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F-box/LRR-repeat protein 2 isoform X3 [Mus musculus]
leucine-rich repeat domain-containing protein( domain architecture ID 1563018)
leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
AMN1 super family | cl39120 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
63-262 | 2.81e-30 | ||||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. The actual alignment was detected with superfamily member cd09293: Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 114.35 E-value: 2.81e-30
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Name | Accession | Description | Interval | E-value | |||||
AMN1 | cd09293 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
63-262 | 2.81e-30 | |||||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 114.35 E-value: 2.81e-30
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
15-272 | 3.64e-05 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.92 E-value: 3.64e-05
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LRR_CC | smart00367 | Leucine-rich repeat - CC (cysteine-containing) subfamily; |
206-231 | 6.91e-05 | |||||
Leucine-rich repeat - CC (cysteine-containing) subfamily; Pssm-ID: 197685 [Multi-domain] Cd Length: 26 Bit Score: 39.31 E-value: 6.91e-05
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Name | Accession | Description | Interval | E-value | |||||
AMN1 | cd09293 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
63-262 | 2.81e-30 | |||||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 114.35 E-value: 2.81e-30
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AMN1 | cd09293 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
23-170 | 1.02e-23 | |||||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 96.63 E-value: 1.02e-23
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AMN1 | cd09293 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
88-279 | 7.08e-20 | |||||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 86.23 E-value: 7.08e-20
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
15-272 | 3.64e-05 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.92 E-value: 3.64e-05
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LRR_CC | smart00367 | Leucine-rich repeat - CC (cysteine-containing) subfamily; |
206-231 | 6.91e-05 | |||||
Leucine-rich repeat - CC (cysteine-containing) subfamily; Pssm-ID: 197685 [Multi-domain] Cd Length: 26 Bit Score: 39.31 E-value: 6.91e-05
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LRR_CC | smart00367 | Leucine-rich repeat - CC (cysteine-containing) subfamily; |
50-75 | 2.34e-03 | |||||
Leucine-rich repeat - CC (cysteine-containing) subfamily; Pssm-ID: 197685 [Multi-domain] Cd Length: 26 Bit Score: 34.69 E-value: 2.34e-03
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Blast search parameters | ||||
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