRVRPVNTYARVLRFfsevRTATTVLIMIVFVICC 343
Cdd:cd15095   157 WPSKAFqKAYMIYTVLLTYVIPLAIIAVCYglilRRLWRRSVDGNNQSEQLSERALRQKR----KVTRMVIVVVVLFAIC 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1370465484 344 WGP-YCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15095   233 WLPnHVLNLWQRFDPNFPETYATYALKIAALCLSYANSAVNPFVYAF 279
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
120-389 2.48e-12

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 67.51  E-value: 2.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDlLTALLCLPaafLDLFtppggsaPAAAAGPWR---GFCAASRFFSSCFGI 196
Cdd:cd15928    17 GNLLTVLVIGRSRDMRTTTNLYLSSLAVSD-LLIFLVLP---LDLY-------RLWRYRPWRfgdLLCRLMYFFSETCTY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLG 274
Cdd:cd15928    86 ASILHITALSVERYLAICHPLRAKvlVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSSGLL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVgLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRtattVLIMIVFV-ICCWGPY------ 347
Cdd:cd15928   166 SVMLW-VSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNHRQTVR----MLAVIVLAfVLCWLPFhvgrvi 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370465484 348 CFLVLLAAARQAQTMQAPSLLSVVAVWLTwanGAINPVIYAI 389
Cdd:cd15928   241 FNHSRASTKHLHYVSQYFNLVSFVLFYLS---AAINPILYNL 279
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
120-389 3.99e-12

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 66.53  E-value: 3.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaaAGPWR---GFCAASRFFSSCFGI 196
Cdd:cd15001    16 GNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYF-----------SPTWSlgaFLCKAVAYLQLLSFI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLP------WELLGAPRELAAAQSFHGClyrtsP 268
Cdd:cd15001    85 CSVLTLTAISIERYYVILHPMKAKSfcTIGRARKVALLIWILSAILASPvlfgqgLVRYESENGVTVYHCQKAW-----P 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAqLGAAFSVGLVVACYLLPFLLMCFChyhicktvrlsdvrvrpvntYARVLRFfsevRTATTVLIMIVFVICCWGPYC 348
Cdd:cd15001   160 STL-YSRLYVVYLAIVIFFIPLIVMTFA--------------------YARDTRK----QVIKMLISVVVLFAVCWGPLL 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 349 FLVLLAAARQAQTMQAPSLLSVVAVW--LTWANGAINPVIYAI 389
Cdd:cd15001   215 IDNLLVSFDVISTLHTQALKYMRIAFhlLSYANSCINPIIYAF 257
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
120-392 4.02e-12

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 66.89  E-value: 4.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLdlftppggsapaaaagPWRGFCAA--SRFFSSCFGIV 197
Cdd:cd14968    17 GNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAIL----------------ISLGLPTNfhGCLFMACLVLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 ----STLSVALISLDRYCAIVRPPREKIG--RRRALQLLAGAWLTALGFSL-P---WElLGAPRELAAAQSFHGCLYRT- 266
Cdd:cd14968    81 ltqsSIFSLLAIAIDRYLAIKIPLRYKSLvtGRRAWGAIAVCWVLSFLVGLtPmfgWN-NGAPLESGCGEGGIQCLFEEv 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 267 SPDPAQLGAAFsvglvVACYLLPFLLMCFCHYHICKTVRlSDVRVRPVNTYARVLRFF--SEVRTATTVLIMIVFVICCW 344
Cdd:cd14968   160 IPMDYMVYFNF-----FACVLVPLLIMLVIYLRIFRVIR-KQLRQIESLLRSRRSRSTlqKEVKAAKSLAIILFLFALCW 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1370465484 345 GPYCflVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd14968   234 LPLH--IINCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIR 279
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
120-393 4.82e-12

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 66.59  E-value: 4.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldlFTppggsAPAAAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15389    17 GNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTP------FT-----LVRFVNSTWvfgKIMCHLSRFAQYCSVY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTS-PDPAQLGA 275
Cdd:cd15389    86 VSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLPSfPEPSDLFW 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AF-SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVrVRPVNTYARVLRFFSEVRTATT-VLIMIVFVIcCWGPY-CFLVL 352
Cdd:cd15389   166 KYlDLATFILQYVLPLLIIGVAYTRVAKKLWLRNA-IGDVTTEQYVAQRRKKKKTIKMlMLVVLLFAI-CWLPLnCYHVL 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 353 LAaarqAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15389   244 LS----SHPIRSNSALFFAFHWLAMSSTCYNPFIYCWLNDS 280
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
120-393 5.02e-12

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 66.29  E-value: 5.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLClPAAFL--DLFTPPGGSAPAaaagpwrgfCAASRFFSSCFGIV 197
Cdd:cd15000    16 GNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVC-PWMFLvhDFFQNYVLGSVG---------CKLEGFLEGSLLLA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRElaaaQSFHGCLYRTSPDPAQLGAAF 277
Cdd:cd15000    86 SVLALCAVSYDRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSYRE----RQWKNFLETYCAENTQVLPIY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHI-CKTVRLSDVRVRPVNtyARVLRFFSEVrTATTVLIMIVFVICCWgPYCFLVLLAAA 356
Cdd:cd15000   162 WHVIITVLVWLPLGIMLICYSAIfWKLDKYERRVLRREH--PSVVRYKKKA-AKTLFIVLITFVVCRI-PFTALIFYRYK 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 357 RQAQTMQAPSLLSVVAVW------LTWANGAINPVIYAIRNPN 393
Cdd:cd15000   238 LVPNDNTQNSVSGSFHILwfaskyLMFLNAAVNPLIYGFTNEN 280
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
120-393 6.05e-12

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 66.30  E-value: 6.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAaaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd14992    17 GNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHF--------LCKIVNYLRTVSVYASS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAF 277
Cdd:cd14992    89 LTLTAIAFDRYFAIIHPlkPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCCQIPPVDNKTYEK 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLV--VACYLLPFLLMCFCHYHIckTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIV--FVIcCWGPycFLVLL 353
Cdd:cd14992   169 VYFLLifVVIFVLPLIVMTLAYARI--SRELWFRKVPGFSIKEVERKRLKCKRRVIKMLVCVVvlFVI-CWLP--FHLFF 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 354 AAARQAQT-MQAPSLLSVVAV--WLTWANGAINPVIYAIRNPN 393
Cdd:cd14992   244 LLRDFFPLiMKEKHTLQVYYFlhWIAMSNSMYNPIIYVTLNNN 286
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
120-391 7.80e-12

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 66.00  E-value: 7.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAaaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15391    17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAP--------MCPIVLYVQLVSVTASV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSV 279
Cdd:cd15391    89 LTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGRVLCGESWPGPDTSRSAYTV 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 280 GLVVACYLLPFLLMCFCHYHICKTVRLsdvRVRPVNtyARVLRFFSEVRTATTVLIMIVFVIC----CWGP-YCFLVLLA 354
Cdd:cd15391   169 FVMLLTYIIPLLILTSTYGYVGFRLWN---RTAPGN--ADKGRDDMQIKSKRKVIKMLVFVVLmfgiCWLPlHLFNLVQD 243
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 355 AARQAQTMQAPSLLSV--VAVWLTWANGAINPVIYAIRN 391
Cdd:cd15391   244 FSTVFRNMPQHTTRLIygACHWIAMSNSFVNPIIYLFMN 282
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
120-393 1.19e-11

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 64.98  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaaAGPWR---GFCAASRFFSSCFGI 196
Cdd:cd15210    17 GNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFL-----------HQAWIhgeTLCRVFPLLRYGLVA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPR-EKIGRRRALQL-LAGAWLTALGFSLP-----WELLGAPRELAAAqSFHGCLYRTSPD 269
Cdd:cd15210    86 VSLLTLVLITLNRYILIAHPSLyPRIYTRRGLALmIAGTWIFSFGSFLPlwlgiWGRFGLDPKVCSC-SILRDKKGRSPK 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PAQLGAAFsvglvvacyLLPFLLMCFCHyhicktVRLSDVRVrpvntyarvlrffsevrTATTVLIMIVFVICcWGPYcF 349
Cdd:cd15210   165 TFLFVFGF---------VLPCLVIIICY------ARREDRRL-----------------TRMMLVIFLCFLVC-YLPI-T 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 350 LVLLAAARQAQTMqapslLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15210   211 LVNVFDDEVAPPV-----LHIIAYVLIWLSSCINPIIYVAMNRQ 249
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
120-391 1.70e-11

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 65.05  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldlFTPPGGSAPAAAAGPWrgFCAASRFFSSCFGIVST 199
Cdd:cd15051    17 GNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLP------FSAIYELRGEWPLGPV--FCNIYISLDVMLCTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFS-LPWELLGAPRELAAAQSFHG--CLYRTSPdpaqlg 274
Cdd:cd15051    89 LNLFAISLDRYLAITAPLRypSRVTPRRVAIALAAIWVVSLAVSfLPIHLGWNTPDGRVQNGDTPnqCRFELNP------ 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 aafSVGLVVA--CYLLPFLLMCFCHYHICKTVRLSDVRVR----PVNTYARVLRFFSEVRTATTVL--IMIVFVIcCWGP 346
Cdd:cd15051   163 ---PYVLLVAigTFYLPLLIMCGVYLRIFRIAREQAKRINaltpASTANSSKSAATAREHKATVTLaaVLGAFII-CWFP 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 347 YCFLVLLAAARQaqtMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15051   239 YFTYFTYRGLCG---DNINETALSVVLWLGYANSALNPILYAFLN 280
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
121-394 2.25e-11

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 64.24  E-value: 2.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 121 NCAVMGVIVKHRQLRTVTNAFILSLSlsdlltALLCLP-AAFLDLFTPPGGSAPAAAAGPWRG-FCAasrFFSScfGIVS 198
Cdd:cd14972    16 NSLVLAAIIKNRRLHKPMYILIANLA------AADLLAgIAFVFTFLSVLLVSLTPSPATWLLrKGS---LVLS--LLAS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 199 TLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFS-LPweLLGAprelaaaqsfhGCLYRTSPDPAQLGA 275
Cdd:cd14972    85 AYSLLAIAVDRYISIVHGLTyvNNVTNKRVKVLIALVWVWSVLLAlLP--VLGW-----------NCVLCDQESCSPLGP 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVAC---YLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTA-TTVLIMIVFVIcCWGPYCFLV 351
Cdd:cd14972   152 GLPKSYLVLIlvfFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQPSTSRKLAkTVVIVLGVFLV-CWLPLLILL 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 352 LL--AAARQAQTMQAPSLLSVVAVWltwaNGAINPVIYAIRNPNI 394
Cdd:cd14972   231 VLdvLCPSVCDIQAVFYYFLVLALL----NSAINPIIYAFRLKEM 271
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
120-393 3.32e-11

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 64.02  E-value: 3.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLD-LFTPPGGSAPAAAAGPWRGFCAA-SRFFSSCFGI- 196
Cdd:cd15093    17 GNSLVIYVVLRYAKMKTVTNIYI--------------LNLAIADeLFMLGLPFLAASNALRHWPFGSVlCRLVLSVDGIn 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 --VSTLSVALISLDRYCAIVRPPREKIGRRR--ALQLLAGAWLTALGFSLPWELLGAPRElaAAQSFHGCLYRTSPDPAQ 272
Cdd:cd15093    83 mfTSIFCLTVMSVDRYLAVVHPIKSARWRRPrvAKVVNLAVWVASLLVILPVVVFAGTRE--NQDGSSACNMQWPEPAAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVrpvntyARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVL 352
Cdd:cd15093   161 WSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRA------GWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQL 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 353 LAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15093   235 VNVFVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDN 275
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
120-389 3.40e-11

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 63.94  E-value: 3.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPWR---GFCAASRFFSSCFGI 196
Cdd:cd14985    17 GNLFVVWVFLFPRGPKRVADIFIANLAA-----------ADLVFVLTLPLWATYTANQYDWPfgaFLCKVSSYVISVNMF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRR--ALQLLAGAWLTALGFSLPWELLgapRELAAAQSFHGCLYRTSPDPAQLG 274
Cdd:cd14985    86 ASIFLLTCMSVDRYLAIVHPVASRRLRRRrqARVTCALIWVVACLLSLPTFLL---RSLQAIENLNKTACIMLYPHEAWH 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffsevRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:cd14985   163 FGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTGKNGRKRR--------KSLKIIFALVVAFLVCWLPFHFFKFLD 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 355 AARQAQTMQAPSLLSVV------AVWLTWANGAINPVIYAI 389
Cdd:cd14985   235 FLAQLGAIRPCFWELFLdlglpiATCLAFTNSCLNPFIYVF 275
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
120-394 4.02e-11

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 63.55  E-value: 4.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLR-TVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAaaagpwrgFCAASRFF--SSCfgI 196
Cdd:cd15104    16 GNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKV--------LCLLRMCFviTSC--A 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTAL--GFsLPWELLG-APRELAAAQSFHGCLYRTspdpa 271
Cdd:cd15104    86 ASVLSLAAIAFDRYLALKQPLRYKqiMTGKSAGALIAGLWLYSGliGF-LPLISPQfQQTSYKGKCSFFAAFHPR----- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 qlgaaFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYA----RVLRFFSEVRTATTVLIMIVFVICCWGPY 347
Cdd:cd15104   160 -----VLLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALarqiHPRRTLSDFKAARTVAVLIGCFLLSWLPF 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 348 CFLVLLAAarqaqTMQAPSLLSVVAVWLtW----ANGAINPVIYAIRNPNI 394
Cdd:cd15104   235 QITGLVQA-----LCDECKLYDVLEDYL-WllglCNSLLNPWIYAFWQKEV 279
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
120-390 5.08e-11

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 63.71  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAaaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15403    17 GNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAH--------FCRISAMLYWFFVLEGV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRpPREKIGRRRALQLLAGAWLTALGFSLP----WELLGAPRElaAAQsfhgCLYRTSPDPAQlgA 275
Cdd:cd15403    89 AILLIISVDRFLIIVQ-RQDKLNPHRAKVMIAISWVLSFCISFPsvvgWTLVEVPAR--APQ----CVLGYTESPAD--R 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPvNTYARVLRFFSEV-------------------RTATTVLIM 336
Cdd:cd15403   160 VYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHN-HADSLCLSQVSKLglmglqrphqmnvdmsfktRAFTTILIL 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 337 IVFVICCWGPYCFLVLLAA-ARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIR 390
Cdd:cd15403   239 FVGFSLCWLPHTVFSLLSVfSRRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWR 293
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
183-394 6.15e-11

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 63.03  E-value: 6.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCAASRFFSSCFGIVSTLSVALISLDRYCAIVRP-PREKIGRRRALQLLAGAWLTALGFSlpwellGAPRELAAAQSFHG 261
Cdd:cd14980    80 PCLLACFLVSLSSLMSVLMMLLITLDRYICIVYPfSNKRLSYKSAKIILILGWLFSIIFA------AIPILYSINQPGDN 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 262 CLYRTSP--------DPAQLG-AAFSVGLVVACyllpFLLMCFCHYHICKTVRLSdvrvrpvNTYARVLRFFSEVRTATT 332
Cdd:cd14980   154 RLYGYSSicmpsnvsNPYYRGwLIAYLLLTFIA----WIIICILYILIFISVRKS-------RKSARRSSSKRDKRIAIR 222
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370465484 333 VLIMIVFVICCWGPYCFLVLLAAARQAQTmqAPSLLSVVAVWLTWANGAINPVIYAIRNPNI 394
Cdd:cd14980   223 LALILITDLICWLPYYIVIFSGLLTSTEI--DIHVLQFIAILALPLNSAINPYLYTLTTPTF 282
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
120-387 6.60e-11

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 62.90  E-value: 6.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapAAAAGPWRGFCAASRFFSSCFGIVST 199
Cdd:cd15054    17 GNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNAL--------YGRWVLARDFCPIWYAFDVMCCSASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWELLGApRELAAAQSFHGCLYRTSPDPAQLGAAF 277
Cdd:cd15054    89 LNLCVISLDRYLLIISPLRYKlrMTPPRALALILAAWTLAALASFLPIELGW-HELGHERTLPNLTSGTVEGQCRLLVSL 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVAC--YLLPFLLMCFchyhicktvrlsdvrvrpvnTYARVLRFFSEVRTATTVL-IMIVFVICCWGPYcflvLLA 354
Cdd:cd15054   168 PYALVASCltFFLPSGAICF--------------------TYCRILLAARKALKASLTLgILLGMFFVTWLPF----FVA 223
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1370465484 355 AARQAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15054   224 NVVQAVCDCVSPGLFDVLTWLGYCNSTMNPIIY 256
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
120-389 1.18e-10

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 62.37  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafLDLFTPPGGSAPAAAAgpwrGFCAASRFFSSCFGIVST 199
Cdd:cd14979    17 GNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLP---VELYNFWWQYPWAFGD----GGCKLYYFLFEACTYATV 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWELlgapreLAAAQSFHGCLYRT---------SP 268
Cdd:cd14979    90 LTIVALSVERYVAICHPLKAKtlVTKRRVKRFILAIWLVSILCAIPILF------LMGIQYLNGPLPGPvpdsavctlVV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAQLGAAFSVGLVVAcYLLPFLLMCFCHYHI---CKTVRLSDVRVRPVNTYARVLRFFSEVRTATT---VLIMIVFVIc 342
Cdd:cd14979   164 DRSTFKYVFQVSTFIF-FVLPMFVISILYFRIgvkLRSMRNIKKGTRAQGTRNVELSLSQQARRQVVkmlGAVVIAFFV- 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370465484 343 CWGPYCFLVLLAAARQAQTM---QAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd14979   242 CWLPFHAQRLMFSYASKEDTflfDFYQYLYPISGILFYLSSAINPILYNL 291
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
184-394 1.40e-10

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 61.70  E-value: 1.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPRE--KIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHG 261
Cdd:cd15220    72 CRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYevKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIAARH 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 262 CLYRTSPDPAQLgaAFSVGLVVACYLLPFLLMcfchyhicktvrlsdvrvrpVNTYARVLRFFSEVRTATTVLIMIVFVI 341
Cdd:cd15220   152 CSLHWSHSGHRG--VFVVLFALVCFLLPLLLI--------------------LVVYCGVFKVFGGGKAALTLAAIVGQFL 209
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370465484 342 CCWGPYcFLVLLAAARQAQTMQAPSLLSVVAvWLTWANGAINPVIYAIRNPNI 394
Cdd:cd15220   210 CCWLPY-FAFHLYSALAASPVSGGEAEEVVT-WLAYSCFAVNPFFYGLLNRQI 260
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
180-387 1.85e-10

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 61.94  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 180 WRGFCAASRFFSSC--FGI-VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAA 256
Cdd:cd15382    67 WLAGDFLCRLMLFFraFGLyLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFIFHVESHPCV 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 257 QSFHGCL-YRTSPDPAQLgAAFSVGLVVACYLLPFLLMCFCH----YHICKTVRLSDVRVRPVNTYARVLR----FFSEV 327
Cdd:cd15382   147 TWFSQCVtFNFFPSHDHE-LAYNIFNMITMYALPLIIIVFCYslilCEISRKSKEKKEDVSEKSSSVRLRRssvgLLERA 225
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370465484 328 RTAT---TVLIMIVFVIcCWGPYCFLVLLAAARQAQTMQAP----SLLSVVAVwltwANGAINPVIY 387
Cdd:cd15382   226 RSRTlkmTIVIVLVFII-CWTPYFIMSLWYWFDRESASKVDpriqKGLFLFAV----SNSCMNPIVY 287
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
205-392 2.41e-10

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 61.18  E-value: 2.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 205 ISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPWELLGApRELAAAQSFHGCLYrtsPDPAqlgaaFSVGLV 282
Cdd:cd15052    95 ISLDRYMAIRYPlrTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGI-IDTTNVLNNGTCVL---FNPN-----FVIYGS 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 283 VACYLLPFLLMcfchyhicktvrlsdvrvrpVNTYARVLRFFSEVRTATTVL--IMIVFVICcWGPYcFLVLLAAARQAQ 360
Cdd:cd15052   166 IVAFFIPLLIM--------------------VVTYALTIRLLSNEQKASKVLgiVFAVFVIC-WCPF-FITNILTGLCEE 223
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1370465484 361 TMQA--PSLLSVVaVWLTWANGAINPVIYAIRNP 392
Cdd:cd15052   224 CNCRisPWLLSVF-VWLGYVSSTINPIIYTIFNK 256
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
120-391 3.03e-10

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 61.01  E-value: 3.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTallclpAAFLDLFTPPGGSAPAaaagpW---RGFCAASRFFSSCFGI 196
Cdd:cd16004    17 GNATVIWIILAHRRMRTVTNYFIVNLALADLSM------AAFNTAFNFVYASHND-----WyfgLEFCRFQNFFPITAMF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRP--PREKIGRRRALqlLAGAWLTALGFSLPwellgaprelaaaQSFHGCLYRTSPD----- 269
Cdd:cd16004    86 VSIYSMTAIAADRYMAIIHPfkPRLSAGSTKVV--IAGIWLVALALAFP-------------QCFYSTVTMDQGRtkciv 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 --PAQLGA----AFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVrvrPVNT----YARVLRFFSEVrTATTVLIMIVF 339
Cdd:cd16004   151 awPGDSGGkhqlTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAV---PGHQahgaYHRQLQAKKKF-VKTMVVVVVTF 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 340 VICcWGPYCFLVLLAAAR----QAQTMQAPSLlsvVAVWLTWANGAINPVIYAIRN 391
Cdd:cd16004   227 AIC-WLPYHLYFILGSFNediyCQKYIQQVYL---AIFWLAMSSTMYNPIIYCCLN 278
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
120-391 3.86e-10

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 60.71  E-value: 3.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTallclpAAFLDLFTppggsAPAAAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd16003    17 GNLIVIWIILAHKRMRTVTNYFLVNLAFSDASM------AAFNTLIN-----FIYALHSEWyfgEAYCRFHNFFPITSVF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQsfhgCLYRTSPDPAQLGAA 276
Cdd:cd16003    86 ASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRT----LCFVAWPGGPDQHFT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 277 FSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVrtattVLIMIVFVIC---CWGPY-CFLVL 352
Cdd:cd16003   162 YHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAKRKV-----VKMMIIVVLTfaiCWLPYhIYFIV 236
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 353 LAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd16003   237 TGLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN 275
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
120-393 4.17e-10

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 60.58  E-value: 4.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPWR---GFCAASRFFSSCFGI 196
Cdd:cd15056    17 GNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVN-----------NRWIygeTFCLVRTSLDVLLTT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPP-REKIGRRRALQLLAGAWLTALGFS-LP----WELLGAPRELAaaqsfHGCLYRTSPDP 270
Cdd:cd15056    86 ASIMHLCCIALDRYYAICCQPlVYKMTPLRVAVMLGGCWVIPTFISfLPimqgWNHIGIEDLIA-----FNCASGSTSCV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVR------LSDVRVRPVNTYA---RVLRFFSEVRTATTV-LIMIVFV 340
Cdd:cd15056   161 FMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAReqahqiRSLQRAGSSNHEAdqhRNSRMRTETKAAKTLgIIMGCFC 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370465484 341 IcCWGPycFLVLLAAARQAQTmQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15056   241 V-CWAP--FFVTNIVDPFIGY-RVPYLLWTAFLWLGYINSGLNPFLYAFFNKS 289
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
120-387 5.42e-10

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 60.36  E-value: 5.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSlSDLLTALLCLPAAFLDLFTppggsapaaaaGPWRGFCAASRFFSSCFGIV-- 197
Cdd:cd14982    17 GNILALWVFLRKMKKRSPTTIYMINLA-LADLLFVLTLPFRIYYYLN-----------GGWWPFGDFLCRLTGLLFYInm 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 --STLSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPweLLGAPRELAAAQSFHGCLYRTSPDPAQL 273
Cdd:cd14982    85 ygSILFLTCISVDRYLAVVHPlkSRRLRRKRYAVGVCAGVWILVLVASVP--LLLLRSTIAKENNSTTCFEFLSEWLASA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 GAAFSVGLVVaCYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFsevrtattVLIMIVFVIcCWGPY--CFLV 351
Cdd:cd14982   163 APIVLIALVV-GFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMI--------LIVLAVFLV-CFLPYhvTRIL 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370465484 352 LLAAARQAQTM-QAPSLLSV---VAVWLTWANGAINPVIY 387
Cdd:cd14982   233 YLLVRLSFIADcSARNSLYKayrITLCLASLNSCLDPLIY 272
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
120-391 5.47e-10

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 59.99  E-value: 5.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFL--------------DLFTPPGGsapaaaagpwrgFCA 185
Cdd:cd15330    17 GNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALyqvlnkwtlgqvtcDLFIALDV------------LCC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 186 ASrffsscfgivSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPwELLG--APRElaaaqsfhg 261
Cdd:cd15330    85 TS----------SILHLCAIALDRYWAITDPIDyvNKRTPRRAAVLISLTWLIGFSISIP-PMLGwrTPED--------- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 262 clyRTSPDPAQLGA--AFSVGLVVACYLLPFLLMcfchyhicktvrlsdvrvrpVNTYARVLRFFS-EVRTATTVLIMIV 338
Cdd:cd15330   145 ---RSDPDACTISKdpGYTIYSTFGAFYIPLILM--------------------LVLYGRIFKAAArERKTVKTLGIIMG 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370465484 339 FVICCWGPYcFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15330   202 TFILCWLPF-FIVALVLPFCESTCHMPELLGAIINWLGYSNSLLNPIIYAYFN 253
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
184-391 1.11e-09

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 59.41  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPRE-KIGRRRALQLLAGAWLTALGFSLPwELLGAPR-ELAAAQSFHG 261
Cdd:cd15075    73 CVLEGFAVAFFGIAALCTVAVIAVDRLFVVCKPLGTlTFQTRHALAGIASSWLWSLIWNTP-PLFGWGSyQLEGVMTSCA 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 262 CLYRtSPDPAQLgaAFSVGLVVACYLLPFLLMCFCHYHICKTVR-LSDVRVRPVNTYARvlrffSEVRTATTVLIMIVFV 340
Cdd:cd15075   152 PDWY-SRDPVNV--SYILCYFSFCFAIPFAIILVSYGYLLWTLRqVAKLGVAEGGSTAK-----AEVQVARMVVVMVMAF 223
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 341 ICCWGPYCFLVLLAAARqaQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15075   224 LLCWLPYAAFALTVVSK--PDVYINPLIATVPMYLAKSSTVYNPIIYIFMN 272
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
182-391 1.35e-09

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 59.18  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 182 GFCA--ASRFFSSCFGIV----STLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPwELLGAPREL 253
Cdd:cd15069    63 GFCTdfHSCLFLACFVLVltqsSIFSLLAVAVDRYLAIKVPLRYKslVTGKRARGVIAVLWVLAFGIGLT-PFLGWNKAM 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 254 AA----------AQSFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHI----CKTVRLSDVRVRPVNTYAR 319
Cdd:cd15069   142 SAtnnstnpadhGTNHSCCLISCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIflvaCRQLQRTELMDHSRTTLQR 221
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370465484 320 vlrffsEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15069   222 ------EIHAAKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRN 287
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
120-386 1.37e-09

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 58.97  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgfCAASRFFSSCFGIVST 199
Cdd:cd14977    17 GNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVM--------CKLVPFIQVTSLGVTV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPwELLgaPRELAAAQSFHG-----CLYRTSPDPAQ 272
Cdd:cd14977    89 FSLCALSIDRYRAAVNSMPMQtiGACLSTCVKLAVIWVGSVLLAVP-EAV--LSTVARESSLDNssltvCIMKPSTPFAE 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFSVGLVVACY-LLPFLLMCFCHYHICKTVRlsdvRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPY--CF 349
Cdd:cd14977   166 TYPKARSWWLFGCYfCLPLAFTAVCYLLMARTLI----RAAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLPEhiSN 241
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 350 LV--LLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVI 386
Cdd:cd14977   242 ILraTLYNEVLIDTRSTLDILDLIGQFLSFFNSCVNPIA 280
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
120-391 1.49e-09

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 58.83  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLftppggsapaaAAGPW---RGFCAASRFFSSCFG 195
Cdd:cd15310    17 GNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPwVVYLEV-----------TGGVWnfsRICCDVFVTLDVMMC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 IVSTLSVALISLDRYCAIVRPPREKIG-----RRRALQLLAGAWLTALGFSLPWeLLGaprelaaaqsfhgclYRTSPDP 270
Cdd:cd15310    86 TASILNLCAISIDRYTAVVMPVHYQHGtgqssCRRVSLMITAVWVLAFAVSCPL-LFG---------------FNTTGDP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQLGAA---FSVGLVVACYLLPFLLMCFchyhicktvrlsdvrvrpvnTYARVLRFFSEVRTATTVLIMIVFV-ICCWGP 346
Cdd:cd15310   150 TVCSISnpdFVIYSSVVSFYLPFGVTLL--------------------VYVRIYVVLLREKKATQMLAIVLGAfIVCWLP 209
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 347 YCFLVLLAAarQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15310   210 FFLTHILNT--HCQACHVPPELYSATTWLGYVNSALNPVIYTTFN 252
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
183-389 1.53e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 59.18  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCAASRFFSSCFGIVSTLSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAA---AQ 257
Cdd:cd14978    76 FLPYIYPLANTFQTASVWLTVALTVERYIAVCHPlkARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENcnnNS 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 258 SFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSD-VRVRPVNTYARVLRFFSEVRTATTVLIM 336
Cdd:cd14978   156 YYYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKkRRRLLRRRRRLLSRSQRRERRTTIMLIA 235
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 337 IVFV-ICCWGPYCFL-VLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd14978   236 VVIVfLICNLPAGILnILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCL 290
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
120-393 1.81e-09

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 58.70  E-value: 1.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLD-LFTPPGG-SAPAAAAGPWRGFCAASRFFSSCFGI- 196
Cdd:cd15971    17 GNTLVIYVILRYAKMKTVTNIYI--------------LNLAIADeLFMLGLPfLAIQVALVHWPFGKAICRVVMTVDGIn 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 --VSTLSVALISLDRYCAIVRPPREKIGRR-RALQLLAGA-WLTALGFSLPWELlgapreLAAAQSFHGCLYRTSPDPAQ 272
Cdd:cd15971    83 qfTSIFCLTVMSIDRYLAVVHPIKSAKWRKpRTAKMINMAvWGVSLLVILPIMI------YAGVQTKHGRSSCTIIWPGE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGA---AFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVrpvntyARVLRFFSEVRTATTVLIMIVFVICCWGPYCF 349
Cdd:cd15971   157 SSAwytGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRV------GSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYI 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 350 LVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15971   231 FNVSSVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDN 274
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
120-388 2.03e-09

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 58.81  E-value: 2.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRT-VTNAFILSLSLSDLLTALLCLPaafldlftpPGGSAPAAAAGPWRGFCAASRFFSSCFGIVS 198
Cdd:cd15319    17 GNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMP---------WKAVAEVAGYWPFGAFCDVWVAFDIMCSTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 199 TLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFS-----LPWELLGAPRELAAAQSFHGCLYRTSPDpA 271
Cdd:cd15319    88 ILNLCVISVDRYWAISSPFRyeRKMTQRVALVMISVAWTLSVLISfipvqLNWHKDSGDDWVGLHNSSISRQVEENCD-S 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAAFSVGLVVACYLLPFLLMCFCHYHIcktVRLSDVRVRPVNTYARVLRFFSEVRTA--------------------- 330
Cdd:cd15319   167 SLNRTYAISSSLISFYIPVAIMIVTYTRI---YRIAQIQIRRISSLERAAEHAQSCRSNridchhhtslrtsikketkvl 243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 331 -TTVLIMIVFViCCWGPYCFLVLLAAARQAQTMQAPSLLSVVA-------VWLTWANGAINPVIYA 388
Cdd:cd15319   244 kTLSVIMGVFV-CCWLPFFILNCMVPFCDRPPADPDAGLPCVSettfdvfVWFGWANSSLNPIIYA 308
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
120-396 2.26e-09

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 58.34  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldlFTPPGGSAPAAAAGPwrGFCAASRFFSSCFGIVST 199
Cdd:cd15978    17 GNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMP------FTLIPNLLKDFIFGS--AVCKTATYFMGISVSVST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAF 277
Cdd:cd15978    89 FNLVAISLERYSAICKPLKSRVwqTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCRLLWPNDVTQQSW 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHIcktvrlsdvrvrPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPycfLVLLAAAR 357
Cdd:cd15978   169 YIFLLLILFLIPGIVMMTAYGLI------------SLELYRGIKFLMAKKRVIRMLIVIVILFFLCWTP---IFSANAWR 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 358 QAQTMQAPSLLSVVAV----WLTWANGAINPVIYAIRNPNISM 396
Cdd:cd15978   234 AFDTRSADRLLSGAPIsfihLLSYTSACVNPIIYCFMNKRFRM 276
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
120-393 3.09e-09

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 57.95  E-value: 3.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPAAFLDLFtppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15092    17 GNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDIF-----------LGFWpfgNALCKTVIAIDYYNMF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSfhgCLYRTSPDPAQLG 274
Cdd:cd15092    85 TSTFTLTAMSVDRYVAICHPIKALDVRtpHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIE---CLVEIPTPQDYWD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKtvRLSDVRVRPVNTYA-RVLRffsevRTATTVLIMIVFVICCWGPYCFLVLL 353
Cdd:cd15092   162 PVFGICVFLFSFIIPVLIISVCYSLMIR--RLRGVRLLSGSKEKdRNLR-----RITRLVLVVVAVFVGCWTPIQIFVLA 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 354 aaarQAQTMQAPSLLSVV----AVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15092   235 ----QGLGVQPSSETAVAilrfCTALGYVNSSLNPVLYAFLDEN 274
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
190-389 3.16e-09

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 57.70  E-value: 3.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 190 FSSCFGIvstlsvALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLgapRE----LAAAQSFHGCL 263
Cdd:cd14974    84 FASVFLL------TAISLDRCLLVLHPVWAQNHRtvRLASVVCVGIWILALVLSVPYFVF---RDtvthHNGRSCNLTCV 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 264 YRTSPDPAQLGAAFSVGLVVAcYLLPFLLMCFCHyhICKTVRLSDVRVRPVNTYARVLrffsevrtatTVLIMIVFVicC 343
Cdd:cd14974   155 EDYDLRRSRHKALTVIRFLCG-FLLPLLIIAICY--SVIAVKLRRKRLAKSSKPLRVL----------LAVVVAFFL--C 219
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370465484 344 WGPYCFLVLLaaarqaQTMQAPSLLSVVAVW------LTWANGAINPVIYAI 389
Cdd:cd14974   220 WLPYHVFALL------ELVAAAGLPEVVLLGlplatgLAYFNSCLNPILYVF 265
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
120-387 5.10e-09

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 57.23  E-value: 5.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFtppggsapaaaagpwrGFCAASRFFSSCFGIV- 197
Cdd:cd15327    17 GNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPfSATLEVL----------------GFWAFGRVFCDIWAAVd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 ------STLSVALISLDRYCAI---VRPPrEKIGRRRALQLLAGAWLTALGFSLPwELLGAPRELAAAQSFhgCLYRTSP 268
Cdd:cd15327    81 vlcctaSILSLCVISVDRYVGVkhsLKYP-TIMTERKAGVILVLLWVSSMVISIG-PLLGWKEPPPPDESI--CSITEEP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAQLGAAFSvglvvacYLLPFLLMCFCHYHIcktvrlsdvrvrpvntYARVLRFFSEVRTATTVLIMIVFVICCWGPYC 348
Cdd:cd15327   157 GYALFSSLFS-------FYLPLMVILVMYFRV----------------YVVALKFSREKKAAKTLAIVVGVFILCWFPFF 213
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 349 FLVLLAAARQAqtMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15327   214 FVLPLGSFFPA--LKPSEMVFKVIFWLGYFNSCVNPIIY 250
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
120-391 5.31e-09

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 57.36  E-value: 5.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFtppggsapaaaaGPW---RGFCAASRFFSSCFG 195
Cdd:cd15065    16 GNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTfAVVNDLL------------GYWlfgETFCNIWISFDVMCS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 IVSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFS-LPWEL-LGAPRELAAAQSFHgclyRTSPDPA 271
Cdd:cd15065    84 TASILNLCAISLDRYIHIKKPLKyeRWMTTRRALVVIASVWILSALISfLPIHLgWHRLSQDEIKGLNH----ASNPKPS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 ---QLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFF--------------SEVRTATTV- 333
Cdd:cd15065   160 calDLNPTYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIKSQKLPSESGSKFqvpslsskhnnqgvSDHKAAVTLg 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370465484 334 LIMIVFVIcCWGPYcFLVLLAAARQAQTMqaPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15065   240 IIMGVFLI-CWLPF-FIINIIAAFCKTCI--PPKCFKILTWLGYFNSCLNPIIYSIFN 293
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
120-391 6.15e-09

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 57.00  E-value: 6.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDLFTPPGGS---APAAAAGPW---RGFCAASRFFSSC 193
Cdd:cd15066    16 GNLLVIISVMRHRKLRVITNYFV--------------VSLAMADMLVALCAMtfnASVEITGRWmfgYFMCDVWNSLDVY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGIVSTLSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPWELLG----APRELAAAQSFHGCLYRTS 267
Cdd:cd15066    82 FSTASILHLCCISVDRYYAIVQPleYPSKMTKRRVAIMLANVWISPALISFLPIFLGwyttEEHLQYRKTHPDQCEFVVN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 268 PDPAQLGAAFSvglvvacYLLPFLLMCFCHYHIcktvrlsdvrvrpvntYARVLRffsEVRTATTV-LIMIVFVIcCWGP 346
Cdd:cd15066   162 KIYALISSSVS-------FWIPCIVMIFTYYRI----------------YLEAKR---EHKAAKTLgIIMGAFIL-CWLP 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 347 YcFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15066   215 F-FLWYVTTTLCGDACPYPPILVSILFWIGYFNSTLNPLIYAYFN 258
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
120-392 6.57e-09

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 56.82  E-value: 6.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppGGSAPAAAAGPWR--GFCAASRFFSSCFGIV 197
Cdd:cd15137    17 GNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASVDLY---YRGVYIKHDEEWRssWLCTFAGFLATLSSEV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPR-EKIGRRRALQLLAGAWLTALGFS----LPWELLGaprelaaaqSFHG----C--LYRT 266
Cdd:cd15137    94 SVLILTLITLDRFICIVFPFSgRRLGLRRAIIVLACIWLIGLLLAvlplLPWDYFG---------NFYGrsgvClpLHIT 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 267 SPDPAqlGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPvntyarvlRFFSEVRTATTVLIMIVFV-ICCWG 345
Cdd:cd15137   165 DERPA--GWEYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAAS--------RKSKRDMAVAKRFFLIVLTdFLCWI 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1370465484 346 PYCFLVLLAAARqaqtMQAPSLLSV-VAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15137   235 PIIVIGILALSG----VPIPGEVYAwVAVFVLPINSALNPILYTLSTP 278
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
121-388 7.01e-09

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 56.76  E-value: 7.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 121 NCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgfCAASRFFSSCFGIVSTL 200
Cdd:cd15078    18 NLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAG--------CVWDGFSNSLFGIVSIM 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 201 SVALISLDRYCAIVRPprEKIGRRRALQLLAGAWLtalgFSLPWE---LLGAPRELAAAQSFHGCLYRTSPDPAQlgAAF 277
Cdd:cd15078    90 TLTVLAYERYIRVVHA--KVVNFSWSWRAITYIWL----YSLAWTgapLLGWNRYTLEVHGLGCSFDWKSKDPND--TSF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVR-LSDVRVRPVNTYARVLRFfsEVRTATTVLIMIVFVICCWGPYCFLVLLAAA 356
Cdd:cd15078   162 VLLFFLGCLVVPLGIMAYCYGHILYEIRmLRSVEDLQTFQVIKILKY--EKKVAKMCLLMISTFLICWMPYAVVSLLVTS 239
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1370465484 357 RQAQTMqAPSlLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15078   240 GYSKLV-TPT-IAIIPSLFAKSSTAYNPVIYI 269
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
120-393 7.21e-09

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 56.57  E-value: 7.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPWRGFCAASRFFSSCFGIVST 199
Cdd:cd15064    17 GNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELT-----------GRWILGQVLCDIWISLDVTCCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 ---LSVALISLDRYCAIVRP---PREKIGrRRALQLLAGAWLTALGFSLPwELLGAPRELAAAQSfhGCLyrTSPDPAQl 273
Cdd:cd15064    86 asiLHLCVIALDRYWAITDAveyAHKRTP-KRAAVMIALVWTLSICISLP-PLFGWRTPDSEDPS--ECL--ISQDIGY- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 gAAFSVglVVACYlLPFLLMCFCHYHICKTVrlsdvrvrpvntyARvlrffsEVRTATTV-LIMIVFVIcCWGPYcFLVL 352
Cdd:cd15064   159 -TIFST--FGAFY-IPLLLMLILYWKIYRAA-------------AR------ERKAAKTLgIILGAFIV-CWLPF-FLVA 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 353 LAAARQAQTmQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15064   214 LIVPLCSHC-WIPLALKSFFLWLGYFNSLINPLIYTFFNKD 253
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
120-393 7.29e-09

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 56.84  E-value: 7.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPWR-GF--CAASRFFSSCFGI 196
Cdd:cd15402    17 GNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFH-----------NGWNlGYlhCQISGFLMGLSVI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPR-EKI-GRRRALQLLAGAWLTALGFSLPWELLGApreLAAAQSFHGCLYRTSpdpaqLG 274
Cdd:cd15402    86 GSIFNITGIAINRYCYICHSLKyDKLySDKNSLCYVLLIWVLTVAAIVPNLFVGS---LQYDPRIYSCTFAQS-----VS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNtyaRVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:cd15402   158 SAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPDN---KPKLKPHDFRNFVTMFVVFVLFAVCWAPLNFIGLAV 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370465484 355 AARQAQTM-QAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15402   235 AVDPETIVpRIPEWLFVASYYMAYFNSCLNAIIYGLLNQN 274
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
120-388 8.26e-09

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 56.94  E-value: 8.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRT-VTNAFILSLSLSDLLTALLCLP-------AAFLDLFTppggsapaaaagpwrgFCAASRFFS 191
Cdd:cd15320    18 GNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPwkavaeiAGFWPFGS----------------FCNIWVAFD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 192 SCFGIVSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAW-LTALGFSLPWELLGAPRELAAAQSFHGCLYRTSP 268
Cdd:cd15320    82 IMCSTASILNLCVISVDRYWAISSPFRyeRKMTPKVAFIMISVAWtLSVLISFIPVQLNWHKAKPTSFLDLNASLRDLTM 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 D--PAQLGAAFSVGLVVACYLLPFLLMCFCHYHIcktVRLSDVRVRPVNTYARV-------------------------- 320
Cdd:cd15320   162 DncDSSLNRTYAISSSLISFYIPVAIMIVTYTRI---YRIAQKQIRRISALERAavhakncqnstgnrgsgdcqqpessf 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370465484 321 -LRFFSEVRTATTV-LIMIVFViCCWGPYCFLVLLAAARQAQTMQAPSLLSV---VAVWLTWANGAINPVIYA 388
Cdd:cd15320   239 kMSFKRETKVLKTLsVIMGVFV-CCWLPFFILNCMVPFCKPTSTEPFCISSTtfdVFVWFGWANSSLNPIIYA 310
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
120-392 9.85e-09

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 56.20  E-value: 9.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15053    17 GNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVN----------GGKWylgPILCDIYIAMDVMCST 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWeLLGaprelaaaqsFHGCLYRTSPDPAQLG 274
Cdd:cd15053    87 ASIFNLCAISIDRYIAVTQPIKYARQKnsKRVLLTIAIVWVVSAAIACPL-LFG----------LNNVPYRDPEECRFYN 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFchyhicktvrlsdvrvrpvnTYARVLRFFSEVRTATTVLIMIVFV-ICCWGPYCFLVLL 353
Cdd:cd15053   156 PDFIIYSSISSFYIPCIVMLL--------------------LYYRIFRALRREKKATKTLAIVLGVfLFCWLPFFTLNIL 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370465484 354 AA---ARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15053   216 NAicpKLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNI 257
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
120-392 1.09e-08

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 56.12  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPW---RGFCaasRFFSSCFGI 196
Cdd:cd15329    17 GNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELS-----------GYWpfgEILC---DVWISFDVL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VST---LSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPwELLGAPRELAAAQSfhgCLYrtSPDPA 271
Cdd:cd15329    83 LCTasiLNLCAISVDRYLVITRPLTYAVKRtpKRMALMIAIVWLLSALISIP-PLFGWKNKVNDPGV---CQV--SQDFG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 -QLGAAFsvglvVACYlLPFLLMCFCHYHICKTVRlsdvrvrpvntyarvlrffSEVRTATTV-LIMIVFVIcCWGPYCF 349
Cdd:cd15329   157 yQIYATF-----GAFY-IPLIVMLVLYYKIYRAAK-------------------SERKAIKTLgIIMGAFTL-CWLPFFI 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 350 LVLLAAARQAQTMQA-PSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15329   211 LALLRPFLKPIKCSCiPLWLSRLFLWLGYANSFLNPIIYAKFNR 254
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
120-387 1.22e-08

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 56.05  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFtppggsapaaaagpwrGFCAASRFFSSCFGIV- 197
Cdd:cd15326    17 GNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPfSATLEIL----------------GYWVFGRIFCDIWAAVd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 ------STLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPwELLGAPRelAAAQSFHGCLYRTSPD 269
Cdd:cd15326    81 vlcctaSILSLCAISIDRYIGVRHSLQYPtiVTRKRAILALLGVWVLSTVISIG-PLLGWKE--PAPPDDKVCEITEEPF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PAQLG--AAFSVGLVVacyllpfLLMCFChyhicktvrlsdvRVrpvntYARVLRFFSEVRTATTVLIMIVFVICCWGPy 347
Cdd:cd15326   158 YALFSslGSFYIPLIV-------ILVMYC-------------RV-----YIVALKFSREKKAAKTLGIVVGMFILCWLP- 211
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370465484 348 cFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15326   212 -FFIALPLGSLFSHLKPPETLFKIIFWLGYFNSCLNPIIY 250
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
120-391 1.22e-08

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 55.86  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldlFTPPGGSApaaaagpwRGF------CAASRFFSSC 193
Cdd:cd15206    17 GNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMP------FTLVGQLL--------RNFifgevmCKLIPYFQAV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGIVSTLSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLPWELLGAPRELaAAQSFHGCLYRTSPDPA 271
Cdd:cd15206    83 SVSVSTFTLVAISLERYFAICHPLKSRVwqTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPM-SRPGGHKCREVWPNEIA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLgaAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVrpvntyarVLRFFsevrtattVLIMIVFVicCWGPYCFL- 350
Cdd:cd15206   162 EQ--AWYVFLDLMLLVIPGLVMSVAYGLISWTLLEAKKRV--------IRMLF--------VIVVEFFI--CWTPLYVIn 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 351 --VLLAAARQAQTMqAPSLLSVVAVwLTWANGAINPVIYAIRN 391
Cdd:cd15206   222 twKAFDPPSAARYV-SSTTISLIQL-LAYISSCVNPITYCFMN 262
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
120-393 1.58e-08

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 55.94  E-value: 1.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgfCAASRFFSSCFGIVST 199
Cdd:cd15209    17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLH--------CQASGFIMGLSVIGSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPR-EKIGRRR-ALQLLAGAWLTALGFSLPWELLGApreLAAAQSFHGCLYRTSPDPaqlgaAF 277
Cdd:cd15209    89 FNITAIAINRYCYICHSLQyDRLYSLRnTCCYLCLTWLLTVLAVLPNFFIGS---LQYDPRIYSCTFAQTVST-----VY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPvntYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAAR 357
Cdd:cd15209   161 TITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKP---DQRPKLKPADVRNFLTMFVVFVLFAVCWAPLNFIGLAVAIN 237
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1370465484 358 QAQTM-QAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15209   238 PKEMApKIPEWLFVASYFMAYFNSCLNAIIYGLLNQN 274
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
117-390 1.58e-08

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 56.10  E-value: 1.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 117 SSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFldlftppggsapaaaaGPWRGFCAASR--FFSSCF 194
Cdd:cd15068    14 AILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI----------------TISTGFCAACHgcLFIACF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 195 GIV----STLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLT--ALGFS--LPWELLGAPRElaaaqsfhGCLY 264
Cdd:cd15068    78 VLVltqsSIFSLLAIAIDRYIAIRIPLRYNglVTGTRAKGIIAICWVLsfAIGLTpmLGWNNCGQPKE--------GKNH 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 265 RTSPDPAQLGAAFSVGLVV---------ACYLLPFLLMCFCHYHICKTVR--LSDVRVRPVNTYARVLRFFSEVRTATTV 333
Cdd:cd15068   150 SQGCGEGQVACLFEDVVPMnymvyfnffACVLVPLLLMLGVYLRIFLAARrqLKQMESQPLPGERARSTLQKEVHAAKSL 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 334 LIMIVFVICCWGPY----CFLVLLAAARqaqtmQAPSLLSVVAVWLTWANGAINPVIYAIR 390
Cdd:cd15068   230 AIIVGLFALCWLPLhiinCFTFFCPDCS-----HAPLWLMYLAIVLSHTNSVVNPFIYAYR 285
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
119-387 1.86e-08

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 55.91  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 119 LGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPW---RGFCAASRFFsSCFG 195
Cdd:cd15384    16 IGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYT-----------VAWlagNTMCKLVKYL-QVFG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 I-VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCL---YRTSPDPA 271
Cdd:cd15384    84 LyLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQCVtygFYTAEWQE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAAFSVGLVvacYLLPFLLMCFCHYHICKTVRLS-----DVRVRPVNTYARVLRFFSEVRTAT---TVLIMIVFVIcC 343
Cdd:cd15384   164 QLYNMLSLVFM---FPIPLVIMVTCYVLIFITLSKSsrdfqGLEIYTRNRGPNRQRLFHKAKVKSlrmSAVIVTAFIL-C 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 344 WGPYCFLVLLAAARQAQTMQapSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15384   240 WTPYYVIMIWFLFFNPYPLN--DILFDVIFFFGMSNSCVNPLIY 281
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
183-387 2.17e-08

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 55.40  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPRE-KIGRRRALQLLAGA-WLTALGFSLPWELLGAPRELAAAQSfh 260
Cdd:cd15168    72 MCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPLRSlGKLKKRHAVAISVAvWILVLLQLLPILFFATTGRKNNRTT-- 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 261 gCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRffsevrtaTTVLIMIVFV 340
Cdd:cd15168   150 -CYDTTSPEELNDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTSALRRKSIR--------LVIIVLALFA 220
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370465484 341 IcCWGPY-------CFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15168   221 V-CFLPFhvtrtinLAARLLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLY 273
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
120-391 2.28e-08

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 54.97  E-value: 2.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLtallcLPAAFLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSCfgiVST 199
Cdd:cd17790    17 GNLLVLISFKVNSELKTVNNYFLLSLACADLI-----IGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASN---ASV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTALGFSLP----WELLGAPRELAAAQsfhgCLYRTSPDPaql 273
Cdd:cd17790    89 MNLLIISFDRYFSITRPLtyRAKRTPRRAAIMIGLAWLISFVLWAPailfWQYLVGERTVLAGQ----CYIQFLSQP--- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 gaAFSVGLVVACYLLPFLLMCFCHYHIcktvrlsdvrvrpvntYARVLRffsEVRTATTVLIMIVFVICCWGPYCFLVLL 353
Cdd:cd17790   162 --IITFGTAIAAFYLPVTIMIILYWRI----------------YRETIK---EKKAARTLSAILLAFILTWTPYNIMVLV 220
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1370465484 354 AAARQAQTmqaPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd17790   221 STFCKDCV---PKTLWELGYWLCYVNSTVNPMCYALCN 255
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
198-387 2.32e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 54.93  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPRE-KIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQsfHGCLYRTSPDPAQlgAA 276
Cdd:cd15196    87 SSYVLVATAIDRYIAICHPLSShRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVGSGV--YDCWATFEPPWGL--RA 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 277 FSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRvrpvntyarvlrffsevrtatTVLIMIVFVIC---CWGPYcFLVLL 353
Cdd:cd15196   163 YITWFTVAVFVVPLIILAFCYGRICYVVWRAKIK---------------------TVKLTLVVVACyivCWTPF-FVVQM 220
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1370465484 354 AAARQAqtmQAPSLLSVVAVWLTWA--NGAINPVIY 387
Cdd:cd15196   221 WAAWDP---TAPIEGPAFVIIMLLAslNSCTNPWIY 253
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
117-390 2.38e-08

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 55.23  E-value: 2.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 117 SSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPW---RGFCAASRFFSSC 193
Cdd:cd15404    14 SFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIIT-----------TRWifgDAFCRVSAMFFWL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGIVSTLSVALISLDRYCAIVRpPREKIGRRRALQLLAGAWLTALGFSLPWElLGAPrELAAAQSFHGCLYRTSPDPAQl 273
Cdd:cd15404    83 FVMEGVAILLIISIDRFLIIVQ-KQDKLNPYRAKVLIAVSWAVSFCVAFPLA-VGSP-DLQIPSRAPQCVFGYTTNPGY- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 gAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpvntyarvlrfFSEVRTATTVLIMIVFVICCWGPYCFLVLL 353
Cdd:cd15404   159 -QAYVILIMLIFFFIPFMVMLYSFMGILNTVR------------------SFKTRAFTTILILFIVFTVCWAPFTTYSLV 219
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1370465484 354 AAARQAQTMQAPSL-LSVVAVWLTWANGAINPVIYAIR 390
Cdd:cd15404   220 ATFNSHFYHKHNFFeISTWLLWLCYLKSALNPLIYYWR 257
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
121-391 2.40e-08

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 55.24  E-value: 2.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 121 NCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDLFTPPGGSAPAAAAGPW------RGFCAASRFFSSCF 194
Cdd:cd15085    18 NVLVIAVTLKNPQLRNPINIFI--------------LNLSFSDLMMALCGTTIVTVTNYEgyfylgDAFCIFQGFAVNYF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 195 GIVSTLSVALISLDRYCAIVRPPRE-KIGRRRALQLLAGAWLTALGFS----LPWELLGaPRELAAAQSFhGCLYRTSPD 269
Cdd:cd15085    84 GIVSLWSLTLLAYERYNVVCKPMGGlKLSTKRGYQGLLFIWLFCLFWAvaplFGWSSYG-PEGVQTSCSI-GWEERSWSN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PAQLGAAFsvglvVACYLLPFLLMCFCHYHICKTVRLSDVRVRPV--NTYARvlrffSEVRTATTVLIMIVFVICCWGPY 347
Cdd:cd15085   162 YSYLILYF-----LMCFVIPVAIIGFSYGNVLRSLHKLNKKIEQQggKNCPE-----EEERAVIMVLAMVIAFLICWLPY 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 348 CFLVLLAAARQAqtMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15085   232 TVFALIVVVNPE--LSISPLAATMPTYFAKTSPVYNPIIYIFLN 273
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
120-389 2.44e-08

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 55.25  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsAPAAAAGPWRGFCAASRFFSSCFGivST 199
Cdd:cd15357    17 GNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWS-----NYPFLFGPVGCYFKTALFETVCFA--SI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIG--RRRALQLLAGAWLTALGFSLPwellgaprelaaAQSFHGCLYRTSPDpAQLGAAF 277
Cdd:cd15357    90 LSVTTVSVERYVAILHPFRAKLNstRERALKIIVVLWVLSVLFSIP------------NTSIHGIKLQYFPN-GTLIPDS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVA---------------CYLLPFLLMCFCHYHIckTVRLSDVRVRPVNTY-ARVLRFFSEVRTATTVLIMIVFVI 341
Cdd:cd15357   157 ATCTVVKplwiynliiqitsllFYVLPMGVISVLYYLM--GLKLRGDKSLEADEMnVNIQRPSRKSVTKMLFVLVLVFAI 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 342 cCWGPYCFLVLLAAARQAQTMQ---APSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15357   235 -CWAPFHVDRLFFSFVVEWTEPlanVFNLIHVVSGVFFYLSSAVNPIIYNL 284
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
198-387 2.65e-08

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 55.14  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQ--SFHGCLyrtsPDPAQL 273
Cdd:cd15372    86 SVLLLMCISLDRYLAVVHPFFARTlrSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNitLCHDVL----PLDEQD 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 GAAFS--VGLVVACYLLPFLLMCFCHYHICKTVRLSDVRvrpvntYARVLRFfsevrtatTVLIMIVFVICCWGPYCFLV 351
Cdd:cd15372   162 TYLFYyfACLAVLGFLLPLVVILFCYGSVLHTLLRSGQR------YGHAMKL--------TVLVLVSFVLCFTPSNLLLL 227
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1370465484 352 LLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15372   228 LHYSDPTLDDGGNLYIVYMVSLAISTLNSCVDPFIY 263
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
120-388 4.32e-08

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 54.36  E-value: 4.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15394    17 GNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFE----------PRGWvfgRFMCYFVFLMQPVTVY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPwellgaprelAAAQSFHGCL----------YRT 266
Cdd:cd15394    87 VSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALP----------AAAHTYYVEFkgldfsiceeFWF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 267 SPDPAQLgaAFSVGLVVACYLLPFLLMCFCHYHIckTVRLSDvRVRPVNTYARVLRFFSEVRTATTVLIMIVFVI--CCW 344
Cdd:cd15394   157 GQEKQRL--AYACSTLLITYVLPLLAISLSYLRI--SVKLRN-RVVPGSMTQSQAEWDRARRRKTFRLLVVVVVAfaICW 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 345 GP-YCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15394   232 LPlHIFNVIRDIDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYA 276
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
198-391 5.06e-08

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 54.26  E-value: 5.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRP---PREKIGRRRALqLLAGAWLTALGFSLP----WELLGAPRELAAAQsfhgCLYRTSPDP 270
Cdd:cd15298    87 SVMNLLIISFDRYFCVTKPltyPARRTTKMAGL-MIAAAWVLSFVLWAPailfWQFVVGKRTVPDNQ----CFIQFLSNP 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AqlgaaFSVGLVVACYLLPFLLMCFCHYHIcktvRLSDVRVRPVntyarvlrffsevrTATTVLIMIVFVICcWGPYCFL 350
Cdd:cd15298   162 A-----VTFGTAIAAFYLPVVIMTVLYIHI----SLASARERKV--------------TRTIFAILLAFILT-WTPYNVM 217
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 351 VLLAAARQAQTmqaPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15298   218 VLVNTFCQSCI---PDTVWSIGYWLCYVNSTINPACYALCN 255
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
198-387 5.33e-08

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 54.37  E-value: 5.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRP---PREKIGRRRALQLLagAWLTALGFSLPWELLGA--PRELAAAQSFHGCLYRTSPDP-- 270
Cdd:cd14999    85 SIFTLTVMSTERYLAVVKPldtVKRSKSYRKLLAGV--IWLLSLLLTLPMAIMIRlvTVEDKSGGSKRICLPTWSEESyk 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQLGAAFSVGLVVacyllPFLLMCFCHYHICKTVRLSdVRVRPVNTYARVLRffseVRTATTVLIMIVFVICCWGPYCFL 350
Cdd:cd14999   163 VYLTLLFSTSIVI-----PGLVIGYLYIRLARKYWLS-QAAASNSSRKRLPK----QKVLKMIFTIVLVFWACFLPFWIW 232
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370465484 351 VLLAAARQAQTMQAPSLLSV--VAVWLTWANGAINPVIY 387
Cdd:cd14999   233 QLLYLYSPSLSLSPRTTTYVnyLLTCLTYSNSCINPFLY 271
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
120-393 5.65e-08

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 54.15  E-value: 5.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAaaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15401    17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNI--------HCQISGFLMGLSVIGSV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPWELLGApreLAAAQSFHGCLYRTSpdpaqLGAAF 277
Cdd:cd15401    89 FNITAIAINRYCYICHSLRydKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGS---LQYDPRIYSCTFAQT-----VSSSY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRpvNTYARVLRfFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAAR 357
Cdd:cd15401   161 TITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHRVR--QDSKQKLK-ANDIRNFLTMFVVFVLFAVCWGPLNFIGLAVAIN 237
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1370465484 358 QAQTM-QAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15401   238 PLKVApKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQN 274
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
120-388 8.84e-08

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 53.45  E-value: 8.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldlFTPPGGSAPAAAAGPWrgFCAASRFFS--SCFGIV 197
Cdd:cd15096    17 GNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVP------FTATDYVLPTWPFGDV--WCKIVQYLVyvTAYASV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLsvALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLGAPRELAaaqsFHGCLYRT---SPDPAQ 272
Cdd:cd15096    89 YTL--VLMSLDRYLAVVHPITSMSIRteRNTLIAIVGIWIVILVANIPVLFLHGVVSYG----FSSEAYSYctfLTEVGT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFSVGLVVACYLLPFLLMCFchYHICKTVRLSDVRVRPVNTYARVLRFFSEVrTATTVLIMIVFVIcCWGPYCFLVL 352
Cdd:cd15096   163 AAQTFFTSFFLFSYLIPLTLICV--LYMLMLRRLRRQKSPGGRRSAESQRGKRRV-TRLVVVVVVVFAI-CWLPIHIILL 238
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1370465484 353 LAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15096   239 LKYYGVLPETVLYVVIQILSNCLAYGNSCVNPILYA 274
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
117-388 9.39e-08

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 53.60  E-value: 9.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 117 SSLGNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPWRGF-C----AASRFFS 191
Cdd:cd15181    14 GVVGNGLVLTILLRRRRSRRTTENYLLHLAL-----------ADLLLLLTFPFSVVESIAGWVFGTFlCklvgAIHKLNF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 192 SCfgivSTLSVALISLDRYCAIVRP-PREKIGRRRALQLLAGA-WLTALGFSLPWELLgapreLAAAQSFHGClyRTSPD 269
Cdd:cd15181    83 YC----SSLLLACISVDRYLAIVHAiHSYRHRRLRSVHLTCGSiWLVCFLLSLPNLVF-----LEVETSTNAN--RTSCS 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PAQLGAAFSVGLV-------VACYLLPFLLMCFCHYHICKTVRLSDVRVrpvntyarvlrffsEVRTATTVLIMIVFVIC 342
Cdd:cd15181   152 FHQYGIHESNWWLtsrflyhVVGFFLPLLIMGYCYATIVVTLCQSSRRL--------------QKQKAIRVAILVTLVFC 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370465484 343 -CWGPYCFLVLLAAARQAQTMQAPSLLS-------VVAVWLTWANGAINPVIYA 388
Cdd:cd15181   218 lCWLPYNIVIFLDTLDDLKAVVKNCKLNdlldaaiTVTESLGFSHCCLNPILYA 271
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
198-394 1.12e-07

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 53.02  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRP---PReKIGRRRALQLLAGAWLTALGFSLP----WELLGAPR-ELAAAQSFHGclyrtspd 269
Cdd:cd15214    86 SMLTLGAIAIDRYYAVLYPmvyPM-KITGNRAVLALVYIWLHSLIGCLPplfgWSSLEFDRfKWMCVAAWHK-------- 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 paqlGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLsdvrvrpvntyarvlrffSEVRTATTVLIMIVFVICCWGPYcF 349
Cdd:cd15214   157 ----EAGYTAFWQVWCALLPFVVMLVCYGFIFRVARA------------------NQCKAFITILVVLGAFVTTWGPY-M 213
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 350 LVLLAAARQAQTMQAPSlLSVVAVWLTWANGAINPVIYAIRNPNI 394
Cdd:cd15214   214 VVISTEALWGKNSVSPQ-LETLATWLSFTSAVCHPLIYGLWNKTV 257
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
182-389 1.18e-07

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 52.85  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 182 GFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPWELLGApreLAAAQSF 259
Cdd:cd15219    71 GFCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSytSKMRYRDAALMVGYSWLHSLTFSLVALFLSW---LGYSSLY 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 260 HGCLYRTSPDPAQLG-AAFSVGLVVACYLLPFLLMCFchyhicktvrlsdvrvrpvnTYARVLRFFSEVRTATTVLIMIV 338
Cdd:cd15219   148 ASCTLHLPREEERRRfAVFTAFFHAFTFLLSLLVLCV--------------------TYLKVLKVRRRQRATKKISIFIG 207
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 339 FVICCWGPYcflVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15219   208 TFVLCFAPY---VITRLVELLPFVTINRYWGIVSKCLTYSKAASDPFVYSL 255
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
198-393 1.19e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 52.90  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTALGFSLPWEL--------LGAPRELAAAQSFHGCLYRTs 267
Cdd:cd15301    87 SVLNLLIISFDRYFSVTRPLtyRARRTTKKAAVMIASAWIISLLLWPPWIYswpyiegkRTVPAGTCYIQFLETNPYVT- 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 268 pdpaqlgaafsVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRvrpvntyarvlrffSEVRTATTVLIMIVFVICCWGPY 347
Cdd:cd15301   166 -----------FGTALAAFYVPVTIMCILYWRIWRETKKRQKK--------------QESKAAKTLSAILLAFIVTWTPY 220
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 348 CFLVLLAAArQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15301   221 NVLVLIKAF-FPCSDTIPTELWDFSYYLCYINSTINPLCYALCNAA 265
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
198-350 1.29e-07

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 53.14  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTS-PDPAQlGAA 276
Cdd:cd15383    88 SAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPQLFLFHTVTATPPVNFTQCATHGSfPAHWQ-ETL 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 277 FSVGLVVACYLLPFLLMCFCHYHI----CKTVRLSDVRVRPVNTYARVLRFFSEVRTAT---TVLIMIVFVIcCWGPYCF 349
Cdd:cd15383   167 YNMFTFFCLFLLPLLIMIFCYTRIlleiSRRMKEKKDSAKNEVALRSSSDNIPKARMRTlkmTIVIVSSFIV-CWTPYYL 245

                  .
gi 1370465484 350 L 350
Cdd:cd15383   246 L 246
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
198-393 1.29e-07

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 52.88  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRR-RALQLL-AGAWLTALGFSLPWELLGAPRElaaaqSFHGClYRTSPDPAQL-G 274
Cdd:cd15974    86 SIFCLTVMSIDRYLAVVHPIKSTKWRRpRVAKLInATVWTLSFLVVLPVIIFSDVQP-----DLNTC-NISWPEPVSVwS 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVrpvntyARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:cd15974   160 TAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRV------GSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVN 233
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370465484 355 AARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15974   234 LIVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDN 272
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
198-387 1.49e-07

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 52.83  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQ--SFHGCLYRTSPDPAQL 273
Cdd:cd15162    87 SILLLTCISIDRYLAIVHPmgHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDitTCHDVLPEQLLVGDWF 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 GAAFSVGLVVacYLLPFLLMCFCHYHICKTvrLSDVRVRPVNT-YARVLRFfsevrtatTVLIMIVFVIcCWGPYCFLVL 352
Cdd:cd15162   167 YYFLSLAIVG--FLIPFILTASCYVATIRT--LAALEDENSEKkKKRAIKL--------AATVLAIFII-CFAPSNLLLL 233
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1370465484 353 L-AAARQAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15162   234 AhYSLISSSGTGHLYFAYLLALCLSTLNSCIDPFIY 269
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
120-385 1.57e-07

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 53.04  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15927    17 GNGTLILIFLRNKSMRNVPNIFILSLAL-----------GDLLLLLTCVPFTSTIYTLDSWpfgEFLCKLSEFLKDTSIG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIG--RRRALQLLAGAWLTALGFSLPwELLGA---PRELAAAQSFHGClyrtSPDPA 271
Cdd:cd15927    86 VSVFTLTALSADRYFAIVNPMRKHRSqaTRRTLVTAASIWIVSILLAIP-EAIFShvvTFTLTDNQTIQIC----YPYPQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAAFSVGLVVAC----YLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPY 347
Cdd:cd15927   161 ELGPNYPKIMVLLRflvyYLIPLLIIGVFYVLMARHLIRSTRNIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLPR 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 348 CFLVL---LAAARQAQTMQAPSLLSVVAVWLTWANGAINPV 385
Cdd:cd15927   241 HVFMLwfhFAPNGLVDYNAFWHVLKIVGFCLSFINSCVNPV 281
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
120-393 1.86e-07

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 52.55  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgfCAASRFFSSCFGIVST 199
Cdd:cd15400    17 GNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMH--------CKVSGFVMGLSVIGSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRP-PREKIGRRR-ALQLLAGAWLTALGFSLPWELLGApreLAAAQSFHGCLYRTSpdpaqLGAAF 277
Cdd:cd15400    89 FNITGIAINRYCYICHSfAYDKLYSRWnTLLYVCLIWALTVVAIVPNFFVGS---LEYDPRIYSCTFVQT-----ASSSY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICktVRLSDVRvRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAAR 357
Cdd:cd15400   161 TIAVVVIHFIVPITVVSFCYLRIW--VLVIQVR-RKVKSESKPRLKPSDFRNFLTMFVVFVIFAICWAPLNLIGLAVAIN 237
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1370465484 358 -QAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15400   238 pQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQN 274
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
117-389 2.17e-07

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 52.47  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 117 SSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPAAFLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSCFgi 196
Cdd:cd15189    14 GLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSG-LPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIYL-- 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 vstlsVALISLDRYCAIVRPPREKIGRRRALQLLAGA--WLTALGFSLPWELLGAPRELAAAQSFhGCLYRTSPDPAQLg 274
Cdd:cd15189    91 -----LVMISQDRYLALVKTMAARRLRRRRYAKLICVliWVVGLLLSIPTFLLRKIKAIPDLNIT-ACVLLYPHEAWHF- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 aAFSVGLVVACYLLPFLLMCFCHYHIcktvrLSDVRVRPVNTYARVLrffSEVRTATTVLIMIVFVICCWGPYCFLVLL- 353
Cdd:cd15189   164 -AHIVLLNIVGFLLPLLVITFCNYNI-----LQALRTREESTRCEDR---NDSKATALVLAVTLLFLVCWGPYHFFTFLd 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 354 -----AAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15189   235 flfdvGVLDECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVF 275
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
184-347 2.35e-07

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 52.17  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWE-LLGAPRELAAAQSfh 260
Cdd:cd15356    78 CRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKrlLSKRRTKWLLALIWASSLGFALPMAfIMGQKYELETADG-- 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 261 gclyrtSPDPAQL-------GAAFSVGLVV---ACYLLPFLLMCFCHYhicktVRLSDVRVRPVNTYARVLRffsevrta 330
Cdd:cd15356   156 ------EPEPSSRvctvlvsRATLKVFIQVnafVSFVLPLALIAFLNG-----VTVSHLRIQSLQHSVQVLR-------- 216
                         170
                  ....*....|....*..
gi 1370465484 331 ttvLIMIVFVIcCWGPY 347
Cdd:cd15356   217 ---AIVIAYVI-CWLPY 229
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
120-387 3.19e-07

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 51.72  E-value: 3.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlSLSLSDLLTALLCLPaafLDLFtppggsapaaaaGPWRG--------FCAASRFFS 191
Cdd:cd15132    17 GNTMTVLIIRRYKDMRTTTNLYL-SSMAVSDLLILLCLP---FDLY------------RLWKSrpwifgefLCRLYHYIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 192 SCFGIVSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWE-LLGAPRELAAAQSFHGCLYRTSP 268
Cdd:cd15132    81 EGCTYATILHITALSIERYLAICFPLRAKvlVTRRRVKCVIAALWAFALLSAGPFLfLVGVEQDNNIHPDDFSRECKHTP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAQLGAAFSVGLVVACY-LLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffsEVRTATTVLIMIVFV---ICCW 344
Cdd:cd15132   161 YAVSSGLLGIMIWVTTTYfFLPMLCLSFLYGFIGRKLWKSKNDLRGPNAAAR------ERSHRQTVRILAVVVlafIICW 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 345 GPYCF-LVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15132   235 LPFHIgRILFANTEDYRTMMFSQYFNIVAMQLFYLSASINPILY 278
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
190-310 4.11e-07

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 51.28  E-value: 4.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 190 FSSCFgivstLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELaaaQSFHGCLyrtSPD 269
Cdd:cd15176    82 FSCGM-----QFLACISVDRYVAITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVREN---SDRYRCL---PVF 150
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 270 PAQLGAAFSVGL----VVACYLLPFLLMCFCHYHICKTV-RLSDVR 310
Cdd:cd15176   151 PPSLVTSAKATIqileVLLGFVLPFLVMVFCYSRVARALsRTPNVK 196
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
184-391 5.22e-07

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 51.45  E-value: 5.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRP-PREKIGRRRALQLLAGAWLTALGFSLPwELLGAPRELAaaqsfHGc 262
Cdd:cd15081    85 CVLEGFTVSVCGITGLWSLTIISWERWVVVCKPfGNIKFDGKLAIVGIIFSWVWSAVWCAP-PIFGWSRYWP-----HG- 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 263 lYRTSPDPAQLGA-------AFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffSEVRTATTVLI 335
Cdd:cd15081   158 -LKTSCGPDVFSGssdpgvqSYMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESESTQK-----AEKEVSRMVVV 231
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 336 MIVFVICCWGPYCFLVLLAAARQAQTMQapSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15081   232 MIFAYCFCWGPYTFFACFAAANPGYAFH--PLAAALPAYFAKSATIYNPIIYVFMN 285
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
198-393 7.55e-07

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 50.68  E-value: 7.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLLA--GAWLTALGFSLPweLLGAPRELAAAQSFHGCLYRTsPDPAQLG- 274
Cdd:cd15970    86 SIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVnlGVWVFSILVILP--IIIFSNTAPNSDGSVACNMQM-PEPSQRWl 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVrpvntyARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:cd15970   163 AVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKA------GWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVS 236
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370465484 355 AARQaqtmQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15970   237 VFVG----QHDATVSQLSVILGYANSCANPILYGFLSDN 271
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
121-315 7.73e-07

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 50.62  E-value: 7.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 121 NCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsaPAAAAGPWRGFCAASRFFSScfgIVSTL 200
Cdd:cd15211    17 NVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGST------GTLLVLGYRLFREGLLFLGL---TVSLL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 201 SVALISLDRYCAIVRPP---REKIGRRRALQLLAGAWLTALGFSLPWELLGAPRElaaaQSFHGCLYRTSPDPAQLGAAF 277
Cdd:cd15211    88 SHSLIALNRYVLITKLPavyQALYQKRNTEWMIALSWALALGLLLPWLTSFRYPT----KSCHDSADGSFAVVSVLSSRY 163
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVN 315
Cdd:cd15211   164 PALLLAFTVLGQTALVLHCYFGIFRRVQISVKRVSVLN 201
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
120-391 7.92e-07

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 50.51  E-value: 7.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAAAGPWrgfcaASRFFSSCfgIVST 199
Cdd:cd15302    17 GNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDYWPLGWVLCDLW-----LSVDYTVC--LVSI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLT-ALGFSLP---WE-LLGAPRELAAAQsfhgCLYRTSPDPaq 272
Cdd:cd15302    90 YTVLLITIDRYCSVKIPAKYRNWRtpRKVLLIIAITWIIpALLFFISifgWQyFTGQGRSLPEGE----CYVQFMTDP-- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 lgaAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpvntyaRVLRFFsevRTATtvLIMIVFVIcCWGPYCFLVL 352
Cdd:cd15302   164 ---YFNMGMYIGYYWTTLIVMLILYAGIYRAAN-------------RARKAL---RTIT--FILGAFVI-CWTPYHILAT 221
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 353 LAAARQAQTMqAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15302   222 IYGFCEAPPC-VNETLYTISYYLCYMNSPINPFCYALAN 259
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
120-388 8.13e-07

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 50.57  E-value: 8.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFtppggsapaaaagpwrGFCAASRFFSSCFGIV- 197
Cdd:cd15062    17 GNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPfSATLEVL----------------GYWAFGRIFCDVWAAVd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 ------STLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPwELLGAPRELAAAQSFHGclyrTSPD 269
Cdd:cd15062    81 vlcctaSIMSLCVISVDRYIGVRYPLNypTIVTARRATVALLIVWVLSLVISIG-PLLGWKEPAPADEQACG----VNEE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PAQlgAAFSvglVVACYLLPFLLMCFCHYHIcktvrlsdvrvrpvntYARVLRFFSEVRTATTVLIMIVFVICCWGPycF 349
Cdd:cd15062   156 PGY--VLFS---SLGSFYLPLAIILVMYCRV----------------YVVAFKFSREKKAAKTLGIVVGAFVLCWFP--F 212
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 350 LVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15062   213 FVVLPLGSLFSTLKPPEPVFKVVFWLGYFNSCLNPIIYP 251
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
121-391 8.72e-07

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 50.57  E-value: 8.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 121 NCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAagpwRGF-------CAASRFFSSC 193
Cdd:cd15082    31 NFAVMLVTFRFKQLRQPLNYIIVNLSV-----------ADFLVSLTGGTISFLTNA----RGYfflgvwaCVLEGFAVTF 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGIVSTLSVALISLDRYCAIVRPPRE-KIGRRRALQLLAGAWLtalgFSLPWELlgaPRELAAAqSFHGCLYRTSPDPAQ 272
Cdd:cd15082    96 FGIVALWSLAVLAFERFFVICRPLGNiRLQGKHAALGLLFVWT----FSFIWTI---PPVLGWS-SYTVSKIGTTCEPNW 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFS-----VGLVVACYLLPFLLMCFCHYHICKTVR-LSDVRVRPVNTYArvlrffSEVRTATTVLIMIVFVICCWGP 346
Cdd:cd15082   168 YSGNMHdhtyiITFFTTCFILPLGVIFVSYGKLLQKLRkVSNTQGRLGNARK------PERQVTRMVVVMIVAFMVCWTP 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 347 YCFLVLLAAArqAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15082   242 YAAFSILVTA--HPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMN 284
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
120-393 9.77e-07

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 50.59  E-value: 9.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLD-LFTppggsapaaaagPW---RGFCAASRFFSSCFG 195
Cdd:cd15981    17 GNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDnLIT------------GWpfdNAMCKMSGLVQGMSV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 IVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWEL-LGAPRElaaAQSFHGCLYRTS------- 267
Cdd:cd15981    85 SASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVtLTVTRE---EHHFMVDDYNNSyplyscw 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 268 ---PDPaQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSE--VRTATTVLIMIVFVIC 342
Cdd:cd15981   162 eawPDT-EMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQGEEEEGRRVSKrkIKVINMLIIVALFFTL 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 343 CWGPYCFLVLLAAARQAQTMQApSLLSV----VAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15981   241 SWLPLWTLMLLTDYGHLSEDQL-NLVTVyvfpFAHWLAFFNSSVNPIIYGYFNEN 294
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
120-393 9.92e-07

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 50.20  E-value: 9.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaaFLDLFTppggsapaaAAGPWRG---FCAASRFFSSCFGI 196
Cdd:cd15399    17 GNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLP--FTLVYT---------LLDEWKFgavLCHLVPYAQALAVH 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPR--ELAAAQSFHGCLYRTSPDPAQLG 274
Cdd:cd15399    86 VSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSviEISPDFKIQACSEKWPNGTLNDG 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKTVRlSDVRVRPVNTYARVLRffsevRTATTVLIMIVFVIC-CWGPYcFLVLL 353
Cdd:cd15399   166 TIYSVSMLLIQYVLPLAIISYAYIRIWTKLK-NHVSPGGGNDHYHQRR-----RKTTKMLVCVVVVFAvSWLPF-HAFQL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 354 AAARQAQTMQAP------SLLSVVAVWLTWAngaiNPVIYAIRNPN 393
Cdd:cd15399   239 ASDIDSKVLDLKeykliyTIFHVIAMCSTFA----NPLLYGWMNNN 280
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
120-391 9.99e-07

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 50.34  E-value: 9.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAaaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15307    17 GNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSE--------HCLTWICLDVLFCTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRP---PREKIGRRRALQLLAgAWLTALGFSLPWELLgaprelaAAQSFHGCLYRTS---PDPaql 273
Cdd:cd15307    89 MHLCTISVDRYLSLRYPmrfGRNKTRRRVTLKIVF-VWLLSIAMSLPLSLM-------YSKDHASVLVNGTcqiPDP--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 gaAFSVGLVVACYLLPFLLMCFCHyhiCKTVRLsdvRVRPVNTYARVLRFfseVRTATTVLIMIVFV-ICCWGPYCFLVL 352
Cdd:cd15307   158 --VYKLVGSIVCFYIPLGVMLLTY---CLTVRL---LARQRSRHGRIIRL---EQKATKVLGVVFFTfVILWSPFFVLNL 226
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 353 LAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15307   227 LPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFN 265
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
120-387 1.02e-06

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 50.12  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSlSDLLTALLCLPAAFLDLFTPPGGSAPAaaagpwrGFCAASRFFSSCFGIVST 199
Cdd:cd14964    15 GNLLVLLSLVRLRKRPRSTRLLLASLA-ACDLLASLVVLVLFFLLGLTEASSRPQ-------ALCYLIYLLWYGANLASI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIGRRRALQLL--AGAWLTALGFSLPWellgapreLAAAQSFHGCLYRTSPDPaqLGAAF 277
Cdd:cd14964    87 WTTLVLTYHRYFALCGPLKYTRLSSPGKTRViiLGCWGVSLLLSIPP--------LVGKGAIPRYNTLTGSCY--LICTT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAar 357
Cdd:cd14964   157 IYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAAS-LNTDKNLKATKSLLILVITFLLCWLPFSIVFILHA-- 233
                         250       260       270
                  ....*....|....*....|....*....|
gi 1370465484 358 QAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd14964   234 LVAAGQGLNLLSILANLLAVLASTLNPFIY 263
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
183-387 1.05e-06

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 50.52  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FC--AASRFFSSCFGIVSTLSValISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPWELL-GAPRELAAAQ 257
Cdd:cd15147    74 LCnvAGCLFFINTYCSVAFLGV--ISYNRYQAVTRPIKtaQSTTRKRGIIISVAIWVIIVASASYFLFMdSTNTVKIDSG 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 258 SFHGCLYRTSPDPAQLGAAFSVGLVVACYLLpFLLMCFCHYHICKTVRLSDVRV-RPVNTYARVLRFFSEVrtattvliM 336
Cdd:cd15147   152 NFTRCFEGYEKDNSKPVLIIHFIIIGLFFLV-FLLILVCNLVIARTLLSQPVQGqRNAGVKRRALWMVCTV--------L 222
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370465484 337 IVFVIC------CWGPYCFLVL-LAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15147   223 AVFVICfvphhvVQGPWTLAVLqQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIY 280
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
120-387 1.11e-06

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 50.08  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPWR---GFCAASRFFSSCFGI 196
Cdd:cd15160    17 ANCLALWVLYLQIKKENVLGVYLLNLSL-----------SDLLYILTLPLWIDYTANHHNWTfgpLSCKVVGFFFYTNIY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRR--ALQLLAGAWLTALGFSLP--WELlgaprELAAAQSFHGCLYRTSPDPAQ 272
Cdd:cd15160    86 ASIGFLCCIAVDRYLAVVHPLRFRGLRTRrfALKVSASIWVLELGTHSVflGHD-----ELFRDEPNHTLCYEKYPMEGW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LgAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRpvNTYARVLRFFsevrtattVLIMIVFVICCwGPYCFLVL 352
Cdd:cd15160   161 Q-ASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPSLER--EEKRKIIGLL--------LSIVVIFLLCF-LPYHVVLL 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 353 LAAARQAQTMQAPSL------LSVVAVWLTWANGAINPVIY 387
Cdd:cd15160   229 VRSVIELVQNGLCGFekrvftAYQISLCLTSLNCVADPILY 269
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
120-392 1.14e-06

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 49.89  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFtppggsapaaaagpwrGFCAASRFFSSCFGIV- 197
Cdd:cd15325    17 GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPfSAIFEIL----------------GYWAFGRVFCNIWAAVd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 ------STLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPwELLGAPRelAAAQSFHGCLYRTSPD 269
Cdd:cd15325    81 vlcctaSIMSLCIISIDRYIGVSYPLRYPsiMTERRGLLALLCVWVLSLVISIG-PLFGWKE--PAPEDETICQITEEPG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PAQLGAAFSVGLVVAcyllpFLLMCFChyhicktvrlsdvRVrpvntYARVLRFFSEVRTATTVLIMIVFVICCWGPycF 349
Cdd:cd15325   158 YALFSALGSFYLPLA-----IILVMYC-------------RV-----YVVALKFSREKKAAKTLGIVVGCFVLCWLP--F 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 350 LVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15325   213 FLVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQ 255
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
120-391 1.40e-06

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 49.58  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLtallcLPAAFLDLFTppggsaPAAAAGPWRGFCAASRFFSSCFGIVST 199
Cdd:cd15297    17 GNILVMVSIKVNRHLQTVNNYFLFSLACADLI-----IGVFSMNLYT------LYTVIGYWPLGPVVCDLWLALDYVVSN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVA---LISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLP----WELLGAPRELAAAQsfhgCLYRTSPDP 270
Cdd:cd15297    86 ASVMnllIISFDRYFCVTKPLTYPVKRttKMAGMMIAAAWVLSFILWAPailfWQFIVGGRTVPEGE----CYIQFFSNA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 aqlgaAFSVGLVVACYLLPFLLMCFCHYHICKtvrlSDVRVRPVntyarvlrffsevrTATTVLIMIVFVIcCWGPYCFL 350
Cdd:cd15297   162 -----AVTFGTAIAAFYLPVIIMTVLYWQISR----ASSREKKV--------------TRTILAILLAFII-TWTPYNVM 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 351 VLLaaarqaQTMQA---PSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15297   218 VLI------NTFCAsciPNTVWTIGYWLCYINSTINPACYALCN 255
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
120-393 2.12e-06

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 49.43  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaaAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15395    17 GNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTL-----------MDHWvfgEAMCKLNSMVQCISIT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELL---------GAPRELAAAQSFHGCLYRTS 267
Cdd:cd15395    86 VSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFqvltdepfkNVNVSLDAYKGKYVCLDQFP 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 268 PDPAQLgaAFSVGLVVACYLLPFLLMCFCHYHI-CKTVRLSDVRVRPVNTYARVlrffSEVRTATTVLIMIV--FVIcCW 344
Cdd:cd15395   166 SDTIRL--SYTTCLLVLQYFGPLCFIFICYLKIyIRLKRRNNMMDKMRDNKYRS----SETKRINIMLISIVvaFAV-CW 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370465484 345 GPY-CFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15395   239 LPLnIFNAVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKN 288
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
120-391 2.44e-06

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 49.04  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAaaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15979    17 GNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEV--------ICKAVAYLMGVSVSVST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAF 277
Cdd:cd15979    89 FSLVAIAIERYSAICNPLQSRVwqTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRHAWPSAQVRQAW 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRpvntyaRVLRFFsevrtattVLIMIVFVIcCWGP-YCFLVLLA-A 355
Cdd:cd15979   169 YVLLLLILFFIPGVVMIVAYGLISRELYRGLLAKK------RVIRML--------VVIVAMFFL-CWLPiFSANTWRAfD 233
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1370465484 356 ARQAQTMQAPSLLSVVAVwLTWANGAINPVIYAIRN 391
Cdd:cd15979   234 PLSAHRALSGAPISFIHL-LSYTSACVNPLVYCFMN 268
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
120-387 2.54e-06

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 49.07  E-value: 2.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFldlftppggsaPAAAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15215    16 GNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVI-----------ATSVPLFWpldSHLCTALVVLMHLFAF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLP----WELLGAPRELAAAQsfhgCLYRTSPDP 270
Cdd:cd15215    85 AGVNTIVVVSVDRYLAIIHPLSypTKMTPRRGYLLIYGTWIVSVLQSTPplygWGQAAFDERNALCS----VIWGSSYSY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQLGAAFSvglvvacYLLPFLLMCFCHYHIcktvrlsdvrvrpvntyARVLRFFSEVRTATTVLIMIVFVICCWGPYCFL 350
Cdd:cd15215   161 TILSVVSS-------FVLPVIIMLACYSMV-----------------FRAARRCYHCKAAKVIFIIIFSYVLSMGPYSFL 216
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1370465484 351 VLLAAARQAQTmqaPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15215   217 SVLAVWVDTQV---PQWVISIILWLFFLQCCIHPYIY 250
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
120-391 2.85e-06

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 48.79  E-value: 2.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLtallcLPAAFLDLFTppggsaPAAAAGPWRGFCAASRFFSSCFGIVST 199
Cdd:cd15299    20 GNILVIVSFKVNKQLKTVNNYFLLSLACADLI-----IGVISMNLFT------TYIIMNRWALGNLACDLWLSIDYVASN 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVA---LISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTALGFSLP----WELLGAPRELAAAQSFhgCLYRTSPdp 270
Cdd:cd15299    89 ASVMnllVISFDRYFSITRPLtyRAKRTTKRAGVMIGLAWVISFVLWAPailfWQYFVGKRTVPPDECF--IQFLSEP-- 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 aqlgaAFSVGLVVACYLLPFLLMCFCHYHICKTVrlsdvrvrpvntyarvlrfFSEVRTATTVLIMIVFVICCWGPYCFL 350
Cdd:cd15299   165 -----IITFGTAIAAFYLPVTIMTILYWRIYKET-------------------IKEKKAAQTLSAILLAFIITWTPYNIM 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 351 VLLAAARQAQTmqaPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15299   221 VLVNTFCDSCI---PKTYWNLGYWLCYINSTVNPVCYALCN 258
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
198-388 3.21e-06

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 48.61  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLL--AGAWLTALGFSLPWELLgapRELAAAQSFHGCLYRTSpdpaqlgA 275
Cdd:cd15115    86 SVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLlcGCIWILALLLCLPVFIY---RTTVTDGNHTRCGYDFL-------V 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRvrpvntyarvlrfFSEVRTATTVLIMIVFVICCWGPYCFLVLLAA 355
Cdd:cd15115   156 AITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFA-------------KSQSKTFRVIIAVVVAFFVCWAPYHIIGILSL 222
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1370465484 356 ARQAQTMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15115   223 YGDPPLSKVLMSWDHLSIALAYANSCLNPVLYV 255
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
188-389 3.42e-06

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 48.62  E-value: 3.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 188 RFFSSCFGI---VSTLSVALISLDRYCAIVRPPREKIGRR-RALQLLAGA-WLTALGFSLPWELLGapRELAAAQSFHGC 262
Cdd:cd15151    73 RFSAVVFYItmyISIILLGLISFDRYLKIVRPFGKSWVQRvRFAKILSGAvWLVMFLLSVPNMILS--NKPATPISVKKC 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 263 LYRTSPdpaqLGAAFSVGLVVACYLL---PFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffseVRTATTVLIMIVF 339
Cdd:cd15151   151 ASLKSP----LGLKWHEVVNYICQFIfwgVFALMVLFYTIISKKVYESYKKSRSKDNKAS-------KKTKAKVFIIVAV 219
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 340 VICCWGPYCF------LVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15151   220 FFVCFAPFHFvrvpytLSQTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIF 275
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
120-388 3.59e-06

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 48.65  E-value: 3.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLslsdlltallclpAAFLDLFTPPGGSAPAAAAGPWRGFCA-ASRFFSSCFGI-- 196
Cdd:cd15972    17 GNTLVIYVVLRYSASESVTNIYILNL-------------ALADELFMLGLPFLAAQNALSYWPFGSfMCRLVMTVDAInq 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 -VSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELL-GAPRELaaaqsfhGCLYRTSPDPAQ 272
Cdd:cd15972    84 fTSIFCLTVMSVDRYLAVVHPIRSSKWRkpPVAKTVNATVWALSFLVVLPVVIFsGVPGGM-------GTCHIAWPEPAQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 L-GAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVlrffSEVRTATTVLIMIVFVICCWGPycFLV 351
Cdd:cd15972   157 VwRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRG----SERKVTRMVVIVVAAFVLCWLP--FYA 230
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 352 LLAAARQAQTMQAPSLLSV--VAVWLTWANGAINPVIYA 388
Cdd:cd15972   231 LNIVNLVCPLPEEPSLFGLyfFVVVLSYANSCANPIIYG 269
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
120-391 3.73e-06

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 48.71  E-value: 3.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSlsdlltallcLPAAFLDLFTPPGGSAPAAAAGPWRG--FCAASRFFSSCFGIV 197
Cdd:cd16002    17 GNIIVMWIILAHKRMRTVTNYFLVNLA----------FAEASMSAFNTVINFTYAIHNEWYYGleYCKFHNFFPIAAVFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQsfhgCLYRTSPDPAQL--GA 275
Cdd:cd16002    87 SIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRV----VCYVEWPEHEERkyET 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVrvrPVNTYArvlRFFSEVRTATTVLIMIVFVIC----CWGPYCFLV 351
Cdd:cd16002   163 VYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEI---PGDSSD---RYHEQVSAKRKVVKMMIVVVCtfaiCWLPYHIYF 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 352 LLAAARQAQTMQAPSLLSVVAV-WLTWANGAINPVIYAIRN 391
Cdd:cd16002   237 LLQYFHPELYEQKFIQQVYLAImWLAMSSTMYNPIIYCCLN 277
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
198-391 5.67e-06

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 47.81  E-value: 5.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPwELLG---APRELaaaqsfhgclyrTSPDPAQ 272
Cdd:cd15060    87 SILNLCAIALDRYWAIHDPINyaQKRTLKRVLLMIVVVWALSALISVP-PLIGwndWPENF------------TETTPCT 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGA--AFSVGLVVACYLLPFLLMCFchyhicktvrlsdvrvrpvnTYARVLRFFSEVRTATTVL--IMIVFVICcWGPyc 348
Cdd:cd15060   154 LTEekGYVIYSSSGSFFIPLLIMTI--------------------VYVKIFIATSKERRAARTLgiIMGVFVVC-WLP-- 210
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 349 FLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15060   211 FFLMYVILPFCETCSPSAKVVNFITWLGYVNSALNPVIYTIFN 253
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
198-387 5.75e-06

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 48.27  E-value: 5.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLLAgAWLTALGFSLPWELLGAPRELAAAqsfhgcLYRTSPDPAQ-LGA- 275
Cdd:cd15387    87 STYMLLLMSIDRCLAICQPLRSLHRRSDRVYVLF-SWLLSLVFSIPQVHIFSLREVGNG------VYDCWADFIQpWGPk 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCH----YHICKTVRLSDVRVRPV---------NTYARV--LRFFS--EVRTATTVLIMIV 338
Cdd:cd15387   160 AYITWITLSVYIIPVLILSVCYglisFKIWQNVKLKTRRETKTplssaasggAALARVssVKLISkaKIRTVKMTFVIVL 239
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1370465484 339 FVICCWGPYcFLVLLAAARQAQTMQAPSLLsVVAVWLTWANGAINPVIY 387
Cdd:cd15387   240 AYIVCWTPF-FFVQMWSVWDPNAPKEASPF-IIAMLLASLNSCCNPWIY 286
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
198-391 5.79e-06

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 47.64  E-value: 5.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAI---VRPPREKIGRRrALQLLAGAWLTALGFSLP---WELLGAPRElaaaqsfHGCLYRTSpdpa 271
Cdd:cd15334    87 SILHLSAIALDRYRAItdaVEYARKRTPKH-AGIMIAVVWIISIFISMPplfWRHQTTSRE-------DECIIKHD---- 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 qlGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpvntyarvlrffSEVRTATTV-LIMIVFVICcWGPycFL 350
Cdd:cd15334   155 --HIVFTIYSTFGAFYIPLALILILYYKIYRAAT-------------------RERKAATTLgLILGAFVIC-WLP--FF 210
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 351 VLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15334   211 VKEVIVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFN 251
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
120-393 6.63e-06

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 47.64  E-value: 6.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSlslsdlltallcLPAAFLDLFTPPGGSAPAAAAGPWR-GFCAASRFFSSCF--GI 196
Cdd:cd15091    17 GNSLVMFVIIRYTKMKTATNIYIFN------------LALADALVTTTMPFQSTVYLMNSWPfGDVLCKIVISIDYynMF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRR--RALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLG 274
Cdd:cd15091    85 TSIFTLTMMSVDRYIAVCHPVKALDFRTplKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDDDYSWWD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHIckTVRLSDVRVRPVNTYA-RVLRffsevRTATTVLIMIVFVICCWGPYCFLVLL 353
Cdd:cd15091   165 TFMKICVFIFAFVIPVLIIIVCYTLM--ILRLKSVRLLSGSREKdRNLR-----RITRLVLVVVAVFVVCWTPIHIFILV 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370465484 354 AAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15091   238 EALGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDEN 277
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
184-391 6.68e-06

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 47.66  E-value: 6.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAW---------LTALGFSLPW-------- 244
Cdd:cd15237    73 CAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRYSVimSRRVCVRLAATSWasgflnslvLTSLTLRLPFcgpnhinh 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 245 ---ELLgAPRELAAAqsfhgclyrtspDPAQLGAA-FSVGLVVacYLLPFLLMCFCHYHICKTV-RLSDVRVRpvntyar 319
Cdd:cd15237   153 ffcEAP-AVLKLACA------------DTSLNEAViFVTSVLV--LLIPFSLILASYIRILATIlRIQSAEGR------- 210
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370465484 320 vLRFFSEVRTATTVlimivfVICCWGPYCFLVLlaaarQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15237   211 -KKAFSTCASHLTV------VTLFYGTAIFMYM-----RPHSTHSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
120-389 6.69e-06

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 47.93  E-value: 6.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPWRG---FCAASRFFSSCFGI 196
Cdd:cd15194    17 GNAILMGALVFKRGVRRLIDIFISNLAA-----------SDFIFLVTLPLWVDKEVVLGPWRSgsfLCKGSSYIISVNMY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRR--ALQLLAGAWLTALGFSLPWELlgaPRELaaaQSFHGCLYRTSPDPAQLG 274
Cdd:cd15194    86 CSVFLLTCMSLDRYLAIVLPLVSRKFRTKhnAKVCCTCVWMLSCLLGLPTLL---SREL---KKYEEKEYCNEDAGTPSK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHyhiCKTVRLSDVRVRPVNTYARVLRffsevRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:cd15194   160 VIFSLVSLIVAFFLPLLSILTCY---CTIIWKLCHHYQKSGKHQKKLR-----KSIKIVFIVVAAFVFSWMPFNLFKALA 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 355 AA---RQAQTMQAPSLLSV---VAVWLTWANGAINPVIYAI 389
Cdd:cd15194   232 IAsglQVEVTCLPYTLAQLgmeVSAPLAFANSCANPFIYYF 272
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
180-397 8.26e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 47.63  E-value: 8.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 180 WRGFCAASRFFS---SCFGIVSTLSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGF-SLPweLLGapreL 253
Cdd:cd14981    69 WDGGQPLCDYFGfmmSFFGLSSLLIVCAMAVERFLAITHPffYNSHVKKRRARLMLGAVWAFALLIaSLP--LLG----L 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 254 AAAQSFHGC------LYRTSPDPAQLGAAFSvGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRffSEV 327
Cdd:cd14981   143 GSYVLQYPGtwcfldFYSKNTGDAAYAYLYS-ILGLLILLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKR--NEI 219
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370465484 328 RTAT-TVLIMIVFVIcCWGPYCFLVLLAAARQAQTMQAPSLLSV-VAVWltwaNGAINPVIYAI-RNPNISML 397
Cdd:cd14981   220 QMVVlLLAITVVFSV-CWLPLMIRVLINATGDSEKNGKTDLLAVrMASW----NQILDPWVYILlRKEVLRRL 287
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
180-307 1.00e-05

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 47.38  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 180 WR---GFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPWELLGA--PRE 252
Cdd:cd15376    67 WRfgeAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPffTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHleVER 146
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370465484 253 LAAAQsfhgCLyrTSPDPAQLGAAFSVGLVVACY--LLPFLLMCFCHYHICKTVRLS 307
Cdd:cd15376   147 HNKTE----CL--GTAVDSRLPTYLPYSLFLAVVgcGLPFLLTLASYLAIVWAVLRS 197
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
120-392 1.26e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 46.96  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPW---RGFCaasRFFSSC--- 193
Cdd:cd15312    17 GNLMVIISISHFKQLHSPTNFLILSLAI-----------TDFLLGFLVMPYSMVRSVESCWyfgDLFC---KIHSSLdmm 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGIVSTLSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTALGFSLPWELLGAprELAAAQSFHGCLYRTSPDPA 271
Cdd:cd15312    83 LSTTSIFHLCFIAVDRYYAVCDPLhyRTKITTPVIKVFLVISWSVPCLFAFGVVFSEV--NLEGIEDYVALVSCTGSCVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAAFSVGLVVACYLLPFLLMCFCHYHICkTVRLSDVRV---RPVNTYARVLRFFSEVR----TATTVLIMIVFVIcCW 344
Cdd:cd15312   161 IFNKLWGVIASLIAFFIPGTVMIGIYIKIF-FVARKHAKVinnRPSVTKGDSKNKLSKKKerkaAKTLSIVMGVFLL-CW 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1370465484 345 GPYCFLVLLAAARQAQTmqaPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15312   239 LPFFVATLIDPFLNFST---PVDLFDALVWLGYFNSTCNPLIYGFFYP 283
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
198-388 1.45e-05

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 46.88  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLL-AGAWLTALGFSLPWELLgapRELAAAQSFHG--CLYRTSPD-PAQL 273
Cdd:cd15178    85 GILLLACISVDRYLAIVHATRALTQKRHLVKFVcAGVWLLSLLLSLPALLN---RDAFKPPNSGRtvCYENLGNEsADKW 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 GAAFSVGLVVACYLLPFLLMCFChYHIcktvrlsdvrvrpvnTYARVLRFFS-EVRTATTVLIMIVFV-ICCWGPYCFLV 351
Cdd:cd15178   162 RVVLRILRHTLGFLLPLVVMLFC-YGF---------------TIKTLLQTRSfQKHRAMRVIFAVVLAfLLCWLPYNVTV 225
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 352 LLAAARQAQT--------MQAPSLLSVVAVwLTWANGAINPVIYA 388
Cdd:cd15178   226 LIDTLMRTKLitetcelrNHVDVALYVTQI-LGFLHSCINPVLYA 269
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
183-388 1.53e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 46.85  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWL--TALGFSLPW-ELLGAPRELAAAQ 257
Cdd:cd15314    72 FCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLlyRSKITVRVVLVMILISWSvsALVGFGIIFlELNIKGIYYNHVA 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 258 SFHGCLYRTSPDPAQLGAAFSvglvvacYLLPFLLMCFCHYHIC----KTVR-LSDVRVRPVNTYARvlrffSEvRTATT 332
Cdd:cd15314   152 CEGGCLVFFSKVSSVVGSVFS-------FYIPAVIMLCIYLKIFlvaqRQARsIQSARTKSGASSSK-----ME-RKATK 218
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370465484 333 VL--IMIVFVIcCWGPYcFLVLlaaarqaqTMQ------APSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15314   219 TLaiVMGVFLL-CWTPF-FLCN--------IIDpfinysIPPVLIEVLNWLGYSNSTLNPFIYA 272
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
120-393 1.72e-05

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 46.75  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaaFLDLFTppggsapaaAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15396    17 GNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIP--FTAVYT---------LMDHWifgETMCKLTSFVQSVSVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPW----ELLGAP-RELAAAQSFHG----CLYRTS 267
Cdd:cd15396    86 VSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFlifhQLTDEPfRNLSSHSDFYKdkvvCIEAWP 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 268 PDPAQLgaAFSVGLVVACYLLP--FLLMCFCHYHICKTVRLSDVRVRPVNTyARVlrffSEVRTATTVLIMIVFVIC-CW 344
Cdd:cd15396   166 SETERL--IFTTSLLVFQYFVPlgFIFICYLKIFVCLKKRNSKIDRMRENE-SRL----SENKRINTMLISIVVTFAaCW 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370465484 345 GPY-CFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15396   239 LPLnIFNVVFDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKN 288
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
314-387 1.97e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 46.32  E-value: 1.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370465484 314 VNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQAQTMqaPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15296   189 LNIQKRRFRLSRDKKVAKSLAIIVCVFGLCWAPYTLLMIIRAACHGHCV--PDYWYETSFWLLWVNSAINPVLY 260
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
127-391 2.03e-05

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 46.36  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 127 VIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDL------FTPPGGSAPAAAAGPWRGFCAASRFFSSCFGIVSTL 200
Cdd:cd15080    24 VTVQHKKLRTPLNYIL--------------LNLAVADLfmvfggFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALW 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 201 SVALISLDRYCAIVRPPRE-KIGRRRALQLLAGAWLTALGFSLPwELLGAPRELAAA-QSFHGCLYRTsPDPAQLGAAFS 278
Cdd:cd15080    90 SLVVLAIERYVVVCKPMSNfRFGENHAIMGVAFTWVMALACAAP-PLVGWSRYIPEGmQCSCGIDYYT-LKPEVNNESFV 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 279 VGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQ 358
Cdd:cd15080   168 IYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQESATTQK-----AEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQ 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1370465484 359 AQTMqAPSLLSVVAvWLTWANGAINPVIYAIRN 391
Cdd:cd15080   243 GSDF-GPIFMTIPA-FFAKSSAVYNPVIYILMN 273
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
120-391 2.33e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 46.08  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15304    17 GNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTIL----------YGYRWplpSKLCAVWIYLDVLFST 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHgCLYrtSPDPAQLG 274
Cdd:cd15304    87 ASIMHLCAISLDRYIAIRNPIHHSRfnSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGS-CLL--ADENFVLI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFsvglvvACYLLPFLLMCFCHYHICKTVRLSdvrvrpvntyarvlrfFSEVRTATTVLIMIVFV-ICCWGPYCFL-VL 352
Cdd:cd15304   164 GSF------VAFFIPLTIMVITYFLTIKSLQQS----------------ISNEQKASKVLGIVFFLfVVMWCPFFITnVM 221
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 353 LAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15304   222 AVICKESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFN 260
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
120-389 2.49e-05

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 45.97  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQL-RTVTNAFILSLSLSDLLTALLCLPaafldlFTPPGGSAPAAAAGPWrgFCAASRFFSSCFGIVS 198
Cdd:cd15097    17 GNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVP------FQATIYSLEGWVFGSF--LCKAVHFFIYLTMYAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 199 TLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWEllgAPRELAAAQSFHGCLyrtspdPAQLGA- 275
Cdd:cd15097    89 SFTLAAVSVDRYLAIRYPLRSRELRtpRNAVAAIALIWGLSLLFAGPYL---SYYDLIDYANSTVCM------PGWEEAr 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 --AFSVGLVVACYLLPFLLMCFCHyhiCKTVRLSDVRVRPVNTYARVLRffsEVRTATTVLIMIVFVIC-CWGPYCFLVL 352
Cdd:cd15097   160 rkAMDTCTFAFGYLIPVLVVSLSY---TRTIKYLWTAVDPLEAMSESKR---AKRKVTKMIIIVTALFClCWLPHHVVIL 233
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1370465484 353 LAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15097   234 CYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYAL 270
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
198-387 2.69e-05

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 45.93  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLLAG--AWLTALGFS---LPWEllgaprELAAAQSFHGCLYRTSPdPAQ 272
Cdd:cd15365    87 STALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSvaIWLLEICFNaviLTWE------DSFHESSSHTLCYDKFP-LED 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLrffsevrtatTVLIMIVFVIcCWGPYCFLVL 352
Cdd:cd15365   160 WQARLNLFRICLGYLLPLLIILFCYWKIYQAVRSNQATEDQEKKKIFKL----------LLLITVTFVI-CFTPYHVVLL 228
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370465484 353 LAAARQAQTMQ-APSLLSV--VAVWLTWANGAINPVIY 387
Cdd:cd15365   229 IRSIVEPCDCRnAKWLYTLykITVALTSLNCIADPFLY 266
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
120-389 3.26e-05

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 45.48  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIV--KHRQLRTVTNAFILSLSLSDLLTALLCLPaaFLdlftppggsAPAAAAGPWR---GFCAASRFFSSCF 194
Cdd:cd15002    16 GNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLFSVP--FR---------AAAYSKGSWPlgwFVCKTADWFGHAC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 195 GIVSTLSVALISLDRYCAIVRPPRE-KIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGClYRTSPDPAQL 273
Cdd:cd15002    85 MAAKSFTIAVLAKACYMYVVNPTKQvTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILC-IPPLAHEFMS 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 gaAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffSEVRTATTVLIMIVFVIcCWGPYCFLVLL 353
Cdd:cd15002   164 --AFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIR-----SRKLTHMLLSVVLAFTI-LWLPEWVAWLW 235
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1370465484 354 AAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15002   236 LIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLL 271
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
197-387 3.55e-05

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 45.45  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLPWE-LLGAPRELAAAQSFHGCLYRTSPDpaQL 273
Cdd:cd14995    88 ASSLSITAFTIERYIAICHPMKAQFicTVSRAKKIICFVWIFTSLYCSPWLfLLDLSIKHYGDDIVVRCGYKVSRH--YY 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 GAAFSVGLVVAcYLLPFLLMCFCHYHIcktvrlsdvrvrpvntyARVLrfFSEVRTATTVLIMIVFVIC-CWGPYCFLVL 352
Cdd:cd14995   166 LPIYLADFVLF-YVIPLLLAIVLYGLI-----------------GRIL--FSSRKQVTKMLAVVVVLFAlLWMPYRTLVV 225
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370465484 353 LAAARQAQTMQAPSLLsvVAVWLTWANGAINPVIY 387
Cdd:cd14995   226 YNSFASPPYLDLWFLL--FCRTCIYLNSAINPILY 258
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
120-392 4.38e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 45.04  E-value: 4.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPWRGFCAASRFFSSCFGIVST 199
Cdd:cd15331    17 GNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVS-----------QHWFLGPEVCDMWISMDVLCCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LS----VAlISLDRYCAIVRPprEKIGRR---RALQLLAGAWLTALGFSLPwellgaPRELAAAQSFHGCLYRTSPDPAQ 272
Cdd:cd15331    86 ASilhlVA-IALDRYWAVTNI--DYIRRRtakRILIMIAVVWFVSLIISIA------PLFGWKDEDDLDRVLKTGVCLIS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFSVGLVVACYLLPFLLMcfchyhicktvrlsdvrvrpVNTYARVLRFFSEVRTATTVLIMI--VFVIcCWGPYCFL 350
Cdd:cd15331   157 QDYGYTIFSTVGAFYVPLLLM--------------------IIIYWKIYQAAKRERKAARTLAIItgAFVV-CWLPFFLV 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370465484 351 VLLAAARQAQtmQAPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15331   216 ALVMPFCGAW--QISRFLESFFLWLGYFNSLLNPIIYTIFSP 255
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
192-393 4.47e-05

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 45.19  E-value: 4.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 192 SCFGIVSTLSvalisLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLPWELLGapRELAAAQSFHGCLYR-TSP 268
Cdd:cd15339    85 ACSAIMTAMS-----LDRYIALVHPFRltSLRTRSKTIRINLLVWAASFILVLPVWVYA--KVIKFRDGLESCAFNlTSP 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAQLgaaFSVGLVVACYLLPFLLMCFCH----YHICKTVRLSDVRVRPVNTYARVlrffSEVRTATTVLIMIVFVICCW 344
Cdd:cd15339   158 DDVLW---YTLYQTITTFFFPLPLILICYililCYTWEMYRKNKKAGRYNTSIPRQ----RVMRLTKMVLVLVGVFLVSA 230
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370465484 345 GPYCFLVLLAAarqaqTMQAPSLLSVVA----VWLTWANGAINPVIYAIRNPN 393
Cdd:cd15339   231 APYHVIQLVNL-----SVSQPTLAFYVSyylsICLSYASSSINPFLYILLSGN 278
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
198-393 4.97e-05

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 45.23  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLL--AGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYrtsPDPAqLGA 275
Cdd:cd15973    86 SVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMinICVWILSLLVISPIIIFADTATRKGQAVACNLIW---PHPA-WSA 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVrpvntyARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLA- 354
Cdd:cd15973   162 AFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKA------GWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNl 235
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1370465484 355 -AARQAQTMQAPSLLsvvavwLTWANGAINPVIYAIRNPN 393
Cdd:cd15973   236 fLPRLDATVNHASLI------LSYANSCANPILYGFLSDN 269
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
181-392 5.06e-05

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 45.17  E-value: 5.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 181 RGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPweLLGAPRelaaAQS 258
Cdd:cd15199    70 GGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGKKnsLSLQAAPYISFLVWLLLVGLTIP--TLLASQ----PKN 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 259 FHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTV--RLSDVRVRPVNTYARVLrffsevrtatTVLIM 336
Cdd:cd15199   144 FTECNSFSPKDDEDFSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLkkRLRDVGKQPKLQRAMAL----------VTSVV 213
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370465484 337 IVFVICCWGPYCFLVLLAAARQAQTMQAPSL---LSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15199   214 VVFGFCFLPCFLARVLMLIFQNKESCNALNIavhTYDVTMCLTYLNSVLDPIVYCFSSP 272
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
120-393 5.27e-05

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 44.73  E-value: 5.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaaAGPWRGFCAASRFFSSCFGIVST 199
Cdd:cd15050    17 LNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLL-----------ESKWILGRPVCLFWLSMDYVAST 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 ---LSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLP---WELL--GAPRELAAAQ---SFHGCLYrt 266
Cdd:cd15050    86 asiFSLFILCIDRYRSVQQPLKylKYRTKTRASLMISGAWLLSFLWVIPilgWHHFarGGERVVLEDKcetDFHDVTW-- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 267 spdpaqlgaaFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvRVRPVntyARVLRFfsevrtattvlIMIVFvICCWGP 346
Cdd:cd15050   164 ----------FKVLTAILNFYIPSLLMLWFYAKIFKAVN----RERKA---AKQLGF-----------IMAAF-ILCWIP 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1370465484 347 YCFLVLLAAARQAQTmqaPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15050   215 YFILFMVIAFCKNCC---NENLHMFTIWLGYINSTLNPFIYPLCNEN 258
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
188-398 5.44e-05

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 45.16  E-value: 5.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 188 RFFSSCFGI---VSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGC 262
Cdd:cd15120    73 KVLNSTLSVgmfTSVFLLTAISLDRYLLTLHPVWSRQHRtnRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQN 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 263 LYRTSPD---------PAQLGAAFSVGLVVACYLLPFLLMCFCHYHIckTVRLSDVRVRPVNTYARVLrffsevrtattv 333
Cdd:cd15120   153 NYALSTNwesaevqasRQWIHVAMFVFRFLLGFLLPFLIITFCYVRM--ALKMKERGLARSSKPFKVM------------ 218
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 334 LIMIVFVICCWGPYCFLVLLAAARQAQTMQAPSLLsVVAVWLTWANGAINPVIYAIRNPNISMLL 398
Cdd:cd15120   219 FTAVVSFFVCWLPYHLHSGLVLTRGRPPSLTDITL-LLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
120-389 5.51e-05

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 44.75  E-value: 5.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15088    17 GNGIVLYVLVRCSKLRTAPDIFIFNLAV-----------ADLLFMLGMPFLIHQFAIDGQWyfgEVMCKIITALDANNQF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRR--ALQLLAGAWLTALGFSLPWELLGapRELAAAQSFHGCLYRTSPDPAqlG 274
Cdd:cd15088    86 TSTYILTAMSVDRYLAVVHPIRSTKYRTRfvAKLVNVGLWAASFLSILPVWVYS--SLIYFPDGTTFCYVSLPSPDD--L 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFfsevrTATTVLIMIVFVIcCWGPYCFLVLLA 354
Cdd:cd15088   162 YWFTIYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKRV-----TKMVILIVVVFIV-CWLPFHVVQLVN 235
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 355 AarqaqTMQAPSLLSVVA----VWLTWANGAINPVIYAI 389
Cdd:cd15088   236 L-----AMNRPTLAFEVAyflsICLGYANSCLNPFVYIL 269
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
120-393 5.85e-05

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 44.88  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDlftppggsapaAAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15980    17 GNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLD-----------NIIAGWpfgSTVCKMSGMVQGISVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSP-------- 268
Cdd:cd15980    86 ASVFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLGSQNKTSPvywcredw 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVrvrPVNTYARVLRFFSEVRTATTVLIMIVFV----ICCW 344
Cdd:cd15980   166 PNQEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAM---PHTGKHNQEQRHVVSRKKQKVIKMLLIVallfILSW 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370465484 345 GPYCFLVLL---AAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15980   243 LPLWTLMMLsdyANLSPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNEN 294
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
196-389 5.88e-05

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 44.80  E-value: 5.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 IVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTsPDPAQLGA 275
Cdd:cd15338    88 ITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVGCALLL-PNPETDTY 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCHYHIcktvrLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVIcCWGPYCFLVLLAA 355
Cdd:cd15338   167 WFTLYQFFLAFALPLVVICVVYFKI-----LQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFI-CWAPFYILQLAHL 240
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370465484 356 ArqaqtMQAPSLLSV----VAVWLTWANGAINPVIYAI 389
Cdd:cd15338   241 S-----IDRPSLAFLyaynVAISMGYANSCINPFLYIM 273
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
189-352 6.37e-05

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 44.76  E-value: 6.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 189 FFSSCFGivSTLSVALISLDRYCAIVRPPREKIGRRR--ALQLLAGAWLTALGFSLPWE---LLGAPRELAAAQSFHGCL 263
Cdd:cd15368    80 FYANMYS--SILTMTCISIERYLGVVYPMRSMRWRKKryAVAACIGMWLLVLTALSPLErtdLTYYVKELNITTCFDVLK 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 264 YRTSPDPAQLgAAFSVGLVVACYLLPFLLMCFCHyhicktVRLSDVRVRPVNTYARvlrffSEVRTATTVLIMIVFV-IC 342
Cdd:cd15368   158 WTMLPNIAAW-AAFLFTLFILLFLIPFIITVYCY------VLIILKLVQTSERYGR-----EQKRRAIYLALIVLLVfIT 225
                         170
                  ....*....|
gi 1370465484 343 CWGPYCFLVL 352
Cdd:cd15368   226 CFAPNNFILL 235
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
185-387 6.63e-05

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 44.70  E-value: 6.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 185 AASRFFSSCFGI---VSTLSVALISLDRYCAIVRPPREKIGRR--RALQLLAGAWLTALGFSLPWELLGAPR-ELAAAQS 258
Cdd:cd15114    70 AACKLLPSLILLnmyASVLLLTAISADRCLLVLRPVWCQNHRRarLAWIACGAAWLLALLLTVPSFIYRRIHqEHFPEKT 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 259 FHGCLYRTSPDPAQLGAAFSVglvVACYLLPFLLMCFCHyhickTVRLSDVRVRPVNTYARVLRFfsevrtattVLIMIV 338
Cdd:cd15114   150 VCVVDYGGSTGVEWAVAIIRF---LLGFLGPLVVIASCH-----GVLLVRTWSRRRQKSRRTLKV---------VTAVVV 212
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 339 FVICCWGPYCF--LVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15114   213 GFFLCWTPYHVvgLIIAASAPNSRLLANALKADPLTVSLAYINSCLNPIIY 263
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
120-389 8.42e-05

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 44.63  E-value: 8.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafLDLFTppggsapAAAAGPWR---GFCAASRFFSSCFGI 196
Cdd:cd15134    17 GNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLP---FELYT-------IWQQYPWVfgeVFCKLRAFLSEMSSY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLPW---------ELLGAPRELAAAQSFHGCLYR 265
Cdd:cd15134    87 ASVLTITAFSVERYLAICHPLRSHTmsKLSRAIRIIIAIWIIAFVCALPFaiqtrivylEYPPTSGEALEESAFCAMLNE 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 266 TSPDPAQLGAAFSVglvvaCYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIV--FVIcC 343
Cdd:cd15134   167 IPPITPVFQLSTFL-----FFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSGGRRSSQSRRTVLRMLVAVVvaFFI-C 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1370465484 344 WGPYC---FLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15134   241 WAPFHaqrLLTVYAKNMTPPYLFINRILFYISGVLYYVSSTVNPILYNV 289
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
183-394 8.69e-05

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 44.48  E-value: 8.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPwelLGAPRELAAAQSFHGC 262
Cdd:cd15006    74 FCKVIKFLHKVFCSVTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVP---VFAVTNVTDIYAMSTC 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 263 lyrTSPDPAQLG-----AAFSVGLVVACYLLPFLLMCFCHYHIC----KTVRLSDVRVrPVNTYARVLRFFSEVRTATTV 333
Cdd:cd15006   151 ---TESWGYSLGhlvyvIIYNITTVILPVAVVFLFMILIRRALSasqkKKVIIAALRT-PQNTISIPYVSQREAELHAML 226
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 334 LIMIVFVICCWGPYCFLVLLAAARQAQtmQAPSLLSVVAVWLTWANGAINPVIYAIRNPNI 394
Cdd:cd15006   227 LSMVLVFILCSVPYATLVIYRTILNIS--DISVFLLLTAIWLPKVSLLANPLLFLTVNKSV 285
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
120-388 9.76e-05

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 44.34  E-value: 9.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLslsdlltallclpAAFLDLFTPPGGSAPAAAAGPWRGF----CAASRFFSSCFG 195
Cdd:cd15087    17 GNTAVIYVILRAPKMKTVTNVFILNL-------------AIADDLFTLVLPINIAEHLLQQWPFgellCKLILSIDHYNI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 IVSTLSVALISLDRYC---AIVRPPREKIGRRRALQLLA-GAWLTALGFSLPWELLGapRELAAAQSFHGCLYrTSPDPA 271
Cdd:cd15087    84 FSSIYFLTVMSVDRYLvvlATVRSRRMPYRTYRAAKIVSlCVWLLVTIIVLPFTVFA--GVYSNELGRKSCVL-SFPSPE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLG-AAFSVGLVVACYLLPFLLMCfchyhICKTVRLSDVRVRPVNTYARVLrffSEVRTATTVLIMIVFVIC--CWGPYC 348
Cdd:cd15087   161 SLWfKASRIYTLVLGFAIPVSTIC-----ILYTMMLYKLRNMRLNSNAKAL---DKAKKKVTLMVLVVLAVClfCWTPFH 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370465484 349 FLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15087   233 LSTVVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYA 272
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
120-393 1.03e-04

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 44.12  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLftppggsapaaaagpwRGFCAASRFFSSCFGIVS 198
Cdd:cd15958    17 GNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPfGATLVV----------------RGRWLYGSFFCELWTSVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 199 TLSVA-------LISLDRYCAIVRPPREK--IGRRRALQLLAGAW-LTALGFSLP----WELLGAPRELAAAQSFHGCLY 264
Cdd:cd15958    81 VLCVTasietlcVIAIDRYLAITSPFRYQslLTRARAKGIVCTVWaISALVSFLPimmhWWRDEDDQALKCYEDPGCCDF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 265 RTSpdpaqlgAAFSVGLVVACYLLPFLLMCFCHYHICKTV------------RLSDVRVRPVNTYARVLRFFSEVRT--- 329
Cdd:cd15958   161 VTN-------RAYAIASSIISFYIPLLIMIFVYLRVYREAkkqikkidkcegRFHNTLTGLGRKCKRRPSRILALREqka 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 330 -ATTVLIMIVFVIcCWGPYcFLVLLAAARQAQTMqaPSLLSVVAVWLTWANGAINPVIYAiRNPN 393
Cdd:cd15958   234 lKTLGIIMGVFTL-CWLPF-FLVNVVNVFNRELV--PDWLFVFFNWLGYANSAFNPIIYC-RSPD 293
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
198-388 1.18e-04

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 44.02  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRAL--QLLAGAWLTALGFSLPwelLGAPRELAAAQSFHGCLYRT-SPDPAQLG 274
Cdd:cd15122    88 SIFIIGLMSLDRCLAVTRPYLAQSLRKKALvrKILLAIWLLALLLALP---AFVYRHVWKDEGMNDRICEPcHASRGHAI 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVAcYLLPFLLMCFCHYHIckTVRLsdvrvrpvntyaRVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:cd15122   165 FHYTFETLVA-FVLPFGVILFSYSVI--LVRL------------KGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQ 229
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 355 AARQAQTMQAPSLLSVVA-------VWLTWANGAINPVIYA 388
Cdd:cd15122   230 VVANLAPGEVLEKLGGAAkaaragaTALAFFSSSVNPLLYV 270
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
120-389 1.26e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 44.06  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLftppggsapaaaagpWR--------GFCAASRFFS 191
Cdd:cd15133    17 GNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYEL---------------WQnypfllgsGGCYFKTFLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 192 SCFGIVSTLSVALISLDRYCAIVRPPREKI--GRRRALQLLAGAWLTALGFSLPWEllgaprelaaaqSFHGCLYRTSPD 269
Cdd:cd15133    82 ETVCLASILNVTALSVERYIAVVHPLAARTcsTRPRVTRVLGCVWGVSMLCALPNT------------SLHGIKFLGSGV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PA-------QLGAAFSVGLVVACYLLPFLLM------CFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTAT----- 331
Cdd:cd15133   150 PAsaqctvrKPQAIYNMIPQHTGHLFFVLPMavisvlYLLMALRLARERGLDATGAGSKIGTRTGQLLQHPRTRAqvtkm 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 332 TVLIMIVFVIcCWGPYCFLVLLAAARQAQT---MQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15133   230 LFILVVVFAI-CWAPFHIDRLMWSFISDWTdnlHEVFQYVHIISGVFFYLSSAVNPILYNL 289
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
184-388 1.36e-04

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 43.65  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRAL--QLLAGAWLTALGFSLPwelLGAPRELAAAQSFHG 261
Cdd:cd15121    72 CKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSvrALLLAIWIVAFLLSLP---MPFYRTVLKKNINMK 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 262 CLYRTSPDPAQLGAAFSVGLVVAcYLLPFLLMCFCHYHICKTVRLSdvrvrpvntyarvlRFFSEVRTATTVLIMIVFVI 341
Cdd:cd15121   149 LCIPYHPSVGHEAFQYLFETITG-FLLPFTAIVTCYSTIGRRLRSA--------------RFRRKRRTNRLVVLIIATFA 213
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370465484 342 CCWGPYCFLVLLAAARQAQT-------MQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15121   214 LFWLPYHVVNLIQVAGALQNqagnasvLKAAKLARPNVTALAFLSSSVNPVLYA 267
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
120-388 1.53e-04

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 43.63  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPWRG--FCAASRFFSSCFGIV 197
Cdd:cd14975    17 GNSFVIWSILIKVKQRSVTMLLVLNLAL-----------ADLAVLLTLPVWIYFLATGTWDFGlaACKGCVYVCAVSMYA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRAL--QLLAGAWLTALGFSLPwelLGAPRELAAAQSFHGCLYRTSPDpAQLGA 275
Cdd:cd14975    86 SVFLITLMSLERFLAVSRPFVSQGWRAKALahKVLAIIWLLAVLLATP---VIAFRHVEETVENGMCKYRHYSD-GQLVF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVAcYLLPFLLMCFCHyhicktvrlSDVRVRpvntyARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAA 355
Cdd:cd14975   162 HLLLETVVG-FAVPFTAVVLCY---------SCLLRR-----LRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEV 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370465484 356 ARqAQTMQAPSLLSVVAVW---------LTWANGAINPVIYA 388
Cdd:cd14975   227 VS-ELIGGSKMAGTLGKVAeagrpiagaLAFLSSSINPLLYA 267
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
120-355 1.56e-04

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 43.50  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDL-FTPPGGSAPAAAAGPW---RGFCaasRFFSSCFG 195
Cdd:cd15182    17 GNGLVLWILVKYEKLKTLTNIFI--------------LNLAISDLlFTFTLPFWASYHSSGWifgEILC---KAVTSIFY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 I---VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGA--WLTALGFSLPWELLGAPRELAAAQSfhGCLYrtSPDP 270
Cdd:cd15182    80 IgfySSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVavWVISILASLPELILSTVMKSDEDGS--LCEY--SSIK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQLGAAFSvglVVACYLLPFLLMCFCHYHICKTVrlsdVRVRPVNTYARVLRFFSevrtattvlIMIVFVIcCWGPYCFL 350
Cdd:cd15182   156 WKLGYYYQ---QNLFFLIPLGIIVYCYVRILQTL----MRTRTMRKHRTVKLIFV---------IVLVFFL-SWAPYNIV 218

                  ....*
gi 1370465484 351 VLLAA 355
Cdd:cd15182   219 IFLRS 223
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
120-391 1.92e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 43.36  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFtppggsapaaAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15305    17 GNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAIL----------YDYAWplpRYLCPIWISLDVLFST 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIvRPPREKI---GRRRALQLLAGAWLTALGFSLPWELLGAPRElaaAQSF-HGCLYRTSPDPAQ 272
Cdd:cd15305    87 ASIMHLCAISLDRYVAI-RNPIEHSrfnSRTKAMMKIAAVWTISIGISMPIPVIGLQDD---EKVFvNGTCVLNDENFVL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAafsvglvVACYLLPFLLMCFCHyhiCKTVRLSDvRVRPVNTYarvlrffsevRTATTVLIMIVFV-ICCWGPYcFL- 350
Cdd:cd15305   163 IGS-------FVAFFIPLIIMVITY---CLTIQVLQ-RQQAINNE----------RRASKVLGIVFFLfLIMWCPF-FIt 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370465484 351 -VLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15305   221 nILSVLCKEACDQKLMEELLNVFVWVGYVSSGINPLVYTLFN 262
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
120-392 1.99e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 43.31  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15316    17 GNLLVMISILHFKQLHSPTNFLIASLAC-----------ADFLVGVTVMPFSTVRSVESCWyfgESFCTFHTCCDVSFCY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQ--LLAGAWLTALGFSLPWELLGAP----RELAAAQS-FHGClyrtspd 269
Cdd:cd15316    86 ASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSgiCISVSWIFSLTYSFSVFYTGVNddglEELVNALNcVGGC------- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 paqlGAAFSVGLVVACYLL---PFLLMCFCHYHICKTVRLSDVRVRPV--------NTY-ARVLRffSEVRTATTVLIMI 337
Cdd:cd15316   159 ----QIILNQNWVLVDFLLffiPTFAMIILYGKIFLVAKQQARKIEMTsskaesssESYkDRVAR--RERKAAKTLGITV 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 338 VFVICCWGPYCFLVLLAAARQAQTmqaPSLLSVVAVWLTWANGAINPVIYAIRNP 392
Cdd:cd15316   233 IAFLVSWLPYLIDVLIDAFMNFIT---PPYIYEICCWCAYYNSAMNPLIYALFYP 284
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
120-393 2.11e-04

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 43.28  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgfCAASRFFSSCFGIVST 199
Cdd:cd15008    16 GNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAM--------CKLVRYFQYLTPGVQI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELlgapreLAAAQSFHGCLYrtSPDPAQLGAAFSV 279
Cdd:cd15008    88 YVLLSICVDRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFVSPALF------FYGSNWGPHCNF--FLPDSWDGAAYAI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 280 GLVVACYLLPFLLMCFCHYHICKTV-RLS----DVRvRPVNTYARvlrffSEVRTATTVLIMIVFVICCWGPYcFLVLLA 354
Cdd:cd15008   160 IHLLVGFLVPSILIILFYQKVIKYIwRIGtdgrTVR-RTMNIVPR-----TKVKTIKMFLMLNSMFLLSWLPF-YVVQLW 232
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370465484 355 AARQAQTMQApSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15008   233 HPRESDYRQS-SLVFLAVTWISFSSSASKPTLYSVYNAN 270
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
120-388 2.16e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 43.20  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLC-LPAAFLDLFtppggsapaaaaGPW---RGFCAASRFFSSCFG 195
Cdd:cd15012    16 GNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCvLQNLSIYLI------------PSWpfgEVLCRMYQFVHSLSY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 196 IVSTLSVALISLDRYCAIVRPPREK----IGRRRALQLLagAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPA 271
Cdd:cd15012    84 TASIGILVVISVERYIAILHPLRCKqlltAARLRVTIVT--VWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLDREM 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDvRVRPVNTYARVLrffsevrtattvlimIVFVICcwgpYCFLV 351
Cdd:cd15012   162 FNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSS-SIEARRKVVRLL---------------VAVVVS----FALCN 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 352 LLAAARQAQTM---------QAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:cd15012   222 LPYHARKMWQYwsepyrcdsNWNALLTPLTFLVLYFNSAVNPLLYA 267
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
183-387 2.39e-04

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 43.17  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRR--ALQLLAGAWLTALGFSLPWELLGAPRELAaaqSFH 260
Cdd:cd15378    71 LCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHILQKKrsAVAISLAIWVLVTLELLPILTFIGPNLKD---NVT 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 261 GCL-YRTSPDPAQlGAAFSVGLVVACYLLPFLLMCFCHYhicKTVRLSDVRVRPVNTYArvlrffSEVRTATTVLIMIVF 339
Cdd:cd15378   148 KCKdYASSGDATN-SLIYSLFLTVTGFLIPLCVMCFFYY---KIALFLKNRNRQLANAT------SFEKPLTLVILAVVI 217
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 340 VICCWGPYCFL--VLLAAARQAQTMQAPSLLSVVAVW-----LTWANGAINPVIY 387
Cdd:cd15378   218 FSVLFTPYHVMrnVRIASRLDSIGVSECTLIIIKSLYivtrpIAFLNSVINPVFY 272
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
198-393 2.42e-04

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 43.02  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQ--LLAGAWLTALGFSLpwellgAPRELAAAQSFHGCLYR--TSPDPAql 273
Cdd:cd15328    88 SIWNVTAIALDRYWSITRHLEYTLRTRRRISnvMIALTWALSAVISL------APLLFGWGETYSEDSEEcqVSQEPS-- 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 gaaFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpvntyarvlrffSEVRTATTVLIMIVFVICCWGPYcFLVLL 353
Cdd:cd15328   160 ---YTVFSTFGAFYLPLCVVLFVYWKIYKAAQ-------------------KEKRAALMVGILIGVFVLCWIPF-FLTEL 216
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1370465484 354 AAARQAQTMqaPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15328   217 ISPLCSCDI--PPIWKSIFLWLGYSNSFFNPLIYTAFNKN 254
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
120-384 2.66e-04

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 43.02  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAfldlftppggsapaaaagpwrgfcaASRFFSS--CFGIV 197
Cdd:cd15125    17 GNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVD-------------------------ASRYFYEewMFGTV 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 ---------------STLSVALISLDRYCAIVRPPREKIGRR--RALQLLAGAWLTALGFSLPWELLGAPRELAAAQ--S 258
Cdd:cd15125    72 gcklipviqltsvgvSVFTLTALSADRYKAIVNPMDIQTSSAvlRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDntT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 259 FHGCL-YRTSPDpaQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMI 337
Cdd:cd15125   152 FTACIpYPQTDE--MHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNIPGEYSEHSKRQMETRKRLAKIVLVFV 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1370465484 338 VFVICCWGPYCFLVLLAA--ARQAQTMQAPSLLSVVAVWLTWANGAINP 384
Cdd:cd15125   230 GLFAFCWFPNHVLYMYRSfnYNEIDSSLGHMIVTLVARVLSFCNSCVNP 278
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
194-391 2.96e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 42.62  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 194 FGIVSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPwELLGAPRElAAAQSFHGCLYRTSpdpa 271
Cdd:cd15323    83 FCTSSIVHLCAISLDRYWSVTQAVEYNLKRtpRRVKAIIVTVWLISAVISFP-PLISMYRD-PEGDVYPQCKLNDE---- 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 qlgAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpvntyARVLRFfsevrTATTVLIMIVFVICcWGPYCF-L 350
Cdd:cd15323   157 ---TWYILSSCIGSFFAPCLIMILVYIRIYRVAK------------AREKRF-----TFVLAVVMGVFVVC-WFPFFFsY 215
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 351 VLLAAARQAqtMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15323   216 SLYGICREA--CEVPEPLFKFFFWIGYCNSSLNPVIYTIFN 254
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
180-393 3.20e-04

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 42.45  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 180 WR---GFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPRE--KIGRRRALQLLAGAWLTALGFSLPWELlgapreLA 254
Cdd:cd15200    66 WRfgaTACQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPHHQlsKASVGCAAKVAAGLWILILLLNIHLLL------LD 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 255 AAQSFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpvntyARVLRFFSEVRTATTVL 334
Cdd:cd15200   140 HVQSNSTCLSYDHGTDPSASDRWHRILFFLEFFLPLGIILFCIFSIILTLK------------QRKLAKQAGPQRAVKVL 207
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 335 IMIVFV-ICCWGPYcfLVLLAAARQAQTMQAPSLLSVV------AVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15200   208 AVIVLVyTVCFLPS--ILFALASLVAFKVSQCRSLDLCtqlfhgSLAFTYLNSALDPVLYCFSSPS 271
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
184-387 3.65e-04

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 42.24  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWEL-LGAPRELAAAQSFH 260
Cdd:cd15130    78 CRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKtlMSRSRTKKFISAIWLASALLAIPMLFtMGLQNESDDGTHPG 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 261 GCLYRTSPDPAQLGAAFSVGLVVAcYLLPFLLMCFCHYHIcktvrlsdvrvrpVNTYARVLRFFSEVRTAttvlIMIVFV 340
Cdd:cd15130   158 GLVCTPIVDTATLKVVIQVNTFMS-FLFPMLVTSILNTVI-------------ANKLVQALRRGVLVLRA----VVIAFV 219
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370465484 341 IcCWGPYCFLVLLAAARQAQTMQAP-----SLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15130   220 V-CWLPYHVRRLMFCYISDEQWTTFlfdfyHYFYMLTNALFYVSSAINPILY 270
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
184-389 4.08e-04

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 42.20  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAI---VRPPReKIGRRRALQLLAGAWLTALGFSLpWELLGapreLAAAQSFH 260
Cdd:cd15964    80 CNTAGFFTVFASELSVYTLTVITLERWYAItfaMRLDR-KIRLRHASAIMLGGWVFCFLLAL-LPLVG----VSSYAKVS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 261 GCLYRTSPDPAqlgAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsDVRVRPVNTYARVLRffsevRTAttVLIMIVFV 340
Cdd:cd15964   154 ICLPMDTETPL---AQAYIVFVLMLNIIAFVIICACYIKIYITVR--NPQYKSGDKDTKIAK-----RMA--VLIFTDFI 221
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1370465484 341 icCWGPYCFLVLLAAARQAQTMQAPSllSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15964   222 --CMAPISFYALSAILNKPLITVSNS--KILLVLFYPLNSCANPFLYAI 266
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
121-391 4.30e-04

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 42.16  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 121 NCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDLFTPPGGSAPAAAAGPWRGF------CAASRFFSSCF 194
Cdd:cd15084    28 NGLVIVVSIKYKKLRSPLNYIL--------------VNLAVADLLVTLFGSSVSFSNNIVGFFvfgktmCEFEGFMVSLT 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 195 GIVSTLSVALISLDRYCAIVRPPRE-KIGRRRALQLLAGAWLTALGFSLPwELLG----APRELaaaqsfhgclyRTSPD 269
Cdd:cd15084    94 GIVGLWSLAILAFERYLVICKPMGDfRFQQRHAVSGCAFTWGWSLLWTSP-PLFGwssyVPEGL-----------RTSCG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 P-----AQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffSEVRTATTVLIMIVFVICCW 344
Cdd:cd15084   162 PnwytgGTNNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESETTQR-----AEKEVTRMVIAMVMAFLICW 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1370465484 345 GPYCFLVLLAAARQAQTMQaPSLLSVVAVWLTWANgAINPVIYAIRN 391
Cdd:cd15084   237 LPYATFAMVVATNKDVVIQ-PTLASLPSYFSKTAT-VYNPIIYVFMN 281
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
120-396 4.76e-04

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 41.99  E-value: 4.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTPPGGSAPAAAAGPW---RGFCAASRFfssCFGI 196
Cdd:cd15967    17 GNVWGLKSLLANWKKLGNINVFVLNLGL-----------ADLLYLLTLPFLVVYYLKGRKWifgQVFCKITRF---CFNL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVAL---ISLDRYCAIVRPPRE--KIGRRRALQLLAGAWLTALGFSLPwellgaprELAAAQSFHG---CLYRTSP 268
Cdd:cd15967    83 NLYGSIGFltcISVYRYLAIVHPMRVmgRITTTHSVVISALVWLLVVIQSLP--------DLFFSKTNSNgtkCFDTTFN 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 269 DPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSdvrvrpvNTYARVLRffseVRTATTVLIMIVFVICCWGPYC 348
Cdd:cd15967   155 DYLESYLTYSLGWTVTGFVIPLLIILGCYGHVVVVLCRN-------NNVDKGLK----QRCLKLVIILIVLFSVCYIPYH 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 349 FLVLLAAARQAQTMQAPSLLSVVAVW--------LTWANGAINPVIYAIRNPNISM 396
Cdd:cd15967   224 VFRNLNLLSRILQKQGSCTQWFRGIYiahqvsrgLVCLNSALNPLVYLMGSEDILS 279
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
198-389 4.84e-04

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 42.06  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLgapRELAAAQSFH--GCLY-------RT 266
Cdd:cd15116    86 SVFLLTVISIDRCISVVFPVWSQNHRsvRLASLVSLAVWVVAFFLSSPSFIF---RDTAPSQNNNkiICFNnfslsgdNS 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 267 SPDPAQLGA----AFSVGLVVACYLLPFLLMCFCHYHI-CKTVRlsdvrvrpvNTYARVLRFFSEVrtattVLIMIVFVI 341
Cdd:cd15116   163 SPEVNQLRNmrhqVMTITRFLLGFLIPFTIIICCYAAIvLKLKR---------NRLAKSSKPFKII-----AAVIVTFFL 228
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1370465484 342 cCWGPYCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15116   229 -CWAPYHILNLLEMEATRSPASVFKIGLPITSSLAFINSCLNPILYVF 275
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
181-391 4.88e-04

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 42.11  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 181 RGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPRE-KIGRRRALQLLAGAWLTALGFSLPwELLGAPRELAaaqsf 259
Cdd:cd15076    70 RTVCALEAFVGSLAGLVTGWSLAFLAFERYIVICKPFGNfRFGSKHALGAVVATWIIGIGVSLP-PFFGWSRYIP----- 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 260 HGCLYRTSPDPAQLGA-----AFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVrtattVL 334
Cdd:cd15076   144 EGLQCSCGPDWYTVGTkyrseYYTWFLFIFCFIVPLSIIIFSYSQLLGALRAVAAQQQESASTQKAEREVSRM-----VV 218
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370465484 335 IMIVFVICCWGPYCFLVLLAAARQAQTMQAPslLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15076   219 VMVGSFCLCYVPYAALAMYMVNNRDHGLDLR--LVTIPAFFSKSSCVYNPIIYCFMN 273
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
183-392 5.11e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 42.05  E-value: 5.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCaasRFFSSC---FGIVSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLtalgfslpwellgapreLAAAQ 257
Cdd:cd15317    72 FC---KFHTGLdllLCTTSIFHLCFIAIDRYYAVCDPLRypSKITVQVAWRFIAIGWL-----------------VPGIY 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 258 SFhGCLYRTSPDPAQLGAAFSVGLVVACYLL---------------PFLLMCFCHYHICKTVRLsdvRVRPVNTYARVLR 322
Cdd:cd15317   132 TF-GLIYTGANDEGLEEYSSEISCVGGCQLLfnkiwvlldfltffiPCLIMIGLYAKIFLVARR---QARKIQNMEDKFR 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 323 FFSEVRTATT-----------VLIMIVFVIcCWGPYCFLVLLAAARQAQTmqaPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15317   208 SSEENSSKASasrerkaaktlAIVMGIFLF-CWLPYFIDTIVDEYSNFIT---PAIVFDAVIWLGYFNSAFNPFIYAFFY 283

                  .
gi 1370465484 392 P 392
Cdd:cd15317   284 P 284
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
120-389 5.50e-04

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 41.79  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlSLSLSDLLTALLCLPaafLDLFTPPGGSAPAAAAGpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15131    17 GNLMTMLVVSKYRDMRTTTNLYL-SSMAFSDLLIFLCMP---LDLYRLWQYRPWNFGDL----LCKLFQFVSESCTYSTI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLP-WELLGAPRElaaaqsfhgclyrTSPDPAQLGA- 275
Cdd:cd15131    89 LNITALSVERYFAICFPLRAKvvVTKRRVKLVILVLWAVSFLSAGPiFVLVGVEHE-------------NGTNPIDTNEc 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 -----AFSVGLVVACYLLP---FLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFV-ICCWGP 346
Cdd:cd15131   156 kateyAVRSGLLTIMVWVSsvfFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDKNNRQTVKMLAVVVFAfVLCWLP 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370465484 347 YCFLVLL-------AAARQAQTMQAPSLLSVVAVWLTwanGAINPVIYAI 389
Cdd:cd15131   236 FHVGRYLfsksfeaGSLEIALISQYCNLVSFVLFYLS---AAINPILYNI 282
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
184-391 5.53e-04

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 42.00  E-value: 5.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRAL--QLLAGAWL---------TALGFSLPweLLGAPR- 251
Cdd:cd15429    73 CVAQLFISLALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLciQLAAASWTsgflnslvqTAFTFRLP--FCGHNTi 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 252 -----ELAAAQSFhGCLYRTSPDPAQLGAAFSVglvvacYLLPFLLMCFCHYHICKTV---RLSDVRVRPVNTYARVLrf 323
Cdd:cd15429   151 nhfscELLAVVRL-ACVDTSLNEVAILVSSVVV------LLTPCFLVLLSYIHIISAIlriRSSEGRHKAFSTCASHL-- 221
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370465484 324 fsevrtatTVLIMivfvicCWGPYCFLVLlaaarQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15429   222 --------TVVSL------CYGTAIFTYM-----RPRSGSSALQEKMISLFYAVVTPMLNPLIYSLRN 270
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
201-394 6.09e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 41.75  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 201 SVALISLDRYCAIVRPP--REKIGRRRALQLLAGAW-LTALGFSLPweLLG---APRELAAAQsfhgcLYRTSPDPAQLG 274
Cdd:cd15341    90 SLLLMAFDRYVCIYYPSeyKALVTRKRALVALAVMWvLTALIAYLP--LMGwncCPLNSPCSE-----LFPLIPNDYLLS 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVGLVVACYLLPFLLMCF-CHYHickTVRLSDVRVRPVNTYARvLRFfsEVRTATTVLIMIVFVICCWGPYCFLVL- 352
Cdd:cd15341   163 WLLLVAILLSGIIYTYGHVLWkAHKH---VVYMEKHQDQQGPGNAR-MRL--DVRLAKTLGLVLAVLLICWSPVLALMMh 236
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 353 -LAAARQAQTMQAPSLLSVvavwLTWANGAINPVIYAIRNPNI 394
Cdd:cd15341   237 sLFTSLSDHIKKAFAFCST----LCLVNSMVNPIIYALRSREL 275
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
198-393 6.22e-04

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 41.86  E-value: 6.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRR--RALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFhgCLYRTSPDPAQLGA 275
Cdd:cd15089    86 SIFTLTMMSVDRYIAVCHPVKALDFRTpaKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVV--CMLQFPSPSWYWDT 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCHYHIckTVRLSDVR-VRPVNTYARVLRffsevRTATTVLIMIVFVICCWGPYCFLVLLA 354
Cdd:cd15089   164 VTKICVFIFAFVVPILVITVCYGLM--ILRLRSVRlLSGSKEKDRNLR-----RITRMVLVVVAAFIICWTPIHIFVIVW 236
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 355 AARQAQTMQapslLSVVAVW-----LTWANGAINPVIYAIRNPN 393
Cdd:cd15089   237 TLVDIDRRN----PLVVAALhlciaLGYANSSLNPVLYAFLDEN 276
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
197-387 6.44e-04

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 41.71  E-value: 6.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRP--PREKIGRRRALQLLAGAWLTALGFSLPWELLgapRELAAAQSFH--GCLYRTsPDPAq 272
Cdd:cd15380    86 ISIFLVVAISQDRYRTLVHTmtSRRQRSRRQAQVICLLIWVFGGLLSIPTFLF---RSVKHVPDLNisACILLF-PHEA- 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 LGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpVNTYARVLRFFSEVRTATTVLIMIVFV--ICCWGPYCFL 350
Cdd:cd15380   161 WHFARRVELNIVGFLLPLAAIVFFNFHIIASLR--------ERTEESRKRCGGLKDTKATRLILTLVLmfLVCWTPYHFF 232
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 351 VLLAAARQAQTMQA------PSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15380   233 AFLDFLFQVEVIQGcfweefIDLGLQLANFFAFANSCLNPVIY 275
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
197-387 6.82e-04

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 41.66  E-value: 6.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPR----EKIGRRRALQLLagAWLTALGFSLPWELL--GAPRElaaaQSFHGCLYRTSPdp 270
Cdd:cd15924    85 TSIVFLGLISIDRYLKIVRPFKtsfpKSVSFAKILSVV--VWALMFLLSLPNMILtnQQPRE----KNVKKCSFLKSE-- 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 aqLGAAF---SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffseVRTATTVLIMIVFVICCWGPY 347
Cdd:cd15924   157 --LGLKWheiVNYICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSSRR-------KKSNVKIFIIVAVFFVCFVPY 227
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 348 CFLVL---LAAARQAQTMQAPSLLSVV---AVWLTWANGAINPVIY 387
Cdd:cd15924   228 HFARIpytLSQTRDVFDCTAENILFYVkeaTLFLSALNVCLDPIIY 273
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
120-388 7.28e-04

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 41.60  E-value: 7.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFTppGGSAPAAAAGPWRGFCAASRFFSSCFGI--- 196
Cdd:cd15180    17 GNGLVLAVLLQKRRNLSVTDTFILHLAL-----------ADILLLVT--LPFWAVQAVHGWIFGTGLCKLAGAVFKInfy 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRP----PREKIGRRRALQLLagAWLTALGFSLP-WELLGAPRElaAAQSFHGCLYRTSPDPA 271
Cdd:cd15180    84 CGIFLLACISFDRYLSIVHAvqmySRKKPMLVHLSCLI--VWLFCLLLSIPdFIFLEATKD--PRQNKTECVHNFPQSDT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDvrvrpvntyarvlRFFSEVRTATTVLIMIVFVICCWGPYCfLV 351
Cdd:cd15180   160 YWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSS-------------QGFQKQRAIRVIVAVVVVFFLCWTPYN-IA 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370465484 352 LLaaarqAQTMQAPSLLSV---------VAVWLTWANG----AINPVIYA 388
Cdd:cd15180   226 LL-----VDTLIDLSVLDRncgtesrldIALSVTSSLGyfhcCLNPLLYA 270
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
198-390 7.96e-04

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 41.37  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLP----WELLGAPRELAAAQSFHGCLYRTSPDPA 271
Cdd:cd15071    85 SILALLAIAVDRYLRVKIPTRYKsvVTPRRAAVAIAGCWILSFLVGLTpmfgWNNLNAVERAWAANSSMGELVIKCQFET 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAAFSVGLVVACYLLP-FLLMCFCHYHICKTVR------LSDVRVRPVNTYARVLRFfsevrTATTVLIMIVFVICcW 344
Cdd:cd15071   165 VISMEYMVYFNFFVWVLPpLLLMLLIYLEVFYLIRkqlnkkVSSSSSDPQKYYGKELKI-----AKSLALILFLFALS-W 238
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1370465484 345 GPycFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIR 390
Cdd:cd15071   239 LP--LHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFR 282
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
278-394 7.98e-04

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 41.17  E-value: 7.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAaar 357
Cdd:cd15961   154 NAAILSVSFLLMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIA--- 230
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1370465484 358 qaqTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNI 394
Cdd:cd15961   231 ---DYTYPSIYTYATLLPATYNSIINPVIYAFRNQEI 264
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
128-396 8.63e-04

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 41.33  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 128 IVKHRQLRTVTNAFILSLSlSDLLTALLCLPaaFLDLFTPPGGSAPAAAAgpwrgFCA--ASRFFSSCFgiVSTLSVALI 205
Cdd:cd15118    24 VVGFRLRRTVISIWILNLA-LSDLLATLSLP--FFTYYLASGHTWELGTT-----FCRihSSIFFLNMF--VSGFLLAAI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 206 SLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFhgCLY---RTSPDPAQLGA---AF 277
Cdd:cd15118    94 SLDRCLLVVKPVWAQNHRnvAAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKL--CYYnfaLFSPSPDNNHPickQR 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFL--LMCFCHYHICKTVRLSDVRVRpvntyaRVLRFFSEVrtattVLIMIVFVIcCWGPYCFLVLLAA 355
Cdd:cd15118   172 QEGLAISKLLLAFLipLVIIAVSYAVVSLIIRHRCRR------RPGRFVRLV-----VSVVVSFAL-CWAPYHIFSIIEV 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 356 ARQAQTMQAPSLLSV--VAVWLTWANGAINPVIYAIRNPNISM 396
Cdd:cd15118   240 MAHNQHSLRPLVIQGlpFATTLAFLNSVLNPVLYVFSCPDFCN 282
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
120-393 9.33e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 41.39  E-value: 9.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP--AAFLDLFTppggsapaaaagpWRGFCAASRFFSSCFGIV 197
Cdd:cd15957    17 GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPfgAAHILLKT-------------WTFGNFWCEFWTSIDVLC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSV---ALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTA-----LGFSLPWELLGAPRELAAAQSFHGCLYRTS 267
Cdd:cd15957    84 VTASIetlCVIAVDRYFAITSPFKYQslLTKNKARVIILMVWIVSgltsfLPIQMHWYRATHQEAINCYAEETCCDFFTN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 268 PdpaqlgaAFSVGLVVACYLLPFLLMCFCHYHI-------CKTVRLSDVRVRPVNTYARVLRFFSEVRTA---------- 330
Cdd:cd15957   164 Q-------AYAIASSIVSFYVPLVIMVFVYSRVfqeakrqLQKIDKSEGRFHNQNIDQNGSGGGGGNRRRskfclkehka 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370465484 331 --TTVLIMIVFVIcCWGPYcFLVLLAAARQAQTMqaPSLLSVVAVWLTWANGAINPVIYAiRNPN 393
Cdd:cd15957   237 lkTLGIIMGTFTL-CWLPF-FIVNIVHVIQDNLI--RKEVYILLNWIGYVNSGFNPLIYC-RSPD 296
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
184-247 1.15e-03

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 40.67  E-value: 1.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREK--IGRRRALQLLAGAWLTALGFSLPWELL 247
Cdd:cd15235    74 CLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYAtvMSPKRCLLLVAGSWLLSHLHSLLHTLL 139
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
198-387 1.19e-03

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 40.58  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRY---CAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQsfhgCLYRTspdpaqlg 274
Cdd:cd15295    87 SVYNIVLISYDRYqsvSNAVSYRNQQTATLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGE----CEPEF-------- 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 aaFSVGLVVAC-----YLLPFLLMCFCHYHICKTVRlSDVRVRpvntyarvlrffsevRTATTVLIMIVFVICCWGPYcf 349
Cdd:cd15295   155 --FSNWYILAItsvleFLVPVILVAYFNTQIYWSLW-KRLRDR---------------KLAKSLAIILGTFAICWAPY-- 214
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370465484 350 lVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIY 387
Cdd:cd15295   215 -SLFTIIRAACEKHRGSPWYNFAFWLQWFNSFINPFLY 251
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
120-400 1.29e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 40.59  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAaagpwrgFCAASRFFSSCFGIVST 199
Cdd:cd15306    17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWPLPLV-------LCPIWLFLDVLFSTASI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSVALISLDRYCAIVRPPREKIGRRRALQLL--AGAWLTALGFSLPWELLGApRELAAAQSFHGCLyrTSPDPAQlgaAF 277
Cdd:cd15306    90 MHLCAISLDRYIAIKKPIQASQYNSRATAFIkiTVVWLISIGIAIPVPIKGI-ETDVDNPNNITCV--LTKERFG---DF 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 278 SVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRvrpvntyarvlrffSEVRTATTVLIMIVFVICCWGPYcFLVLLAAAR 357
Cdd:cd15306   164 ILFGSLAAFFTPLAIMIVTYFLTIHALRKQTIT--------------NEQRASKVLGIVFFLFLLMWCPF-FITNITSVL 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 358 QAQTMQAP-SLLSVVAVWLTWANGAINPVIYAIRNPNISMLLGR 400
Cdd:cd15306   229 CDSCNQTTlQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGR 272
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
197-389 1.37e-03

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 40.62  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPR-EKIGRRRALQLLAGAWLtaLGFSLPWELLGAPRELaaaQSFHG----CLYRTSPDPA 271
Cdd:cd15965    93 VSVLLLTYLTLEKYICIVYPFRcLTPGKCRTITILILIWI--IGFIIAFIPLSNKEFF---RNYYGtngvCFPLHSEQPE 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 QLGAA-FSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffSEVRTATTVLIMIVFVICCWGPYCFL 350
Cdd:cd15965   168 STGAQiYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQTAIMATEISNHIK-----KEMTLAKRFFFIVFTDALCWIPIFIL 242
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370465484 351 VLLAAArqaQTMQAPSLLSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15965   243 KLLSLL---QVEIPGTISSWVVIFILPINSALNPILYTL 278
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
202-389 1.54e-03

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 40.52  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 202 VALISLDRYCAIVRPprEKIGRRRA-----LQLLAgAWLTALGFSLPWELLgapRELAAAQSFH--GCLYrtspDPAQLG 274
Cdd:cd15381    91 LMMVSIDRYLALVKT--MSSGRMRRpacakLNCLI-IWMFGLLMSTPMIVF---RTVMYFPEYNitACVL----DYPSEG 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAFSVG--LVVACYLLPFLLMCFCHYHICKTVRLSDvrvrpvntyarvLRFFSEVRTAT--TVLIMIVFV--ICCWGPYC 348
Cdd:cd15381   161 WHVALNilLNVVGFLIPLSIITFCSTQIIQVLRNNK------------MQKFKEIQTERkaTVLVLAVLLmfFICWLPFH 228
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1370465484 349 FLVLLAAARQAQTMQAPSL------LSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15381   229 IFTFLDTLHKLGLISGCRWedildiGTQIATFLAYSNSCLNPLLYVI 275
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
120-393 2.18e-03

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 40.11  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaaFLDLFTppggsapaaAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15397    17 GNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLP--FTVVYT---------LMDYWifgEVLCKMTPFIQCMSVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWE----LLGAP-RELAAAQSFHG----CLyrTS 267
Cdd:cd15397    86 VSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLafhiLTDEPyKNLSHFFAPLAdkavCT--ES 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 268 PDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHIckTVRLSDvRVRPVNTYARVLRFFSEVRTATTVLIMIV--FVIcCWG 345
Cdd:cd15397   164 WPSEHHKLAYTTWLLLFQYCLPLLFILVCYLRI--YLRLRR-RKDMLERRGEYNRRAGHSKRINVMLVSLVaaFAL-CWL 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1370465484 346 P-YCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15397   240 PlNVFNAIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSN 288
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
183-398 2.38e-03

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 39.73  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLGAPRELAAA---- 256
Cdd:cd15119    71 LCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRtlKSALILCGIVWLSAAAISGPALYFRDTMELSINvtic 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 257 -QSFHgclyRTSPDPAQLGAAFSVGL-VVACYLLPFLLMCFChyHICKTVRLSDVRVRPVNTYARvlrffsevrtaTTVL 334
Cdd:cd15119   151 fNNFH----KHDGDLIVMRHTILVWVrFFFGFLFPLLTMVVC--YSLLAIKVKRRTLLISSKFFW-----------TISA 213
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370465484 335 IMIVFVIcCWGPYCFLVLLAAARQA-----QTMQAPSLLSVVavwLTWANGAINPVIYAIRNPNISMLL 398
Cdd:cd15119   214 VIVAFFV-CWTPYHIFSILELSIHHssylhNVLRAGIPLATS---LAFINSCLNPILYVLIGKKFKAHL 278
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
198-342 2.39e-03

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 39.78  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRP------PREKIgrrrALQLLAGAWLTALGFSLPWELLGAPRELAAAQ--SFHGCLYR-TSP 268
Cdd:cd15371    86 SILLLTCISINRYLAIVHPfiyrslPKKTY----AVLICALVWTIVFLYMLPFFILKQTYYLKELNitTCHDVLPEcEQN 161
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370465484 269 DPAQLgaAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVrvrpvntyarvlRFFSEVRtaTTVLIMIVFVIC 342
Cdd:cd15371   162 SNFQF--YYFISMAVFGFLIPLVITIFCYISIIRTLNAYEH------------KWFWYVK--ITALVLIIFTIC 219
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
198-391 2.58e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 39.77  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRR--RALQLLAGAWLTA--LGF--SLPWELLGAPRELAAAQSFHGCLYrtspdpa 271
Cdd:cd15349    86 STFSLLVTAVERYATMVRPVAENTATKtyRVYGMIVLCWILAflIGFlpLLGWNCLCDFRSCSSLLPLYSKSY------- 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 272 qlgAAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvRVRPVNTYARVLRFFSevrtatTVLIMIVFVICCWGPYCFLV 351
Cdd:cd15349   159 ---ILFCLVIFFIILLTIIGLYFAIYCLVRASGQ----RVISARSRRRSLRLLK------TVLMILGAFMVCWGPLFILL 225
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1370465484 352 LLAAARQAQTMQAPSLLSVVaVWLTWANGAINPVIYAIRN 391
Cdd:cd15349   226 LVDFFCSSRSCKPLFGMEWV-LALAVLNSAINPLIYSFRS 264
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
120-384 3.43e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 39.52  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAafldlftppggSAPAAAAGPW---RGFCAASRFFSSCFGI 196
Cdd:cd15123    17 GNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPV-----------DATRYIADTWlfgRIGCKLLSFIQLTSVG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRpPREKIGRRRALQLLAGA---WLTALGFSLPWELLGAPRELAAAQ---SFHGClyrtSPDP 270
Cdd:cd15123    86 VSVFTLTVLSADRYRAIVK-PLELQTSDAVLKTCCKAgcvWIVSMLFAIPEAVFSDLYSFRDPEkntTFEAC----APYP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 271 AQ---LGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVrPVNTYARVLRFF-SEVRTATTVLIMIVFVICCWGP 346
Cdd:cd15123   161 VSekiLQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNM-PAEEHSHARKQIeSRKRVAKTVLVLVALFAFCWLP 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370465484 347 YCFLVLLAAARQAQTMQAPSLLSVVAVW---LTWANGAINP 384
Cdd:cd15123   240 NHILYLYRSFTYHTSVDSSAFHLIATIFsrvLAFSNSCVNP 280
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
120-391 3.44e-03

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 39.24  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDL----FTPPGGSAPAAAAGPWRGFCAASRFFSSCF- 194
Cdd:cd15300    17 GNVLVMISFKVNSQLKTVNNYYL--------------LSLACADLiigiFSMNLYTSYILMGYWALGSLACDLWLALDYv 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 195 -GIVSTLSVALISLDRYCAIVRPP--REKIGRRRALQLLAGAWLTALGFSLP----WELLGAPRELAAAQsfhgCLYRTS 267
Cdd:cd15300    83 aSNASVMNLLVISFDRYFSITRPLtyRAKRTPKRAGIMIGLAWLISFILWAPpilcWQYFVGKRTVPERE----CQIQFL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 268 PDPaqlgaAFSVGLVVACYLLPFLLMCFCHYHICKTVrlsdvrvrpvntyarvlrfFSEVRTATTVLIMIVFVICCWGPY 347
Cdd:cd15300   159 SEP-----TITFGTAIAAFYIPVSVMTILYCRIYKET-------------------IKERKAAQTLSAILLAFIITWTPY 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1370465484 348 CFLVLLAAarqAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15300   215 NIMVLVST---FCSDCIPLTLWHLGYWLCYVNSTVNPMCYALCN 255
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
184-389 3.49e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 39.46  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 184 CAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPR--EKIGRRRALQLLAGAWLTALGFSLpWELLGapreLAAAQSFHG 261
Cdd:cd15360    80 CAAAGFFTVFASELSVYTLTVITLERWHTITYAMQldRKVRLRHAAVIMVGGWIFAFTVAL-LPIFG----ISSYMKVSI 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 262 CLyrtspdPAQLGAAFSVGLVVACYLL---PFLLMCFCHYHICKTVRLSDVrvrpVNTYarvlrffSEVRTATTVLIMIV 338
Cdd:cd15360   155 CL------PMDIESPLSQAYIIFILVLnvlAFLIICACYIKIYLTVRNPNF----VSSN-------SDTKIAKRMAVLIF 217
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 339 FVICCWGPYCFLVLLAAARQAQTMQAPSllSVVAVWLTWANGAINPVIYAI 389
Cdd:cd15360   218 TDFLCMAPISFFAISASLKVPLITVSKS--KILLVLFYPINSCANPFLYAI 266
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
202-353 3.71e-03

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 39.38  E-value: 3.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 202 VALISLDRYCAIV--RPPREKIGRRRALQLLAGAWLTALGFSLP-------WELLGAPRELAAAQSFHGCLYRTspdpaq 272
Cdd:cd15188    90 VSCMSLDKYLEIVhaQSPHRLRTRRKSLLVLVAVWVLSIALSVPdmvfvqtHHTNNGVWVCHADYGGHHTIWKL------ 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 273 lgaAFSVGLVVACYLLPFLLMCFCHYHI-CKTVRLsdvrvRPVNTyARVLRFfsevrtaTTVLIMIVFVIccWGPYCFLV 351
Cdd:cd15188   164 ---VFQFQQNLLGFLFPLLAMVFFYSRIaCVLTRL-----RPPGQ-GRALRF-------VAALVVVFFVL--WFPYNLTL 225

                  ..
gi 1370465484 352 LL 353
Cdd:cd15188   226 FL 227
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
183-391 3.79e-03

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 39.43  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 183 FCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGR-RRALQLLAGAWLTALGFSLPwELLGAPRELAAA-QSFH 260
Cdd:cd15077    72 ACKIEGFTATLGGMVSLWSLAVVAFERFLVICKPLGNFTFRgTHAIIGCIATWVFGLAASLP-PLFGWSRYIPEGlQCSC 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 261 GCLYRTSPDPAQlGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARvlrffSEVRTATTVLIMIVFV 340
Cdd:cd15077   151 GPDWYTTNNKWN-NESYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSASTQK-----AEREVTKMVVVMVLGF 224
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 341 ICCWGPYCFLVLLAAARQAQTMQApSLLSVVAVwLTWANGAINPVIYAIRN 391
Cdd:cd15077   225 LVCWLPYASFALWVVTNRGEPFDL-RLASIPSV-FSKASTVYNPVIYVFMN 273
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
180-391 4.18e-03

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 39.13  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 180 WRGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPwELLGAPRELAAAQ 257
Cdd:cd15321    75 RKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRtpRRIKCIILIVWLIAAVISLP-PLIYKGKQKDEQG 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 258 SFHGCLYRTSPdpaqlgaAFSVGLVVACYLLPFLLMCFCHYHICKTVRlsdvrvrpvntyARVLRFfsevrTATTVLIMI 337
Cdd:cd15321   154 GLPQCKLNEEA-------WYILSSSIGSFFAPCLIMILVYLRIYLIAK------------NREKRF-----TFVLAVVIG 209
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370465484 338 VFVICcWGPYCFLVLLAAArQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRN 391
Cdd:cd15321   210 VFVLC-WFPFFFSYSLGAI-CPELCKVPHSLFQFFFWIGYCNSSLNPVIYTIFN 261
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
198-387 4.73e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 39.03  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPRE-KIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGClYRTSPDPAQLgAA 276
Cdd:cd15385    87 STYMLVMMTADRYIAICHPLKTlQQPTKRSYLMIGSAWALSFILSTPQYFIFSLSEIENGSGVYDC-WANFIVPWGI-KA 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 277 FSVGLVVACYLLPFLLMCFCH----YHI-----CKTVR----------LSDVRVRPVNTYARvlrffSEVRTATTVLIMI 337
Cdd:cd15385   165 YITWITISIFVVPVIILLTCYgficYNIwrnikCKTRRglsdnalkniLLAVCVSSVKTISR-----AKIRTVKMTFVIV 239
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370465484 338 VFVICCWGPYcFLVLLAAARQAQTMQAPSLLSVVAVWLTWA--NGAINPVIY 387
Cdd:cd15385   240 LAYIVCWAPF-FTIQMWSVWDQNFPWDESENTAVTITALLAslNSCCNPWIY 290
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
120-387 4.74e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 38.97  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTppggsapaaaaGPWRGFCAASRFFSSCFGIVST 199
Cdd:cd15058    17 GNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVT-----------GKWQLGNFWCELWTSVDVLCVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 200 LSV---ALISLDRYCAIVRPPREK--IGRRRALQLLAGAWL-TALGFSLP----WELLGAPRELAAAQSFHGCLYRTSpd 269
Cdd:cd15058    86 ASIetlCVIAVDRYIAITRPLRYQvlLTKRRARVIVCVVWIvSALVSFVPimnqWWRANDPEANDCYQDPTCCDFRTN-- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 paqlgAAFSVGLVVACYLLPFLLMCFCHYHI----CKTVRLSD-VRVR-----PVNTYARVLRFFSEVRTATTV------ 333
Cdd:cd15058   164 -----MAYAIASSVVSFYIPLLIMIFVYARVfliaTRQLQLIDkRRLRfqsecPAPQTTSPEGKRSSGRRPSRLtvvkeh 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370465484 334 -------LIMIVFVIcCWGPYcFLVLLAAARQAQTMQAPSLLSVvaVWLTWANGAINPVIY 387
Cdd:cd15058   239 kalktlgIIMGTFTL-CWLPF-FIANIINVFNRNLPPGEVFLLL--NWLGYINSGLNPIIY 295
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
197-388 4.80e-03

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 38.99  E-value: 4.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRP----PREKIGRRRALQLLagAWLTALGFSLPWELlgapreLAAAQSFHGCLYRT---SPD 269
Cdd:PHA03087  124 NSMNFITVMSVDRYIAIVHPvksnKINTVKYGYIVSLV--IWIISIIETTPILF------VYTTKKDHETLICCmfyNNK 195
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 270 PAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLrffsevrtattvLIMIVFVIcCWGPYCF 349
Cdd:PHA03087  196 TMNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKSKKNKKAIKLVL------------IIVILFVI-FWLPFNV 262
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1370465484 350 LVLLAAARQAQ------TMQAPSLLSVVAVWLTWANGAINPVIYA 388
Cdd:PHA03087  263 SVFVYSLHILHfksgckAVKYIQYALHVTEIISLSHCCINPLIYA 307
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
198-342 5.03e-03

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 38.90  E-value: 5.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGRRRALQLLAGA--WLTALGFSLPWELLGAPRElaaAQSFHGCLYRTSPDPAQLGA 275
Cdd:cd15375    87 SILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAvvWVISLAEVSPMTFLITTKE---KNNRTICLDFTSSDNLNTIW 163
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLrffsevrtatTVLIMIVFVIC 342
Cdd:cd15375   164 WYNWILTVLGFLLPLVIVTLCYTRIIYTLAKGPHTGSASKQKARRL----------IILILLVFYVC 220
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
198-393 5.35e-03

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 38.82  E-value: 5.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 198 STLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLPWELLGAPRelaAAQSFHGCLYRTSPDPAQLGA 275
Cdd:cd15090    86 SIFTLCTMSVDRYIAVCHPVKALDFRtpRNAKIVNVCNWILSSAIGLPVMFMATTK---YRQGSIDCTLTFSHPSWYWEN 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 276 AFSVGLVVACYLLPFLLMCFCHYHIckTVRLSDVR-VRPVNTYARVLRffsevRTATTVLIMIVFVICCWGPYCFLVLLa 354
Cdd:cd15090   163 LLKICVFIFAFIMPVLIITVCYGLM--ILRLKSVRmLSGSKEKDRNLR-----RITRMVLVVVAVFIVCWTPIHIYVII- 234
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1370465484 355 aarQAQTMQAPSLLSVVA----VWLTWANGAINPVIYAIRNPN 393
Cdd:cd15090   235 ---KALVTIPETTFQTVSwhfcIALGYTNSCLNPVLYAFLDEN 274
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
120-393 5.43e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 38.61  E-value: 5.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 120 GNCAVMGVIVKHRQLRTVTNAFILSlslsdlltallcLPAAFLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSCFGI--- 196
Cdd:cd15094    17 GNGLVIYVVLRYAKMKTVTNLYILN------------LAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSInqf 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRRR--ALQLLAGAWLTALGFSLPWELLGAPRELAAAQSfhgC-LYRTSPDPAQL 273
Cdd:cd15094    85 TSSFTLTVMSADRYLAVCHPIRSMRYRTPfiAKVVCATTWSISFLVMLPIILYASTVPDSGRYS---CtIVWPDSSAVNG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 274 GAAFSVGLVVACYLLPFLLMCFchYHICKTVRLSdvRVRPVNTYARVLRffSEVRTATTVLIMIVFVICCWGPY-CFLVL 352
Cdd:cd15094   162 QKAFTLYTFLLGFAIPLLLISV--FYTLVILRLR--TVGPKNKSKEKRR--SHRKVTRLVLTVISVYIICWLPYwAFQVH 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370465484 353 LAAARQAQTMQAPS-LLSVVAVWLTWANGAINPVIYAIRNPN 393
Cdd:cd15094   236 LIFLPPGTDMPKWEiLMFLLLTVLSYANSMVNPLLYAFLSEN 277
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
197-356 5.49e-03

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 38.62  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 197 VSTLSVALISLDRYCAIVRPPREKIGRR--RALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFhgCLYRTspdPAQLG 274
Cdd:cd15366    86 ISIAFLCCISVDRYLAVAHPLRFAKVRRvkTAVAVSAVVWAIEIGANSAPLFHDELFRDRYNHTF--CFEKY---PMEDW 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 275 AAF-SVGLVVACYLLPFLLMCFCHYHICKTVRLSdvrvrpVNTYARvlrffSEVRTATTVLIMIVFVICCWGPYCFLVLL 353
Cdd:cd15366   161 VAWmNLYRVFVGFLFPWVLMLFSYRGILRAVRGN------VSTEQQ-----EKAKIKRLALSLIAIVLLCFAPYHVLLLS 229

                  ...
gi 1370465484 354 AAA 356
Cdd:cd15366   230 RSV 232
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
317-391 8.25e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 38.28  E-value: 8.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465484 317 YARVLRFFSEVRTATTVLIMIVFV-ICCWGPYcFLVLLAAARQAQTMQAPSLLSVVAvWLTWANGAINPVIYAIRN 391
Cdd:cd15308   178 YCAMFRGLGRERKAMRVLPVVVGAfLFCWTPF-FVVHITRALCESCSIPPQLISIVT-WLGYVNSALNPVIYTVFN 251
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
181-342 9.68e-03

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 38.08  E-value: 9.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 181 RGFC--AASRFFSSCFGivSTLSVALISLDRYCAIVRPPREKIGR--RRALQLLAGAWLTALGFSLP-WELLGAPRElaA 255
Cdd:cd15165    68 RTLCsfLESLYFVNMYG--SILIIVCISVDRYIAIRHPFLAKRLRspRKAAIVCLTIWVFVWAGSIPiYSFHDKPTN--N 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465484 256 AQSFHGCLYRTspdpaqLGAAFSVGLVVACYLLPFLLMCFCHYHICKTvrLSDVRvRPVNtyarvlrffSEVRTATTVLI 335
Cdd:cd15165   144 TRCFHGFSNKT------WSKKVIVVVEEFGFLIPMAVMVFCSVQIIRT--LLDMR-RPEQ---------PKVKQNKSVKI 205
                         170
                  ....*....|.
gi 1370465484 336 MI----VFVIC 342
Cdd:cd15165   206 VLsnlvVFLVC 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH