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Conserved domains on  [gi|1443095408|ref|XP_025883422|]
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eukaryotic translation initiation factor 3 subunit I isoform X2 [Oryza sativa Japonica Group]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-302 2.43e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 2.43e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   2 RPILMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDV 81
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  82 QTGRELFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLN 158
Cdd:COG2319   192 ATGKLLRTLTgHTGAVRSVAFS-PDGklLASGSADG------TVRLWDLA------TGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 159 RTIITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVTER-PVNA 237
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRS 335

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1443095408 238 VDISPLLDHVVIGGGQDAmnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRR 302
Cdd:COG2319   336 VAFSPDGKTLASGSDDGT--VRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRT 386
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-302 2.43e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 2.43e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   2 RPILMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDV 81
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  82 QTGRELFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLN 158
Cdd:COG2319   192 ATGKLLRTLTgHTGAVRSVAFS-PDGklLASGSADG------TVRLWDLA------TGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 159 RTIITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVTER-PVNA 237
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRS 335

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1443095408 238 VDISPLLDHVVIGGGQDAmnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRR 302
Cdd:COG2319   336 VAFSPDGKTLASGSDDGT--VRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRT 386
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-302 1.59e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 1.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   7 KGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRE 86
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  87 LFTFR-FDAPARSVEFaIGDGLAVITT--DN--FMENVPTAQVKRiaedpddqseesllVITGIKGRINRAVWGPLNRTI 161
Cdd:cd00200    86 VRTLTgHTSYVSSVAF-SPDGRILSSSsrDKtiKVWDVETGKCLT--------------TLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 162 ITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDI 240
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1443095408 241 SPlLDHVVIGGGQDamnvtmtdrraGKFeaKFFHKILQEEIGGVKGHFGPINALAFNPDGRR 302
Cdd:cd00200   228 SP-DGYLLASGSED-----------GTI--RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-80 1.04e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.04e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1443095408   41 NGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-80 1.71e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 1.71e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1443095408  42 GDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-302 2.43e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 2.43e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   2 RPILMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDV 81
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  82 QTGRELFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLN 158
Cdd:COG2319   192 ATGKLLRTLTgHTGAVRSVAFS-PDGklLASGSADG------TVRLWDLA------TGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 159 RTIITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVTER-PVNA 237
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRS 335

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1443095408 238 VDISPLLDHVVIGGGQDAmnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRR 302
Cdd:COG2319   336 VAFSPDGKTLASGSDDGT--VRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRT 386
WD40 COG2319
WD40 repeat [General function prediction only];
8-302 6.95e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.08  E-value: 6.95e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   8 GHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGREL 87
Cdd:COG2319    76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  88 FTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvptaQVKRIaedpDDQSEESLLVITGIKGRINRAVWGPLNRTIITA 164
Cdd:COG2319   156 RTLTgHSGAVTSVAFS-PDGklLASGSDDG--------TVRLW----DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 165 GEDATIRIWDTETGQCLKEsdkEQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDISPL 243
Cdd:COG2319   223 SADGTVRLWDLATGKLLRT---LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPD 299

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1443095408 244 LDHVVIGGGQDAmnVTMTDRRAGKfeakffhkilqeEIGGVKGHFGPINALAFNPDGRR 302
Cdd:COG2319   300 GKLLASGSDDGT--VRLWDLATGK------------LLRTLTGHTGAVRSVAFSPDGKT 344
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-302 1.59e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 1.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   7 KGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRE 86
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  87 LFTFR-FDAPARSVEFaIGDGLAVITT--DN--FMENVPTAQVKRiaedpddqseesllVITGIKGRINRAVWGPLNRTI 161
Cdd:cd00200    86 VRTLTgHTSYVSSVAF-SPDGRILSSSsrDKtiKVWDVETGKCLT--------------TLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 162 ITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDI 240
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1443095408 241 SPlLDHVVIGGGQDamnvtmtdrraGKFeaKFFHKILQEEIGGVKGHFGPINALAFNPDGRR 302
Cdd:cd00200   228 SP-DGYLLASGSED-----------GTI--RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
WD40 COG2319
WD40 repeat [General function prediction only];
7-222 1.07e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 1.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   7 KGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRE 86
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  87 LFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLNRTIIT 163
Cdd:COG2319   281 LRTLTgHSGGVNSVAFS-PDGklLASGSDDG------TVRLWDLA------TGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1443095408 164 AGEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRT 222
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTL---TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
8-302 2.03e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 2.03e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   8 GHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGREL 87
Cdd:COG2319    34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  88 FTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLNRTIITA 164
Cdd:COG2319   114 RTLTgHTGAVRSVAFS-PDGktLASGSADG------TVRLWDLA------TGKLLRTLTGHSGAVTSVAFSPDGKLLASG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 165 GEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDISPl 243
Cdd:COG2319   181 SDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSP- 256

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 244 lD-HVVIGGGQDAMnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRR 302
Cdd:COG2319   257 -DgRLLASGSADGT-VRLWDLATGELLRTL------------TGHSGGVNSVAFSPDGKL 302
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-301 1.61e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.07  E-value: 1.61e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  45 LGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRELFTFR--FDAPARSVEFAIGDGLAVITTDNfmenvpTA 122
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghTGPVRDVAASADGTYLASGSSDK------TI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 123 QVKriaedpDDQSEESLLVITGIKGRINRAVWGPLNRTIITAGEDATIRIWDTETGQCLKEsdkEQGHQKTITSLSKSAD 202
Cdd:cd00200    76 RLW------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT---LRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 203 wSHFLT-GSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDISPLLDHVVIGGGqdAMNVTMTDRRAGKfeakffhkilqeE 280
Cdd:cd00200   147 -GTFVAsSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSS--DGTIKLWDLSTGK------------C 211

                         250       260
                  ....*....|....*....|.
gi 1443095408 281 IGGVKGHFGPINALAFNPDGR 301
Cdd:cd00200   212 LGTLRGHENGVNSVAFSPDGY 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-219 6.21e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 6.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   6 MKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGR 85
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  86 ELFTFR-FDAPARSVEFaIGDGLAVITT--DNfmenvptaQVKRIaedpDDQSEESLLVITGIKGRINRAVWGPLNRTII 162
Cdd:cd00200   169 CVATLTgHTGEVNSVAF-SPDGEKLLSSssDG--------TIKLW----DLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1443095408 163 TAGEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWD 219
Cdd:cd00200   236 SGSEDGTIRVWDLRTGECVQTL---SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
5-177 4.50e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 4.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408   5 LMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTG 84
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408  85 RELFTFrfdaparsvefaigdglavittdnfmenvptaqvkriaedpddqseesllviTGIKGRINRAVWGPLNRTIITA 164
Cdd:COG2319   363 ELLRTL----------------------------------------------------TGHTGAVTSVAFSPDGRTLASG 390

                         170
                  ....*....|...
gi 1443095408 165 GEDATIRIWDTET 177
Cdd:COG2319   391 SADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-80 3.18e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 3.18e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1443095408   5 LMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-80 1.04e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.04e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1443095408   41 NGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-80 1.71e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 1.71e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1443095408  42 GDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-219 4.97e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 4.97e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1443095408  177 TGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWD 219
Cdd:smart00320   1 SGELLKTL---KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-219 8.59e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 8.59e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1443095408 188 QGHQKTITSLSKSADWSHFLTGSLDKSAKLWD 219
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 1.86e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1443095408  135 SEESLLVITGIKGRINRAVWGPLNRTIITAGEDATIRIWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
137-174 2.32e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1443095408 137 ESLLVITGIKGRINRAVWGPLNRTIITAGEDATIRIWD 174
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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