NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720428381|ref|XP_030099637|]
View 

probable cysteine--tRNA ligase, mitochondrial isoform X6 [Mus musculus]

Protein Classification

cysteine--tRNA ligase( domain architecture ID 1002819)

cysteine--tRNA ligase catalyzes the attachment of cysteine to tRNA(Cys)

EC:  6.1.1.16
Gene Ontology:  GO:0005524|GO:0006423|GO:0004817|GO:0046872|GO:0000049

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTZ00399 super family cl36555
cysteinyl-tRNA-synthetase; Provisional
 8-497 3.67e-125

cysteinyl-tRNA-synthetase; Provisional


The actual alignment was detected with superfamily member PTZ00399:

Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 379.37  E-value: 3.67e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYStATGSVYFDLHA-RGDK--YGKLVNTVPSAT 84
Cdd:PTZ00399  128 LARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQKIIDNGFAYE-SNGSVYFDVEAfRKAGhvYPKLEPESVADE 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  85 AEPGD---------SDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENE 155
Cdd:PTZ00399  207 DRIAEgegalgkvsGEKRSPNDFALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNE 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 156 IAQSEVFHQCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCrlsgrslldsclhccfdsiaepsrgpkgkqdlplr 235
Cdd:PTZ00399  287 LAQSEAYFDKHQWVNYFLHSGHLHIKG--LKMSKSLKNFITIRQA----------------------------------- 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 236 cdlhggttdpvhilhkgllnrvtqlpfwskdfLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARA 315
Cdd:PTZ00399  330 --------------------------------LSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKI 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 316 YVKGQLTCGPVEEDV----LWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKeasgPRSPTVFgAIIS 391
Cdd:PTZ00399  378 KLRESELTSPQKWTQhdfeLNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLR-SVAQ 452

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 392 YVEQFFETVGISLANRQC-VSGDSSTV-TLRCVVDELVRFRLKVRQYAldtpgAAGEARKRQLQERQPLLEACDTLR-QD 468
Cdd:PTZ00399  453 YVTKILSIFGLVEGSDGLgSQGQNSTSeNFKPLLEALLRFRDEVRDAA-----KAEMKLISLDKKKKQLLQLCDKLRdEW 527

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1720428381 469 LVTHGINVKDRGSAASTWELLDP----RTRHQK 497
Cdd:PTZ00399  528 LPNLGIRIEDKPDGPSVWKLDDKeelqREKEEK 560
 
Name Accession Description Interval E-value
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
 8-497 3.67e-125

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 379.37  E-value: 3.67e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYStATGSVYFDLHA-RGDK--YGKLVNTVPSAT 84
Cdd:PTZ00399  128 LARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQKIIDNGFAYE-SNGSVYFDVEAfRKAGhvYPKLEPESVADE 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  85 AEPGD---------SDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENE 155
Cdd:PTZ00399  207 DRIAEgegalgkvsGEKRSPNDFALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNE 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 156 IAQSEVFHQCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCrlsgrslldsclhccfdsiaepsrgpkgkqdlplr 235
Cdd:PTZ00399  287 LAQSEAYFDKHQWVNYFLHSGHLHIKG--LKMSKSLKNFITIRQA----------------------------------- 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 236 cdlhggttdpvhilhkgllnrvtqlpfwskdfLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARA 315
Cdd:PTZ00399  330 --------------------------------LSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKI 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 316 YVKGQLTCGPVEEDV----LWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKeasgPRSPTVFgAIIS 391
Cdd:PTZ00399  378 KLRESELTSPQKWTQhdfeLNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLR-SVAQ 452

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 392 YVEQFFETVGISLANRQC-VSGDSSTV-TLRCVVDELVRFRLKVRQYAldtpgAAGEARKRQLQERQPLLEACDTLR-QD 468
Cdd:PTZ00399  453 YVTKILSIFGLVEGSDGLgSQGQNSTSeNFKPLLEALLRFRDEVRDAA-----KAEMKLISLDKKKKQLLQLCDKLRdEW 527

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1720428381 469 LVTHGINVKDRGSAASTWELLDP----RTRHQK 497
Cdd:PTZ00399  528 LPNLGIRIEDKPDGPSVWKLDDKeelqREKEEK 560
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
 2-488 6.82e-121

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 362.11  E-value: 6.82e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   2 NVTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYsTATGSVYFDLhARGDKYGKLVNTVP 81
Cdd:COG0215    82 GESIWELAERYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAY-EADGDVYFDV-RSFPDYGKLSGRNL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  82 -----SATAEPgDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEI 156
Cdd:COG0215   160 ddlraGARVEV-DEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEI 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 157 AQSEVFHqCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrc 236
Cdd:COG0215   239 AQSEAAT-GKPFARYWMHNGFLTVNG--EKMSKSLGNFFTV--------------------------------------- 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 237 dlhggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARAY 316
Cdd:COG0215   277 ----------------------------RDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEA 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 317 VKgqltcgpvEEDVLWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLravskeaSGPRSPTVFGAIISYVEQF 396
Cdd:COG0215   329 LG--------AADSSAEEIEELREEFIAAMDDDFNTPEALAVLFELVREINKAL-------DEGEDKAALAALAALLRAL 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 397 FETVGISLANRQCVSGDSSTVtlrcVVDELVRFRLKVRQyaldtpgaagEARKRQLQERqplleAcDTLRQDLVTHGINV 476
Cdd:COG0215   394 GGVLGLLLLEPEAWQGAAEDE----LLDALIEALIEERA----------EARKAKDFAR-----A-DRIRDELAALGIVL 453

                         490
                  ....*....|..
gi 1720428381 477 KDrGSAASTWEL 488
Cdd:COG0215   454 ED-TPDGTTWRR 464
tRNA-synt_1e pfam01406
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ...
 8-300 1.09e-90

tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.


Pssm-ID: 396128 [Multi-domain]  Cd Length: 301  Bit Score: 278.87  E-value: 1.09e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYFDLHArGDKYGKL----VNTVPSA 83
Cdd:pfam01406  75 LAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSDNGDVYFDVSS-FPDYGKLsgqnLEQLEAG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  84 TAEPGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSEVFH 163
Cdd:pfam01406 154 ARGEVSEGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQIDIHGGGIDLAFPHHENEIAQSEAAF 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 164 QcQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlhggtt 243
Cdd:pfam01406 234 D-KQLANYWLHNGHVMIDG--EKMSKSLGNFFTI---------------------------------------------- 264

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720428381 244 dpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK 300
Cdd:pfam01406 265 ---------------------RDVLKRYDPEILRYFLLSVHYRSPLDFSEELLEQAK 300
cysS TIGR00435
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ...
 2-367 1.02e-89

cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273076 [Multi-domain]  Cd Length: 464  Bit Score: 281.96  E-value: 1.02e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   2 NVTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYFDLHARgDKYGKLVNTVP 81
Cdd:TIGR00435  81 GESVYEVSERFIEAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSDNGDVYFDVSKF-KDYGKLSKQDL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  82 S-----ATAEPgDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEI 156
Cdd:TIGR00435 160 DqleagARVDV-DEAKRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEI 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 157 AQSEVFHQcQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrc 236
Cdd:TIGR00435 239 AQSEAAFG-KQLAKYWMHNGFLMIDN--EKMSKSLGNFFTV--------------------------------------- 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 237 dlhggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK----HLLLGLASFVED 312
Cdd:TIGR00435 277 ----------------------------RDVLKNYDPEILRYFLLSVHYRSPLDFSEELLEAAKnaleRLYKALRVLDTS 328

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720428381 313 ArAYVKGQ-LTCGPVEEDVlwerltstKKAVKAALANDFDTPRAVNTILDLVHHAN 367
Cdd:TIGR00435 329 L-AYSGNQsLNKFPDEKEF--------EARFVEAMDDDLNTANALAVLFELAKSIN 375
CysRS_core cd00672
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ...
 1-292 1.44e-49

catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173899 [Multi-domain]  Cd Length: 213  Bit Score: 168.91  E-value: 1.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   1 MNVTPASLASLFEEEFKQDMAALKVLPPTVYLRVtenipqiiafiegiiahghaystatgsvyfdlhargdkygklvntv 80
Cdd:cd00672    79 EGLSWKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------------------------- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  81 psataepgdsdkrhssdfalwkaakpqevfwaspwgdgrpgWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSE 160
Cdd:cd00672   113 -----------------------------------------WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQSE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 161 VFHQCqQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlhg 240
Cdd:cd00672   152 AATGK-PFARYWLHTGHLTIDG--EKMSKSLGNFITV------------------------------------------- 185

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720428381 241 gttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYS 292
Cdd:cd00672   186 ------------------------RDALKKYDPEVLRLALLSSHYRSPLDFS 213
 
Name Accession Description Interval E-value
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
 8-497 3.67e-125

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 379.37  E-value: 3.67e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYStATGSVYFDLHA-RGDK--YGKLVNTVPSAT 84
Cdd:PTZ00399  128 LARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQKIIDNGFAYE-SNGSVYFDVEAfRKAGhvYPKLEPESVADE 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  85 AEPGD---------SDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENE 155
Cdd:PTZ00399  207 DRIAEgegalgkvsGEKRSPNDFALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNE 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 156 IAQSEVFHQCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCrlsgrslldsclhccfdsiaepsrgpkgkqdlplr 235
Cdd:PTZ00399  287 LAQSEAYFDKHQWVNYFLHSGHLHIKG--LKMSKSLKNFITIRQA----------------------------------- 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 236 cdlhggttdpvhilhkgllnrvtqlpfwskdfLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARA 315
Cdd:PTZ00399  330 --------------------------------LSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKI 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 316 YVKGQLTCGPVEEDV----LWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKeasgPRSPTVFgAIIS 391
Cdd:PTZ00399  378 KLRESELTSPQKWTQhdfeLNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLR-SVAQ 452

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 392 YVEQFFETVGISLANRQC-VSGDSSTV-TLRCVVDELVRFRLKVRQYAldtpgAAGEARKRQLQERQPLLEACDTLR-QD 468
Cdd:PTZ00399  453 YVTKILSIFGLVEGSDGLgSQGQNSTSeNFKPLLEALLRFRDEVRDAA-----KAEMKLISLDKKKKQLLQLCDKLRdEW 527

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1720428381 469 LVTHGINVKDRGSAASTWELLDP----RTRHQK 497
Cdd:PTZ00399  528 LPNLGIRIEDKPDGPSVWKLDDKeelqREKEEK 560
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
 2-488 6.82e-121

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 362.11  E-value: 6.82e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   2 NVTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYsTATGSVYFDLhARGDKYGKLVNTVP 81
Cdd:COG0215    82 GESIWELAERYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAY-EADGDVYFDV-RSFPDYGKLSGRNL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  82 -----SATAEPgDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEI 156
Cdd:COG0215   160 ddlraGARVEV-DEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEI 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 157 AQSEVFHqCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrc 236
Cdd:COG0215   239 AQSEAAT-GKPFARYWMHNGFLTVNG--EKMSKSLGNFFTV--------------------------------------- 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 237 dlhggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARAY 316
Cdd:COG0215   277 ----------------------------RDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEA 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 317 VKgqltcgpvEEDVLWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLravskeaSGPRSPTVFGAIISYVEQF 396
Cdd:COG0215   329 LG--------AADSSAEEIEELREEFIAAMDDDFNTPEALAVLFELVREINKAL-------DEGEDKAALAALAALLRAL 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 397 FETVGISLANRQCVSGDSSTVtlrcVVDELVRFRLKVRQyaldtpgaagEARKRQLQERqplleAcDTLRQDLVTHGINV 476
Cdd:COG0215   394 GGVLGLLLLEPEAWQGAAEDE----LLDALIEALIEERA----------EARKAKDFAR-----A-DRIRDELAALGIVL 453

                         490
                  ....*....|..
gi 1720428381 477 KDrGSAASTWEL 488
Cdd:COG0215   454 ED-TPDGTTWRR 464
tRNA-synt_1e pfam01406
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ...
 8-300 1.09e-90

tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.


Pssm-ID: 396128 [Multi-domain]  Cd Length: 301  Bit Score: 278.87  E-value: 1.09e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYFDLHArGDKYGKL----VNTVPSA 83
Cdd:pfam01406  75 LAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSDNGDVYFDVSS-FPDYGKLsgqnLEQLEAG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  84 TAEPGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSEVFH 163
Cdd:pfam01406 154 ARGEVSEGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQIDIHGGGIDLAFPHHENEIAQSEAAF 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 164 QcQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlhggtt 243
Cdd:pfam01406 234 D-KQLANYWLHNGHVMIDG--EKMSKSLGNFFTI---------------------------------------------- 264

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720428381 244 dpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK 300
Cdd:pfam01406 265 ---------------------RDVLKRYDPEILRYFLLSVHYRSPLDFSEELLEQAK 300
cysS TIGR00435
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ...
 2-367 1.02e-89

cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273076 [Multi-domain]  Cd Length: 464  Bit Score: 281.96  E-value: 1.02e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   2 NVTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYFDLHARgDKYGKLVNTVP 81
Cdd:TIGR00435  81 GESVYEVSERFIEAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSDNGDVYFDVSKF-KDYGKLSKQDL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  82 S-----ATAEPgDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEI 156
Cdd:TIGR00435 160 DqleagARVDV-DEAKRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEI 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 157 AQSEVFHQcQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrc 236
Cdd:TIGR00435 239 AQSEAAFG-KQLAKYWMHNGFLMIDN--EKMSKSLGNFFTV--------------------------------------- 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 237 dlhggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK----HLLLGLASFVED 312
Cdd:TIGR00435 277 ----------------------------RDVLKNYDPEILRYFLLSVHYRSPLDFSEELLEAAKnaleRLYKALRVLDTS 328

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720428381 313 ArAYVKGQ-LTCGPVEEDVlwerltstKKAVKAALANDFDTPRAVNTILDLVHHAN 367
Cdd:TIGR00435 329 L-AYSGNQsLNKFPDEKEF--------EARFVEAMDDDLNTANALAVLFELAKSIN 375
PLN02946 PLN02946
cysteine-tRNA ligase
 5-198 1.68e-56

cysteine-tRNA ligase


Pssm-ID: 178532 [Multi-domain]  Cd Length: 557  Bit Score: 197.46  E-value: 1.68e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   5 PASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTAtGSVYFDLHaRGDKYGKLV------N 78
Cdd:PLN02946  143 PISLSRRYCEEFLSDMAYLHCLPPSVEPRVSDHIPQIIDMIKQILDNGCAYRVD-GDVYFSVD-KFPEYGKLSgrkledN 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  79 TVPSATAEpgDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQ 158
Cdd:PLN02946  221 RAGERVAV--DSRKKNPADFALWKAAKEGEPFWDSPWGPGRPGWHIECSAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQ 298

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1720428381 159 SEVfHQCQQWGNYFLHSGHLHVKgtEEKMSKSLKNYITIK 198
Cdd:PLN02946  299 SCA-ACCDSNISYWIHNGFVTVD--SEKMSKSLGNFFTIR 335
cysS PRK14535
cysteinyl-tRNA synthetase; Provisional
 4-386 9.83e-55

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 173001 [Multi-domain]  Cd Length: 699  Bit Score: 195.32  E-value: 9.83e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   4 TPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYF---DLHARGDKYGKLVNTV 80
Cdd:PRK14535  310 TIGELTARFIQAMHEDADALGVLRPDIEPKATENIPQMIAMIETLIQNGKAYPAANGDVYYavrEFAAYGQLSGKSLDDL 389

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  81 PSATAEPGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQS- 159
Cdd:PRK14535  390 RAGERVEVDGFKRDPLDFVLWKAAKAGEPAWESPWGNGRPGWHIECSAMSENLFGDTFDIHGGGADLQFPHHENEIAQSv 469

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 160 -EVFHQCQQWG-------------NYFLHSGHLHVKGteEKMSKSLKNYITIKDCrlsgrslldsclhccfdsiaepsrg 225
Cdd:PRK14535  470 gATGHTCGHHHaqthhgqsiashvKYWLHNGFIRVDG--EKMSKSLGNFFTIREV------------------------- 522

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 226 pkgkqdlplrcdlhggttdpvhilhkgllnrvtqlpfwskdfLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLG 305
Cdd:PRK14535  523 ------------------------------------------LKQYDPEVVRFFILRAHYRSPLNYSDAHLDDAKGALTR 560

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 306 LASFVEDArayvkgqltcgPVEEDVLWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANR----QLRAVSKEASG-- 379
Cdd:PRK14535  561 LYTTLKNT-----------PAAEFMLSENVNDYTRRFYAAMNDDFGTVEAVAVLFELAGEVNKtndaQLAGCLKALGGii 629

                         410
                  ....*....|
gi 1720428381 380 ---PRSPTVF 386
Cdd:PRK14535  630 gllQRDPTEF 639
CysRS_core cd00672
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ...
 1-292 1.44e-49

catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173899 [Multi-domain]  Cd Length: 213  Bit Score: 168.91  E-value: 1.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   1 MNVTPASLASLFEEEFKQDMAALKVLPPTVYLRVtenipqiiafiegiiahghaystatgsvyfdlhargdkygklvntv 80
Cdd:cd00672    79 EGLSWKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------------------------- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  81 psataepgdsdkrhssdfalwkaakpqevfwaspwgdgrpgWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSE 160
Cdd:cd00672   113 -----------------------------------------WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQSE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 161 VFHQCqQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlhg 240
Cdd:cd00672   152 AATGK-PFARYWLHTGHLTIDG--EKMSKSLGNFITV------------------------------------------- 185

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720428381 241 gttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYS 292
Cdd:cd00672   186 ------------------------RDALKKYDPEVLRLALLSSHYRSPLDFS 213
PRK12418 PRK12418
cysteinyl-tRNA synthetase; Provisional
 16-359 2.55e-46

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 183518 [Multi-domain]  Cd Length: 384  Bit Score: 165.87  E-value: 2.55e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  16 FKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAY---STATGSVYFDLHARGDkYGKLVNTVPSATAE------ 86
Cdd:PRK12418   83 FREDMEALRVLPPRDYVGAVESIPEVVELVEKLLASGAAYvvdDEEYPDVYFSVDATPQ-FGYESGYDRATMLElfaerg 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  87 --PGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSEVFHQ 164
Cdd:PRK12418  162 gdPDRPGKRDPLDALLWRAARPGEPSWPSPFGPGRPGWHIECSAIALNRLGSGFDIQGGGSDLIFPHHEFSAAHAEAATG 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 165 CQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCRLSGrslldsclhccfdsiaepsrgpkgkqdlplrcdlhggtTD 244
Cdd:PRK12418  242 ERRFARHYVHAGMIGLDG--EKMSKSRGNLVFVSRLRAAG--------------------------------------VD 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 245 PVHIlhkgllnrvtqlpfwskdflktfspdvfRLFCLRTNYRSAIEYSDSTLVEAKHLLlglasfvEDARAYVKgqLTCG 324
Cdd:PRK12418  282 PAAI----------------------------RLALLAGHYRADREWTDAVLAEAEARL-------ARWRAAAA--LPAG 324

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1720428381 325 PVEEDVLwerltstkKAVKAALANDFDTPRAVNTI 359
Cdd:PRK12418  325 PDAADVV--------ARVRAALADDLDTPGALAAV 351
mycothiol_MshC TIGR03447
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this ...
 16-355 6.88e-44

cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 132488 [Multi-domain]  Cd Length: 411  Bit Score: 159.89  E-value: 6.88e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  16 FKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAY---STATGSVYFDLHArGDKYGKLVN----TVPSATAE-- 86
Cdd:TIGR03447 110 FREDMEALRVLPPRDYIGAVESIDEVVEMVEKLLASGAAYiveGPEYPDVYFSIDA-TEQFGYESGydraTMLELFAErg 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  87 --PGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSEVFHQ 164
Cdd:TIGR03447 189 gdPDRPGKRDPLDALLWRAAREGEPSWDSPFGRGRPGWHIECSAIALNRLGAGFDIQGGGSDLIFPHHEFSAAHAEAATG 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 165 CQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCRLSGrslldsclhccfdsiaepsrgpkgkqdlplrcdlhggtTD 244
Cdd:TIGR03447 269 VRRMARHYVHAGMIGLDG--EKMSKSLGNLVFVSKLRAAG--------------------------------------VD 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 245 PVHIlhkgllnrvtqlpfwskdflktfspdvfRLFCLRTNYRSAIEYSDSTLVEAKHLLlglasfvedARAYVKGQLTCG 324
Cdd:TIGR03447 309 PAAI----------------------------RLGLLAGHYRQDRDWTDAVLAEAEARL---------ARWRAALALPDA 351

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1720428381 325 PVEEDVLwerltstkKAVKAALANDFDTPRA 355
Cdd:TIGR03447 352 PDATDLI--------ARLRQHLANDLDTPAA 374
cysS PRK14536
cysteinyl-tRNA synthetase; Provisional
 8-363 3.39e-40

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 184731 [Multi-domain]  Cd Length: 490  Bit Score: 151.61  E-value: 3.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYsTATGSVYFDLHARGDkYGKLVNT----VPSA 83
Cdd:PRK14536   99 IAAHYTAAFFRDTARLNIERPSIVCNATEHIQDMIALIKRLEARGHTY-CAGGNVYFDIRTFPS-YGSLASAavedLQAG 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  84 TAEPGDSDKRHSSDFALW---KAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSE 160
Cdd:PRK14536  177 ARIEHDTNKRNPHDFVLWftrSKFENHALTWDSPWGRGYPGWHIECSAMSMKYLGEQCDIHIGGVDHIRVHHTNEIAQCE 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 161 VFhQCQQWGNYFLHSGHLHVKgtEEKMSKSLKNYITIKDcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlhg 240
Cdd:PRK14536  257 AA-TGKPWVRYWLHHEFLLMN--KGKMSKSAGQFLTLSS----------------------------------------- 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381 241 gttdpvhILHKGllnrvtqlpfwskdflktFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK----HLLLGLASFVEDARAY 316
Cdd:PRK14536  293 -------LQEKG------------------FQPLDYRFFLLGGHYRSQLAFSWEALKTAKaarrSLVRRVARVVDAARAT 347

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720428381 317 ---VKGQLTcgpveeDVLWERLTSTKKA--------VKAALANDFDTPRAVNTILDLV 363
Cdd:PRK14536  348 tgsVRGTLA------ECAAERVAESRASesellltdFRAALEDDFSTPKALSELQKLV 399
cysS PRK14534
cysteinyl-tRNA synthetase; Provisional
 3-209 1.32e-33

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 173000 [Multi-domain]  Cd Length: 481  Bit Score: 132.67  E-value: 1.32e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381   3 VTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYsTATGSVYFDLhARGDKYGKL----VN 78
Cdd:PRK14534   92 LTVYEISRFFTEAFFDDCKKLNIVYPDKVLVASEYIPIMIEVVKVLEENGFTY-FVNGNVYFDT-SCFKSYGQMaginLN 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428381  79 TVPSATAEPGDSD--KRHSSDFALW---KAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHE 153
Cdd:PRK14534  170 DFKDMSVSRVEIDksKRNKSDFVLWftnSKFKDQEMKWDSPWGFGYPSWHLECAAMNLEYFKSTLDIHLGGVDHIGVHHI 249

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720428381 154 NEIAQSEVFHQcQQWGNYFLHSGHLHVKgtEEKMSKSLKNYITIKDCRLSGRSLLD 209
Cdd:PRK14534  250 NEIAIAECYLN-KKWCDMFVHGEFLIME--YEKMSKSNNNFITIKDLEDQGFSPLD 302
class_I_aaRS_core cd00802
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ...
 121-191 1.34e-04

catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173901 [Multi-domain]  Cd Length: 143  Bit Score: 42.08  E-value: 1.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720428381 121 GWHIECSTMASEVFGSHLDIHTGGIDLAFpHHENEIAQSEVFHqcQQWGNYFLHSGHLHVKGTeEKMSKSL 191
Cdd:cd00802    77 EYMFLQAADFLLLYETECDIHLGGSDQLG-HIELGLELLKKAG--GPARPFGLTFGRVMGADG-TKMSKSK 143
DALR_2 pfam09190
DALR domain; This DALR domain is found in cysteinyl-tRNA-synthetases.
 341-377 2.15e-03

DALR domain; This DALR domain is found in cysteinyl-tRNA-synthetases.


Pssm-ID: 462711 [Multi-domain]  Cd Length: 63  Bit Score: 36.41  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720428381 341 AVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKEA 377
Cdd:pfam09190   1 KFIEAMDDDFNTPEALAVLFELAKEINRALKTNDAEA 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH