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Conserved domains on  [gi|1370474845|ref|XP_024307218|]
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tetraspanin-16 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 95-176 1.56e-20

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


:

Pssm-ID: 239409  Cd Length: 114  Bit Score: 82.20  E-value: 1.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474845  95 LEHTFVTLRKNYRG--YNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGSSF----EMTTGHTYPRSCCKSIGSVSCDGRD- 167
Cdd:cd03156     9 LEDSFKNLLKNNYGnyNSTGDAITSTWNRVMIELKCCGVNGPTDFVDSTSffrqKNEPNSPYPESCCKRNSNSQIVDLDc 88

                          90
                  ....*....|..
gi 1370474845 168 ---VSPNVIHQK 176
Cdd:cd03156    89 pklGSPNSYNKK 100
Tetraspanin super family cl28961
Tetraspanin family;
19-130 1.78e-04

Tetraspanin family;


The actual alignment was detected with superfamily member pfam00335:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 40.38  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474845  19 NGFVAVSGIILVGLGIGGKcggASLTNVLGLSSAYLLHVGNLCLVMGCITVLLGCAGWYGATKESRGTL---------LF 89
Cdd:pfam00335   9 NLLFWLLGLLLLGVGVWLL---SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLltyfvllllLF 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370474845  90 VGDVAL----------------EHTFVTLRKNYR-GYNEPDDYSTQWNLVMEKLKCCG 130
Cdd:pfam00335  86 LAELAAgilafvyrdklsgllsNWLKKSLEDGYRdWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 95-176 1.56e-20

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 82.20  E-value: 1.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474845  95 LEHTFVTLRKNYRG--YNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGSSF----EMTTGHTYPRSCCKSIGSVSCDGRD- 167
Cdd:cd03156     9 LEDSFKNLLKNNYGnyNSTGDAITSTWNRVMIELKCCGVNGPTDFVDSTSffrqKNEPNSPYPESCCKRNSNSQIVDLDc 88

                          90
                  ....*....|..
gi 1370474845 168 ---VSPNVIHQK 176
Cdd:cd03156    89 pklGSPNSYNKK 100
Tetraspanin pfam00335
Tetraspanin family;
19-130 1.78e-04

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 40.38  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474845  19 NGFVAVSGIILVGLGIGGKcggASLTNVLGLSSAYLLHVGNLCLVMGCITVLLGCAGWYGATKESRGTL---------LF 89
Cdd:pfam00335   9 NLLFWLLGLLLLGVGVWLL---SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLltyfvllllLF 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370474845  90 VGDVAL----------------EHTFVTLRKNYR-GYNEPDDYSTQWNLVMEKLKCCG 130
Cdd:pfam00335  86 LAELAAgilafvyrdklsgllsNWLKKSLEDGYRdWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 95-176 1.56e-20

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 82.20  E-value: 1.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474845  95 LEHTFVTLRKNYRG--YNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGSSF----EMTTGHTYPRSCCKSIGSVSCDGRD- 167
Cdd:cd03156     9 LEDSFKNLLKNNYGnyNSTGDAITSTWNRVMIELKCCGVNGPTDFVDSTSffrqKNEPNSPYPESCCKRNSNSQIVDLDc 88

                          90
                  ....*....|..
gi 1370474845 168 ---VSPNVIHQK 176
Cdd:cd03156    89 pklGSPNSYNKK 100
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 101-156 1.43e-11

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 57.90  E-value: 1.43e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370474845 101 TLRKNYRGYNEPDDYSTQWNLVMEKLKCCGVNNYTDFsgssfeMTTGHTYPRSCCK 156
Cdd:cd03127    14 TLNDAWDEYYVDDDFQEAMDALQSTFECCGVNGPTDY------LDLRLLVPSSCCK 63
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 108-176 4.89e-11

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 56.72  E-value: 4.89e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370474845 108 GYNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGssFEMTTGHTYPRSCCKSIgSVSCdGRDVSPNVIHQK 176
Cdd:cd03166    21 NYNKTNDFRKILDRMQKDLKCCGANNYTDWEN--IPSLDTDSVPDSCCINV-TKGC-GINFDEKVIHLE 85
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 101-189 1.49e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 53.12  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474845 101 TLRKNYRGYNEPDdySTQ-WNLVMEKLKCCGVNNYTDFSGSSFE---MTTGHTYPRSCCKSIgSVSCDGRDVSPNVIHQK 176
Cdd:cd03155    18 TMQENYGQSGEEA--LTLtVDELQQEFKCCGSNNYTDWQDSEWInsnEANGRLVPDSCCKTV-VDRCGCLRDHPSNIYKV 94

                          90
                  ....*....|...
gi 1370474845 177 LPGILATLLLFIK 189
Cdd:cd03155    95 EGGCIPKLEDFLY 107
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 104-158 7.33e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 48.92  E-value: 7.33e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370474845 104 KNYRGYNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGSSFEMT-TGHTYPRSCCKSI 158
Cdd:cd03160    21 QNYGGNPENKTAEEAWDYVQFQLQCCGWTGPQDWTDNSLIKNsSEPLYPCSCCNSS 76
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 99-176 5.81e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 46.20  E-value: 5.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474845  99 FVTLRKNYRGYNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGSSFemTTGHTYPRSCCKSigSVSCDGRD-----VSPNVI 173
Cdd:cd03161    12 LRTYNEAVSNYNGDDERSDAVDTVQRTLHCCGVENYTDWLNSPY--FLEKGIPLSCCKN--RSDCSPQDlknltKAATKV 87


                  ...
gi 1370474845 174 HQK 176
Cdd:cd03161    88 YQQ 90
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 119-163 7.24e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 45.82  E-value: 7.24e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1370474845 119 WNLVMEKLKCCGVNNYTDFsgssFEMTTGHTYPRSCCKSIgSVSC 163
Cdd:cd03165    34 WDITQTEFRCCGVTNYTDW----YEVLGENRVPDSCCQED-SQDC 73
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 101-175 9.07e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 45.49  E-value: 9.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370474845 101 TLRKNYRGYNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGSS-FEMTTGHTYPRSCCKSIGSvSCDGRDVSPNVIHQ 175
Cdd:cd03163    15 SIDKVFNKYNGTNAESRAVDYLQRQLQCCGIHNYTDWENTPwFKESKNNSVPLSCCKETFT-SCTGSLTQPKDLYQ 89
Tetraspanin pfam00335
Tetraspanin family;
19-130 1.78e-04

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 40.38  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474845  19 NGFVAVSGIILVGLGIGGKcggASLTNVLGLSSAYLLHVGNLCLVMGCITVLLGCAGWYGATKESRGTL---------LF 89
Cdd:pfam00335   9 NLLFWLLGLLLLGVGVWLL---SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLltyfvllllLF 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370474845  90 VGDVAL----------------EHTFVTLRKNYR-GYNEPDDYSTQWNLVMEKLKCCG 130
Cdd:pfam00335  86 LAELAAgilafvyrdklsgllsNWLKKSLEDGYRdWLDLYSCLNSALDSLQSEFGCCG 143
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 101-157 6.82e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 37.07  E-value: 6.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370474845 101 TLRKNYRGYNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGSSfemttghtyPRSCCKS 157
Cdd:cd03164    14 GLTDSLEQYHKDNNTSEAWDMIQSNLQCCGINGTTDWGSGV---------PSSCCSS 61
TM4SF12_like_LEL cd03157
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. ...
 119-155 2.77e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human transmembrane 4 superfamily member 12 (TM4SF12).


Pssm-ID: 239410  Cd Length: 103  Bit Score: 36.06  E-value: 2.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370474845 119 WNLVMEKLKCCGVNNYTDFsgssFEMTTGHTYPRSCC 155
Cdd:cd03157    35 WNSFQTEFKCCGVIYFTDW----LEMTEMEWPPDSCC 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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