NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907070456|ref|XP_030099044|]
View 

ankyrin repeat domain-containing protein 45 isoform X1 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
123-268 8.96e-17

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.84  E-value: 8.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 123 HEHAVQLLLE-------EDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVD 195
Cdd:COG0666   132 NLEIVKLLLEagadvnaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907070456 196 IEALNFRGEKARDVAARYSQVECVNFLDWADARLILKKIITKSSLIITDPEKGPGKLFKEDKSTILNACRLKN 268
Cdd:COG0666   212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
PTZ00009 super family cl36495
heat shock 70 kDa protein; Provisional
 246-300 1.08e-04

heat shock 70 kDa protein; Provisional


The actual alignment was detected with superfamily member PTZ00009:

Pssm-ID: 240227 [Multi-domain]  Cd Length: 653  Bit Score: 43.63  E-value: 1.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070456 246 EKGPGKLFKEDKSTILNACRLKNEWLESHPEASISEiFEQKQ-QLEDIVSPILAKM 300
Cdd:PTZ00009  558 EKVKGKLSDSDKATIEKAIDEALEWLEKNQLAEKEE-FEHKQkEVESVCNPIMTKM 612
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
123-268 8.96e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.84  E-value: 8.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 123 HEHAVQLLLE-------EDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVD 195
Cdd:COG0666   132 NLEIVKLLLEagadvnaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907070456 196 IEALNFRGEKARDVAARYSQVECVNFLDWADARLILKKIITKSSLIITDPEKGPGKLFKEDKSTILNACRLKN 268
Cdd:COG0666   212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
Ank_2 pfam12796
Ankyrin repeats (3 copies);
123-200 1.40e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.74  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 123 HEHAVQLLLEE-------DIVGRNLLYAACMAGKSDVIKALAKYgVNLNEATaRGYTLLHCAAAWGRLETLKALVELDVD 195
Cdd:pfam12796   9 NLELVKLLLENgadanlqDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGAD 86


                  ....*
gi 1907070456 196 IEALN 200
Cdd:pfam12796  87 INVKD 91
PTZ00009 PTZ00009
heat shock 70 kDa protein; Provisional
 246-300 1.08e-04

heat shock 70 kDa protein; Provisional


Pssm-ID: 240227 [Multi-domain]  Cd Length: 653  Bit Score: 43.63  E-value: 1.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070456 246 EKGPGKLFKEDKSTILNACRLKNEWLESHPEASISEiFEQKQ-QLEDIVSPILAKM 300
Cdd:PTZ00009  558 EKVKGKLSDSDKATIEKAIDEALEWLEKNQLAEKEE-FEHKQkEVESVCNPIMTKM 612
PHA03095 PHA03095
ankyrin-like protein; Provisional
 130-213 2.85e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 2.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 130 LLEEDIVGRNLLYAaCMAGKS---DVIKALAKYGVNLNEATARGYTLLHCAAAWGR--LETLKALVELDVDIEALNFRGE 204
Cdd:PHA03095  110 VNAKDKVGRTPLHV-YLSGFNinpKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFR 188


                  ....*....
gi 1907070456 205 KARDVAARY 213
Cdd:PHA03095  189 SLLHHHLQS 197
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 169-198 7.89e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 7.89e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907070456  169 RGYTLLHCAAAWGRLETLKALVELDVDIEA 198
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
123-268 8.96e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.84  E-value: 8.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 123 HEHAVQLLLE-------EDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVD 195
Cdd:COG0666   132 NLEIVKLLLEagadvnaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907070456 196 IEALNFRGEKARDVAARYSQVECVNFLDWADARLILKKIITKSSLIITDPEKGPGKLFKEDKSTILNACRLKN 268
Cdd:COG0666   212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
123-222 1.79e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.38  E-value: 1.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 123 HEHAVQLLLEE-------DIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVD 195
Cdd:COG0666    99 DLEIVKLLLEAgadvnarDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                          90       100
                  ....*....|....*....|....*..
gi 1907070456 196 IEALNFRGEKARDVAARYSQVECVNFL 222
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
137-222 5.95e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 5.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 137 GRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQV 216
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166


                  ....*.
gi 1907070456 217 ECVNFL 222
Cdd:COG0666   167 EIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
123-200 1.40e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.74  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 123 HEHAVQLLLEE-------DIVGRNLLYAACMAGKSDVIKALAKYgVNLNEATaRGYTLLHCAAAWGRLETLKALVELDVD 195
Cdd:pfam12796   9 NLELVKLLLENgadanlqDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGAD 86


                  ....*
gi 1907070456 196 IEALN 200
Cdd:pfam12796  87 INVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
141-222 4.65e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 4.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 141 LYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVE-LDVDIealNFRGEKARDVAARYSQVECV 219
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEhADVNL---KDNGRTALHYAARSGHLEIV 77


                  ...
gi 1907070456 220 NFL 222
Cdd:pfam12796  78 KLL 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
129-222 3.35e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 3.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 129 LLLEEDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARD 208
Cdd:COG0666    46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                          90
                  ....*....|....
gi 1907070456 209 VAARYSQVECVNFL 222
Cdd:COG0666   126 LAAYNGNLEIVKLL 139
Ank_4 pfam13637
Ankyrin repeats (many copies);
137-190 4.76e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 4.76e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907070456 137 GRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALV 190
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
170-222 4.30e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 4.30e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907070456 170 GYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQVECVNFL 222
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PTZ00009 PTZ00009
heat shock 70 kDa protein; Provisional
 246-300 1.08e-04

heat shock 70 kDa protein; Provisional


Pssm-ID: 240227 [Multi-domain]  Cd Length: 653  Bit Score: 43.63  E-value: 1.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907070456 246 EKGPGKLFKEDKSTILNACRLKNEWLESHPEASISEiFEQKQ-QLEDIVSPILAKM 300
Cdd:PTZ00009  558 EKVKGKLSDSDKATIEKAIDEALEWLEKNQLAEKEE-FEHKQkEVESVCNPIMTKM 612
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 169-198 2.74e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 2.74e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907070456 169 RGYTLLHCAAAWGRLETLKALVELDVDIEA 198
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 130-213 2.85e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 2.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 130 LLEEDIVGRNLLYAaCMAGKS---DVIKALAKYGVNLNEATARGYTLLHCAAAWGR--LETLKALVELDVDIEALNFRGE 204
Cdd:PHA03095  110 VNAKDKVGRTPLHV-YLSGFNinpKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFR 188


                  ....*....
gi 1907070456 205 KARDVAARY 213
Cdd:PHA03095  189 SLLHHHLQS 197
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 151-222 5.13e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 5.13e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907070456 151 DVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQVECVNFL 222
Cdd:PHA03100  173 NRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 169-198 7.89e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 7.89e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907070456  169 RGYTLLHCAAAWGRLETLKALVELDVDIEA 198
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 151-240 1.30e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.01  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070456 151 DVIKALAKYGVNLNEATARGYTLLH--CAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQ--VECVNFLDWAD 226
Cdd:PHA03095   98 DVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAG 177

                          90
                  ....*....|....
gi 1907070456 227 ARLILKKIITKSSL 240
Cdd:PHA03095  178 ADVYAVDDRFRSLL 191
Ank_5 pfam13857
Ankyrin repeats (many copies);
156-210 2.61e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 2.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907070456 156 LAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVA 210
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH