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Conserved domains on  [gi|1720428492|ref|XP_030099659|]
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proline-rich protein 36 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 382-790 8.00e-13

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 73.43  E-value: 8.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  382 PPPRAVISSSPPPLIQNMPPNQASSA------TLPQETLSAMPF-----SPAPLSLASSPPQLLPSPPISPQNLPTSLVT 450
Cdd:PHA03247  2559 APPAAPDRSVPPPRPAPRPSEPAVTSrarrpdAPPQSARPRAPVddrgdPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  451 SSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLflAISPPVSSSTSISPPL--PTSSVVTPPLRLPLSQTLPTSQA 528
Cdd:PHA03247  2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALV 2716

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  529 SLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLPLSSPPASPPLP 608
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  609 ALLSPPASPPLESPLSPSASPSSPLATP-PPEAPPSLGSPTLSPLATPPPQTPPLAF-----------PPLPASTSSLDT 676
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrRPPSRSPAAKPA 2876

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  677 ATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPPLQIPLVVLPTLQTPPSPLTTFPPGVPPGL 756
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1720428492  757 TSPVVQPPSPPASPPLQAPR-RPPTPGPDVPITGP 790
Cdd:PHA03247  2957 GAVPQPWLGALVPGRVAVPRfRVPQPAPSREAPAS 2991
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
 1004-1046 1.02e-09

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


:

Pssm-ID: 464673  Cd Length: 46  Bit Score: 54.93  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720428492 1004 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1046
Cdd:pfam15363    5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
10-261 3.34e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 3.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   10 APGVCKAALPQTSKAALPQTSKAALPQTSKAALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGK--GERAPMKT 87
Cdd:PRK07003   368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADrgDDAADGDA 447

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   88 PGQGSISSPGRASSGIARPGPvvqkrlQPPTKEPSARGKTPETPKRNTLNSGTRRVLSADSLGPTSGAPS-PAITRRSRA 166
Cdd:PRK07003   448 PVPAKANARASADSRCDERDA------QPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARaPAAASREDA 521

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  167 PAtevglPQPAPSARQRPLTTEAARKPGSSASEPSATEL--SPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVsP 244
Cdd:PRK07003   522 PA-----AAAPPAPEARPPTPAAAAPAARAGGAAAALDVlrNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAV-Q 595

                          250
                   ....*....|....*..
gi 1720428492  245 RVTPRAPAHTSQLKSKG 261
Cdd:PRK07003   596 VPTPRARAATGDAPPNG 612
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 382-790 8.00e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 73.43  E-value: 8.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  382 PPPRAVISSSPPPLIQNMPPNQASSA------TLPQETLSAMPF-----SPAPLSLASSPPQLLPSPPISPQNLPTSLVT 450
Cdd:PHA03247  2559 APPAAPDRSVPPPRPAPRPSEPAVTSrarrpdAPPQSARPRAPVddrgdPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  451 SSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLflAISPPVSSSTSISPPL--PTSSVVTPPLRLPLSQTLPTSQA 528
Cdd:PHA03247  2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALV 2716

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  529 SLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLPLSSPPASPPLP 608
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  609 ALLSPPASPPLESPLSPSASPSSPLATP-PPEAPPSLGSPTLSPLATPPPQTPPLAF-----------PPLPASTSSLDT 676
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrRPPSRSPAAKPA 2876

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  677 ATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPPLQIPLVVLPTLQTPPSPLTTFPPGVPPGL 756
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1720428492  757 TSPVVQPPSPPASPPLQAPR-RPPTPGPDVPITGP 790
Cdd:PHA03247  2957 GAVPQPWLGALVPGRVAVPRfRVPQPAPSREAPAS 2991
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
 1004-1046 1.02e-09

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


Pssm-ID: 464673  Cd Length: 46  Bit Score: 54.93  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720428492 1004 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1046
Cdd:pfam15363    5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
10-261 3.34e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 3.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   10 APGVCKAALPQTSKAALPQTSKAALPQTSKAALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGK--GERAPMKT 87
Cdd:PRK07003   368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADrgDDAADGDA 447

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   88 PGQGSISSPGRASSGIARPGPvvqkrlQPPTKEPSARGKTPETPKRNTLNSGTRRVLSADSLGPTSGAPS-PAITRRSRA 166
Cdd:PRK07003   448 PVPAKANARASADSRCDERDA------QPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARaPAAASREDA 521

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  167 PAtevglPQPAPSARQRPLTTEAARKPGSSASEPSATEL--SPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVsP 244
Cdd:PRK07003   522 PA-----AAAPPAPEARPPTPAAAAPAARAGGAAAALDVlrNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAV-Q 595

                          250
                   ....*....|....*..
gi 1720428492  245 RVTPRAPAHTSQLKSKG 261
Cdd:PRK07003   596 VPTPRARAATGDAPPNG 612
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 329-727 6.74e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 6.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  329 QPQASSQAVPHSQSGQGSPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPP-PLIQNMPPNQASSA 407
Cdd:pfam03154  163 QQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  408 TLPQETLSAMPFSPAPlslassppqllpsPPISPQNLPTSLVTSSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPL 487
Cdd:pfam03154  243 PSPHPPLQPMTQPPPP-------------SQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  488 FLAISPPVSSSTSISPPLPTSSVVTPPLRLPLSQTLPTSQASLL------TLPPSLASSPQPATPPPLALSPLSTQLSTG 561
Cdd:pfam03154  310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhikpppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSN 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  562 SPSLQASPSFLPTPPMQPRALPSPSLQAPPvtYPLPLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAP 641
Cdd:pfam03154  390 LPPPPALKPLSSLSTHHPPSAHPPPLQLMP--QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  642 PSLGSPTLSPLATPPPQTPPLAFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIP-CPQTPPslalPSLQSPSSP 720
Cdd:pfam03154  468 VPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAeEPESPP----PPPRSPSPE 543


                   ....*..
gi 1720428492  721 LATATPP 727
Cdd:pfam03154  544 PTVVNTP 550
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 382-790 8.00e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 73.43  E-value: 8.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  382 PPPRAVISSSPPPLIQNMPPNQASSA------TLPQETLSAMPF-----SPAPLSLASSPPQLLPSPPISPQNLPTSLVT 450
Cdd:PHA03247  2559 APPAAPDRSVPPPRPAPRPSEPAVTSrarrpdAPPQSARPRAPVddrgdPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  451 SSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLflAISPPVSSSTSISPPL--PTSSVVTPPLRLPLSQTLPTSQA 528
Cdd:PHA03247  2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALV 2716

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  529 SLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLPLSSPPASPPLP 608
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  609 ALLSPPASPPLESPLSPSASPSSPLATP-PPEAPPSLGSPTLSPLATPPPQTPPLAF-----------PPLPASTSSLDT 676
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrRPPSRSPAAKPA 2876

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  677 ATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPPLQIPLVVLPTLQTPPSPLTTFPPGVPPGL 756
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1720428492  757 TSPVVQPPSPPASPPLQAPR-RPPTPGPDVPITGP 790
Cdd:PHA03247  2957 GAVPQPWLGALVPGRVAVPRfRVPQPAPSREAPAS 2991
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
 1004-1046 1.02e-09

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


Pssm-ID: 464673  Cd Length: 46  Bit Score: 54.93  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720428492 1004 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1046
Cdd:pfam15363    5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
PHA03247 PHA03247
large tegument protein UL36; Provisional
 67-663 1.10e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   67 PRSPANRPPASGKGERAPMKTPGQGSISSPGRAssgiARPGPVVQKrlqpPTKEPSARGKTPETPKRNTLNSGTRRVLSA 146
Cdd:PHA03247  2475 PGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPD----APPAPSRLA----PAILPDEPVGEPVHPRMLTWIRGLEELASD 2546

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  147 DSLGPTSGAPSPAitrRSRAPATEVGLPQPAPSARQRPLTTEAAR----------------------KPGSSASEPSATE 204
Cdd:PHA03247  2547 DAGDPPPPLPPAA---PPAAPDRSVPPPRPAPRPSEPAVTSRARRpdappqsarprapvddrgdprgPAPPSPLPPDTHA 2623

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  205 LSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVSPRVTPRAPAHTSQLKSKGQ----QALHPTQTTVPRKNKPSV 280
Cdd:PHA03247  2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQrprrRAARPTVGSLTSLADPPP 2703

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  281 QSLIPASSlVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSGQGSPSPPPLSLQNLPST 360
Cdd:PHA03247  2704 PPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  361 PATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPliqNMPPNQASSATLPQETlSAMPFSPAPLSlASSPPQLLPSPPIS 440
Cdd:PHA03247  2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAA---ALPPAASPAGPLPPPT-SAQPTAPPPPP-GPPPPSLPLGGSVA 2857

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  441 P----QNLPTSLVTSSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLFLAISPPVSSSTSISPPLPTSSVVTPPLR 516
Cdd:PHA03247  2858 PggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  517 LPLSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSflPTPPMQPRALPSPSLQAPPVTYPL 596
Cdd:PHA03247  2938 RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS--STPPLTGHSLSRVSSWASSLALHE 3015

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720428492  597 PLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAPPSLGSPTLSPLATPPP----QTPPLA 663
Cdd:PHA03247  3016 ETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEagarESPSSQ 3086
PHA03247 PHA03247
large tegument protein UL36; Provisional
 27-593 1.38e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   27 PQTSKAALPQTSKAALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGErapmkTPGQGSISSPGRASSGIARP 106
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGD-----PRGPAPPSPLPPDTHAPDPP 2627

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  107 GPVVQKRLQPPTKEPSARGKTPETPKRNTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPATEVGlpqpapsarqrPLT 186
Cdd:PHA03247  2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG-----------SLT 2696

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  187 TEAARKPGSSASEPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVSPRVTPRAPAHTSQLKSKGQQAlh 266
Cdd:PHA03247  2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA-- 2774

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  267 PTQTTVPRKNKPSVQSLIPA-SSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSGQG 345
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESrESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  346 SPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPLIQNMPPNQASSATLPQETLSAMPF-SPAPL 424
Cdd:PHA03247  2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQpQPPPP 2934

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  425 SLASSPPQLLPSPPISPQNLPTSLVTSSQLPLSTPFRA---NFSESPPLPRATLANRTTPSLQDPLFLAISPPVSSSTSI 501
Cdd:PHA03247  2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVavpRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALH 3014

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  502 SPPLPTSSVVTPPLRLPLSQTLPTSQASLLTLPPSL-ASSPQPATPPPlalsplstqlstgsPSLQASPSFLPTPPMQPR 580
Cdd:PHA03247  3015 EETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSdLEALDPLPPEP--------------HDPFAHEPDPATPEAGAR 3080

                          570
                   ....*....|...
gi 1720428492  581 ALPSPSLQAPPVT 593
Cdd:PHA03247  3081 ESPSSQFGPPPLS 3093
PHA03247 PHA03247
large tegument protein UL36; Provisional
 503-936 9.15e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 9.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  503 PPLPTSSVVTPPlrlplSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLP---TPPMQP 579
Cdd:PHA03247  2553 PPLPPAAPPAAP-----DRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPpdtHAPDPP 2627

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  580 RALPSPSLQAPPVTYPLPLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAPPSLGSptLSPLATPPPQt 659
Cdd:PHA03247  2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGS--LTSLADPPPP- 2704

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  660 pPLAFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIPC----------PQTPPSLALP-SLQSPSSPLATATPPL 728
Cdd:PHA03247  2705 -PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAgpatpggparPARPPTTAGPpAPAPPAAPAAGPPRRL 2783

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  729 QIPLVVLPTLQTPPSPLTTFPPGVPPGLTSPVVQPPSPPASPPLQAPRRPPTPGPDVPITGP------------------ 790
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPpppslplggsvapggdvr 2863

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  791 -RLTLALAPAPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGCPTISPAPDADLAACHPASWSRSSAPQLA 869
Cdd:PHA03247  2864 rRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720428492  870 VRSTPGVPLPWPPTAGPGSSDGLCTIYESEGPESVAPTPGSLDVEPEPMPGSGSAKVTAADCAGASS 936
Cdd:PHA03247  2944 APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
10-261 3.34e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 3.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   10 APGVCKAALPQTSKAALPQTSKAALPQTSKAALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGK--GERAPMKT 87
Cdd:PRK07003   368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADrgDDAADGDA 447

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   88 PGQGSISSPGRASSGIARPGPvvqkrlQPPTKEPSARGKTPETPKRNTLNSGTRRVLSADSLGPTSGAPS-PAITRRSRA 166
Cdd:PRK07003   448 PVPAKANARASADSRCDERDA------QPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARaPAAASREDA 521

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  167 PAtevglPQPAPSARQRPLTTEAARKPGSSASEPSATEL--SPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVsP 244
Cdd:PRK07003   522 PA-----AAAPPAPEARPPTPAAAAPAARAGGAAAALDVlrNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAV-Q 595

                          250
                   ....*....|....*..
gi 1720428492  245 RVTPRAPAHTSQLKSKG 261
Cdd:PRK07003   596 VPTPRARAATGDAPPNG 612
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-353 1.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492    2 GRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTSKAALPQTSKAALPQTTIHG-APARSAGAGPRSPANRPPASGKG 80
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLApAAALPPAASPAGPLPPPTSAQPT 2837

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   81 ERAPMKTPGQGSISSPGrassGIARPGPVvqkRLQPPTKEPSARGKTPETPK-RNTLNSGTRRVLSADSLGPTSGA--PS 157
Cdd:PHA03247  2838 APPPPPGPPPPSLPLGG----SVAPGGDV---RRRPPSRSPAAKPAAPARPPvRRLARPAVSRSTESFALPPDQPErpPQ 2910

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  158 PAITRRSRAPATEVGLPQPAPSARQRPLTTEAARKPGSSASEPSATELSPAFRRRSVAGGSLqkPVSRSLIPSATPQLSP 237
Cdd:PHA03247  2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRV--AVPRFRVPQPAPSREA 2988

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  238 SRSGVSPRVTPRAPAHTSQLKSkgqQALHPTQTTVPRKNKpsvQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPT 317
Cdd:PHA03247  2989 PASSTPPLTGHSLSRVSSWASS---LALHEETDPPPVSLK---QTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEP 3062

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1720428492  318 TPPLPASLQLLQPQASSQAVPHSQSGqgspsPPPLS 353
Cdd:PHA03247  3063 HDPFAHEPDPATPEAGARESPSSQFG-----PPPLS 3093
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 57-394 1.29e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   57 GAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTKEPSARGKTPETPKRNTL 136
Cdd:PRK07764   398 APSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPT 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  137 nsgtrrvlSADSLGPTSGAPSPAITRRSRAPATEVGlPQPAPSARQ-----------RPLTTEAARKPGSSASEPSATEL 205
Cdd:PRK07764   478 --------AAPAPAPPAAPAPAAAPAAPAAPAAPAG-ADDAATLRErwpeilaavpkRSRKTWAILLPEATVLGVRGDTL 548

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  206 SPAFRR-------------------------------------RSVAGGSLQKPVSRSLIPSATPQLSPSRSGV-----S 243
Cdd:PRK07764   549 VLGFSTgglarrfaspgnaevlvtalaeelggdwqveavvgpaPGAAGGEGPPAPASSGPPEEAARPAAPAAPAapaapA 628

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  244 PRVTPRAPAHTSQLKSKGQQALHPTQTTVPRknkPSVQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPA 323
Cdd:PRK07764   629 PAGAAAAPAEASAAPAPGVAAPEHHPKHVAV---PDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720428492  324 SLQLLQPQASSQAVPHSQSGQGSPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPP 394
Cdd:PRK07764   706 AATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776
PHA03247 PHA03247
large tegument protein UL36; Provisional
 534-955 4.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  534 PPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPvtyplplssppASPPLPALLSP 613
Cdd:PHA03247  2512 PSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVP-----------PPRPAPRPSEP 2580

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  614 PASPPLESPLSPSASPSSPLATPPPEAPPSLGSPTLSPLATPPPQTPPLAFPPLPASTSSLDTATCFPQgpllalPPLQT 693
Cdd:PHA03247  2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPP------ERPRD 2654

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  694 SPSPLTIPCPQTPPSLALPSlqSPSSPLATATPPLQIPLVV-LPTLQTPPSPltTFPPGVPPGLTSPVVQPPSPPASPPL 772
Cdd:PHA03247  2655 DPAPGRVSRPRRARRLGRAA--QASSPPQRPRRRAARPTVGsLTSLADPPPP--PPTPEPAPHALVSATPLPPGPAAARQ 2730

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  773 QAPRRPPTPGPDVPITGPRLTLALAPAPPPPPSRSPSSTLSGPDLAGHSSSATSTPeelrgydSGPEGCPTISPAPDADL 852
Cdd:PHA03247  2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP-------AVASLSESRESLPSPWD 2803

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  853 AACHPASWSrSSAPQLAVRSTPGVPLPWPPTAGPGSSdglctiyesegPESVAPTPGSLDVEPEPMPGSGSAKVTAADCA 932
Cdd:PHA03247  2804 PADPPAAVL-APAAALPPAASPAGPLPPPTSAQPTAP-----------PPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP 2871

                          410       420
                   ....*....|....*....|...
gi 1720428492  933 GASSRSPKSARLGELPLGALQAS 955
Cdd:PHA03247  2872 AAKPAAPARPPVRRLARPAVSRS 2894
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 6-255 5.29e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 5.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492    6 LVERAPGVCKAALPQTSKAALPQTSKAALPQTSKAALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPM 85
Cdd:PHA03307   134 LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPI 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   86 KTPGQGSISSPGRASSGIARPGPVVQKRLQPPTKEPSARGKTPE-TPKRNTLNSGTRRVLSADSLGPTSGAPSPAITRRS 164
Cdd:PHA03307   214 SASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLpRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRE 293

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  165 RAPATEVGLPQPAPSARQRPLTTEAARKPGSSASEPSATelSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVSP 244
Cdd:PHA03307   294 RSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS--SESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRP 371

                          250
                   ....*....|.
gi 1720428492  245 RVTPRAPAHTS 255
Cdd:PHA03307   372 SRAPSSPAASA 382
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 329-727 6.74e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 6.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  329 QPQASSQAVPHSQSGQGSPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPP-PLIQNMPPNQASSA 407
Cdd:pfam03154  163 QQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  408 TLPQETLSAMPFSPAPlslassppqllpsPPISPQNLPTSLVTSSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPL 487
Cdd:pfam03154  243 PSPHPPLQPMTQPPPP-------------SQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  488 FLAISPPVSSSTSISPPLPTSSVVTPPLRLPLSQTLPTSQASLL------TLPPSLASSPQPATPPPLALSPLSTQLSTG 561
Cdd:pfam03154  310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhikpppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSN 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  562 SPSLQASPSFLPTPPMQPRALPSPSLQAPPvtYPLPLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAP 641
Cdd:pfam03154  390 LPPPPALKPLSSLSTHHPPSAHPPPLQLMP--QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492  642 PSLGSPTLSPLATPPPQTPPLAFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIP-CPQTPPslalPSLQSPSSP 720
Cdd:pfam03154  468 VPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAeEPESPP----PPPRSPSPE 543


                   ....*..
gi 1720428492  721 LATATPP 727
Cdd:pfam03154  544 PTVVNTP 550
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
16-235 8.16e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 8.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   16 AALPQTSKAALPQTSKAALPQTSKAALPQTSKAALPQTTIHGAPARS--AGAGPRSPAnrppasgkgeRAPMKTPGQGSI 93
Cdd:PRK12323   372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAvaAAPARRSPA----------PEALAAARQASA 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   94 SSPGRASSGIARPGPVVQKRLQPPTKEPSARGKTPETPKRNTLNSGTRRVLSAD-----SLGPTSGAPSPAITRRSRAPA 168
Cdd:PRK12323   442 RGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppweELPPEFASPAPAQPDAAPAGW 521

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720428492  169 TEVGLPQPAPSARQRPLTTEAARKPGSSASEPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQL 235
Cdd:PRK12323   522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARL 588
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
10-198 8.52e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 8.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   10 APGVCKAALPQTSKAALPQTSKAALPQTSKAALPQTSKAALPQTtiHGAPARSAGAGPRSPANRPPASGKGERAPMKTPG 89
Cdd:PRK12323   393 AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAA--RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPR 470

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428492   90 QGSISSPGRASSGIARPGPVVQKRLQPPTKEPSArgkTPETPKRNTLNSGTRRVLSADSLGPTSGAPSPAitrrsRAPAT 169
Cdd:PRK12323   471 PVAAAAAAAPARAAPAAAPAPADDDPPPWEELPP---EFASPAPAQPDAAPAGWVAESIPDPATADPDDA-----FETLA 542

                          170       180
                   ....*....|....*....|....*....
gi 1720428492  170 EVGLPQPAPSARQRPLTTEAARKPGSSAS 198
Cdd:PRK12323   543 PAPAAAPAPRAAAATEPVVAPRPPRASAS 571
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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