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Conserved domains on  [gi|1720356997|ref|XP_030098661|]
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WD repeat and FYVE domain-containing protein 1 isoform X3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-138 2.67e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 2.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  10 QSSRPVLLSKIEGHQDAVTAALLIPkeDG--VITASEDRTIRVWlKRDSGQYWPSIY-HTmaSPCSAMAYHHDSRRIFVG 86
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSP--DGktLASGSADGTVRLW-DLATGKLLRTLTgHS--GAVTSVAFSPDGKLLASG 180

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720356997  87 QDNGAVMEFHVSEDfnkmNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDKCV 138
Cdd:COG2319   181 SDDGTVRLWDLATG----KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-138 2.67e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 2.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  10 QSSRPVLLSKIEGHQDAVTAALLIPkeDG--VITASEDRTIRVWlKRDSGQYWPSIY-HTmaSPCSAMAYHHDSRRIFVG 86
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSP--DGktLASGSADGTVRLW-DLATGKLLRTLTgHS--GAVTSVAFSPDGKLLASG 180

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720356997  87 QDNGAVMEFHVSEDfnkmNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDKCV 138
Cdd:COG2319   181 SDDGTVRLWDLATG----KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-138 7.48e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 7.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  20 IEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRD---SGQYWpsiYHTmaSPCSAMAYHHDSRRIFVGQDNGAVMEFh 96
Cdd:cd00200   173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTgkcLGTLR---GHE--NGVNSVAFSPDGYLLASGSEDGTIRVW- 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720356997  97 vseDFNKMNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDKCV 138
Cdd:cd00200   247 ---DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 pfam00400
WD domain, G-beta repeat;
16-51 1.93e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1720356997  16 LLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-51 2.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.37e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720356997   16 LLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-138 2.67e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 2.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  10 QSSRPVLLSKIEGHQDAVTAALLIPkeDG--VITASEDRTIRVWlKRDSGQYWPSIY-HTmaSPCSAMAYHHDSRRIFVG 86
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSP--DGktLASGSADGTVRLW-DLATGKLLRTLTgHS--GAVTSVAFSPDGKLLASG 180

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720356997  87 QDNGAVMEFHVSEDfnkmNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDKCV 138
Cdd:COG2319   181 SDDGTVRLWDLATG----KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-138 7.48e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 7.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  20 IEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRD---SGQYWpsiYHTmaSPCSAMAYHHDSRRIFVGQDNGAVMEFh 96
Cdd:cd00200   173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTgkcLGTLR---GHE--NGVNSVAFSPDGYLLASGSEDGTIRVW- 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720356997  97 vseDFNKMNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDKCV 138
Cdd:cd00200   247 ---DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
16-138 2.18e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 2.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  16 LLSKIEGHQDAVTAALLIPkeDG--VITASEDRTIRVWlKRDSGQYWPSIYHTMASPcSAMAYHHDSRRIFVGQDNGAVM 93
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSP--DGrlLASGSADGTVRLW-DLATGELLRTLTGHSGGV-NSVAFSPDGKLLASGSDDGTVR 313

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720356997  94 EFHVSEDfnkmNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDKCV 138
Cdd:COG2319   314 LWDLATG----KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 COG2319
WD40 repeat [General function prediction only];
16-136 2.20e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 2.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  16 LLSKIEGHQDAVTAALLIPkeDG--VITASEDRTIRVWlKRDSGQYWPSIY-HTmaSPCSAMAYHHDSRRIFVGQDNGAV 92
Cdd:COG2319   154 LLRTLTGHSGAVTSVAFSP--DGklLASGSDDGTVRLW-DLATGKLLRTLTgHT--GAVRSVAFSPDGKLLASGSADGTV 228

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720356997  93 MEFHVSEDfnkmNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDK 136
Cdd:COG2319   229 RLWDLATG----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADG 268
WD40 COG2319
WD40 repeat [General function prediction only];
16-136 5.74e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 5.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  16 LLSKIEGHQDAVTAALLIPkeDG--VITASEDRTIRVWlKRDSGQyWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVM 93
Cdd:COG2319   280 LLRTLTGHSGGVNSVAFSP--DGklLASGSDDGTVRLW-DLATGK-LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1720356997  94 EFhvseDFNKMNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDK 136
Cdd:COG2319   356 LW----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-136 8.11e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 8.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  20 IEGHQDAVTAALLIPKEDGVITASEDRTIRVWlkrdSGQYWPSIY----HTmaSPCSAMAYHHDSRRIFVGQDNGAVMEF 95
Cdd:cd00200   131 LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW----DLRTGKCVAtltgHT--GEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1720356997  96 hvseDFNKMNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDK 136
Cdd:cd00200   205 ----DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241
WD40 COG2319
WD40 repeat [General function prediction only];
13-136 3.55e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 3.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  13 RPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTmaSPCSAMAYHHDSRRIFVGQDNGAV 92
Cdd:COG2319    67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720356997  93 MEFHVSEDfnkmNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDK 136
Cdd:COG2319   145 RLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG 184
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-138 1.87e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720356997  16 LLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWlKRDSGQYWPSIY-HTmaSPCSAMAYHHDSRRIFVGQDNGAVME 94
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-DLETGELLRTLKgHT--GPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720356997  95 FhvseDFNKMNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDKCV 138
Cdd:cd00200    78 W----DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117
WD40 COG2319
WD40 repeat [General function prediction only];
16-92 1.74e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 1.74e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720356997  16 LLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTmaSPCSAMAYHHDSRRIFVGQDNGAV 92
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT--GAVTSVAFSPDGRTLASGSADGTV 396
WD40 pfam00400
WD domain, G-beta repeat;
16-51 1.93e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1720356997  16 LLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-51 2.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.37e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720356997   16 LLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
16-51 4.51e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 4.51e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720356997  16 LLSKIEGHQDAVTAALLIPkeDG--VITASEDRTIRVW 51
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSP--DGrtLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-51 2.39e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 37.70  E-value: 2.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720356997  15 VLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVW 51
Cdd:cd00200   252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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