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Conserved domains on  [gi|1443080800|ref|XP_025881400|]
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probable folate-biopterin transporter 7 isoform X2 [Oryza sativa Japonica Group]

Protein Classification

folate/biopterin family MFS transporter( domain architecture ID 709015)

folate/biopterin family major facilitator superfamily (MFS) transporter facilitates folate monoglutamate transport involved in tetrahydrofolate biosynthesis, as well as the transport of antifolates such as methotrexate and aminopterin

CATH:  1.20.1250.20
Gene Ontology:  GO:0016020|GO:0022857|GO:0055085
PubMed:  19923217|26758938|23403214|18537473|26098515
SCOP:  3000310
TCDB:  2.A.71

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BT1 super family cl26451
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ...
 28-154 1.83e-34

BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).


The actual alignment was detected with superfamily member pfam03092:

Pssm-ID: 308617  Cd Length: 432  Bit Score: 124.38  E-value: 1.83e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443080800  28 QGFRL-FPWLGVNFFLKDGMGVAASSLQILQASANLPMVAKPLLGLLSDAVPIRGHRRLPYVAIGALLQAISWLAIALWP 106
Cdd:pfam03092   1 QGVALgLSRLATQFMLKDRLGLDPARYQRLSGLATLPWSIKPLYGMLSDGFALFGYRRRWYLALSGLLGGAFWLLYGLLP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1443080800 107 A--ISLPVLTIFLLLSNFGASICEVANDAIVAEAGKQATLSSGSVLHYCG 154
Cdd:pfam03092  81 AseASAPVAAAFIFLSSLGVAIVDVLVDALVSERARQSPTPGPSLQSWIW 130
 
Name Accession Description Interval E-value
BT1 pfam03092
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ...
 28-154 1.83e-34

BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).


Pssm-ID: 308617  Cd Length: 432  Bit Score: 124.38  E-value: 1.83e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443080800  28 QGFRL-FPWLGVNFFLKDGMGVAASSLQILQASANLPMVAKPLLGLLSDAVPIRGHRRLPYVAIGALLQAISWLAIALWP 106
Cdd:pfam03092   1 QGVALgLSRLATQFMLKDRLGLDPARYQRLSGLATLPWSIKPLYGMLSDGFALFGYRRRWYLALSGLLGGAFWLLYGLLP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1443080800 107 A--ISLPVLTIFLLLSNFGASICEVANDAIVAEAGKQATLSSGSVLHYCG 154
Cdd:pfam03092  81 AseASAPVAAAFIFLSSLGVAIVDVLVDALVSERARQSPTPGPSLQSWIW 130
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
 19-148 9.91e-31

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 113.86  E-value: 9.91e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443080800  19 WVIAVGFWVQGFRLFPWLGVNFFLKDGMGVAASSLQILQASANLPMVAKPLLGLLSDAVPIRGHRRLPYVAIGALLQAIS 98
Cdd:cd17484     1 SVIAVVYFSQGVAGLSWLAVSYYYKDDLHLGPASVQALTSIASLPWAIKPLYGLLSDSVPIFGYRRKPYLILAGALGALS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1443080800  99 WLAIALWPAISLPVLTIFLLLSNFGASICEVANDAIVAEAGKQATLSSGS 148
Cdd:cd17484    81 WLALALVSNSSLALALLLLLLASLGVAFSDVVIDALVVEASRGAPQSLAG 130
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
16-137 6.87e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.59  E-value: 6.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443080800  16 TRRWVIAVGFWVQGFRLFPWLGVNF---FLKDGMGVAASSLQILQASANL-PMVAKPLLGLLSDAVPIRGHRRLPYVAIG 91
Cdd:COG2211     8 SLKEKLAYGLGDLGLNLAFGLLSAYllyFYTDVLGLSAALVGLILLVARLwDAITDPLIGALSDRTRTRWGRRRPWILIG 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1443080800  92 ALLQAISWLAIALWPAIS----LPVLTIFLLLSNFGASICEVANDAIVAE 137
Cdd:COG2211    88 AIPLALSFVLLFTAPDLSptgkLIYALVTYLLLGLAYTLVNIPYSALGAE 137
 
Name Accession Description Interval E-value
BT1 pfam03092
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ...
 28-154 1.83e-34

BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).


Pssm-ID: 308617  Cd Length: 432  Bit Score: 124.38  E-value: 1.83e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443080800  28 QGFRL-FPWLGVNFFLKDGMGVAASSLQILQASANLPMVAKPLLGLLSDAVPIRGHRRLPYVAIGALLQAISWLAIALWP 106
Cdd:pfam03092   1 QGVALgLSRLATQFMLKDRLGLDPARYQRLSGLATLPWSIKPLYGMLSDGFALFGYRRRWYLALSGLLGGAFWLLYGLLP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1443080800 107 A--ISLPVLTIFLLLSNFGASICEVANDAIVAEAGKQATLSSGSVLHYCG 154
Cdd:pfam03092  81 AseASAPVAAAFIFLSSLGVAIVDVLVDALVSERARQSPTPGPSLQSWIW 130
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
 19-148 9.91e-31

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 113.86  E-value: 9.91e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443080800  19 WVIAVGFWVQGFRLFPWLGVNFFLKDGMGVAASSLQILQASANLPMVAKPLLGLLSDAVPIRGHRRLPYVAIGALLQAIS 98
Cdd:cd17484     1 SVIAVVYFSQGVAGLSWLAVSYYYKDDLHLGPASVQALTSIASLPWAIKPLYGLLSDSVPIFGYRRKPYLILAGALGALS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1443080800  99 WLAIALWPAISLPVLTIFLLLSNFGASICEVANDAIVAEAGKQATLSSGS 148
Cdd:cd17484    81 WLALALVSNSSLALALLLLLLASLGVAFSDVVIDALVVEASRGAPQSLAG 130
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
16-137 6.87e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.59  E-value: 6.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443080800  16 TRRWVIAVGFWVQGFRLFPWLGVNF---FLKDGMGVAASSLQILQASANL-PMVAKPLLGLLSDAVPIRGHRRLPYVAIG 91
Cdd:COG2211     8 SLKEKLAYGLGDLGLNLAFGLLSAYllyFYTDVLGLSAALVGLILLVARLwDAITDPLIGALSDRTRTRWGRRRPWILIG 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1443080800  92 ALLQAISWLAIALWPAIS----LPVLTIFLLLSNFGASICEVANDAIVAE 137
Cdd:COG2211    88 AIPLALSFVLLFTAPDLSptgkLIYALVTYLLLGLAYTLVNIPYSALGAE 137
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 66-124 1.42e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 37.86  E-value: 1.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1443080800  66 AKPLLGLLSDAVPIRGHRRLPYVAIGALLQAIS-WLA--IALWPAISLPVLTIFLLLSNFGA 124
Cdd:cd06176    51 LRVWIGHRSDTHPLRGYRRTPYIWLGMLLLALGlALApfAALLLAGAAFWLGLALAVLAFLL 112
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 64-127 1.84e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 37.61  E-value: 1.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1443080800  64 MVAKPLLGLLSDAVPIRGHRRLPYVAIGALLQAIS--------WLAIAL-----WPAISLPVLTIFLLlsNFGASIC 127
Cdd:cd17313    48 LFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAALGlilipnaaDIGLALgdgprTWALVLFVLGIVLL--DFAMNVC 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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