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Conserved domains on  [gi|1944676947|ref|XP_027300367|]
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lymphocyte function-associated antigen 3 isoform X2 [Anas platyrhynchos]

Protein Classification

IgV_CD2_like_N and Ig_2 domain-containing protein( domain architecture ID 11566358)

IgV_CD2_like_N and Ig_2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 24-120 8.04e-35

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


:

Pssm-ID: 409431  Cd Length: 98  Bit Score: 123.23  E-value: 8.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944676947  24 CEEKVFGILGENFTFPVKADN-KIDEVIWTKDKDKVAEWEAQSEPTYFNSLRSRSLLNKESGNLTIFKLENSDSGTYELE 102
Cdd:cd05775     1 SSGEVYGALGGNVTLTISSLQdDIDEIKWKKTKDKIVEWENNIGPTYFGSFKDRVLLDKESGSLTIKNLTKEDSGTYELE 80

                          90
                  ....*....|....*...
gi 1944676947 103 RFSSHKENGVFTFKLTVL 120
Cdd:cd05775    81 ITSTNGKVLSSKFTLEVL 98
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 135-192 5.47e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 41.23  E-value: 5.47e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1944676947 135 DNLMLTCEANFQGPLSYVWKITGRETSTGPKVLIPKENVDTGGKATCIVTYFEVSKSS 192
Cdd:pfam13895  15 EPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFFTLSVSAEDSGTYTCVARNGRGGKVS 72
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 24-120 8.04e-35

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 123.23  E-value: 8.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944676947  24 CEEKVFGILGENFTFPVKADN-KIDEVIWTKDKDKVAEWEAQSEPTYFNSLRSRSLLNKESGNLTIFKLENSDSGTYELE 102
Cdd:cd05775     1 SSGEVYGALGGNVTLTISSLQdDIDEIKWKKTKDKIVEWENNIGPTYFGSFKDRVLLDKESGSLTIKNLTKEDSGTYELE 80

                          90
                  ....*....|....*...
gi 1944676947 103 RFSSHKENGVFTFKLTVL 120
Cdd:cd05775    81 ITSTNGKVLSSKFTLEVL 98
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 135-192 5.47e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 41.23  E-value: 5.47e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1944676947 135 DNLMLTCEANFQGPLSYVWKITGRETSTGPKVLIPKENVDTGGKATCIVTYFEVSKSS 192
Cdd:pfam13895  15 EPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFFTLSVSAEDSGTYTCVARNGRGGKVS 72
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 25-120 9.66e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 35.51  E-value: 9.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944676947  25 EEKVFGILGENFTFPVK----ADNKIDEVIWTKDK-DKVAEWE-AQSEPTYFNSLRS-----RSLLNKESGNLTIFKLEN 93
Cdd:pfam07686   3 PREVTVALGGSVTLPCTysssMSEASTSVYWYRQPpGKGPTFLiAYYSNGSEEGVKKgrfsgRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*..
gi 1944676947  94 SDSGTYELERFSSHKENGVFTFKLTVL 120
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRLTVL 109
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 24-120 8.04e-35

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 123.23  E-value: 8.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944676947  24 CEEKVFGILGENFTFPVKADN-KIDEVIWTKDKDKVAEWEAQSEPTYFNSLRSRSLLNKESGNLTIFKLENSDSGTYELE 102
Cdd:cd05775     1 SSGEVYGALGGNVTLTISSLQdDIDEIKWKKTKDKIVEWENNIGPTYFGSFKDRVLLDKESGSLTIKNLTKEDSGTYELE 80

                          90
                  ....*....|....*...
gi 1944676947 103 RFSSHKENGVFTFKLTVL 120
Cdd:cd05775    81 ITSTNGKVLSSKFTLEVL 98
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 25-119 8.69e-06

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 44.05  E-value: 8.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944676947  25 EEKVFGILGENFTFPVKA-DNKIDEVIWTKDK-----DKVAEWE-AQSEPTYFNSLRSRSLLNKEsGNLTIFKLENSDSG 97
Cdd:cd05741     2 SEQFYGAEGKNVLLLVPNlQTPLKSVSWYKGKqvsrnDEIAEYEnSSDEFRAGSAFSGREYIYTN-GSLLIQNITLSDTG 80

                          90       100
                  ....*....|....*....|..
gi 1944676947  98 TYELERFSSHKENGVFTFKLTV 119
Cdd:cd05741    81 FYTLESTNIGGKTESATFQLHV 102
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 28-102 4.60e-05

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 41.92  E-value: 4.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944676947  28 VFGILGENFTFPVK--ADNKIDEVIWTKDKDKVA-EWEAQSEPT---YFNSLRSRSLLNKESGNLTIFKLENSDSGTYEL 101
Cdd:cd16842     3 VNGILGGSVTFPLNisDGQEIENITWSFKTSLAViAPGEGGAPEiiiTDKSYKERLNISQNDYSLQISNLTMEDAGSYRA 82


                  .
gi 1944676947 102 E 102
Cdd:cd16842    83 R 83
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 135-192 5.47e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 41.23  E-value: 5.47e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1944676947 135 DNLMLTCEANFQGPLSYVWKITGRETSTGPKVLIPKENVDTGGKATCIVTYFEVSKSS 192
Cdd:pfam13895  15 EPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFFTLSVSAEDSGTYTCVARNGRGGKVS 72
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 25-120 9.66e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 35.51  E-value: 9.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944676947  25 EEKVFGILGENFTFPVK----ADNKIDEVIWTKDK-DKVAEWE-AQSEPTYFNSLRS-----RSLLNKESGNLTIFKLEN 93
Cdd:pfam07686   3 PREVTVALGGSVTLPCTysssMSEASTSVYWYRQPpGKGPTFLiAYYSNGSEEGVKKgrfsgRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*..
gi 1944676947  94 SDSGTYELERFSSHKENGVFTFKLTVL 120
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRLTVL 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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