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Conserved domains on  [gi|1443042482|ref|XP_025878140|]
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tubby-like F-box protein 3 [Oryza sativa Japonica Group]

Protein Classification

tubby-like F-box protein( domain architecture ID 17778958)

tubby-like F-box protein may participate in the abscisic acid (ABA) signaling pathway in plants

CATH:  1.20.1280.50
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  29109004|36589128|31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
121-443 9.91e-140

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 400.41  E-value: 9.91e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 121 KQPGPRDGMIQCYIKRNRSK----STYHLYLCLSNVvtaEGGKFVLAAKRHRKTTCTEYTISMVSGNISRSSRTNIGKLR 196
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGmgltPTYHLYLELSPG---DGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 197 SNFLGTKFIIYDTQPPYNGAVVPhVGRTSkrFNSTKVSPkvpsVTYNIAQVSYELNVLGTRGPRRMRCMMHSIPASSVEp 276
Cdd:pfam01167  78 SNFLGTKFTLYDNQPPYNGANPS-KSRSS--FGSKKVSP----GRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQ- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 277 ggiVPGQPEqivpraledsfrsttsfsqsfrsttsFSKSIMDpsmDFSSARFSDisgsimggddngeikerPLVLRNKPP 356
Cdd:pfam01167 150 ---VPIQPQ--------------------------SESSLLE---DFKSGRLDE-----------------LLVLKNKPP 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 357 RWHEQLQCWCLNFRGRVTIASVKNFQLVAapspppagaptpsqpgPADPEKVILQFGKVARDMFTMDYRYPLSAFQAFAI 436
Cdd:pfam01167 181 RWNEQLQCYCLNFHGRVTVASVKNFQLVA----------------PEDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAI 244


                  ....*..
gi 1443042482 437 CLSSFDT 443
Cdd:pfam01167 245 CLSSFDT 251
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 59-103 2.05e-22

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438924  Cd Length: 45  Bit Score: 89.41  E-value: 2.05e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1443042482  59 WASLPPELLREVIRRLEADESTWPSRRNVVCFAAVCRTWREMCKE 103
Cdd:cd22153     1 WANLPPELLRDIIQRVEESESAWPSRKNVVACASVCKSWREITKE 45
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
121-443 9.91e-140

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 400.41  E-value: 9.91e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 121 KQPGPRDGMIQCYIKRNRSK----STYHLYLCLSNVvtaEGGKFVLAAKRHRKTTCTEYTISMVSGNISRSSRTNIGKLR 196
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGmgltPTYHLYLELSPG---DGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 197 SNFLGTKFIIYDTQPPYNGAVVPhVGRTSkrFNSTKVSPkvpsVTYNIAQVSYELNVLGTRGPRRMRCMMHSIPASSVEp 276
Cdd:pfam01167  78 SNFLGTKFTLYDNQPPYNGANPS-KSRSS--FGSKKVSP----GRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQ- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 277 ggiVPGQPEqivpraledsfrsttsfsqsfrsttsFSKSIMDpsmDFSSARFSDisgsimggddngeikerPLVLRNKPP 356
Cdd:pfam01167 150 ---VPIQPQ--------------------------SESSLLE---DFKSGRLDE-----------------LLVLKNKPP 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 357 RWHEQLQCWCLNFRGRVTIASVKNFQLVAapspppagaptpsqpgPADPEKVILQFGKVARDMFTMDYRYPLSAFQAFAI 436
Cdd:pfam01167 181 RWNEQLQCYCLNFHGRVTVASVKNFQLVA----------------PEDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAI 244


                  ....*..
gi 1443042482 437 CLSSFDT 443
Cdd:pfam01167 245 CLSSFDT 251
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 59-103 2.05e-22

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438924  Cd Length: 45  Bit Score: 89.41  E-value: 2.05e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1443042482  59 WASLPPELLREVIRRLEADESTWPSRRNVVCFAAVCRTWREMCKE 103
Cdd:cd22153     1 WANLPPELLRDIIQRVEESESAWPSRKNVVACASVCKSWREITKE 45
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 59-106 1.44e-04

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 39.00  E-value: 1.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1443042482  59 WASLPPELLREVIRRLeadestwpSRRNVVCFAAVCRTWREMCKETVL 106
Cdd:pfam12937   1 LSSLPDEILLQIFSYL--------DPKDLLRLALVCRRWRELASDDSL 40
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
121-443 9.91e-140

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 400.41  E-value: 9.91e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 121 KQPGPRDGMIQCYIKRNRSK----STYHLYLCLSNVvtaEGGKFVLAAKRHRKTTCTEYTISMVSGNISRSSRTNIGKLR 196
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGmgltPTYHLYLELSPG---DGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 197 SNFLGTKFIIYDTQPPYNGAVVPhVGRTSkrFNSTKVSPkvpsVTYNIAQVSYELNVLGTRGPRRMRCMMHSIPASSVEp 276
Cdd:pfam01167  78 SNFLGTKFTLYDNQPPYNGANPS-KSRSS--FGSKKVSP----GRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQ- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 277 ggiVPGQPEqivpraledsfrsttsfsqsfrsttsFSKSIMDpsmDFSSARFSDisgsimggddngeikerPLVLRNKPP 356
Cdd:pfam01167 150 ---VPIQPQ--------------------------SESSLLE---DFKSGRLDE-----------------LLVLKNKPP 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443042482 357 RWHEQLQCWCLNFRGRVTIASVKNFQLVAapspppagaptpsqpgPADPEKVILQFGKVARDMFTMDYRYPLSAFQAFAI 436
Cdd:pfam01167 181 RWNEQLQCYCLNFHGRVTVASVKNFQLVA----------------PEDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAI 244


                  ....*..
gi 1443042482 437 CLSSFDT 443
Cdd:pfam01167 245 CLSSFDT 251
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 59-103 2.05e-22

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438924  Cd Length: 45  Bit Score: 89.41  E-value: 2.05e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1443042482  59 WASLPPELLREVIRRLEADESTWPSRRNVVCFAAVCRTWREMCKE 103
Cdd:cd22153     1 WANLPPELLRDIIQRVEESESAWPSRKNVVACASVCKSWREITKE 45
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 59-106 1.44e-04

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 39.00  E-value: 1.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1443042482  59 WASLPPELLREVIRRLeadestwpSRRNVVCFAAVCRTWREMCKETVL 106
Cdd:pfam12937   1 LSSLPDEILLQIFSYL--------DPKDLLRLALVCRRWRELASDDSL 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 60-102 6.17e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 37.04  E-value: 6.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1443042482  60 ASLPPELLREVIRRLEADEstwpsrrnVVCFAAVCRTWREMCK 102
Cdd:cd09917     1 SDLPDEILLKILSYLDPRD--------LLRLSLVCKRWRELAS 35
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 59-102 6.85e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 6.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1443042482  59 WASLPPELLREVIRRLeadestwpSRRNVVCFAAVCRTWREMCK 102
Cdd:pfam00646   1 LLDLPDDLLLEILSRL--------DPKDLLRLSLVSKRWRSLVD 36
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 59-103 1.84e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 36.04  E-value: 1.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1443042482  59 WASLPPELLREVIRRLEADESTWPSRRnvvcfaaVCRTWREMCKE 103
Cdd:cd22164     2 WLDLPDDLTASILSRLGAIDILTNAQK-------VCKLWRRICKD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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