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Conserved domains on  [gi|1720427031|ref|XP_030099306|]
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hairy and enhancer of split-related protein HELT isoform X3 [Mus musculus]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 10539994)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor; similar to Homo sapiens transcription cofactor HES-6, a member of the Hairy/Enhancer of split family of bHLH transcription factors, which acts as a transcriptional repressor in myoblasts

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hairy_orange pfam07527
Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and ...
 29-70 1.24e-05

Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute.


:

Pssm-ID: 462193  Cd Length: 40  Bit Score: 40.55  E-value: 1.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1720427031  29 YFHYGYHECMKNLVHYLTTVERMETkDTKyARILAFLQSKAR 70
Cdd:pfam07527   1 RFRAGFNECANEVSRFLSTLEGVDP-DLR-QRLLNHLQRCLA 40
PLN02983 super family cl33616
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 90-156 1.32e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


The actual alignment was detected with superfamily member PLN02983:

Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 38.28  E-value: 1.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720427031  90 QLHAASPEFPGHSPGEATMFPqgatpgsFPWPPGAARSPALPYLSSATVPLPSPAQ----QHSPFLAPMQG 156
Cdd:PLN02983  143 QPPPPAPVVMMQPPPPHAMPP-------ASPPAAQPAPSAPASSPPPTPASPPPAKapksSHPPLKSPMAG 206
 
Name Accession Description Interval E-value
Hairy_orange pfam07527
Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and ...
 29-70 1.24e-05

Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute.


Pssm-ID: 462193  Cd Length: 40  Bit Score: 40.55  E-value: 1.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1720427031  29 YFHYGYHECMKNLVHYLTTVERMETkDTKyARILAFLQSKAR 70
Cdd:pfam07527   1 RFRAGFNECANEVSRFLSTLEGVDP-DLR-QRLLNHLQRCLA 40
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 90-156 1.32e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 38.28  E-value: 1.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720427031  90 QLHAASPEFPGHSPGEATMFPqgatpgsFPWPPGAARSPALPYLSSATVPLPSPAQ----QHSPFLAPMQG 156
Cdd:PLN02983  143 QPPPPAPVVMMQPPPPHAMPP-------ASPPAAQPAPSAPASSPPPTPASPPPAKapksSHPPLKSPMAG 206
 
Name Accession Description Interval E-value
Hairy_orange pfam07527
Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and ...
 29-70 1.24e-05

Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute.


Pssm-ID: 462193  Cd Length: 40  Bit Score: 40.55  E-value: 1.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1720427031  29 YFHYGYHECMKNLVHYLTTVERMETkDTKyARILAFLQSKAR 70
Cdd:pfam07527   1 RFRAGFNECANEVSRFLSTLEGVDP-DLR-QRLLNHLQRCLA 40
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 90-156 1.32e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 38.28  E-value: 1.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720427031  90 QLHAASPEFPGHSPGEATMFPqgatpgsFPWPPGAARSPALPYLSSATVPLPSPAQ----QHSPFLAPMQG 156
Cdd:PLN02983  143 QPPPPAPVVMMQPPPPHAMPP-------ASPPAAQPAPSAPASSPPPTPASPPPAKapksSHPPLKSPMAG 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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