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Conserved domains on  [gi|1720432065|ref|XP_030100300|]
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zinc finger protein 778 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
70-483 2.75e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 2.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065  70 KKSYECKECGKSFKYSANLNIHMRTHTGEKPYQC--KECGKAFSRCYPLTQHLKTHTEEKPFEC--KVCGKCFRNSSCLN 145
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 146 DHFRVHTgIKPYKCKDCGKAFTGRSGLSKHLPTHTGEKPYECKECGKAFPSTSGLIKHMKSHMGERPFECDHCGKAFASS 225
Cdd:COG5048   111 SSSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 226 STLITHLRTH--------TGEKPFECQVCGKAFTCSSYLrIHMRTHTGEKPYVCKecgraftERTSLTKHLRTHTGENPF 297
Cdd:COG5048   190 SNVSTSIPSSsensplssSYSIPSSSSDQNLENSSSSLP-LTTNSQLSPKSLLSQ-------SPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 298 ECNMCGKAFACSSYLHNHIRTHTG-EKPYVCKECGKAFTVSSHLSKHVR--IHTGE--KPHKCEE--CGKAFTVRSGLTK 370
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 371 HIRTHTGEKPYNCK--ECGKAFTTSS-----GLLEHKRSHTGEKPYECD--QCGKAFASSSYLIAHLRIHTGEKP--FEC 439
Cdd:COG5048   342 HILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1720432065 440 NECGKAFTCSSYLHIHMRTHTGEKPYDCkECGKTFAVYSHLSKH 483
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
70-483 2.75e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 2.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065  70 KKSYECKECGKSFKYSANLNIHMRTHTGEKPYQC--KECGKAFSRCYPLTQHLKTHTEEKPFEC--KVCGKCFRNSSCLN 145
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 146 DHFRVHTgIKPYKCKDCGKAFTGRSGLSKHLPTHTGEKPYECKECGKAFPSTSGLIKHMKSHMGERPFECDHCGKAFASS 225
Cdd:COG5048   111 SSSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 226 STLITHLRTH--------TGEKPFECQVCGKAFTCSSYLrIHMRTHTGEKPYVCKecgraftERTSLTKHLRTHTGENPF 297
Cdd:COG5048   190 SNVSTSIPSSsensplssSYSIPSSSSDQNLENSSSSLP-LTTNSQLSPKSLLSQ-------SPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 298 ECNMCGKAFACSSYLHNHIRTHTG-EKPYVCKECGKAFTVSSHLSKHVR--IHTGE--KPHKCEE--CGKAFTVRSGLTK 370
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 371 HIRTHTGEKPYNCK--ECGKAFTTSS-----GLLEHKRSHTGEKPYECD--QCGKAFASSSYLIAHLRIHTGEKP--FEC 439
Cdd:COG5048   342 HILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1720432065 440 NECGKAFTCSSYLHIHMRTHTGEKPYDCkECGKTFAVYSHLSKH 483
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
87-112 6.03e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.03e-05
                          10        20
                  ....*....|....*....|....*.
gi 1720432065  87 NLNIHMRTHTGEKPYQCKECGKAFSR 112
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 211-262 3.34e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720432065 211 RPFeCDHCGKAFASSSTLITHLRTHTgekpFECQVCGKAFTCSSYLRIHMRT 262
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
70-483 2.75e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 2.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065  70 KKSYECKECGKSFKYSANLNIHMRTHTGEKPYQC--KECGKAFSRCYPLTQHLKTHTEEKPFEC--KVCGKCFRNSSCLN 145
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 146 DHFRVHTgIKPYKCKDCGKAFTGRSGLSKHLPTHTGEKPYECKECGKAFPSTSGLIKHMKSHMGERPFECDHCGKAFASS 225
Cdd:COG5048   111 SSSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 226 STLITHLRTH--------TGEKPFECQVCGKAFTCSSYLrIHMRTHTGEKPYVCKecgraftERTSLTKHLRTHTGENPF 297
Cdd:COG5048   190 SNVSTSIPSSsensplssSYSIPSSSSDQNLENSSSSLP-LTTNSQLSPKSLLSQ-------SPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 298 ECNMCGKAFACSSYLHNHIRTHTG-EKPYVCKECGKAFTVSSHLSKHVR--IHTGE--KPHKCEE--CGKAFTVRSGLTK 370
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 371 HIRTHTGEKPYNCK--ECGKAFTTSS-----GLLEHKRSHTGEKPYECD--QCGKAFASSSYLIAHLRIHTGEKP--FEC 439
Cdd:COG5048   342 HILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1720432065 440 NECGKAFTCSSYLHIHMRTHTGEKPYDCkECGKTFAVYSHLSKH 483
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-259 1.18e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065  99 KPYQCKECGKAFSRCYPLTQHLKT--HTEE--KPFECKV--CGKCFRNSSCLNDHFRVHTGIKPYKCK--DCGKAFTGRS 170
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 171 GLSKHLPTH-----TGEKPYEC--KECGKAFPSTSGLIKHMKSHMGERP--FECDHCGKAFASSSTLITHLRTHTGEKPF 241
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*...
gi 1720432065 242 ECQVCGKAFTCSSYLRIH 259
Cdd:COG5048   448 LCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-498 3.48e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 211 RPFECDHCGKAFASSSTLITHLRTHTGEKPFECQVCGKAFTCSSY--LRIHMRTHTGEKPYVCKECGRAFTERTSLTKHL 288
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 289 RTHTGENPFE-CNMCGKAFACSSYLHNHIRTHTGEKPYVCKEC-GKAFTVSSHLSKHVRIHTGEKPHKCEECGKAFTVRS 366
Cdd:COG5048   112 SSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 367 GLTKHIRTHTGE------KPYNCKECGKAFTTSSGLLEHKRSHTGEKPYecDQCGKAFASSSYLIAHLRIH--------- 431
Cdd:COG5048   192 VSTSIPSSSENSplsssySIPSSSSDQNLENSSSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESprsslptas 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 432 ---------------TGEKPFECNECGKAFTCSSYLHIHMRT--HTGE--KPYDCKE--CGKTFAVYSHLSKHVRIHSGE 490
Cdd:COG5048   270 sqssspnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                  ....*...
gi 1720432065 491 KAYTCKSD 498
Cdd:COG5048   350 SPAKEKLL 357
zf-H2C2_2 pfam13465
Zinc-finger double domain;
87-112 6.03e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.03e-05
                          10        20
                  ....*....|....*....|....*.
gi 1720432065  87 NLNIHMRTHTGEKPYQCKECGKAFSR 112
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-363 2.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.81e-04
                          10        20
                  ....*....|....*....|....*
gi 1720432065 339 HLSKHVRIHTGEKPHKCEECGKAFT 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 181-264 2.97e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 181 GEKPYECK--ECGKAFPSTSGLIKHMKShmgerpfecDHCGKAFASSSTLITHLRTHTGEKPFECQVCGKAFTCSSYLRI 258
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720432065 259 HmRTHT 264
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-279 5.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.32e-04
                          10        20
                  ....*....|....*....|....*
gi 1720432065 255 YLRIHMRTHTGEKPYVCKECGRAFT 279
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-420 6.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.35e-04
                          10        20
                  ....*....|....*....|....*
gi 1720432065 396 LLEHKRSHTGEKPYECDQCGKAFAS 420
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-392 6.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.87e-04
                          10        20
                  ....*....|....*....|....*
gi 1720432065 368 LTKHIRTHTGEKPYNCKECGKAFTT 392
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
155-316 7.58e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 155 KPYKCKDCGKAFTGRSGLSKHLPT--HTGE--KPYECKE--CGKAFPSTSGLIKHMKSHMGERPFEC--DHCGKAFASSS 226
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432065 227 TLITHLRTH-----TGEKPFECQV--CGKAFTCSSYLRIHMRTHTGEKPYVCK--ECGRAFTERTSLTKHLRTHTGENPF 297
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1720432065 298 ECNMCGKAFACSSYLHNHI 316
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-252 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*
gi 1720432065 228 LITHLRTHTGEKPFECQVCGKAFTC 252
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-224 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....*
gi 1720432065 200 LIKHMKSHMGERPFECDHCGKAFAS 224
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
423-448 1.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.80e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720432065 423 YLIAHLRIHTGEKPFECNECGKAFTC 448
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 73-95 2.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.36e-03
                          10        20
                  ....*....|....*....|...
gi 1720432065  73 YECKECGKSFKYSANLNIHMRTH 95
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-475 2.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.42e-03
                          10        20
                  ....*....|....*....|.
gi 1720432065 455 HMRTHTGEKPYDCKECGKTFA 475
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 211-262 3.34e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720432065 211 RPFeCDHCGKAFASSSTLITHLRTHTgekpFECQVCGKAFTCSSYLRIHMRT 262
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-335 3.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|.
gi 1720432065 315 HIRTHTGEKPYVCKECGKAFT 335
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
435-499 4.68e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432065 435 KPFECNECGKAFTCSSYLHIHMRTHTGEKPYDC--KECGKTFAVYSHLSKHVRIHSGEKAYTCKSDG 499
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSL 98
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-308 5.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720432065 283 SLTKHLRTHTGENPFECNMCGKAFAC 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
116-140 7.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.40e-03
                          10        20
                  ....*....|....*....|....*
gi 1720432065 116 LTQHLKTHTEEKPFECKVCGKCFRN 140
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
144-167 7.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.78e-03
                          10        20
                  ....*....|....*....|....
gi 1720432065 144 LNDHFRVHTGIKPYKCKDCGKAFT 167
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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