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Conserved domains on  [gi|1370487333|ref|XP_024309922|]
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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 isoform X1 [Homo sapiens]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 11425670)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
496-999 1.82e-141

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 439.66  E-value: 1.82e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  496 SLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:COG0553    241 TLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLV 320
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRfnihsRYEDYNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 655
Cdd:COG0553    321 LDGTRERAKGAN-----PFEDADLVITSYGLL---RRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLAL 392
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  656 TGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQsiYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKK 735
Cdd:COG0553    393 TGTPVENRLEELWSLLDFLNPGLLGSLKA-----FRERFARPIEK--GDEEALERLRRLLRPFLLRRTKEDVLKDLPEKT 465
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  736 DRIELCAMSEKQEQLYLGLFNRLKKSINNLVTEKNTEmcNV---MMQLRKMANHPllhrqyytaeklkemsQLMLKEPTh 812
Cdd:COG0553    466 EETLYVELTPEQRALYEAVLEYLRRELEGAEGIRRRG--LIlaaLTRLRQICSHP----------------ALLLEEGA- 526
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  813 ceanpdlifedmevmtdfelhvlckqyrhinnfqldmDLILDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLL 892
Cdd:COG0553    527 -------------------------------------ELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERL 569
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  893 KHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTK 972
Cdd:COG0553    570 EERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTR 649
                          490       500
                   ....*....|....*....|....*..
gi 1370487333  973 EVLVIKLISQGTIEESMLKINQQKLKL 999
Cdd:COG0553    650 DVQVYKLVAEGTIEEKILELLEEKRAL 676
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
496-999 1.82e-141

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 439.66  E-value: 1.82e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  496 SLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:COG0553    241 TLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLV 320
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRfnihsRYEDYNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 655
Cdd:COG0553    321 LDGTRERAKGAN-----PFEDADLVITSYGLL---RRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLAL 392
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  656 TGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQsiYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKK 735
Cdd:COG0553    393 TGTPVENRLEELWSLLDFLNPGLLGSLKA-----FRERFARPIEK--GDEEALERLRRLLRPFLLRRTKEDVLKDLPEKT 465
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  736 DRIELCAMSEKQEQLYLGLFNRLKKSINNLVTEKNTEmcNV---MMQLRKMANHPllhrqyytaeklkemsQLMLKEPTh 812
Cdd:COG0553    466 EETLYVELTPEQRALYEAVLEYLRRELEGAEGIRRRG--LIlaaLTRLRQICSHP----------------ALLLEEGA- 526
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  813 ceanpdlifedmevmtdfelhvlckqyrhinnfqldmDLILDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLL 892
Cdd:COG0553    527 -------------------------------------ELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERL 569
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  893 KHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTK 972
Cdd:COG0553    570 EERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTR 649
                          490       500
                   ....*....|....*....|....*..
gi 1370487333  973 EVLVIKLISQGTIEESMLKINQQKLKL 999
Cdd:COG0553    650 DVQVYKLVAEGTIEEKILELLEEKRAL 676
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
497-679 1.18e-124

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 377.11  E-value: 1.18e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 576
Cdd:cd17998      1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 YGSQEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLT 656
Cdd:cd17998     81 YGSQEERKHLRYDILKGLEDFDVIVTTYNLATSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
                          170       180
                   ....*....|....*....|...
gi 1370487333  657 GTPVQNNLLELMSLLNFVMPHMF 679
Cdd:cd17998    161 GTPLQNNLLELMSLLNFIMPKPF 183
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
476-1000 1.20e-113

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 375.68  E-value: 1.20e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  476 LTGNGGGWNIEQPSILNQSLslKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPA 554
Cdd:PLN03142   151 LGGSGGTRLLVQPSCIKGKM--RDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEyRGITGPHMVVAPK 228
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  555 STIDNWLREVNLWCPTLKVLCYYGSQEERKQIRFNIHSRyEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLK 634
Cdd:PLN03142   229 STLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVA-GKFDVCVTSFEMAIK---EKTALKRFSWRYIIIDEAHRIK 304
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  635 NMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKsADEQsiyekERIAHAKQI 714
Cdd:PLN03142   305 NENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSA-ETFDEWFQISGE-NDQQ-----EVVQQLHKV 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  715 IKPFILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLYLGLFNRLKKSINNLVTEKntEMCNVMMQLRKMANHPLLHRQyy 794
Cdd:PLN03142   378 LRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVNAGGERK--RLLNIAMQLRKCCNHPYLFQG-- 453
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  795 taeklkemsqlmlkepthCEANPDLIFEDmevmtdfelHvlckqyrhinnfqldmdLILDSGKFRVLGCILSELKQKGDR 874
Cdd:PLN03142   454 ------------------AEPGPPYTTGE---------H-----------------LVENSGKMVLLDKLLPKLKERDSR 489
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  875 VVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTD-MDIFVFLLSTKAGGLGINLTSANVVILHDIDC 953
Cdd:PLN03142   490 VLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLLSTRAGGLGINLATADIVILYDSDW 569
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 1370487333  954 NPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLE 1000
Cdd:PLN03142   570 NPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALD 616
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
500-787 7.24e-76

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 251.06  E-value: 7.24e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  500 YQKVGLNWL-ALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN--GPHLIVVPASTIDNWLREVNLWC--PTLKVL 574
Cdd:pfam00176    1 YQIEGVNWMlSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNwgGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  575 CYYGSQEERKQIrFNIHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLL 654
Cdd:pfam00176   81 VLHGNKRPQERW-KNDPNFLADFDVVITTYETLRK---HKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWI 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  655 LTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSktksaDEQSIYEKERIAHAKQIIKPFILRRVKEEVLKQLPPK 734
Cdd:pfam00176  157 LTGTPLQNNLEELWALLNFLRPGPFGSL-STFRNWFDR-----PIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPK 230
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370487333  735 KDRIELCAMSEKQEQLYLGL-----FNRLKKSinNLVTEKNTEMCNVMMQLRKMANHP 787
Cdd:pfam00176  231 VEYILFCRLSKLQRKLYQTFllkkdLNAIKTG--EGGREIKASLLNILMRLRKICNHP 286
DEXDc smart00487
DEAD-like helicases superfamily;
497-676 3.59e-31

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 121.44  E-value: 3.59e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333   497 LKPYQKVGLNWLalvHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVP-ASTIDNWLREVNLWCP--TLKV 573
Cdd:smart00487    9 LRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPslGLKV 85
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333   574 LCYYGSQEERKQIRFNIHSryeDYNVIVTTYNCAISSSDDRSLFRRlKLNYAIFDEGHMLKNMGsiRYQHLMTI-----N 648
Cdd:smart00487   86 VGLYGGDSKREQLRKLESG---KTDILVTTPGRLLDLLENDKLSLS-NVDLVILDEAHRLLDGG--FGDQLEKLlkllpK 159
                           170       180       190
                    ....*....|....*....|....*....|.
gi 1370487333   649 ANNRLLLTGTP---VQNNLLELMSLLNFVMP 676
Cdd:smart00487  160 NVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
DpdE NF041062
protein DpdE;
520-732 9.00e-05

protein DpdE;


Pssm-ID: 468989 [Multi-domain]  Cd Length: 1048  Bit Score: 46.50  E-value: 9.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  520 LADEMGLGKTIQA-IAFLAYLYQEgnngPH---LIVVPASTIDNWLREvnlwcptLKVlcyygsqeerkqiRFNI-HSRY 594
Cdd:NF041062   175 LADEVGLGKTIEAgLVIRQHLLDN----PDarvLVLVPDALVRQWRRE-------LRD-------------KFFLdDFPG 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  595 EDYNVivttynCAISS-SDDRSLFRRLKLnyAIFDEGHMLKNMG-------SIRYQHLMTI--NANNRLLLTGTPVQNNL 664
Cdd:NF041062   231 ARVRV------LSHEEpERWEPLLDAPDL--LVVDEAHQLARLAwsgdppeRARYRELAALahAAPRLLLLSATPVLGNE 302
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370487333  665 LELMSLLNFVMPHMFSSSTSEirrmfssktksADEQSIYEKERIAHAKQIIKP----FILRRVKEEVLKQLP 732
Cdd:NF041062   303 ETFLALLHLLDPDLYPLDDLE-----------AFRERLEEREELGRLVLGLDPdnpnFLLRQALDELRALFP 363
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
496-999 1.82e-141

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 439.66  E-value: 1.82e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  496 SLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:COG0553    241 TLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLV 320
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRfnihsRYEDYNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 655
Cdd:COG0553    321 LDGTRERAKGAN-----PFEDADLVITSYGLL---RRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLAL 392
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  656 TGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQsiYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKK 735
Cdd:COG0553    393 TGTPVENRLEELWSLLDFLNPGLLGSLKA-----FRERFARPIEK--GDEEALERLRRLLRPFLLRRTKEDVLKDLPEKT 465
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  736 DRIELCAMSEKQEQLYLGLFNRLKKSINNLVTEKNTEmcNV---MMQLRKMANHPllhrqyytaeklkemsQLMLKEPTh 812
Cdd:COG0553    466 EETLYVELTPEQRALYEAVLEYLRRELEGAEGIRRRG--LIlaaLTRLRQICSHP----------------ALLLEEGA- 526
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  813 ceanpdlifedmevmtdfelhvlckqyrhinnfqldmDLILDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLL 892
Cdd:COG0553    527 -------------------------------------ELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERL 569
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  893 KHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTK 972
Cdd:COG0553    570 EERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTR 649
                          490       500
                   ....*....|....*....|....*..
gi 1370487333  973 EVLVIKLISQGTIEESMLKINQQKLKL 999
Cdd:COG0553    650 DVQVYKLVAEGTIEEKILELLEEKRAL 676
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
497-679 1.18e-124

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 377.11  E-value: 1.18e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 576
Cdd:cd17998      1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 YGSQEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLT 656
Cdd:cd17998     81 YGSQEERKHLRYDILKGLEDFDVIVTTYNLATSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
                          170       180
                   ....*....|....*....|...
gi 1370487333  657 GTPVQNNLLELMSLLNFVMPHMF 679
Cdd:cd17998    161 GTPLQNNLLELMSLLNFIMPKPF 183
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
476-1000 1.20e-113

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 375.68  E-value: 1.20e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  476 LTGNGGGWNIEQPSILNQSLslKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPA 554
Cdd:PLN03142   151 LGGSGGTRLLVQPSCIKGKM--RDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEyRGITGPHMVVAPK 228
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  555 STIDNWLREVNLWCPTLKVLCYYGSQEERKQIRFNIHSRyEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLK 634
Cdd:PLN03142   229 STLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVA-GKFDVCVTSFEMAIK---EKTALKRFSWRYIIIDEAHRIK 304
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  635 NMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKsADEQsiyekERIAHAKQI 714
Cdd:PLN03142   305 NENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSA-ETFDEWFQISGE-NDQQ-----EVVQQLHKV 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  715 IKPFILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLYLGLFNRLKKSINNLVTEKntEMCNVMMQLRKMANHPLLHRQyy 794
Cdd:PLN03142   378 LRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVNAGGERK--RLLNIAMQLRKCCNHPYLFQG-- 453
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  795 taeklkemsqlmlkepthCEANPDLIFEDmevmtdfelHvlckqyrhinnfqldmdLILDSGKFRVLGCILSELKQKGDR 874
Cdd:PLN03142   454 ------------------AEPGPPYTTGE---------H-----------------LVENSGKMVLLDKLLPKLKERDSR 489
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  875 VVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTD-MDIFVFLLSTKAGGLGINLTSANVVILHDIDC 953
Cdd:PLN03142   490 VLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLLSTRAGGLGINLATADIVILYDSDW 569
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 1370487333  954 NPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLE 1000
Cdd:PLN03142   570 NPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALD 616
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
497-679 2.13e-81

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 262.12  E-value: 2.13e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17919      1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKErGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRfnIHSRYEDYNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 655
Cdd:cd17919     81 YHGSQRERAQIR--AKEKLDKFDVVLTTYETL---RRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLL 155
                          170       180
                   ....*....|....*....|....
gi 1370487333  656 TGTPVQNNLLELMSLLNFVMPHMF 679
Cdd:cd17919    156 TGTPLQNNLEELWALLDFLDPPFL 179
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
497-722 5.20e-79

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 257.28  E-value: 5.20e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18003      1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLaCEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFNiHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 655
Cdd:cd18003     81 YYGSAKERKLKRQG-WMKPNSFHVCITSYQLVVQ---DHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLL 156
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370487333  656 TGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMFSSKTKSADEQS-IYEKERIAHAKQIIKPFILRR 722
Cdd:cd18003    157 TGTPLQNSLMELWSLMHFLMPHIFQSHQ-EFKEWFSNPLTAMSEGSqEENEELVRRLHKVLRPFLLRR 223
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
500-787 7.24e-76

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 251.06  E-value: 7.24e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  500 YQKVGLNWL-ALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN--GPHLIVVPASTIDNWLREVNLWC--PTLKVL 574
Cdd:pfam00176    1 YQIEGVNWMlSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNwgGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  575 CYYGSQEERKQIrFNIHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLL 654
Cdd:pfam00176   81 VLHGNKRPQERW-KNDPNFLADFDVVITTYETLRK---HKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWI 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  655 LTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSktksaDEQSIYEKERIAHAKQIIKPFILRRVKEEVLKQLPPK 734
Cdd:pfam00176  157 LTGTPLQNNLEELWALLNFLRPGPFGSL-STFRNWFDR-----PIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPK 230
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370487333  735 KDRIELCAMSEKQEQLYLGL-----FNRLKKSinNLVTEKNTEMCNVMMQLRKMANHP 787
Cdd:pfam00176  231 VEYILFCRLSKLQRKLYQTFllkkdLNAIKTG--EGGREIKASLLNILMRLRKICNHP 286
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
497-724 7.08e-75

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 246.53  E-value: 7.08e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 576
Cdd:cd18009      4 MRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLLY 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 YGSQEERKQIRFNIHSR---YEDYNVIVTTYNCAIsssDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRL 653
Cdd:cd18009     84 HGTKEERERLRKKIMKRegtLQDFPVVVTSYEIAM---RDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370487333  654 LLTGTPVQNNLLELMSLLNFVMPHMFSS-STSEIRRMFSSKTKSADEQSIYEKERIAHA----KQIIKPFILRRVK 724
Cdd:cd18009    161 LLTGTPLQNNLSELWSLLNFLLPDVFDDlSSFESWFDFSSLSDNAADISNLSEEREQNIvhmlHAILKPFLLRRLK 236
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
497-724 9.39e-72

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 237.22  E-value: 9.39e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17997      4 MRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHyKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVVV 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFNIhSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 655
Cdd:cd17997     84 LIGDKEERADIIRDV-LLPGKFDVCITSYEMVIK---EKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLL 159
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370487333  656 TGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKSADEQsiyekERIAHAKQIIKPFILRRVK 724
Cdd:cd17997    160 TGTPLQNNLHELWALLNFLLPDVFTSS-EDFDEWFNVNNCDDDNQ-----EVVQRLHKVLRPFLLRRIK 222
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
497-724 5.42e-70

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 232.07  E-value: 5.42e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 576
Cdd:cd18012      5 LRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVLVI 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 YGSQEERKQIRfnihsRYEDYNVIVTTYNcaisssddrsLFRRL-------KLNYAIFDEGHMLKNMGSIRYQHLMTINA 649
Cdd:cd18012     85 HGTKRKREKLR-----ALEDYDLVITSYG----------LLRRDiellkevKFHYLVLDEAQNIKNPQTKTAKAVKALKA 149
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370487333  650 NNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQSiYEKERIAHAKQIIKPFILRRVK 724
Cdd:cd18012    150 DHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKR-----FKKRFAKPIEKD-GDEEALEELKKLISPFILRRLK 218
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
497-724 5.92e-65

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 218.78  E-value: 5.92e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17996      4 LKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEkKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKIV 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFNIhsRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT-INANNRLL 654
Cdd:cd17996     84 YKGTPDVRKKLQSQI--RAGKFNVLLTTYEYIIK---DKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLL 158
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370487333  655 LTGTPVQNNLLELMSLLNFVMPHMFSSSTSeIRRMFS---SKTKSADEQSIYEKER---IAHAKQIIKPFILRRVK 724
Cdd:cd17996    159 LTGTPLQNNLPELWALLNFLLPKIFKSCKT-FEQWFNtpfANTGEQVKIELNEEETlliIRRLHKVLRPFLLRRLK 233
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
497-722 5.79e-64

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 215.83  E-value: 5.79e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18002      1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIwGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFNI---HSRYED--YNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINAN 650
Cdd:cd18002     81 YWGNPKDRKVLRKFWdrkNLYTRDapFHVVITSYQLVVQ---DEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCR 157
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370487333  651 NRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKS-ADEQSIYEKERIAHAKQIIKPFILRR 722
Cdd:cd18002    158 NRLLLTGTPIQNSMAELWALLHFIMPTLFDSH-DEFNEWFSKDIEShAENKTGLNEHQLKRLHMILKPFMLRR 229
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
497-722 7.18e-62

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 209.52  E-value: 7.18e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17993      2 LRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQqYGPFLVVVPLSTMPAWQREFAKWAPDMNVIV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIR----FNIHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANN 651
Cdd:cd17993     82 YLGDIKSRDTIReyefYFSQTKKLKFNVLLTTYEIILK---DKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNN 158
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370487333  652 RLLLTGTPVQNNLLELMSLLNFVMPHMFssstsEIRRMFSsktksaDEQSIYEKERIAHAKQIIKPFILRR 722
Cdd:cd17993    159 RLLITGTPLQNSLKELWALLHFLMPGKF-----DIWEEFE------EEHDEEQEKGIADLHKELEPFILRR 218
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
497-722 4.51e-58

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 199.01  E-value: 4.51e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCpTLKVLC 575
Cdd:cd17995      1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGiRGPFLVIAPLSTIPNWQREFETWT-DMNVVV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFnihsrYEDY---------------NVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIR 640
Cdd:cd17995     80 YHGSGESRQIIQQ-----YEMYfkdaqgrkkkgvykfDVLITTYEMVIA---DAEELRKIPWRVVVVDEAHRLKNRNSKL 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  641 YQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQSIYEKERiahakQIIKPFIL 720
Cdd:cd17995    152 LQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEE-----FLEEFGDLKTAEQVEKLQ-----ALLKPYML 221

                   ..
gi 1370487333  721 RR 722
Cdd:cd17995    222 RR 223
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
855-980 3.81e-56

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 190.38  E-value: 3.81e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  855 SGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAG 934
Cdd:cd18793     10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1370487333  935 GLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLI 980
Cdd:cd18793     90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
497-722 2.53e-54

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 188.42  E-value: 2.53e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18006      1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLaGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFNIHSrYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 655
Cdd:cd18006     81 YMGDKEKRLDLQQDIKS-TNRFHVLLTTYEICLK---DASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLL 156
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370487333  656 TGTPVQNNLLELMSLLNFVMPHMFSSSTSEirRMFSSKTKSADEQSIYEKeriahAKQIIKPFILRR 722
Cdd:cd18006    157 TGTPIQNSLQELYALLSFIEPNVFPKDKLD--DFIKAYSETDDESETVEE-----LHLLLQPFLLRR 216
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
497-722 2.44e-53

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 186.04  E-value: 2.44e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 576
Cdd:cd18001      1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 YG-SQEERKQIRFNIHSRYedyNVIVTTYNCAISSSDDRSLFRR--LKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRL 653
Cdd:cd18001     81 HGtSKKERERNLERIQRGG---GVLLTTYGMVLSNTEQLSADDHdeFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRI 157
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370487333  654 LLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKERI------AHAKQIIKPFILRR 722
Cdd:cd18001    158 ILTGTPIQNNLKELWALFDFACNGSLLGTRKTFKMEFENPITRGRDKDATQGEKAlgsevaENLRQIIKPYFLRR 232
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
497-735 5.18e-52

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 182.94  E-value: 5.18e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18064     16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNiPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFNIHSRYEdYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 655
Cdd:cd18064     96 LIGDKDQRAAFVRDVLLPGE-WDVCVTSYEMLIK---EKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLL 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  656 TGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKSADEQSIyekERIahaKQIIKPFILRRVKEEVLKQLPPKK 735
Cdd:cd18064    172 TGTPLQNNLHELWALLNFLLPDVFNSA-EDFDSWFDTNNCLGDQKLV---ERL---HMVLRPFLLRRIKADVEKSLPPKK 244
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
486-722 7.00e-50

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 176.35  E-value: 7.00e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  486 EQPSIL-NQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLY-QEGNNGPHLIVVPASTIDNWLRE 563
Cdd:cd18054      9 KQPSYIgGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFhQHQLYGPFLLVVPLSTLTSWQRE 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  564 VNLWCPTLKVLCYYGSQEERKQIRFN--IHSRYE--DYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSI 639
Cdd:cd18054     89 FEIWAPEINVVVYIGDLMSRNTIREYewIHSQTKrlKFNALITTYEILLK---DKTVLGSINWAFLGVDEAHRLKNDDSL 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  640 RYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstSEIRRMFSSKTKSADEQSIYekeriahakQIIKPFI 719
Cdd:cd18054    166 LYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEF--WEDFEEDHGKGRENGYQSLH---------KVLEPFL 234

                   ...
gi 1370487333  720 LRR 722
Cdd:cd18054    235 LRR 237
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
497-722 6.65e-49

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 173.31  E-value: 6.65e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLA---YLYQEGNNG---PHLIVVPASTIDNWLREVNLWCPT 570
Cdd:cd17999      1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhHKRANSFNSenlPSLVVCPPTLVGHWVAEIKKYFPN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  571 --LKVLCYYGSQEERKQIRfnihSRYEDYNVIVTTYNCAISSSDdrsLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTIN 648
Cdd:cd17999     81 afLKPLAYVGPPQERRRLR----EQGEKHNVIVASYDVLRNDIE---VLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLK 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  649 ANNRLLLTGTPVQNNLLELMSLLNFVMPHmFSSSTSEIRRMFSSK-TKSAD-EQSIYEKERIAHA-----KQIIkPFILR 721
Cdd:cd17999    154 ANHRLILSGTPIQNNVLELWSLFDFLMPG-YLGTEKQFQRRFLKPiLASRDsKASAKEQEAGALAlealhKQVL-PFLLR 231

                   .
gi 1370487333  722 R 722
Cdd:cd17999    232 R 232
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
486-724 7.22e-48

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 170.58  E-value: 7.22e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  486 EQPSILNQSlSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREV 564
Cdd:cd18065      6 ESPSYVKGG-TLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNiPGPHMVLVPKSTLHNWMNEF 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  565 NLWCPTLKVLCYYGSQEERKQIRFNIHSRYEdYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 644
Cdd:cd18065     85 KRWVPSLRAVCLIGDKDARAAFIRDVMMPGE-WDVCVTSYEMVIK---EKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  645 MTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKSADEQSIyekERIaHAkqIIKPFILRRVK 724
Cdd:cd18065    161 REFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA-DDFDSWFDTKNCLGDQKLV---ERL-HA--VLKPFLLRRIK 233
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
497-676 2.45e-46

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 164.80  E-value: 2.45e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVL- 574
Cdd:cd18000      1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALhHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVv 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  575 ----CYYGSQEERKQIRFN----IHSRYEDYNVIVTTYNCAISSSDdrsLFRRLKLNYAIFDEGHMLKNMG---SIRYQH 643
Cdd:cd18000     81 lhssGSGTGSEEKLGSIERksqlIRKVVGDGGILITTYEGFRKHKD---LLLNHNWQYVILDEGHKIRNPDaeiTLACKQ 157
                          170       180       190
                   ....*....|....*....|....*....|...
gi 1370487333  644 LMTInanNRLLLTGTPVQNNLLELMSLLNFVMP 676
Cdd:cd18000    158 LRTP---HRLILSGTPIQNNLKELWSLFDFVFP 187
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
485-724 2.46e-44

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 160.98  E-value: 2.46e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  485 IEQPSILNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLRE 563
Cdd:cd18062     12 VEKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRiNGPFLIIVPLSTLSNWVYE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  564 VNLWCPTLKVLCYYGSQEERKQirFNIHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQH 643
Cdd:cd18062     92 FDKWAPSVVKVSYKGSPAARRA--FVPQLRSGKFNVLLTTYEYIIK---DKQILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  644 LMT-INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKER---IAHAKQIIKPFI 719
Cdd:cd18062    167 LNThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETiliIRRLHKVLRPFL 246

                   ....*
gi 1370487333  720 LRRVK 724
Cdd:cd18062    247 LRRLK 251
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
485-724 6.13e-44

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 159.84  E-value: 6.13e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  485 IEQPSILNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLRE 563
Cdd:cd18063     12 VEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRlNGPYLIIVPLSTLSNWTYE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  564 VNLWCPTLKVLCYYGSQEERKQIRFNIhsRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQH 643
Cdd:cd18063     92 FDKWAPSVVKISYKGTPAMRRSLVPQL--RSGKFNVLLTTYEYIIK---DKHILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  644 LMT-INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKER---IAHAKQIIKPFI 719
Cdd:cd18063    167 LNThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETiliIRRLHKVLRPFL 246

                   ....*
gi 1370487333  720 LRRVK 724
Cdd:cd18063    247 LRRLK 251
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
486-722 4.40e-43

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 157.13  E-value: 4.40e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  486 EQPSIL--NQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLR 562
Cdd:cd18053      8 KQPSYIggHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQlYGPFLLVVPLSTLTSWQR 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  563 EVNLWCPTLKVLCYYGSQEERKQIR----FNIHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGS 638
Cdd:cd18053     88 EIQTWAPQMNAVVYLGDINSRNMIRthewMHPQTKRLKFNILLTTYEILLK---DKSFLGGLNWAFIGVDEAHRLKNDDS 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  639 IRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstSEIRRMFSSKTKSADEQSIYEKeriahakqiIKPF 718
Cdd:cd18053    165 LLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSS--WEDFEEEHGKGREYGYASLHKE---------LEPF 233

                   ....
gi 1370487333  719 ILRR 722
Cdd:cd18053    234 LLRR 237
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
497-722 5.93e-42

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 152.21  E-value: 5.93e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17994      1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHsKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSqeerkqirfnihsryedyNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 655
Cdd:cd17994     81 YVGD------------------HVLLTSYELI---SIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLL 139
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370487333  656 TGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFssktkSADEQSIYEKERIAHAKQIIKPFILRR 722
Cdd:cd17994    140 TGTPLQNNLEELFHLLNFLTPERFNNLQG-----F-----LEEFADISKEDQIKKLHDLLGPHMLRR 196
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
497-722 8.94e-42

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 153.21  E-value: 8.94e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLaLVHkhGlnGILADEMGLGKTIQAIA----------FLAYLYQEGNNGPH--------LIVVPASTID 558
Cdd:cd18008      1 LLPYQKQGLAWM-LPR--G--GILADEMGLGKTIQALAlilatrpqdpKIPEELEENSSDPKklylskttLIVVPLSLLS 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  559 NWLREVN--LWCPTLKVLCYYGSQEERkqirfNIHSrYEDYNVIVTTYN-CAISSSDDRSLFRRLKLNYA---------- 625
Cdd:cd18008     76 QWKDEIEkhTKPGSLKVYVYHGSKRIK-----SIEE-LSDYDIVITTYGtLASEFPKNKKGGGRDSKEKEasplhrirwy 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  626 --IFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNF--VMP-HMFSSSTSEIRRMFSSktksadeq 700
Cdd:cd18008    150 rvILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFlrVEPfGDYPWFNSDISKPFSK-------- 221
                          250       260
                   ....*....|....*....|..
gi 1370487333  701 siYEKERIAHAKQIIKPFILRR 722
Cdd:cd18008    222 --NDRKALERLQALLKPILLRR 241
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
497-722 1.45e-40

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 149.74  E-value: 1.45e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWL--ALVHKHGLNG---ILADEMGLGKTIQAIAFLAYLYQEGNNGPH-----LIVVPASTIDNWLREVNL 566
Cdd:cd18004      1 LRPHQREGVQFLydCLTGRRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPtakkaLIVCPSSLVGNWKAEFDK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  567 WCP--TLKVLCYYGSQEERKQIRFNIHSRyEDYNVIVTTYNCAISSSddRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 644
Cdd:cd18004     81 WLGlrRIKVVTADGNAKDVKASLDFFSSA-STYPVLIISYETLRRHA--EKLSKKISIDLLICDEGHRLKNSESKTTKAL 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  645 MTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMF------SSKTKSADEQSIYEKERIAHAKQIIKPF 718
Cdd:cd18004    158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSL-ASFRKVFeepilrSRDPDASEEDKELGAERSQELSELTSRF 236

                   ....
gi 1370487333  719 ILRR 722
Cdd:cd18004    237 ILRR 240
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
497-722 2.08e-38

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 142.87  E-value: 2.08e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 576
Cdd:cd18058      1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIVY 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 YGSQEERKQI-RFNIHSRYED---------YNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT 646
Cdd:cd18058     80 HGSQISRQMIqQYEMYYRDEQgnplsgifkFQVVITTFEMILA---DCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKL 156
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370487333  647 INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 722
Cdd:cd18058    157 MALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKT----------EEQVKKLQSILKPMMLRR 222
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
497-722 2.56e-37

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 140.20  E-value: 2.56e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18057      1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSkGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFNIHSrYED-------------------YNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNM 636
Cdd:cd18057     81 YTGDKESRSVIRENEFS-FEDnairsgkkvfrmkkeaqikFHVLLTSYELI---TIDQAILGSIEWACLVVDEAHRLKNN 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  637 GSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktksADeqsIYEKERIAHAKQIIK 716
Cdd:cd18057    157 QSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF-------AD---ISKEDQIKKLHDLLG 226

                   ....*.
gi 1370487333  717 PFILRR 722
Cdd:cd18057    227 PHMLRR 232
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
497-722 7.92e-37

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 139.05  E-value: 7.92e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-------------EGNNGPH--------LIVVPAS 555
Cdd:cd18005      1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGktgtrrdrennrpRFKKKPPassakkpvLIVAPLS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  556 TIDNWLREVNLWcPTLKVLCYYGSQEERKQIRFNIHSRYEdynVIVTTYncaisssddrSLFRR-------LKLNYAIFD 628
Cdd:cd18005     81 VLYNWKDELDTW-GHFEVGVYHGSRKDDELEGRLKAGRLE---VVVTTY----------DTLRRcidslnsINWSAVIAD 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  629 EGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFS-------SKTKSADEQS 701
Cdd:cd18005    147 EAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSR-SQFKKHFSepikrgqRHTATARELR 225
                          250       260
                   ....*....|....*....|.
gi 1370487333  702 IYEKeRIAHAKQIIKPFILRR 722
Cdd:cd18005    226 LGRK-RKQELAVKLSKFFLRR 245
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
497-722 9.60e-37

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 138.24  E-value: 9.60e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 576
Cdd:cd18059      1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVY 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 YGSQEERKQIRFN-----------IHSRYEdYNVIVTTYNCAISSSDDrslFRRLKLNYAIFDEGHMLKNMGSIRYQHLM 645
Cdd:cd18059     80 HGSQASRRTIQLYemyfkdpqgrvIKGSYK-FHAIITTFEMILTDCPE---LRNIPWRCVVIDEAHRLKNRNCKLLEGLK 155
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370487333  646 TINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 722
Cdd:cd18059    156 MMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
497-692 2.72e-36

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 137.42  E-value: 2.72e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLN--WLALVHKHGLNG-----ILADEMGLGKTIQAIAFL-AYLYQEGNNGPHLIVVPASTIDNWLREVNLWC 568
Cdd:cd18007      1 LKPHQVEGVRflWSNLVGTDVGSDegggcILAHTMGLGKTLQVITFLhTYLAAAPRRSRPLVLCPASTLYNWEDEFKKWL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  569 P----TLKVLCYYGSQEERKQIRFNIHSRYED-------YNVIVTTYNCAISSSDDRSLFRRLKL----NYAIFDEGHML 633
Cdd:cd18007     81 PpdlrPLLVLVSLSASKRADARLRKINKWHKEggvlligYELFRNLASNATTDPRLKQEFIAALLdpgpDLLVLDEGHRL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370487333  634 KNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMFSS 692
Cdd:cd18007    161 KNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLK-EFKKKFVK 218
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
497-722 8.02e-36

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 135.57  E-value: 8.02e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 576
Cdd:cd18060      1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 YGSQEERKQIRfnihsRYEDY---------------NVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRY 641
Cdd:cd18060     80 HGSLASRQMIQ-----QYEMYckdsrgrlipgaykfDALITTFEMILS---DCPELREIEWRCVIIDEAHRLKNRNCKLL 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  642 QHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILR 721
Cdd:cd18060    152 DSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKT----------EEQVQKLQAILKPMMLR 221

                   .
gi 1370487333  722 R 722
Cdd:cd18060    222 R 222
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
497-722 8.09e-36

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 135.91  E-value: 8.09e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18055      1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTkGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFNIHSrYED-------------------YNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNM 636
Cdd:cd18055     81 YTGDKDSRAIIRENEFS-FDDnavkggkkafkmkreaqvkFHVLLTSYELV---TIDQAALGSIRWACLVVDEAHRLKNN 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  637 GSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktksADeqsIYEKERIAHAKQIIK 716
Cdd:cd18055    157 QSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF-------AD---ISKEDQIKKLHDLLG 226

                   ....*.
gi 1370487333  717 PFILRR 722
Cdd:cd18055    227 PHMLRR 232
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
497-722 1.59e-35

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 135.19  E-value: 1.59e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18056      1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSkGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGSQEERKQIRFNIHSrYED-------------------YNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNM 636
Cdd:cd18056     81 YVGDKDSRAIIRENEFS-FEDnairggkkasrmkkeasvkFHVLLTSYELI---TIDMAILGSIDWACLIVDEAHRLKNN 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  637 GSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktksADeqsIYEKERIAHAKQIIK 716
Cdd:cd18056    157 QSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEF-------AD---IAKEDQIKKLHDMLG 226

                   ....*.
gi 1370487333  717 PFILRR 722
Cdd:cd18056    227 PHMLRR 232
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
497-722 2.05e-32

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 125.89  E-value: 2.05e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 576
Cdd:cd18061      1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVY 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 YGSQEERKQI-RFNIHSRYED---------YNVIVTTYNCAISSSDDrslFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT 646
Cdd:cd18061     80 HGSLISRQMIqQYEMYFRDSQgriirgayrFQAIITTFEMILGGCPE---LNAIDWRCVIIDEAHRLKNKNCKLLEGLKL 156
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370487333  647 INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 722
Cdd:cd18061    157 MNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
DEXDc smart00487
DEAD-like helicases superfamily;
497-676 3.59e-31

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 121.44  E-value: 3.59e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333   497 LKPYQKVGLNWLalvHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVP-ASTIDNWLREVNLWCP--TLKV 573
Cdd:smart00487    9 LRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPslGLKV 85
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333   574 LCYYGSQEERKQIRFNIHSryeDYNVIVTTYNCAISSSDDRSLFRRlKLNYAIFDEGHMLKNMGsiRYQHLMTI-----N 648
Cdd:smart00487   86 VGLYGGDSKREQLRKLESG---KTDILVTTPGRLLDLLENDKLSLS-NVDLVILDEAHRLLDGG--FGDQLEKLlkllpK 159
                           170       180       190
                    ....*....|....*....|....*....|.
gi 1370487333   649 ANNRLLLTGTP---VQNNLLELMSLLNFVMP 676
Cdd:smart00487  160 NVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
497-688 4.34e-30

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 118.85  E-value: 4.34e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWlALvhKHGLNGILADEMGLGKTIQAIAFLAYLYQEgnnGPHLIVVPASTIDNWLREVNLWCPTLKVlcy 576
Cdd:cd18010      1 LLPFQREGVCF-AL--RRGGRVLIADEMGLGKTVQAIAIAAYYREE---WPLLIVCPSSLRLTWADEIERWLPSLPP--- 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  577 ygsqeerkqirfnihsryEDYNVIVTTyNCAISSSDDR------SLFRRL-------KLNYAIFDEGHMLKNMGSIRYQH 643
Cdd:cd18010     72 ------------------DDIQVIVKS-KDGLRDGDAKvvivsyDLLRRLekqllarKFKVVICDESHYLKNSKAKRTKA 132
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1370487333  644 LMTI--NANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRR 688
Cdd:cd18010    133 ALPLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRR 179
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
497-722 2.61e-29

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 117.25  E-value: 2.61e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWL-----ALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPH------LIVVPASTIDNWLREVN 565
Cdd:cd18066      1 LRPHQREGIEFLyecvmGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKpvikraLIVTPGSLVKNWKKEFQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  566 LWCPTLKVLCYYGSQEerKQIRFNIHSRYedYNVIVTTYNCAISSSDDrslFRRLKLNYAIFDEGHMLKNMGSIRYQHLM 645
Cdd:cd18066     81 KWLGSERIKVFTVDQD--HKVEEFIASPL--YSVLIISYEMLLRSLDQ---ISKLNFDLVICDEGHRLKNTSIKTTTALT 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  646 TINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFsSSTSEIRRMF------SSKTKSADEQSIYEKERIAHAKQIIKPFI 719
Cdd:cd18066    154 SLSCERRIILTGTPIQNDLQEFFALIDFVNPGIL-GSLSTYRKVYeepivrSREPTATPEEKKLGEARAAELTRLTGLFI 232

                   ...
gi 1370487333  720 LRR 722
Cdd:cd18066    233 LRR 235
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
497-722 1.92e-27

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 112.18  E-value: 1.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWL----ALVHKHGLNG-ILADEMGLGKTIQAIAFLAYLYQEGNNGPHLI-----VVPASTIDNWLREVNL 566
Cdd:cd18067      1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaivVSPSSLVKNWANELGK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  567 WC-PTLKVLCYYGSQEE---RKQIRF-NIHSRYEDYNVIVTTYNCAISSSDdrsLFRRLKLNYAIFDEGHMLKNMGSIRY 641
Cdd:cd18067     81 WLgGRLQPLAIDGGSKKeidRKLVQWaSQQGRRVSTPVLIISYETFRLHVE---VLQKGEVGLVICDEGHRLKNSDNQTY 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  642 QHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSS------KTKSADEQSIYEKERIAHAKQII 715
Cdd:cd18067    158 QALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTA-AEFKKNFELpilkgrDADASEKERQLGEEKLQELISIV 236

                   ....*..
gi 1370487333  716 KPFILRR 722
Cdd:cd18067    237 NRCIIRR 243
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
856-969 2.35e-25

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 101.52  E-value: 2.35e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  856 GKFRVLGCILSelKQKGDRVVLFSQFTMMLDIlEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDmDIFVfLLSTKAGG 935
Cdd:pfam00271    1 EKLEALLELLK--KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKG-KIDV-LVATDVAE 75
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1370487333  936 LGINLTSANVVILHDIDCNPYNDKQAEDRCHRVG 969
Cdd:pfam00271   76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
497-721 3.63e-25

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 105.89  E-value: 3.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLaLVHKhglnGILADEMGLGKTIQAIAFLA----------------------YLYQEGNN----GPHLI 550
Cdd:cd18070      1 LLPYQRRAVNWM-LVPG----GILADEMGLGKTVEVLALILlhprpdndldaadddsdemvccPDCLVAETpvssKATLI 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  551 VVPASTIDNWLREVNLWCPT-LKVLCYYGsQEERKQIRFNIHSRYEDYNVIVTTYN-------CAISSSDDRSLfRRLKL 622
Cdd:cd18070     76 VCPSAILAQWLDEINRHVPSsLKVLTYQG-VKKDGALASPAPEILAEYDIVVTTYDvlrtelhYAEANRSNRRR-RRQKR 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  623 NYAI-------------FDEGHMLKnmGSIRYQHLMT--INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIR 687
Cdd:cd18070    154 YEAPpsplvlvewwrvcLDEAQMVE--SSTSKAAEMArrLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDWWAR 231
                          250       260       270
                   ....*....|....*....|....*....|....
gi 1370487333  688 RMFssktksadeQSIYEKERIAHAKQIIKPFILR 721
Cdd:cd18070    232 VLI---------RPQGRNKAREPLAALLKELLWR 256
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
515-690 1.93e-23

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 99.89  E-value: 1.93e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  515 GLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCP-----------TLKVLCYYGSQEER 583
Cdd:cd18069     28 GFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKWLPppealpnvrprPFKVFILNDEHKTT 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  584 KQIRFNIHSRYEDYNVIVTTYncaisssddrSLFR-RLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQN 662
Cdd:cd18069    108 AARAKVIEDWVKDGGVLLMGY----------EMFRlRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQN 177
                          170       180
                   ....*....|....*....|....*...
gi 1370487333  663 NLLELMSLLNFVMPHMFSSSTsEIRRMF 690
Cdd:cd18069    178 NLIEYWCMVDFVRPDFLGTRQ-EFSNMF 204
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
497-722 3.76e-22

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 96.78  E-value: 3.76e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLALVHKHGLNG-ILADEMGLGKTIQAIAFLayLYQEGN-------------------------NGPHLI 550
Cdd:cd18072      1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIALI--LAQKNTqnrkeeekekalteweskkdstlvpSAGTLV 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  551 VVPASTIDNWLREVN--LWCPTLKVLCYYGSQEERKQirfnihSRYEDYNVIVTTYNCAIS------SSDDRSLFRRLKL 622
Cdd:cd18072     79 VCPASLVHQWKNEVEsrVASNKLRVCLYHGPNRERIG------EVLRDYDIVITTYSLVAKeiptykEESRSSPLFRIAW 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  623 NYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstseirrmFSSKTKSADEQSI 702
Cdd:cd18072    153 ARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDD--------LKVWKKQVDNKSR 224
                          250       260
                   ....*....|....*....|
gi 1370487333  703 YEKERIAhakQIIKPFILRR 722
Cdd:cd18072    225 KGGERLN---ILTKSLLLRR 241
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
515-674 1.51e-21

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 94.84  E-value: 1.51e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  515 GLNGILADEMGLGKTIQAIAFLAYlyqegnnGPHLIVVPASTIDNWLREV--NLWCPTLKVLCYYGSQEERKQirfnihS 592
Cdd:cd18071     48 VRGGILADDMGLGKTLTTISLILA-------NFTLIVCPLSVLSNWETQFeeHVKPGQLKVYTYHGGERNRDP------K 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  593 RYEDYNVIVTTYNCAIS--SSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSL 670
Cdd:cd18071    115 LLSKYDIVLTTYNTLASdfGAKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSL 194

                   ....
gi 1370487333  671 LNFV 674
Cdd:cd18071    195 LSFL 198
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
497-690 1.54e-20

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 92.26  E-value: 1.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWL---------ALVHKHGLNGILADEMGLGKTIQAIAFLAYLY---QEGNNGPHLIVVPASTIDNWLREV 564
Cdd:cd18068      1 LKPHQVDGVQFMwdccceslkKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLlceKLENFSRVLVVCPLNTVLNWLNEF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  565 NLWCPTLK--------VLCYYGSQEERkqiRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKL-------------N 623
Cdd:cd18068     81 EKWQEGLKdeekievnELATYKRPQER---SYKLQRWQEEGGVMIIGYDMYRILAQERNVKSREKLkeifnkalvdpgpD 157
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370487333  624 YAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMF 690
Cdd:cd18068    158 FVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIK-EFRNRF 223
HELICc smart00490
helicase superfamily c-terminal domain;
886-969 1.20e-19

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 84.19  E-value: 1.20e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333   886 DILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMdiFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRC 965
Cdd:smart00490    1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78

                    ....
gi 1370487333   966 HRVG 969
Cdd:smart00490   79 GRAG 82
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
497-672 1.92e-19

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 87.73  E-value: 1.92e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNwLALVHKHgLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREvnLW-CPTLKVLC 575
Cdd:cd18011      1 PLPHQIDAVL-RALRKPP-VRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDE--LQdKFGLPFLI 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  576 YYGsqEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTI------NA 649
Cdd:cd18011     77 LDR--ETAAQLRRLIGNPFEEFPIVIVSLDLLKRSEERRGLLLSEEWDLVVVDEAHKLRNSGGGKETKRYKLgrllakRA 154
                          170       180
                   ....*....|....*....|....*.
gi 1370487333  650 NNRLLLTGTPVQNN---LLELMSLLN 672
Cdd:cd18011    155 RHVLLLTATPHNGKeedFRALLSLLD 180
ResIII pfam04851
Type III restriction enzyme, res subunit;
495-659 1.01e-10

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 61.15  E-value: 1.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  495 LSLKPYQKVGL-NWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDN-WLREVNLWCPTLK 572
Cdd:pfam04851    2 LELRPYQIEAIeNLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPRKDLLEqALEEFKKFLPNYV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  573 VLCYYGSQEERKQIrfnihsrYEDYNVIVTTYNCAISSSDDRSL-FRRLKLNYAIFDEGHMLknmGSIRYQHLMTINANN 651
Cdd:pfam04851   82 EIGEIISGDKKDES-------VDDNKIVVTTIQSLYKALELASLeLLPDFFDVIIIDEAHRS---GASSYRNILEYFKPA 151

                   ....*....
gi 1370487333  652 RLL-LTGTP 659
Cdd:pfam04851  152 FLLgLTATP 160
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
497-659 2.50e-09

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 56.93  E-value: 2.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGL-NWLAlvHKHGLNGILADEMGLGKTIQAIAFLAYLYQEgnngPHLIVVP-ASTIDNWLREvnlwcptlkvL 574
Cdd:cd17926      1 LRPYQEEALeAWLA--HKNNRRGILVLPTGSGKTLTALALIAYLKEL----RTLIVVPtDALLDQWKER----------F 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  575 CYYGSQEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLnYAIFDEGHmlkNMGSIRYQHLMTI-NANNRL 653
Cdd:cd17926     65 EDFLGDSSIGLIGGGKKKDFDDANVVVATYQSLSNLAEEEKDLFDQFG-LLIVDEAH---HLPAKTFSEILKElNAKYRL 140

                   ....*.
gi 1370487333  654 LLTGTP 659
Cdd:cd17926    141 GLTATP 146
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
497-667 6.12e-09

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 57.36  E-value: 6.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  497 LKPYQKVGLNWLAlvhKHGLNGILADeMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTI-DNWLREVNLW--CPTLKV 573
Cdd:cd18013      1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVArSTWPDEVEKWnhLRNLTV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  574 LCYYGSQEERkqirfnihSRYEDYNVIVTTYN-----CAISSSDDRSLFRRLklnyaIFDEGHMLKNMGSIRYQHLMTIN 648
Cdd:cd18013     77 SVAVGTERQR--------SKAANTPADLYVINrenlkWLVNKSGDPWPFDMV-----VIDELSSFKSPRSKRFKALRKVR 143
                          170       180
                   ....*....|....*....|.
gi 1370487333  649 --ANNRLLLTGTPVQNNLLEL 667
Cdd:cd18013    144 pvIKRLIGLTGTPSPNGLMDL 164
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
494-660 6.15e-09

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 59.65  E-value: 6.15e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  494 SLSLKPYQKVGLN-WLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYqegNNGPHLIVVPASTI-DNWLREVnlwcptL 571
Cdd:COG1061     78 SFELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTVLALALAAELL---RGKRVLVLVPRRELlEQWAEEL------R 148
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  572 KVLCYYGSQEERKQIrfnihsryeDYNVIVTTYNCAISSSDDRSLFRRLKLnyAIFDEGHmlkNMGSIRYQHLMT-INAN 650
Cdd:COG1061    149 RFLGDPLAGGGKKDS---------DAPITVATYQSLARRAHLDELGDRFGL--VIIDEAH---HAGAPSYRRILEaFPAA 214
                          170
                   ....*....|
gi 1370487333  651 NRLLLTGTPV 660
Cdd:COG1061    215 YRLGLTATPF 224
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
517-658 7.30e-06

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 47.01  E-value: 7.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  517 NGILADEMGLGKTIQA--IAFLAYLYQEGNNgphLIVVPASTIDN----WLREvnLWCPTLKVLCYYG--SQEERKQIRF 588
Cdd:cd00046      3 NVLITAPTGSGKTLAAllAALLLLLKKGKKV---LVLVPTKALALqtaeRLRE--LFGPGIRVAVLVGgsSAEEREKNKL 77
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370487333  589 NihsryeDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHML----KNMGSIRYQHLMTINANNR-LLLTGT 658
Cdd:cd00046     78 G------DADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALlidsRGALILDLAVRKAGLKNAQvILLSAT 146
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
525-662 2.02e-05

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 46.08  E-value: 2.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  525 GLGKTiqAIAFLAYLYQ--EGNNGPH-LIVVP--------ASTIDNWLREVNLwcptlKVLCYYGSQEERKQIRfnihsR 593
Cdd:pfam00270   24 GSGKT--LAFLLPALEAldKLDNGPQaLVLAPtrelaeqiYEELKKLGKGLGL-----KVASLLGGDSRKEQLE-----K 91
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370487333  594 YEDYNVIVTTYNCAISSSDDRSLFRRLKlnYAIFDEGHMLKNMGSIR--YQHLMTINANNR-LLLTGTPVQN 662
Cdd:pfam00270   92 LKGPDILVGTPGRLLDLLQERKLLKNLK--LLVLDEAHRLLDMGFGPdlEEILRRLPKKRQiLLLSATLPRN 161
DpdE NF041062
protein DpdE;
520-732 9.00e-05

protein DpdE;


Pssm-ID: 468989 [Multi-domain]  Cd Length: 1048  Bit Score: 46.50  E-value: 9.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  520 LADEMGLGKTIQA-IAFLAYLYQEgnngPH---LIVVPASTIDNWLREvnlwcptLKVlcyygsqeerkqiRFNI-HSRY 594
Cdd:NF041062   175 LADEVGLGKTIEAgLVIRQHLLDN----PDarvLVLVPDALVRQWRRE-------LRD-------------KFFLdDFPG 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  595 EDYNVivttynCAISS-SDDRSLFRRLKLnyAIFDEGHMLKNMG-------SIRYQHLMTI--NANNRLLLTGTPVQNNL 664
Cdd:NF041062   231 ARVRV------LSHEEpERWEPLLDAPDL--LVVDEAHQLARLAwsgdppeRARYRELAALahAAPRLLLLSATPVLGNE 302
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370487333  665 LELMSLLNFVMPHMFSSSTSEirrmfssktksADEQSIYEKERIAHAKQIIKP----FILRRVKEEVLKQLP 732
Cdd:NF041062   303 ETFLALLHLLDPDLYPLDDLE-----------AFRERLEEREELGRLVLGLDPdnpnFLLRQALDELRALFP 363
PRK04914 PRK04914
RNA polymerase-associated protein RapA;
520-661 1.59e-03

RNA polymerase-associated protein RapA;


Pssm-ID: 235319 [Multi-domain]  Cd Length: 956  Bit Score: 42.52  E-value: 1.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  520 LADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVnlwcptLKvlcyygsqeerkqiRFNIH------SR 593
Cdd:PRK04914   174 LADEVGLGKTIEAGMIIHQQLLTGRAERVLILVPETLQHQWLVEM------LR--------------RFNLRfslfdeER 233
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  594 YED-----YNVIVTTyNCAISSSDdrsLFRRLKLNY----------AIFDEGHML---KNMGSIRYQHLMTINANNR--L 653
Cdd:PRK04914   234 YAEaqhdaDNPFETE-QLVICSLD---FLRRNKQRLeqalaaewdlLVVDEAHHLvwsEEAPSREYQVVEQLAEVIPgvL 309

                   ....*...
gi 1370487333  654 LLTGTPVQ 661
Cdd:PRK04914   310 LLTATPEQ 317
SF2_C_XPB cd18789
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ...
856-947 2.99e-03

C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350176 [Multi-domain]  Cd Length: 153  Bit Score: 39.54  E-value: 2.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487333  856 GKFRVLGCILSELKQkGDRVVLFSQFTMMLD-ILEVLLKhhqhrYLrLDGKTQISERIHLIDEF-----NTdmdIFVfll 929
Cdd:cd18789     34 NKLRALEELLKRHEQ-GDKIIVFTDNVEALYrYAKRLLK-----PF-ITGETPQSEREEILQNFregeyNT---LVV--- 100
                           90
                   ....*....|....*...
gi 1370487333  930 sTKAGGLGINLTSANVVI 947
Cdd:cd18789    101 -SKVGDEGIDLPEANVAI 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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