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Conserved domains on  [gi|1720356723|ref|XP_030098284|]
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integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X15 [Mus musculus]

Protein Classification

PP2C family serine/threonine-protein phosphatase( domain architecture ID 10065450)

PP2C family protein-serine/threonine phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates

CATH:  3.60.40.10
EC:  3.1.3.16
Gene Ontology:  GO:0004722|GO:0006470|GO:0046872
PubMed:  9192069|8819174
SCOP:  3000909

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
1-200 8.90e-47

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


:

Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 154.41  E-value: 8.90e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   1 MQDAHVILNDITQEcnppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDIISvEKTVKRCLLDTFKHTDE 80
Cdd:cd00143    15 NEDAVVIKPNLNNE---------DGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLS-EEDIEEALRKAFLRADE 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  81 EFLKQASSQ----------------------------------------------------------------DGRVLGV 96
Cdd:cd00143    85 EILEEAQDEpddarsgttavvalirgnklyvanvgdsravlcrngeavqltkdhkpvneeereriekaggrvsNGRVPGV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  97 LEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDDKIQtregkpavdaryeAA 176
Cdd:cd00143   165 LAVTRALGDFDLK-PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSELAKEDLQ-------------EA 230
                         250       260
                  ....*....|....*....|....
gi 1720356723 177 CNRLANKAVQRGSADNVTVMVVRI 200
Cdd:cd00143   231 AQELVDLALRRGSHDNITVVVVRL 254
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
1-200 8.90e-47

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 154.41  E-value: 8.90e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   1 MQDAHVILNDITQEcnppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDIISvEKTVKRCLLDTFKHTDE 80
Cdd:cd00143    15 NEDAVVIKPNLNNE---------DGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLS-EEDIEEALRKAFLRADE 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  81 EFLKQASSQ----------------------------------------------------------------DGRVLGV 96
Cdd:cd00143    85 EILEEAQDEpddarsgttavvalirgnklyvanvgdsravlcrngeavqltkdhkpvneeereriekaggrvsNGRVPGV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  97 LEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDDKIQtregkpavdaryeAA 176
Cdd:cd00143   165 LAVTRALGDFDLK-PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSELAKEDLQ-------------EA 230
                         250       260
                  ....*....|....*....|....
gi 1720356723 177 CNRLANKAVQRGSADNVTVMVVRI 200
Cdd:cd00143   231 AQELVDLALRRGSHDNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
1-198 8.12e-45

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 149.06  E-value: 8.12e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723    1 MQDAHVILNDitqecnppssLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDiiSVEKTVKRCLLDTFKHTDE 80
Cdd:smart00332  23 MEDAHVITPD----------LSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEK--DELEDVEEALRKAFLSTDE 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   81 EFLKQAS--------------------------------------SQD---------------------GRVLGVLEVSR 101
Cdd:smart00332  91 EILEELEalsgstavvalisgnklyvanvgdsravlcrngkavqlTEDhkpsnederarieaaggfvinGRVNGVLALSR 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  102 SIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDDkiqtregkpavdarYEAACNRLA 181
Cdd:smart00332 171 AIGDFFLK-PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQEVVDIVRKHLSKD--------------PKEAAKRLI 235
                          250
                   ....*....|....*..
gi 1720356723  182 NKAVQRGSADNVTVMVV 198
Cdd:smart00332 236 DLALARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
1-193 1.21e-31

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 115.13  E-value: 1.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   1 MQDAHVILNDitQECNPPSSLItrvSYFAVFDGHGGIRASKFAAQNLHQNLIRK--FPKGDiisvekTVKRCLLDTF-KH 77
Cdd:pfam00481  15 MEDAHIDLPN--LNSSSGKDSW---SFFAVFDGHGGSEAAKYCGKHLHTILALRrsFLEGE------KLEDALRKSFlED 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  78 TDEEFLKQAS---------------------------------------------------------------SQDGRVL 94
Cdd:pfam00481  84 TDEVLRSAEKedldsgctavvalisgnklyvanvgdsravlcrngnaikrltkdhkpsdederrriraaggfvSRNGRVN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  95 GVLEVSRSIGDGQYKR--CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDDKIQTRegkpavdar 172
Cdd:pfam00481 164 GVLAVSRAFGDFELKPgeQAVSAEPDITSHTITEDDEFLILACDGLWDVLSDQEVVDLVRSELSDGGSPME--------- 234
                         250       260
                  ....*....|....*....|.
gi 1720356723 173 yeaACNRLANKAVQRGSADNV 193
Cdd:pfam00481 235 ---AAEELRDEAIAYGSEDNI 252
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
1-200 2.81e-18

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 81.36  E-value: 2.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   1 MQDAHVILnditqecnppssLITRVSYFAVFDGHGGIRASKFAAQNLHQnLIRKFPKGdiISVEKTVKRCLldtfkHTDE 80
Cdd:PTZ00224   36 MEDAHLLY------------LTDDWGFFGVFDGHVNDECSQYLARAWPQ-ALEKEPEP--MTDERMEELCL-----EIDE 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  81 EFLKQA-----------------------------------------------------------SSQDGRVLGVLEVSR 101
Cdd:PTZ00224   96 EWMDSGreggstgtfcvimkdvhlqvgnvgdsrvlvcrdgklvfatedhkpnnpgerqrieacggRVVSNRVDGDLAVSR 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723 102 SIGDGQYKRCG--------VTSVPDIRRCQLTPNDrFILLACDGLFK-VFTPEEAVNFILSCLEDdkiqtregkpaVDAR 172
Cdd:PTZ00224  176 AFGDRSFKVKGtgdyleqkVIAVPDVTHLTCQSND-FIILACDGVFEgNFSNEEVVAFVKEQLET-----------CDDL 243
                         250       260
                  ....*....|....*....|....*...
gi 1720356723 173 YEAACnRLANKAVQRGSADNVTVMVVRI 200
Cdd:PTZ00224  244 AVVAG-RVCDEAIRRGSKDNISCLIVQL 270
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
117-201 3.88e-10

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 57.53  E-value: 3.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723 117 PDIRRCQLTPNDRFiLLACDGLFKVFTPEEavnfILSCLeddkiqtREGKPAvdaryEAACNRLANKAVQRGSADNVTVM 196
Cdd:COG0631   174 PDISPLELEPGDRL-LLCSDGLTDMVSDEE----IAEIL-------ASAGDP-----QEAAEALIELALEAGGPDNITVV 236

                  ....*
gi 1720356723 197 VVRIG 201
Cdd:COG0631   237 LVRVE 241
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
1-200 8.90e-47

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 154.41  E-value: 8.90e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   1 MQDAHVILNDITQEcnppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDIISvEKTVKRCLLDTFKHTDE 80
Cdd:cd00143    15 NEDAVVIKPNLNNE---------DGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLS-EEDIEEALRKAFLRADE 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  81 EFLKQASSQ----------------------------------------------------------------DGRVLGV 96
Cdd:cd00143    85 EILEEAQDEpddarsgttavvalirgnklyvanvgdsravlcrngeavqltkdhkpvneeereriekaggrvsNGRVPGV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  97 LEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDDKIQtregkpavdaryeAA 176
Cdd:cd00143   165 LAVTRALGDFDLK-PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSELAKEDLQ-------------EA 230
                         250       260
                  ....*....|....*....|....
gi 1720356723 177 CNRLANKAVQRGSADNVTVMVVRI 200
Cdd:cd00143   231 AQELVDLALRRGSHDNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
1-198 8.12e-45

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 149.06  E-value: 8.12e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723    1 MQDAHVILNDitqecnppssLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDiiSVEKTVKRCLLDTFKHTDE 80
Cdd:smart00332  23 MEDAHVITPD----------LSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEK--DELEDVEEALRKAFLSTDE 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   81 EFLKQAS--------------------------------------SQD---------------------GRVLGVLEVSR 101
Cdd:smart00332  91 EILEELEalsgstavvalisgnklyvanvgdsravlcrngkavqlTEDhkpsnederarieaaggfvinGRVNGVLALSR 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  102 SIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDDkiqtregkpavdarYEAACNRLA 181
Cdd:smart00332 171 AIGDFFLK-PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQEVVDIVRKHLSKD--------------PKEAAKRLI 235
                          250
                   ....*....|....*..
gi 1720356723  182 NKAVQRGSADNVTVMVV 198
Cdd:smart00332 236 DLALARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
1-193 1.21e-31

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 115.13  E-value: 1.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   1 MQDAHVILNDitQECNPPSSLItrvSYFAVFDGHGGIRASKFAAQNLHQNLIRK--FPKGDiisvekTVKRCLLDTF-KH 77
Cdd:pfam00481  15 MEDAHIDLPN--LNSSSGKDSW---SFFAVFDGHGGSEAAKYCGKHLHTILALRrsFLEGE------KLEDALRKSFlED 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  78 TDEEFLKQAS---------------------------------------------------------------SQDGRVL 94
Cdd:pfam00481  84 TDEVLRSAEKedldsgctavvalisgnklyvanvgdsravlcrngnaikrltkdhkpsdederrriraaggfvSRNGRVN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  95 GVLEVSRSIGDGQYKR--CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDDKIQTRegkpavdar 172
Cdd:pfam00481 164 GVLAVSRAFGDFELKPgeQAVSAEPDITSHTITEDDEFLILACDGLWDVLSDQEVVDLVRSELSDGGSPME--------- 234
                         250       260
                  ....*....|....*....|.
gi 1720356723 173 yeaACNRLANKAVQRGSADNV 193
Cdd:pfam00481 235 ---AAEELRDEAIAYGSEDNI 252
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
1-200 2.81e-18

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 81.36  E-value: 2.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   1 MQDAHVILnditqecnppssLITRVSYFAVFDGHGGIRASKFAAQNLHQnLIRKFPKGdiISVEKTVKRCLldtfkHTDE 80
Cdd:PTZ00224   36 MEDAHLLY------------LTDDWGFFGVFDGHVNDECSQYLARAWPQ-ALEKEPEP--MTDERMEELCL-----EIDE 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  81 EFLKQA-----------------------------------------------------------SSQDGRVLGVLEVSR 101
Cdd:PTZ00224   96 EWMDSGreggstgtfcvimkdvhlqvgnvgdsrvlvcrdgklvfatedhkpnnpgerqrieacggRVVSNRVDGDLAVSR 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723 102 SIGDGQYKRCG--------VTSVPDIRRCQLTPNDrFILLACDGLFK-VFTPEEAVNFILSCLEDdkiqtregkpaVDAR 172
Cdd:PTZ00224  176 AFGDRSFKVKGtgdyleqkVIAVPDVTHLTCQSND-FIILACDGVFEgNFSNEEVVAFVKEQLET-----------CDDL 243
                         250       260
                  ....*....|....*....|....*...
gi 1720356723 173 YEAACnRLANKAVQRGSADNVTVMVVRI 200
Cdd:PTZ00224  244 AVVAG-RVCDEAIRRGSKDNISCLIVQL 270
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
1-198 9.83e-14

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 68.40  E-value: 9.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723   1 MQDAHVILNDITQECNPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLI--RKFPKgdiisvekTVKRCLLDTFKHT 78
Cdd:PLN03145   79 MEDVYICVDNFMSDFGLKNSEDGPSAFYGVFDGHGGKHAADFACYHLPRFIVedEDFPR--------EIEKVVSSAFLQT 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  79 DEEFLKQASSQ---------------------------------------------------------------DGRVLG 95
Cdd:PLN03145  151 DTAFAEACSLDaslasgttalaalvvgrslvvanagdcravlcrrgkaiemsrdhkpmcskerkrieasggyvyDGYLNG 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723  96 VLEVSRSIGDGQY-----KRCGVTSV-PDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDdkiqtrEGKPAv 169
Cdd:PLN03145  231 QLNVARALGDWHMegmkgSDGGPLSAePELMTTQLTEEDEFLIIGCDGIWDVFRSQNAVDFARRRLQE------HNDPV- 303
                         250       260
                  ....*....|....*....|....*....
gi 1720356723 170 daryeAACNRLANKAVQRGSADNVTVMVV 198
Cdd:PLN03145  304 -----MCSKELVDEALKRKSGDNLAVVVV 327
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
117-201 3.88e-10

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 57.53  E-value: 3.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356723 117 PDIRRCQLTPNDRFiLLACDGLFKVFTPEEavnfILSCLeddkiqtREGKPAvdaryEAACNRLANKAVQRGSADNVTVM 196
Cdd:COG0631   174 PDISPLELEPGDRL-LLCSDGLTDMVSDEE----IAEIL-------ASAGDP-----QEAAEALIELALEAGGPDNITVV 236

                  ....*
gi 1720356723 197 VVRIG 201
Cdd:COG0631   237 LVRVE 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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