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Conserved domains on  [gi|1370454560|ref|XP_024305589|]
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dynein axonemal intermediate chain 4 isoform X10 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
232-534 7.43e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 7.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 232 WSIKNPMWPERIYQSPYGVTAVDFSigaPN--LLAVGYHNGTIAIYNVRSNSNVPVLdssespQKHLGPVWQLQWieqdr 309
Cdd:COG2319   105 WDLATGLLLRTLTGHTGAVRSVAFS---PDgkTLASGSADGTVRLWDLATGKLLRTL------TGHSGAVTSVAF----- 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 310 gtTGDGKReiLVSISADGRISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLA 389
Cdd:COG2319   171 --SPDGKL--LASGSDDGTVRLWDLATG-------KLLRT-----------------LTGHTGAVRSVAFSP-DGKLLAS 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 390 GTEEGHIHKCSCSyNEQYLDTYRGHKGPVYKVTWNPfchD--VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWS 467
Cdd:COG2319   222 GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSP---DgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370454560 468 PKSSYIFAAANENRVEIWDLhiSTLDPLIVNTANPGiKFTTILFAKQTDCLLVGDSDGQVSVYELRN 534
Cdd:COG2319   298 PDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
232-534 7.43e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 7.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 232 WSIKNPMWPERIYQSPYGVTAVDFSigaPN--LLAVGYHNGTIAIYNVRSNSNVPVLdssespQKHLGPVWQLQWieqdr 309
Cdd:COG2319   105 WDLATGLLLRTLTGHTGAVRSVAFS---PDgkTLASGSADGTVRLWDLATGKLLRTL------TGHSGAVTSVAF----- 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 310 gtTGDGKReiLVSISADGRISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLA 389
Cdd:COG2319   171 --SPDGKL--LASGSDDGTVRLWDLATG-------KLLRT-----------------LTGHTGAVRSVAFSP-DGKLLAS 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 390 GTEEGHIHKCSCSyNEQYLDTYRGHKGPVYKVTWNPfchD--VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWS 467
Cdd:COG2319   222 GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSP---DgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370454560 468 PKSSYIFAAANENRVEIWDLhiSTLDPLIVNTANPGiKFTTILFAKQTDCLLVGDSDGQVSVYELRN 534
Cdd:COG2319   298 PDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 204-486 1.04e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 1.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 204 WNKTNPDLLAVGYGHFGFKE------QKRGLACC--------WSIKNPMWPERIYQSPYGVTAVDFSiGAPNLLAVGYHN 269
Cdd:cd00200    36 WDLETGELLRTLKGHTGPVRdvaasaDGTYLASGssdktirlWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRD 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 270 GTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWIEQDRgttgdgkreILVSISADGRISKWVIRKGldcydlmRLKRT 349
Cdd:cd00200   115 KTIKVWDVETGKCLTTLRG------HTDWVNSVAFSPDGT---------FVASSSQDGTIKLWDLRTG-------KCVAT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 350 taasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLAGTEEGHIhKCSCSYNEQYLDTYRGHKGPVYKVTWNPfCHD 429
Cdd:cd00200   173 -----------------LTGHTGEVNSVAFSP-DGEKLLSSSSDGTI-KLWDLSTGKCLGTLRGHENGVNSVAFSP-DGY 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370454560 430 VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWD 486
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 404-443 4.01e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1370454560  404 NEQYLDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIW 443
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
406-443 3.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1370454560 406 QYLDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIW 443
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
232-534 7.43e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 7.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 232 WSIKNPMWPERIYQSPYGVTAVDFSigaPN--LLAVGYHNGTIAIYNVRSNSNVPVLdssespQKHLGPVWQLQWieqdr 309
Cdd:COG2319   105 WDLATGLLLRTLTGHTGAVRSVAFS---PDgkTLASGSADGTVRLWDLATGKLLRTL------TGHSGAVTSVAF----- 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 310 gtTGDGKReiLVSISADGRISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLA 389
Cdd:COG2319   171 --SPDGKL--LASGSDDGTVRLWDLATG-------KLLRT-----------------LTGHTGAVRSVAFSP-DGKLLAS 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 390 GTEEGHIHKCSCSyNEQYLDTYRGHKGPVYKVTWNPfchD--VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWS 467
Cdd:COG2319   222 GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSP---DgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370454560 468 PKSSYIFAAANENRVEIWDLhiSTLDPLIVNTANPGiKFTTILFAKQTDCLLVGDSDGQVSVYELRN 534
Cdd:COG2319   298 PDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
199-487 8.68e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 8.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 199 VSSLAWNktnPD--LLAVGYGhfgfkeqkRGLACCWSIKNPMWPERIYQSPYGVTAVDFSigaPN--LLAVGYHNGTIAI 274
Cdd:COG2319   165 VTSVAFS---PDgkLLASGSD--------DGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 275 YNVRSNSNVPVLDSsespqkHLGPVWQLQWieqdrgtTGDGKReiLVSISADGRISKWVIRKGldcydlmRLKRTtaasn 354
Cdd:COG2319   231 WDLATGKLLRTLTG------HSGSVRSVAF-------SPDGRL--LASGSADGTVRLWDLATG-------ELLRT----- 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 355 kkggekekkdeaLISRQAPGMCFAFHPkDTNIYLAGTEEGHIH-------KCscsyneqyLDTYRGHKGPVYKVTWNPFc 427
Cdd:COG2319   284 ------------LTGHSGGVNSVAFSP-DGKLLASGSDDGTVRlwdlatgKL--------LRTLTGHTGAVRSVAFSPD- 341

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 428 HDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDL 487
Cdd:COG2319   342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 204-486 1.04e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 1.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 204 WNKTNPDLLAVGYGHFGFKE------QKRGLACC--------WSIKNPMWPERIYQSPYGVTAVDFSiGAPNLLAVGYHN 269
Cdd:cd00200    36 WDLETGELLRTLKGHTGPVRdvaasaDGTYLASGssdktirlWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRD 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 270 GTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWIEQDRgttgdgkreILVSISADGRISKWVIRKGldcydlmRLKRT 349
Cdd:cd00200   115 KTIKVWDVETGKCLTTLRG------HTDWVNSVAFSPDGT---------FVASSSQDGTIKLWDLRTG-------KCVAT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 350 taasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLAGTEEGHIhKCSCSYNEQYLDTYRGHKGPVYKVTWNPfCHD 429
Cdd:cd00200   173 -----------------LTGHTGEVNSVAFSP-DGEKLLSSSSDGTI-KLWDLSTGKCLGTLRGHENGVNSVAFSP-DGY 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370454560 430 VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWD 486
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
249-534 4.37e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 4.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 249 GVTAVDFSigaPN--LLAVGYHNGTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWieqdrgtTGDGKReiLVSISAD 326
Cdd:COG2319   164 AVTSVAFS---PDgkLLASGSDDGTVRLWDLATGKLLRTLTG------HTGAVRSVAF-------SPDGKL--LASGSAD 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 327 GRISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLAGTEEGHIHKCSCSyNEQ 406
Cdd:COG2319   226 GTVRLWDLATG-------KLLRT-----------------LTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA-TGE 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 407 YLDTYRGHKGPVYKVTWNPfchD--VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEI 484
Cdd:COG2319   280 LLRTLTGHSGGVNSVAFSP---DgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370454560 485 WDLHISTLDPLIVNTANPgikFTTILFAKQTDCLLVGDSDGQVSVYELRN 534
Cdd:COG2319   357 WDLATGELLRTLTGHTGA---VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 249-531 2.25e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 2.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 249 GVTAVDFSIGAPNLLAVGYhNGTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWieqdrgttgDGKREILVSISADGR 328
Cdd:cd00200    53 PVRDVAASADGTYLASGSS-DKTIRLWDLETGECVRTLTG------HTSYVSSVAF---------SPDGRILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 329 ISKWVIRKGLDCYdlmrlkrttaasnkkggekekkdeALISRQAPGMCFAFHPkDTNIYLAGTEEGHIH-----KCSCSY 403
Cdd:cd00200   117 IKVWDVETGKCLT------------------------TLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKlwdlrTGKCVA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 404 neqyldTYRGHKGPVYKVTWNPfchD--VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENR 481
Cdd:cd00200   172 ------TLTGHTGEVNSVAFSP---DgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370454560 482 VEIWDLHISTLDPLIVNTANPgikFTTILFAKQTDCLLVGDSDGQVSVYE 531
Cdd:cd00200   243 IRVWDLRTGECVQTLSGHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 295-544 5.27e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 5.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 295 HLGPVWQLQWieqdrgttgDGKREILVSISADGRISKWvirkgldCYDLMRLKRTtaasnkkggekekkdeaLISRQAPG 374
Cdd:cd00200     8 HTGGVTCVAF---------SPDGKLLATGSGDGTIKVW-------DLETGELLRT-----------------LKGHTGPV 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 375 MCFAFHPKDTNIYLAGTEeghiHKCSC--SYNEQYLDTYRGHKGPVYKVTWNPFCHdVFLSCSADWGVIIWQQENVKPSL 452
Cdd:cd00200    55 RDVAASADGTYLASGSSD----KTIRLwdLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLT 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 453 SFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDLhistldplivNTANPGIKFT-------TILFAKQTDCLLVGDSDG 525
Cdd:cd00200   130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL----------RTGKCVATLTghtgevnSVAFSPDGEKLLSSSSDG 199

                         250
                  ....*....|....*....
gi 1370454560 526 QVSVYELRnMPTVLETGRG 544
Cdd:cd00200   200 TIKLWDLS-TGKCLGTLRG 217
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 410-487 4.70e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 4.70e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370454560 410 TYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDL 487
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
WD40 COG2319
WD40 repeat [General function prediction only];
408-534 9.11e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 9.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370454560 408 LDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDL 487
Cdd:COG2319    71 LATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370454560 488 H----ISTLDPlivntanPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRN 534
Cdd:COG2319   150 AtgklLRTLTG-------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 404-443 4.01e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1370454560  404 NEQYLDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIW 443
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
406-443 3.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1370454560 406 QYLDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIW 443
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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