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Conserved domains on  [gi|1370479218|ref|XP_024308937|]
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ELMO domain-containing protein 3 isoform X1 [Homo sapiens]

Protein Classification

ELMO domain-containing protein( domain architecture ID 10520379)

ELMO domain-containing protein acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family

Gene Ontology:  GO:0005096

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELMO_CED12 pfam04727
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ...
 154-313 1.30e-39

ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.


:

Pssm-ID: 461411  Cd Length: 161  Bit Score: 138.51  E-value: 1.30e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479218 154 DLVLTIAQCGLDSQDPVHGRVLQTIYKKLTGSKFDCALHGNHWEDLGFQGANPATDLRGAGFlallhllYLVMD-----S 228
Cdd:pfam04727   1 NLLRKRRKTPFDSENPEHERLLKELWKALFPDEPLESRISEKWKRLGFQGEDPATDFRGMGL-------LGLENllyfaR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479218 229 KTLPMAQEIFRLSRHHIQQFPFCLMSVNITHIAIQALREECLSRECNRQQKVIPVVNSF---YAATFLHLAHVWRTQRKT 305
Cdd:pfam04727  74 NHPDSFQKILLEQSHRPQRYPFAVASINLTSLLYELLKIGKLDPEENKSYLFFPLLLAFeelYCAAFQLFDRTWKEMGAT 153


                  ....*...
gi 1370479218 306 ISDSGFVL 313
Cdd:pfam04727 154 IMDFNKVL 161
 
Name Accession Description Interval E-value
ELMO_CED12 pfam04727
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ...
 154-313 1.30e-39

ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.


Pssm-ID: 461411  Cd Length: 161  Bit Score: 138.51  E-value: 1.30e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479218 154 DLVLTIAQCGLDSQDPVHGRVLQTIYKKLTGSKFDCALHGNHWEDLGFQGANPATDLRGAGFlallhllYLVMD-----S 228
Cdd:pfam04727   1 NLLRKRRKTPFDSENPEHERLLKELWKALFPDEPLESRISEKWKRLGFQGEDPATDFRGMGL-------LGLENllyfaR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479218 229 KTLPMAQEIFRLSRHHIQQFPFCLMSVNITHIAIQALREECLSRECNRQQKVIPVVNSF---YAATFLHLAHVWRTQRKT 305
Cdd:pfam04727  74 NHPDSFQKILLEQSHRPQRYPFAVASINLTSLLYELLKIGKLDPEENKSYLFFPLLLAFeelYCAAFQLFDRTWKEMGAT 153


                  ....*...
gi 1370479218 306 ISDSGFVL 313
Cdd:pfam04727 154 IMDFNKVL 161
 
Name Accession Description Interval E-value
ELMO_CED12 pfam04727
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ...
 154-313 1.30e-39

ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.


Pssm-ID: 461411  Cd Length: 161  Bit Score: 138.51  E-value: 1.30e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479218 154 DLVLTIAQCGLDSQDPVHGRVLQTIYKKLTGSKFDCALHGNHWEDLGFQGANPATDLRGAGFlallhllYLVMD-----S 228
Cdd:pfam04727   1 NLLRKRRKTPFDSENPEHERLLKELWKALFPDEPLESRISEKWKRLGFQGEDPATDFRGMGL-------LGLENllyfaR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370479218 229 KTLPMAQEIFRLSRHHIQQFPFCLMSVNITHIAIQALREECLSRECNRQQKVIPVVNSF---YAATFLHLAHVWRTQRKT 305
Cdd:pfam04727  74 NHPDSFQKILLEQSHRPQRYPFAVASINLTSLLYELLKIGKLDPEENKSYLFFPLLLAFeelYCAAFQLFDRTWKEMGAT 153


                  ....*...
gi 1370479218 306 ISDSGFVL 313
Cdd:pfam04727 154 IMDFNKVL 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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