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Conserved domains on  [gi|1370487400|ref|XP_024309936|]
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rap1 GTPase-GDP dissociation stimulator 1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 6-37 7.34e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.13  E-value: 7.34e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1370487400   6 VDAGLISPLVQLLNSKDQEVLLQTGRALGNIC 37
Cdd:pfam00514   9 IEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 266-309 7.03e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.41  E-value: 7.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1370487400  266 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 309
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLS 40
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 6-184 1.29e-03

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 41.63  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487400    6 VDAGLISPLVQLLNSK-DQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDhlrslcSITDPANEKLLTVFCGMLMN 84
Cdd:PLN03200   228 LDAGAVKQLLKLLGQGnEVSVRAEAAGALEALSSQSKEAKQAIADAGGIPALIN------ATVAPSKEFMQGEFAQALQE 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487400   85 YSnendsLQAqLINM-GVIPTLVKLLGIHCQNAALTEMCLVAFGNLA-------ELESSKEQFASTNIAEELVKLFKKQI 156
Cdd:PLN03200   302 NA-----MGA-LANIcGGMSALILYLGELSESPRSPAPIADTLGALAyalmvfdSSAESTRAFDPTVIEQILVKLLKPRD 375

                          170       180       190
                   ....*....|....*....|....*....|
gi 1370487400  157 EHDKREMIFEVLAPLAEND--AIKLQLVEA 184
Cdd:PLN03200   376 TKLVQERIIEALASLYGNAylSRKLNHAEA 405
chemoreceptor_sensor super family cl00144
4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand ...
 281-364 3.45e-03

4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand binding sensor domain of chemoreceptors and related sensor histidine kinases forms homodimers and binds to ligands via the dimerization interface, a feature that appears to be conserved in this domain superfamily. This family includes ligand binding sensor domain of several chemoreceptors, such as Escherichia coli Tar, Tsr, NarQ, NarX, Pseudomonas aeruginosa KinB, Rhodopseudomonas palustris histidine kinase HK9 chemoreceptors, Comamonas testosteroni CNB-2 MCP2201 and Anaeromyxobacter dehalogenans histidine kinase Adeh_2942, among others.


The actual alignment was detected with superfamily member cd19411:

Pssm-ID: 444710 [Multi-domain]  Cd Length: 138  Bit Score: 38.00  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487400 281 KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKA-KMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQ 359
Cdd:cd19411    54 ELLKKLEKLITSPEGKALLAAIAEARAAYLAARDKVlELKKAGDREEARALLLGELRPAQAAYLAALDALVDYQEELMDA 133


                  ....*
gi 1370487400 360 LGKNV 364
Cdd:cd19411   134 AAAEA 138
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 6-37 7.34e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.13  E-value: 7.34e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1370487400   6 VDAGLISPLVQLLNSKDQEVLLQTGRALGNIC 37
Cdd:pfam00514   9 IEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 1-38 2.43e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 2.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1370487400    1 MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY 38
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 266-309 7.03e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.41  E-value: 7.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1370487400  266 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 309
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 6-184 1.29e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 41.63  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487400    6 VDAGLISPLVQLLNSK-DQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDhlrslcSITDPANEKLLTVFCGMLMN 84
Cdd:PLN03200   228 LDAGAVKQLLKLLGQGnEVSVRAEAAGALEALSSQSKEAKQAIADAGGIPALIN------ATVAPSKEFMQGEFAQALQE 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487400   85 YSnendsLQAqLINM-GVIPTLVKLLGIHCQNAALTEMCLVAFGNLA-------ELESSKEQFASTNIAEELVKLFKKQI 156
Cdd:PLN03200   302 NA-----MGA-LANIcGGMSALILYLGELSESPRSPAPIADTLGALAyalmvfdSSAESTRAFDPTVIEQILVKLLKPRD 375

                          170       180       190
                   ....*....|....*....|....*....|
gi 1370487400  157 EHDKREMIFEVLAPLAEND--AIKLQLVEA 184
Cdd:PLN03200   376 TKLVQERIIEALASLYGNAylSRKLNHAEA 405
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 266-309 3.28e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 3.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1370487400 266 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 309
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLS----SPDEEVQEEAAWALSNLA 40
MCP2201-like_sensor cd19411
ligand-binding sensor domain of Comamonas testosteroni CNB-2 MCP2201 and similar ...
 281-364 3.45e-03

ligand-binding sensor domain of Comamonas testosteroni CNB-2 MCP2201 and similar chemoreceptors; This family includes the ligand-binding sensor domain of Comamonas testosteroni transmembrane chemoreceptor CNB-2 MCP2201 and similar chemoreceptors. The C. testosteroni methyl-accepting chemotaxis protein MCP2201 triggers chemotaxis towards tricarboxylic acid cycle intermediates such as citric acid and aromatic compounds. While the apo-form ligand binding domain (LBD) forms a typical four-helix bundle homodimer, similar to other chemoreceptors in the superfamily such as Escherichia coli Tar and Tsr, the citrate-bound LBD reveals a four-helix bundle homotrimer. This type of oligomerization has never been observed in other bacterial chemoreceptor LBD. Site-directed mutations of key amino acid residues have demonstrated the physiological importance of the homotrimer for chemotaxis.


Pssm-ID: 438629 [Multi-domain]  Cd Length: 138  Bit Score: 38.00  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487400 281 KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKA-KMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQ 359
Cdd:cd19411    54 ELLKKLEKLITSPEGKALLAAIAEARAAYLAARDKVlELKKAGDREEARALLLGELRPAQAAYLAALDALVDYQEELMDA 133


                  ....*
gi 1370487400 360 LGKNV 364
Cdd:cd19411   134 AAAEA 138
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
6-62 4.70e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 39.49  E-value: 4.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370487400   6 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRS 62
Cdd:COG5064   154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLS 210
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 6-37 7.34e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.13  E-value: 7.34e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1370487400   6 VDAGLISPLVQLLNSKDQEVLLQTGRALGNIC 37
Cdd:pfam00514   9 IEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 1-38 2.43e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 2.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1370487400    1 MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY 38
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 266-309 7.03e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.41  E-value: 7.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1370487400  266 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 309
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 6-184 1.29e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 41.63  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487400    6 VDAGLISPLVQLLNSK-DQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDhlrslcSITDPANEKLLTVFCGMLMN 84
Cdd:PLN03200   228 LDAGAVKQLLKLLGQGnEVSVRAEAAGALEALSSQSKEAKQAIADAGGIPALIN------ATVAPSKEFMQGEFAQALQE 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487400   85 YSnendsLQAqLINM-GVIPTLVKLLGIHCQNAALTEMCLVAFGNLA-------ELESSKEQFASTNIAEELVKLFKKQI 156
Cdd:PLN03200   302 NA-----MGA-LANIcGGMSALILYLGELSESPRSPAPIADTLGALAyalmvfdSSAESTRAFDPTVIEQILVKLLKPRD 375

                          170       180       190
                   ....*....|....*....|....*....|
gi 1370487400  157 EHDKREMIFEVLAPLAEND--AIKLQLVEA 184
Cdd:PLN03200   376 TKLVQERIIEALASLYGNAylSRKLNHAEA 405
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 266-309 3.28e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 3.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1370487400 266 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 309
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLS----SPDEEVQEEAAWALSNLA 40
MCP2201-like_sensor cd19411
ligand-binding sensor domain of Comamonas testosteroni CNB-2 MCP2201 and similar ...
 281-364 3.45e-03

ligand-binding sensor domain of Comamonas testosteroni CNB-2 MCP2201 and similar chemoreceptors; This family includes the ligand-binding sensor domain of Comamonas testosteroni transmembrane chemoreceptor CNB-2 MCP2201 and similar chemoreceptors. The C. testosteroni methyl-accepting chemotaxis protein MCP2201 triggers chemotaxis towards tricarboxylic acid cycle intermediates such as citric acid and aromatic compounds. While the apo-form ligand binding domain (LBD) forms a typical four-helix bundle homodimer, similar to other chemoreceptors in the superfamily such as Escherichia coli Tar and Tsr, the citrate-bound LBD reveals a four-helix bundle homotrimer. This type of oligomerization has never been observed in other bacterial chemoreceptor LBD. Site-directed mutations of key amino acid residues have demonstrated the physiological importance of the homotrimer for chemotaxis.


Pssm-ID: 438629 [Multi-domain]  Cd Length: 138  Bit Score: 38.00  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487400 281 KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKA-KMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQ 359
Cdd:cd19411    54 ELLKKLEKLITSPEGKALLAAIAEARAAYLAARDKVlELKKAGDREEARALLLGELRPAQAAYLAALDALVDYQEELMDA 133


                  ....*
gi 1370487400 360 LGKNV 364
Cdd:cd19411   134 AAAEA 138
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
6-62 4.70e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 39.49  E-value: 4.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370487400   6 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRS 62
Cdd:COG5064   154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLS 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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