|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
2-302 |
2.43e-46 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 161.23 E-value: 2.43e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 2 RPILMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDV 81
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 82 QTGRELFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLN 158
Cdd:COG2319 192 ATGKLLRTLTgHTGAVRSVAFS-PDGklLASGSADG------TVRLWDLA------TGKLLRTLTGHSGSVRSVAFSPDG 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 159 RTIITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVTER-PVNA 237
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRS 335
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1443095408 238 VDISPLLDHVVIGGGQDAmnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRR 302
Cdd:COG2319 336 VAFSPDGKTLASGSDDGT--VRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRT 386
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
7-302 |
1.59e-45 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 155.96 E-value: 1.59e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 7 KGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRE 86
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 87 LFTFR-FDAPARSVEFaIGDGLAVITT--DN--FMENVPTAQVKRiaedpddqseesllVITGIKGRINRAVWGPLNRTI 161
Cdd:cd00200 86 VRTLTgHTSYVSSVAF-SPDGRILSSSsrDKtiKVWDVETGKCLT--------------TLRGHTDWVNSVAFSPDGTFV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 162 ITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDI 240
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1443095408 241 SPlLDHVVIGGGQDamnvtmtdrraGKFeaKFFHKILQEEIGGVKGHFGPINALAFNPDGRR 302
Cdd:cd00200 228 SP-DGYLLASGSED-----------GTI--RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
41-80 |
1.04e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 50.39 E-value: 1.04e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1443095408 41 NGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
42-80 |
1.71e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 49.65 E-value: 1.71e-08
10 20 30
....*....|....*....|....*....|....*....
gi 1443095408 42 GDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
2-302 |
2.43e-46 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 161.23 E-value: 2.43e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 2 RPILMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDV 81
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 82 QTGRELFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLN 158
Cdd:COG2319 192 ATGKLLRTLTgHTGAVRSVAFS-PDGklLASGSADG------TVRLWDLA------TGKLLRTLTGHSGSVRSVAFSPDG 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 159 RTIITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVTER-PVNA 237
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRS 335
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1443095408 238 VDISPLLDHVVIGGGQDAmnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRR 302
Cdd:COG2319 336 VAFSPDGKTLASGSDDGT--VRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRT 386
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
8-302 |
6.95e-46 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 160.08 E-value: 6.95e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 8 GHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGREL 87
Cdd:COG2319 76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 88 FTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvptaQVKRIaedpDDQSEESLLVITGIKGRINRAVWGPLNRTIITA 164
Cdd:COG2319 156 RTLTgHSGAVTSVAFS-PDGklLASGSDDG--------TVRLW----DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 165 GEDATIRIWDTETGQCLKEsdkEQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDISPL 243
Cdd:COG2319 223 SADGTVRLWDLATGKLLRT---LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPD 299
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1443095408 244 LDHVVIGGGQDAmnVTMTDRRAGKfeakffhkilqeEIGGVKGHFGPINALAFNPDGRR 302
Cdd:COG2319 300 GKLLASGSDDGT--VRLWDLATGK------------LLRTLTGHTGAVRSVAFSPDGKT 344
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
7-302 |
1.59e-45 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 155.96 E-value: 1.59e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 7 KGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRE 86
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 87 LFTFR-FDAPARSVEFaIGDGLAVITT--DN--FMENVPTAQVKRiaedpddqseesllVITGIKGRINRAVWGPLNRTI 161
Cdd:cd00200 86 VRTLTgHTSYVSSVAF-SPDGRILSSSsrDKtiKVWDVETGKCLT--------------TLRGHTDWVNSVAFSPDGTFV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 162 ITAGEDATIRIWDTETGQCLKESDkeqGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDI 240
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1443095408 241 SPlLDHVVIGGGQDamnvtmtdrraGKFeaKFFHKILQEEIGGVKGHFGPINALAFNPDGRR 302
Cdd:cd00200 228 SP-DGYLLASGSED-----------GTI--RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
7-222 |
1.07e-41 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 148.91 E-value: 1.07e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 7 KGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRE 86
Cdd:COG2319 201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 87 LFTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLNRTIIT 163
Cdd:COG2319 281 LRTLTgHSGGVNSVAFS-PDGklLASGSDDG------TVRLWDLA------TGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1443095408 164 AGEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRT 222
Cdd:COG2319 348 GSDDGTVRLWDLATGELLRTL---TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
8-302 |
2.03e-38 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 140.05 E-value: 2.03e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 8 GHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGREL 87
Cdd:COG2319 34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 88 FTFR-FDAPARSVEFAiGDG--LAVITTDNfmenvpTAQVKRIAedpddqSEESLLVITGIKGRINRAVWGPLNRTIITA 164
Cdd:COG2319 114 RTLTgHTGAVRSVAFS-PDGktLASGSADG------TVRLWDLA------TGKLLRTLTGHSGAVTSVAFSPDGKLLASG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 165 GEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDISPl 243
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSP- 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 244 lD-HVVIGGGQDAMnVTMTDRRAGKFEAKFfhkilqeeiggvKGHFGPINALAFNPDGRR 302
Cdd:COG2319 257 -DgRLLASGSADGT-VRLWDLATGELLRTL------------TGHSGGVNSVAFSPDGKL 302
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
45-301 |
1.61e-34 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 127.07 E-value: 1.61e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 45 LGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGRELFTFR--FDAPARSVEFAIGDGLAVITTDNfmenvpTA 122
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghTGPVRDVAASADGTYLASGSSDK------TI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 123 QVKriaedpDDQSEESLLVITGIKGRINRAVWGPLNRTIITAGEDATIRIWDTETGQCLKEsdkEQGHQKTITSLSKSAD 202
Cdd:cd00200 76 RLW------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT---LRGHTDWVNSVAFSPD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 203 wSHFLT-GSLDKSAKLWDTRTLTLIKTYVT-ERPVNAVDISPLLDHVVIGGGqdAMNVTMTDRRAGKfeakffhkilqeE 280
Cdd:cd00200 147 -GTFVAsSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSS--DGTIKLWDLSTGK------------C 211
|
250 260
....*....|....*....|.
gi 1443095408 281 IGGVKGHFGPINALAFNPDGR 301
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGY 232
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
6-219 |
6.21e-33 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 122.83 E-value: 6.21e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 6 MKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTGR 85
Cdd:cd00200 89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 86 ELFTFR-FDAPARSVEFaIGDGLAVITT--DNfmenvptaQVKRIaedpDDQSEESLLVITGIKGRINRAVWGPLNRTII 162
Cdd:cd00200 169 CVATLTgHTGEVNSVAF-SPDGEKLLSSssDG--------TIKLW----DLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1443095408 163 TAGEDATIRIWDTETGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWD 219
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTL---SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
5-177 |
4.50e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 92.67 E-value: 4.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 5 LMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWDVQTG 84
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443095408 85 RELFTFrfdaparsvefaigdglavittdnfmenvptaqvkriaedpddqseesllviTGIKGRINRAVWGPLNRTIITA 164
Cdd:COG2319 363 ELLRTL----------------------------------------------------TGHTGAVTSVAFSPDGRTLASG 390
|
170
....*....|...
gi 1443095408 165 GEDATIRIWDTET 177
Cdd:COG2319 391 SADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
5-80 |
3.18e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 80.07 E-value: 3.18e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1443095408 5 LMKGHERPLTFLRYNRDGDLLFSCAKDHTPNVWFADNGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:cd00200 214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
41-80 |
1.04e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 50.39 E-value: 1.04e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1443095408 41 NGDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
42-80 |
1.71e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 49.65 E-value: 1.71e-08
10 20 30
....*....|....*....|....*....|....*....
gi 1443095408 42 GDRLGTYRGHNGAVWSCDVSRDSTRLITGSADQTAKLWD 80
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
177-219 |
4.97e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 4.97e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1443095408 177 TGQCLKESdkeQGHQKTITSLSKSADWSHFLTGSLDKSAKLWD 219
Cdd:smart00320 1 SGELLKTL---KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
188-219 |
8.59e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.25 E-value: 8.59e-05
10 20 30
....*....|....*....|....*....|..
gi 1443095408 188 QGHQKTITSLSKSADWSHFLTGSLDKSAKLWD 219
Cdd:pfam00400 8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
135-174 |
1.86e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 1.86e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1443095408 135 SEESLLVITGIKGRINRAVWGPLNRTIITAGEDATIRIWD 174
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
137-174 |
2.32e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 35.01 E-value: 2.32e-03
10 20 30
....*....|....*....|....*....|....*...
gi 1443095408 137 ESLLVITGIKGRINRAVWGPLNRTIITAGEDATIRIWD 174
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
|