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Conserved domains on  [gi|1370475974|ref|XP_024307493|]
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epoxide hydrolase 3 isoform X1 [Homo sapiens]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 80-358 2.83e-39

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 138.98  E-value: 2.83e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  80 LKSSGLRLHYVSAGRgNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVdcYTIDLLLVDIKDVI 159
Cdd:COG0596     7 VTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGG--YTLDDLADDLAALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 160 LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGApmsvyqdyslhhiSQFFRSHYmflfqlpwlpekllsmsdf 239
Cdd:COG0596    84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEV-------------LAALAEPL------------------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 240 qilkttlthrktGIPCLTPSELEAFLYNFSQPggltgplnyyrnlfrNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIG 319
Cdd:COG0596   132 ------------RRPGLAPEALAALLRALART---------------DLRERLARITVPTLVIWGEKDPIVPPALARRLA 184

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370475974 320 SRFvpGRLEAHILPGIGHWIPQSNPQEMHQYMWAFLQDL 358
Cdd:COG0596   185 ELL--PNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 80-358 2.83e-39

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 138.98  E-value: 2.83e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  80 LKSSGLRLHYVSAGRgNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVdcYTIDLLLVDIKDVI 159
Cdd:COG0596     7 VTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGG--YTLDDLADDLAALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 160 LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGApmsvyqdyslhhiSQFFRSHYmflfqlpwlpekllsmsdf 239
Cdd:COG0596    84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEV-------------LAALAEPL------------------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 240 qilkttlthrktGIPCLTPSELEAFLYNFSQPggltgplnyyrnlfrNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIG 319
Cdd:COG0596   132 ------------RRPGLAPEALAALLRALART---------------DLRERLARITVPTLVIWGEKDPIVPPALARRLA 184

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370475974 320 SRFvpGRLEAHILPGIGHWIPQSNPQEMHQYMWAFLQDL 358
Cdd:COG0596   185 ELL--PNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PRK05855 PRK05855
SDR family oxidoreductase;
81-347 8.07e-27

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 111.23  E-value: 8.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  81 KSSGLRLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVIL 160
Cdd:PRK05855    9 SSDGVRLAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSAPKRTAAYTLARLADDFAAVID 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 161 GLGYSKCI-LVAHDWGALLAWHFsIYYPSLVERM---VVVSGaPmsvyqdySLHHI--------------------SQFF 216
Cdd:PRK05855   89 AVSPDRPVhLLAHDWGSIQGWEA-VTRPRAAGRIasfTSVSG-P-------SLDHVgfwlrsglrrptprrlaralGQLL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 217 RSHYMFLFQLPWLPEKLLsmsdfqilkttlthrKTGIPCLTPSELEAfLYNFSQPGGLTGP--------LNYYR-NLFRN 287
Cdd:PRK05855  160 RSWYIYLFHLPVLPELLW---------------RLGLGRAWPRLLRR-VEGTPVDPIPTQTtlsdgahgVKLYRaNMIRS 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370475974 288 FpLEPQE--LTTPTLLLWGEKDTYLELGLVEAIgSRFVPgRLEAHILPGiGHWIPQSNPQEM 347
Cdd:PRK05855  224 L-SRPREryTDVPVQLIVPTGDPYVRPALYDDL-SRWVP-RLWRREIKA-GHWLPMSHPQVL 281
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 98-339 2.88e-22

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 94.11  E-value: 2.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  98 PLMLFLHGFPENWFSWRYQLREFQ-SRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVILGLGYSKCILVAHDWGA 176
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 177 LLAWHFSIYYPSLVERMVVVSGAPMSvyqdyslHHISQFFRshyMFLFQLPWLPEKLLSmSDFQILKTTLTHRKTGiPCL 256
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPP-------HELDEADR---FILALFPGFFDGFVA-DFAPNPLGRLVAKLLA-LLL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 257 TPSELEAFLYNFS----------QPGGLTGPLNYYRNLFRNFPLEP-QELTTPTLLLWGEKDTYLELGLVEAIGSRFvPG 325
Cdd:pfam00561 149 LRLRLLKALPLLNkrfpsgdyalAKSLVTGALLFIETWSTELRAKFlGRLDEPTLIIWGDQDPLVPPQALEKLAQLF-PN 227

                         250
                  ....*....|....
gi 1370475974 326 RLEAHILPGiGHWI 339
Cdd:pfam00561 228 ARLVVIPDA-GHFA 240
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 93-206 2.35e-03

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 39.03  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  93 GRGNGPLMLfLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDcytidllLVDIKDVILGLGYSKCILVAH 172
Cdd:TIGR01738   1 GQGNVHLVL-IHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPLS-------LADMAEAIAAQAPDPAIWLGW 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1370475974 173 DWGALLAWHFSIYYPSLVERMVVVSGAPMSVYQD 206
Cdd:TIGR01738  73 SLGGLVALHIAATHPDRVRALVTVASSPCFSARE 106
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 80-358 2.83e-39

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 138.98  E-value: 2.83e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  80 LKSSGLRLHYVSAGRgNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVdcYTIDLLLVDIKDVI 159
Cdd:COG0596     7 VTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGG--YTLDDLADDLAALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 160 LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGApmsvyqdyslhhiSQFFRSHYmflfqlpwlpekllsmsdf 239
Cdd:COG0596    84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEV-------------LAALAEPL------------------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 240 qilkttlthrktGIPCLTPSELEAFLYNFSQPggltgplnyyrnlfrNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIG 319
Cdd:COG0596   132 ------------RRPGLAPEALAALLRALART---------------DLRERLARITVPTLVIWGEKDPIVPPALARRLA 184

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1370475974 320 SRFvpGRLEAHILPGIGHWIPQSNPQEMHQYMWAFLQDL 358
Cdd:COG0596   185 ELL--PNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PRK05855 PRK05855
SDR family oxidoreductase;
81-347 8.07e-27

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 111.23  E-value: 8.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  81 KSSGLRLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVIL 160
Cdd:PRK05855    9 SSDGVRLAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSAPKRTAAYTLARLADDFAAVID 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 161 GLGYSKCI-LVAHDWGALLAWHFsIYYPSLVERM---VVVSGaPmsvyqdySLHHI--------------------SQFF 216
Cdd:PRK05855   89 AVSPDRPVhLLAHDWGSIQGWEA-VTRPRAAGRIasfTSVSG-P-------SLDHVgfwlrsglrrptprrlaralGQLL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 217 RSHYMFLFQLPWLPEKLLsmsdfqilkttlthrKTGIPCLTPSELEAfLYNFSQPGGLTGP--------LNYYR-NLFRN 287
Cdd:PRK05855  160 RSWYIYLFHLPVLPELLW---------------RLGLGRAWPRLLRR-VEGTPVDPIPTQTtlsdgahgVKLYRaNMIRS 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370475974 288 FpLEPQE--LTTPTLLLWGEKDTYLELGLVEAIgSRFVPgRLEAHILPGiGHWIPQSNPQEM 347
Cdd:PRK05855  224 L-SRPREryTDVPVQLIVPTGDPYVRPALYDDL-SRWVP-RLWRREIKA-GHWLPMSHPQVL 281
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 98-339 2.88e-22

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 94.11  E-value: 2.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  98 PLMLFLHGFPENWFSWRYQLREFQ-SRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVILGLGYSKCILVAHDWGA 176
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 177 LLAWHFSIYYPSLVERMVVVSGAPMSvyqdyslHHISQFFRshyMFLFQLPWLPEKLLSmSDFQILKTTLTHRKTGiPCL 256
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPP-------HELDEADR---FILALFPGFFDGFVA-DFAPNPLGRLVAKLLA-LLL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 257 TPSELEAFLYNFS----------QPGGLTGPLNYYRNLFRNFPLEP-QELTTPTLLLWGEKDTYLELGLVEAIGSRFvPG 325
Cdd:pfam00561 149 LRLRLLKALPLLNkrfpsgdyalAKSLVTGALLFIETWSTELRAKFlGRLDEPTLIIWGDQDPLVPPQALEKLAQLF-PN 227

                         250
                  ....*....|....
gi 1370475974 326 RLEAHILPGiGHWI 339
Cdd:pfam00561 228 ARLVVIPDA-GHFA 240
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
82-357 1.55e-13

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 68.88  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  82 SSGLRLHYVS--AGRGNGPLMLFLHGFPENWFSWRYQLREFQSR-FHVVAVDLRGYGPSDAPRdVDCYTIDLLLVDIKDV 158
Cdd:COG2267    11 RDGLRLRGRRwrPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAgYAVLAFDLRGHGRSDGPR-GHVDSFDDYVDDLRAA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 159 I---LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGApmsvYQDYSLHHISQffrshymflfqlPWLpeklls 235
Cdd:COG2267    90 LdalRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA----YRADPLLGPSA------------RWL------ 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 236 mSDFQILKttlthrktgipcltpseleaflynfsqpggltgplnyyrnlfrnfplEPQELTTPTLLLWGEKDTYLELGLV 315
Cdd:COG2267   148 -RALRLAE-----------------------------------------------ALARIDVPVLVLHGGADRVVPPEAA 179

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1370475974 316 EAIGSRFVPgRLEAHILPGIGHWIPQS-NPQEMHQYMWAFLQD 357
Cdd:COG2267   180 RRLAARLSP-DVELVLLPGARHELLNEpAREEVLAAILAWLER 221
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 84-358 3.17e-12

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 66.17  E-value: 3.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  84 GLRLHYVSAGrgNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAP----------RDVDCYtIDLLlv 153
Cdd:PRK03592   16 GSRMAYIETG--EGDPIVFLHGNPTSSYLWRNIIPHLAGLGRCLAPDLIGMGASDKPdidytfadhaRYLDAW-FDAL-- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 154 DIKDVilglgyskcILVAHDWGALLAWHFSIYYPSLVERMVVVSGA--PMSvYQDYSLH--HISQFFRSH---YMFLFQL 226
Cdd:PRK03592   91 GLDDV---------VLVGHDWGSALGFDWAARHPDRVRGIAFMEAIvrPMT-WDDFPPAvrELFQALRSPgegEEMVLEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 227 PWLPEKLLSMSdfqILKTtlthrktgipcLTPSELEAFLYNFSQPGG----LTGPlnyyrnlfRNFPL--EPQE------ 294
Cdd:PRK03592  161 NVFIERVLPGS---ILRP-----------LSDEEMAVYRRPFPTPESrrptLSWP--------RELPIdgEPADvvalve 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370475974 295 -----LTT---PTLLLWGEKDTYLELGLVEAIGSRFVPGRLEAHILPGiGHWIPQSNPQEMHQYMWAFLQDL 358
Cdd:PRK03592  219 eyaqwLATsdvPKLLINAEPGAILTTGAIRDWCRSWPNQLEITVFGAG-LHFAQEDSPEEIGAAIAAWLRRL 289
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 85-195 7.27e-12

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 65.37  E-value: 7.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  85 LRLHYVSAGRGNGPLMLFLHGFPenwfSWRYQLRE----FQSRFH-VVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVI 159
Cdd:PRK00870   34 LRMHYVDEGPADGPPVLLLHGEP----SWSYLYRKmipiLAAAGHrVIAPDLIGFGRSDKPTRREDYTYARHVEWMRSWF 109

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1370475974 160 LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVV 195
Cdd:PRK00870  110 EQLDLTDVTLVCQDWGGLIGLRLAAEHPDRFARLVV 145
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
82-359 1.29e-11

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 63.88  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  82 SSGLRLH---YVSAGRGNGPLMLFLHGFPEN-WFSWRYQLREFQSR-FHVVAVDLRGYGPSDAprdvdcytiDLLLVDIK 156
Cdd:COG1506     5 ADGTTLPgwlYLPADGKKYPVVVYVHGGPGSrDDSFLPLAQALASRgYAVLAPDYRGYGESAG---------DWGGDEVD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 157 DVILGLGY---------SKCILVAHDWGALLAWHFSIYYPSLVErmVVVSGAPMSVYQDYSlhHISQFFRSHYMFlfqlp 227
Cdd:COG1506    76 DVLAAIDYlaarpyvdpDRIGIYGHSYGGYMALLAAARHPDRFK--AAVALAGVSDLRSYY--GTTREYTERLMG----- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 228 wlpekllsmsdfqilkttlthrktgipclTPSELEAFLYNFSqpggltgPLNYYRNlfrnfplepqeLTTPTLLLWGEKD 307
Cdd:COG1506   147 -----------------------------GPWEDPEAYAARS-------PLAYADK-----------LKTPLLLIHGEAD 179

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370475974 308 TYLELG----LVEAIGSRFVPGRLeaHILPGIGHWIPQSNPQEMHQYMWAFLQDLL 359
Cdd:COG1506   180 DRVPPEqaerLYEALKKAGKPVEL--LVYPGEGHGFSGAGAPDYLERILDFLDRHL 233
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 82-347 1.44e-09

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 58.33  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  82 SSGLRLHYVSagRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPrDVDCYTIDLLLVDIKDVILG 161
Cdd:PRK03204   21 SSRGRIHYID--EGTGPPILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSERP-SGFGYQIDEHARVIGEFVDH 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 162 LGYSKCILVAHDWGAllawhfSIYYPSLVERMVVVSGApmsVYQDYSLHHISQFFRSHYMFLFQLPWLPEKLLSMSDF-- 239
Cdd:PRK03204   98 LGLDRYLSMGQDWGG------PISMAVAVERADRVRGV---VLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNFFve 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 240 QILKTTLTHRktgipcltPSELEAFLYNFSQPGG--------LTGPLNYYRNLFRNFPLE-PQEL-TTPTLLLWGEKDTY 309
Cdd:PRK03204  169 RLIPAGTEHR--------PSSAVMAHYRAVQPNAaarrgvaeMPKQILAARPLLARLAREvPATLgTKPTLLVWGMKDVA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370475974 310 LElglVEAIGSRF--VPGRLEAHILPGIGHWIPQSNPQEM 347
Cdd:PRK03204  241 FR---PKTILPRLraTFPDHVLVELPNAKHFIQEDAPDRI 277
PLN02578 PLN02578
hydrolase
 84-199 3.18e-08

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 54.85  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  84 GLRLHYVSAGRGNgPLMLfLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDapRDVDCYTIDLLLVDIKDVILGLG 163
Cdd:PLN02578   75 GHKIHYVVQGEGL-PIVL-IHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSD--KALIEYDAMVWRDQVADFVKEVV 150

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1370475974 164 YSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGA 199
Cdd:PLN02578  151 KEPAVLVGNSLGGFTALSTAVGYPELVAGVALLNSA 186
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 100-347 4.55e-08

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 52.86  E-value: 4.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 100 MLFLHGFpenWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRdvdcYTIDlLLVDIKDVILGLGYSK-CILVAHDWGALL 178
Cdd:pfam12697   1 VVLVHGA---GLSAAPLAALLAAGVAVLAPDLPGHGSSSPPP----LDLA-DLADLAALLDELGAARpVVLVGHSLGGAV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 179 AWHFSIYYPslVERMVVVSGAPMSVYQDYSLHHISQFFRSHYMFLFQLPWLPEKLLSMSDFQILKTTLTHRktgipcltp 258
Cdd:pfam12697  73 ALAAAAAAL--VVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALA--------- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 259 seleaflynfsqpggltgPLNYYRNLFRNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIGSRfvpGRLEAHILPGIGHW 338
Cdd:pfam12697 142 ------------------RLAALLAALALLPLAAWRDLPVPVLVLAEEDRLVPELAQRLLAAL---AGARLVVLPGAGHL 200


                  ....*....
gi 1370475974 339 iPQSNPQEM 347
Cdd:pfam12697 201 -PLDDPEEV 208
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 84-347 5.06e-08

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 53.59  E-value: 5.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  84 GLRLHYVSAGrGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDA--PRDV---DCYTIDLLLVDIKDV 158
Cdd:PLN02824   17 GYNIRYQRAG-TSGPALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKpnPRSAppnSFYTFETWGEQLNDF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 159 ILGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVsgapmsvyqDYSLH--HIS--QFFRSHYMFLFQlPWLPEKLL 234
Cdd:PLN02824   96 CSDVVGDPAFVICNSVGGVVGLQAAVDAPELVRGVMLI---------NISLRglHIKkqPWLGRPFIKAFQ-NLLRETAV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 235 SMSDFQILKTTLTHRKTGIPC------LTPSELEAFLYNFSQPGGLtgplnyyrNLFRNF------PLePQEL----TTP 298
Cdd:PLN02824  166 GKAFFKSVATPETVKNILCQCyhddsaVTDELVEAILRPGLEPGAV--------DVFLDFisysggPL-PEELlpavKCP 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370475974 299 TLLLWGEKDTYLELGLVEAIGS-----RFVPgrleahiLPGIGHwIPQSNPQEM 347
Cdd:PLN02824  237 VLIAWGEKDPWEPVELGRAYANfdaveDFIV-------LPGVGH-CPQDEAPEL 282
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 86-140 1.43e-07

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 52.58  E-value: 1.43e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370475974  86 RLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAP 140
Cdd:PLN03084  116 RWFCVESGSNNNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDKP 170
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 99-337 2.55e-07

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 51.06  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  99 LMLFLHGFpeNWFSWRYQL--REFQSR-FHVVAVDLRGYGPSDAPR----DVDCYTIDLLLVdIKDVILGLGYSKCILVA 171
Cdd:pfam12146   6 VVVLVHGL--GEHSGRYAHlaDALAAQgFAVYAYDHRGHGRSDGKRghvpSFDDYVDDLDTF-VDKIREEHPGLPLFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 172 HDWGALLAWHFSIYYPSLVERMVVVsgAPMSVYQDYSLHHISQFFrsHYMFLFQLPWLPEKLlsmsdfQILKTTLTHRkt 251
Cdd:pfam12146  83 HSMGGLIAALYALRYPDKVDGLILS--APALKIKPYLAPPILKLL--AKLLGKLFPRLRVPN------NLLPDSLSRD-- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 252 gipcltPSELEAFlYNFSQPGGLTgPLNYYRNLFR--NFPLEP-QELTTPTLLLWGEKDTYLELG----LVEAIGSRfvp 324
Cdd:pfam12146 151 ------PEVVAAY-AADPLVHGGI-SARTLYELLDagERLLRRaAAITVPLLLLHGGADRVVDPAgsreFYERAGST--- 219

                         250
                  ....*....|...
gi 1370475974 325 gRLEAHILPGIGH 337
Cdd:pfam12146 220 -DKTLKLYPGLYH 231
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 85-344 7.88e-05

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 44.85  E-value: 7.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974   85 LRLHYVSAgRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSD----APRDVDCYTIDLLLVdiKDVIL 160
Cdd:PLN02980  1360 IKVHEVGQ-NAEGSVVLFLHGFLGTGEDWIPIMKAISGSARCISIDLPGHGGSKiqnhAKETQTEPTLSVELV--ADLLY 1436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  161 GLGYS----KCILVAHDWGALLAWHFSIYYPSLVERMVVVSGAP---------MSVYQDYSLhhiSQFFRSHYMFLFQLP 227
Cdd:PLN02980  1437 KLIEHitpgKVTLVGYSMGARIALYMALRFSDKIEGAVIISGSPglkdevarkIRSAKDDSR---ARMLIDHGLEIFLEN 1513

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  228 W----LPEKLLSMSDF-QILKTTLTHRKtgIPCLtpSELEAFLYNFSQPggltgplnyyrnlfrnfPL--EPQELTTPTL 300
Cdd:PLN02980  1514 WysgeLWKSLRNHPHFnKIVASRLLHKD--VPSL--AKLLSDLSIGRQP-----------------SLweDLKQCDTPLL 1572

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370475974  301 LLWGEKDT---------YLELGLVEAIGSRFVPGRLEAHILPGIGHWIPQSNP 344
Cdd:PLN02980  1573 LVVGEKDVkfkqiaqkmYREIGKSKESGNDKGKEIIEIVEIPNCGHAVHLENP 1625
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 93-348 1.16e-04

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 43.75  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  93 GRGNGPLMLFLHGFPEnwfSWRYQLREFQ---SRFHVVAVDLRGYGPSDAPrDVDCYTI----DLLLVDIKDVILGLGYS 165
Cdd:PLN02894  101 SKEDAPTLVMVHGYGA---SQGFFFRNFDalaSRFRVIAIDQLGWGGSSRP-DFTCKSTeeteAWFIDSFEEWRKAKNLS 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 166 KCILVAHDWGALLAWHFSIYYPSLVERMVVVSGAPMSVYQDYSLHHISQFFRSHYMFLFQLPW----LPEKLLSMSD--- 238
Cdd:PLN02894  177 NFILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFSSESDDKSEWLTKFRATWKGAVLNHLWesnfTPQKIIRGLGpwg 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 239 ----FQILKTTLTHRKTGIPcLTPSEL----EAFLYNFSQPGGLTGPLNYYRNL--FRNFPLEPQ--ELTTPTLLLWGEK 306
Cdd:PLN02894  257 pnlvRRYTTARFGAHSTGDI-LSEEESklltDYVYHTLAAKASGELCLKYIFSFgaFARKPLLESasEWKVPTTFIYGRH 335

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370475974 307 DTYLELGLVEAIGSRFVPGRLEahILPGIGHWIPQSNPQEMH 348
Cdd:PLN02894  336 DWMNYEGAVEARKRMKVPCEII--RVPQGGHFVFLDNPSGFH 375
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
93-200 2.24e-04

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 42.31  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  93 GRGNGPLMLfLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAprdvdcyTIDLLLVDIKDVILGLGYSKCILVAH 172
Cdd:PRK10349   10 GQGNVHLVL-LHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRG-------FGALSLADMAEAVLQQAPDKAIWLGW 81

                          90       100
                  ....*....|....*....|....*...
gi 1370475974 173 DWGALLAWHFSIYYPSLVERMVVVSGAP 200
Cdd:PRK10349   82 SLGGLVASQIALTHPERVQALVTVASSP 109
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 101-200 1.81e-03

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 40.18  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974 101 LFLHGFPENWFSWRYQL-----REFQSRFHVVAVDLRGYGPSDAPRDvDCYTIDLLLVDI-KDVILGLGYSKCILVAHDW 174
Cdd:PLN03087  205 LFIHGFISSSAFWTETLfpnfsDAAKSTYRLFAVDLLGFGRSPKPAD-SLYTLREHLEMIeRSVLERYKVKSFHIVAHSL 283

                          90       100
                  ....*....|....*....|....*.
gi 1370475974 175 GALLAWHFSIYYPSLVERMVVVsgAP 200
Cdd:PLN03087  284 GCILALALAVKHPGAVKSLTLL--AP 307
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 93-206 2.35e-03

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 39.03  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  93 GRGNGPLMLfLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDcytidllLVDIKDVILGLGYSKCILVAH 172
Cdd:TIGR01738   1 GQGNVHLVL-IHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPLS-------LADMAEAIAAQAPDPAIWLGW 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1370475974 173 DWGALLAWHFSIYYPSLVERMVVVSGAPMSVYQD 206
Cdd:TIGR01738  73 SLGGLVALHIAATHPDRVRALVTVASSPCFSARE 106
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 84-159 3.05e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 38.74  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  84 GLRLH---YVSAGRGNG-PLMLFLHGFPENWFSWRYQLREFQSR-FHVVAVDLRGYGPSD-APRDVDCYTIDlllvDIKD 157
Cdd:COG1073    20 GIKLAgdlYLPAGASKKyPAVVVAHGNGGVKEQRALYAQRLAELgFNVLAFDYRGYGESEgEPREEGSPERR----DARA 95


                  ..
gi 1370475974 158 VI 159
Cdd:COG1073    96 AV 97
PRK08775 PRK08775
homoserine O-succinyltransferase;
85-205 5.57e-03

homoserine O-succinyltransferase;


Pssm-ID: 181553 [Multi-domain]  Cd Length: 343  Bit Score: 38.23  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475974  85 LRLHYVSAGRGNGPLMLFLHG------------FPEN-WfsWRYQLREFQ----SRFHVVAVDLRGygpSDAPRDVDCYT 147
Cdd:PRK08775   46 LRLRYELIGPAGAPVVFVAGGisahrhvaatatFPEKgW--WEGLVGSGRaldpARFRLLAFDFIG---ADGSLDVPIDT 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370475974 148 ID-----LLLVDIkdviLGLGYSKCIlVAHDWGALLAWHFSIYYPSLVERMVVVSGA----PMSVYQ 205
Cdd:PRK08775  121 ADqadaiALLLDA----LGIARLHAF-VGYSYGALVGLQFASRHPARVRTLVVVSGAhrahPYAAAW 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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