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Conserved domains on  [gi|1443086615|ref|XP_025882188|]
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MORC family CW-type zinc finger protein 3 isoform X1 [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase super family cl00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 229-350 3.75e-44

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


The actual alignment was detected with superfamily member cd16931:

Pssm-ID: 469604 [Multi-domain]  Cd Length: 118  Bit Score: 155.26  E-value: 3.75e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 229 YLRTLSQTHAgWVFGAIAELIDNSRDADASRLNIsvksLFSKKADKK-IPVLSVIDDGHGMTCAEMMRMISFGHKRPDKQ 307
Cdd:cd16931     1 FLHSNSTTHS-WPFGAVAELVDNARDADATRLDI----FIDDINLLRgGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSD 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1443086615 308 RQDQIGRFGIGFKTGAMKLGRDAIVLTQTSSSRSVAFLSQSFN 350
Cdd:cd16931    76 DHDHIGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 471-612 8.66e-13

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 66.41  E-value: 8.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 471 YSLQSYLEVMFLN--PRMKISVQGSSVKTRPLAKTLNKTSVI-----SGEIMGRTIQLTLG------RSNVewdrmnCGI 537
Cdd:pfam17942   1 YSLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKItykpqVGGGKEVVVITTIGflkeapHINV------HGF 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1443086615 538 FLYWHGRLIESYKRVGGQkhNADMGRGVIGV--ADITDLIDDedgnswvlnsKQGFQDCEMYAKLEEWLGRKADEYW 612
Cdd:pfam17942  75 NVYHKNRLIKPFWRVGNQ--AGSKGRGVIGVleANFIEPTHD----------KQDFERTSLYQRLEARLKQMLKEYW 139
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 693-735 1.89e-11

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 59.63  E-value: 1.89e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1443086615 693 WVQCYSCRKWRILNAGFDTKSLPDEWFCYM---PPFNgKCEVAEQQ 735
Cdd:pfam07496   2 WVQCDSCLKWRRLPTEIDPYELPEPWYCSMnpdPKYN-SCDAPEEI 46
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 229-350 3.75e-44

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 155.26  E-value: 3.75e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 229 YLRTLSQTHAgWVFGAIAELIDNSRDADASRLNIsvksLFSKKADKK-IPVLSVIDDGHGMTCAEMMRMISFGHKRPDKQ 307
Cdd:cd16931     1 FLHSNSTTHS-WPFGAVAELVDNARDADATRLDI----FIDDINLLRgGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSD 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1443086615 308 RQDQIGRFGIGFKTGAMKLGRDAIVLTQTSSSRSVAFLSQSFN 350
Cdd:cd16931    76 DHDHIGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 241-375 1.41e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 97.02  E-value: 1.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 241 VFGAIAELIDNSRDADASRLNISVksLFSKKADKKIpvlSVIDDGHGMTCAEMMRMISFGHKRPDKQR-QDQIGRFGIGF 319
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEV--NKNRGGGTEI---VIEDDGHGMSPEELINALRLATSAKEAKRgSTDLGRYGIGL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1443086615 320 KTGAMKLGRDAIVLTQTSSSRSVAFLSQSFNENKDNLEIPVVTYRKEGQYMEVDSS 375
Cdd:pfam13589  76 KLASLSLGAKLTVTSKKEGKSSTLTLDRDKISNENDWLLPLLTPAPIENFDELDKD 131
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 471-612 8.66e-13

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 66.41  E-value: 8.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 471 YSLQSYLEVMFLN--PRMKISVQGSSVKTRPLAKTLNKTSVI-----SGEIMGRTIQLTLG------RSNVewdrmnCGI 537
Cdd:pfam17942   1 YSLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKItykpqVGGGKEVVVITTIGflkeapHINV------HGF 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1443086615 538 FLYWHGRLIESYKRVGGQkhNADMGRGVIGV--ADITDLIDDedgnswvlnsKQGFQDCEMYAKLEEWLGRKADEYW 612
Cdd:pfam17942  75 NVYHKNRLIKPFWRVGNQ--AGSKGRGVIGVleANFIEPTHD----------KQDFERTSLYQRLEARLKQMLKEYW 139
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 693-735 1.89e-11

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 59.63  E-value: 1.89e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1443086615 693 WVQCYSCRKWRILNAGFDTKSLPDEWFCYM---PPFNgKCEVAEQQ 735
Cdd:pfam07496   2 WVQCDSCLKWRRLPTEIDPYELPEPWYCSMnpdPKYN-SCDAPEEI 46
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
 247-319 5.32e-05

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 46.65  E-value: 5.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 247 ELIDNSRDA-DASR-LNISVKSLFSKKADKKIPV--------LSVIDDGHGMTCAEMMRMIS---------FGHKRPDKQ 307
Cdd:COG0326    33 ELISNASDAiDKLRfLALTDPELKEEDGDLKIRIevdkeaktLTISDNGIGMTREEVIENLGtiaksgtreFLEKLKGDQ 112

                          90
                  ....*....|....
gi 1443086615 308 RQDQ--IGRFGIGF 319
Cdd:COG0326   113 KKDSdlIGQFGVGF 126
PRK05218 PRK05218
heat shock protein 90; Provisional
 247-319 1.98e-03

heat shock protein 90; Provisional


Pssm-ID: 235366 [Multi-domain]  Cd Length: 613  Bit Score: 41.64  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 247 ELIDNSRDAdASRLN---ISVKSLFSKKADKKIPV--------LSVIDDGHGMTCAEMMRMI---------SFGHKRPDK 306
Cdd:PRK05218   33 ELISNASDA-IDKLRfeaLTDPALYEGDGDLKIRIsfdkeartLTISDNGIGMTREEVIENLgtiaksgtkEFLEKLKGD 111

                          90
                  ....*....|....*
gi 1443086615 307 QRQDQ--IGRFGIGF 319
Cdd:PRK05218  112 QKKDSqlIGQFGVGF 126
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 229-350 3.75e-44

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 155.26  E-value: 3.75e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 229 YLRTLSQTHAgWVFGAIAELIDNSRDADASRLNIsvksLFSKKADKK-IPVLSVIDDGHGMTCAEMMRMISFGHKRPDKQ 307
Cdd:cd16931     1 FLHSNSTTHS-WPFGAVAELVDNARDADATRLDI----FIDDINLLRgGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSD 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1443086615 308 RQDQIGRFGIGFKTGAMKLGRDAIVLTQTSSSRSVAFLSQSFN 350
Cdd:cd16931    76 DHDHIGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 241-375 1.41e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 97.02  E-value: 1.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 241 VFGAIAELIDNSRDADASRLNISVksLFSKKADKKIpvlSVIDDGHGMTCAEMMRMISFGHKRPDKQR-QDQIGRFGIGF 319
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEV--NKNRGGGTEI---VIEDDGHGMSPEELINALRLATSAKEAKRgSTDLGRYGIGL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1443086615 320 KTGAMKLGRDAIVLTQTSSSRSVAFLSQSFNENKDNLEIPVVTYRKEGQYMEVDSS 375
Cdd:pfam13589  76 KLASLSLGAKLTVTSKKEGKSSTLTLDRDKISNENDWLLPLLTPAPIENFDELDKD 131
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 471-612 8.66e-13

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 66.41  E-value: 8.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 471 YSLQSYLEVMFLN--PRMKISVQGSSVKTRPLAKTLNKTSVI-----SGEIMGRTIQLTLG------RSNVewdrmnCGI 537
Cdd:pfam17942   1 YSLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKItykpqVGGGKEVVVITTIGflkeapHINV------HGF 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1443086615 538 FLYWHGRLIESYKRVGGQkhNADMGRGVIGV--ADITDLIDDedgnswvlnsKQGFQDCEMYAKLEEWLGRKADEYW 612
Cdd:pfam17942  75 NVYHKNRLIKPFWRVGNQ--AGSKGRGVIGVleANFIEPTHD----------KQDFERTSLYQRLEARLKQMLKEYW 139
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 693-735 1.89e-11

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 59.63  E-value: 1.89e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1443086615 693 WVQCYSCRKWRILNAGFDTKSLPDEWFCYM---PPFNgKCEVAEQQ 735
Cdd:pfam07496   2 WVQCDSCLKWRRLPTEIDPYELPEPWYCSMnpdPKYN-SCDAPEEI 46
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
 247-319 5.32e-05

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 46.65  E-value: 5.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 247 ELIDNSRDA-DASR-LNISVKSLFSKKADKKIPV--------LSVIDDGHGMTCAEMMRMIS---------FGHKRPDKQ 307
Cdd:COG0326    33 ELISNASDAiDKLRfLALTDPELKEEDGDLKIRIevdkeaktLTISDNGIGMTREEVIENLGtiaksgtreFLEKLKGDQ 112

                          90
                  ....*....|....
gi 1443086615 308 RQDQ--IGRFGIGF 319
Cdd:COG0326   113 KKDSdlIGQFGVGF 126
HATPase_SMCHD1-like cd16937
Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge ...
 244-320 9.99e-05

Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein; This family includes histidine kinase-like ATPase (HATPase) domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein, which is involved in gene silencing and in DNA damage. It has critical roles in X-chromosome inactivation and is also an important regulator of autosomal gene clusters. Upon DNA damage, SMCHD1 promotes non-homologous end joining and inhibits homologous recombination repair. SMCHD1 is implicated in the pathogenesis of facioscapulohumeral muscular dystrophy.


Pssm-ID: 340414 [Multi-domain]  Cd Length: 119  Bit Score: 42.67  E-value: 9.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 244 AIAELIDNSRDADASRLN---ISVKSLFSKKADKkiPVLSVIDDGHGMTCAEM-----MRMISF-----------GHKRP 304
Cdd:cd16937    17 ALAELIDNSLSATRRNTDirrIQIKLLFDEAQGK--PAVAVIDNGRGMTSKQLnnwavYRLSKFtrqgdfesdhsGYVRP 94

                          90
                  ....*....|....*....
gi 1443086615 305 D---KQRQDQIGRFGIGFK 320
Cdd:cd16937    95 DpvpRSLNSDISYFGVGGK 113
PRK05218 PRK05218
heat shock protein 90; Provisional
 247-319 1.98e-03

heat shock protein 90; Provisional


Pssm-ID: 235366 [Multi-domain]  Cd Length: 613  Bit Score: 41.64  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443086615 247 ELIDNSRDAdASRLN---ISVKSLFSKKADKKIPV--------LSVIDDGHGMTCAEMMRMI---------SFGHKRPDK 306
Cdd:PRK05218   33 ELISNASDA-IDKLRfeaLTDPALYEGDGDLKIRIsfdkeartLTISDNGIGMTREEVIENLgtiaksgtkEFLEKLKGD 111

                          90
                  ....*....|....*
gi 1443086615 307 QRQDQ--IGRFGIGF 319
Cdd:PRK05218  112 QKKDSqlIGQFGVGF 126
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 247-289 3.43e-03

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 39.34  E-value: 3.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1443086615 247 ELIDNSRDADASRLNISVKSLFSKKadkkipvLSVIDDGHGMT 289
Cdd:cd16926    20 ELVENSIDAGATRIDVEIEEGGLKL-------IRVTDNGSGIS 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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