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Conserved domains on  [gi|1720360825|ref|XP_030100830|]
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monocarboxylate transporter 2 isoform X1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 11489922)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
5-431 0e+00

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


:

Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 731.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825   5 PSAPLPQPLPPDGGWGWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNY 84
Cdd:TIGR00892   2 PPALPPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  85 GSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAP 164
Cdd:TIGR00892  82 GCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 165 FNQYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKASKVSTAQKVNRFLDFSLFMHR 244
Cdd:TIGR00892 162 LNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKEGLPPDGSTKKLSKKSTAEKINRFLDFSLFTHR 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 245 GFLIYLSGNVILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTG 324
Cdd:TIGR00892 242 GFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNG 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 325 ICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKY 404
Cdd:TIGR00892 322 LTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKY 401
                         410       420
                  ....*....|....*....|....*..
gi 1720360825 405 LYIASGTVVLVSGTYLLIGNAINYRLL 431
Cdd:TIGR00892 402 IFYASGSIVVSAGLFLAIGNYINYRLL 428
 
Name Accession Description Interval E-value
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
5-431 0e+00

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 731.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825   5 PSAPLPQPLPPDGGWGWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNY 84
Cdd:TIGR00892   2 PPALPPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  85 GSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAP 164
Cdd:TIGR00892  82 GCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 165 FNQYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKASKVSTAQKVNRFLDFSLFMHR 244
Cdd:TIGR00892 162 LNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKEGLPPDGSTKKLSKKSTAEKINRFLDFSLFTHR 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 245 GFLIYLSGNVILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTG 324
Cdd:TIGR00892 242 GFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNG 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 325 ICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKY 404
Cdd:TIGR00892 322 LTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKY 401
                         410       420
                  ....*....|....*....|....*..
gi 1720360825 405 LYIASGTVVLVSGTYLLIGNAINYRLL 431
Cdd:TIGR00892 402 IFYASGSIVVSAGLFLAIGNYINYRLL 428
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
20-424 0e+00

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 562.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17427     1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17427    81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRPVGPspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17427   161 LILGGLLLNCCVAGSLMRPLGP--------------------------------------LFKHRGFLIYLSGNVIMFLG 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17427   203 FFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGL 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17427   283 VIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIW 362

                  ....*
gi 1720360825 420 LLIGN 424
Cdd:cd17427   363 LFIGN 367
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
21-416 6.74e-29

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 117.67  E-value: 6.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  21 WVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIG 100
Cdd:COG2223     4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 101 MILASYSNSvIELYLTVGFIGGLGLAFNLQPALTIIGKYFY-RRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:COG2223    84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLhscVAGCLMRPVGPSPNTKKSKSKVGSRHDStlkkaskvstaqkvnrfldFSLFMHRGFLIYLSGNVILFLG 259
Cdd:COG2223   163 LILGILLL---VVAVLAWLFLRDPPAGAAAAAKASLRDQ-------------------LEALRDPRFWLLSLLYFGTFGS 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAK-HIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtslirpRIQYLFSSAIIFTGICHLLCPLATTYSA 338
Cdd:COG2223   221 FIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSD------RIGGRRVLLIVFALMALGLLLLALALGS 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 339 LVVYVVFF---GLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLV 415
Cdd:COG2223   295 LWLFLVLFlllGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV 374

                  .
gi 1720360825 416 S 416
Cdd:COG2223   375 A 375
MFS_1 pfam07690
Major Facilitator Superfamily;
22-389 4.71e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 108.66  E-value: 4.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  22 VVVCASFISIGFSYAFPkavtVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGM 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGP----ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 102 ILASYSNSVIELYLtVGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFL 180
Cdd:pfam07690  77 LLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 181 ILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSrhdstlkkaskvstaqkvnRFLDFSLFMHRGFLIYLSGNVILFLGI 260
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLS-------------------LIVAWKALLRDPVLWLLLALLLFGFAF 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 261 FAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIqYLFSSAIIFTGICHLLCPLATTYSALV 340
Cdd:pfam07690 217 FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL-LLALLLLILAALGLLLLSLTLSSLWLL 295
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1720360825 341 VYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGP 389
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
5-431 0e+00

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 731.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825   5 PSAPLPQPLPPDGGWGWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNY 84
Cdd:TIGR00892   2 PPALPPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  85 GSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAP 164
Cdd:TIGR00892  82 GCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 165 FNQYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKASKVSTAQKVNRFLDFSLFMHR 244
Cdd:TIGR00892 162 LNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKEGLPPDGSTKKLSKKSTAEKINRFLDFSLFTHR 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 245 GFLIYLSGNVILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTG 324
Cdd:TIGR00892 242 GFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNG 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 325 ICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKY 404
Cdd:TIGR00892 322 LTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKY 401
                         410       420
                  ....*....|....*....|....*..
gi 1720360825 405 LYIASGTVVLVSGTYLLIGNAINYRLL 431
Cdd:TIGR00892 402 IFYASGSIVVSAGLFLAIGNYINYRLL 428
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
20-424 0e+00

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 562.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17427     1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17427    81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRPVGPspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17427   161 LILGGLLLNCCVAGSLMRPLGP--------------------------------------LFKHRGFLIYLSGNVIMFLG 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17427   203 FFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGL 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17427   283 VIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIW 362

                  ....*
gi 1720360825 420 LLIGN 424
Cdd:cd17427   363 LFIGN 367
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
20-423 9.53e-180

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 508.26  E-value: 9.53e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17426     1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17426    81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRPVGPSPntkkskskvgsrhdstlkkaskvstaqkvnrFLDFSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17426   161 LILGGLLLNCCVAGSLMRPIGPKP-------------------------------FLDLTLFTHRGFLLYLSGNVIMFFG 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17426   210 LFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGF 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17426   290 CIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIY 369

                  ....
gi 1720360825 420 LLIG 423
Cdd:cd17426   370 LFIG 373
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
20-424 8.51e-142

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 411.43  E-value: 8.51e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17430     1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17430    81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRPvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfLDFSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17430   161 LILGGLLLNCCTCGAVMRP-------------------------------------LDFSVFRDRGFVIYTIAKFIMVLG 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17430   204 LFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGL 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17430   284 VVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALF 363

                  ....*
gi 1720360825 420 LLIGN 424
Cdd:cd17430   364 LALGN 368
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
20-422 9.40e-112

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 334.52  E-value: 9.40e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17352     1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17352    81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17352   161 LILGGLCLNLCVCGLLLR------------------------------------------LLKDPTFVLLALGVSFAMLG 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtsLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17352   199 FFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAD--KPRIGRLYLYIFTLLILGLSLLAFPLATTYVGL 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17352   277 IVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVL 356

                  ...
gi 1720360825 420 LLI 422
Cdd:cd17352   357 LFL 359
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
20-422 4.29e-105

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 317.48  E-value: 4.29e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17425     1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17425    81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRPvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17425   161 LVFGGVLLNCCVCGAVMRP-----------------------------------------FCSNTRYQIYTLGVTWMVLG 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17425   200 FVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVL 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17425   280 LVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALF 359

                  ...
gi 1720360825 420 LLI 422
Cdd:cd17425   360 MGL 362
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
20-423 4.56e-84

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 264.25  E-value: 4.56e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17423     1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17423    81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRPVGPSPNTKKskskvgsrhdstlkkaskvsTAQKVNRFLDFSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17423   161 LLLSALSLHLVPCGALLRPLALPGDPPA--------------------PPRSLSAAFGLSLLTHRAFLRYALATTLINTG 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIR-PRIQYLFSSaiiFTGICHLLCPLATTYSA 338
Cdd:cd17423   221 YFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRlLHLLVLWTA---LTGLSLLLLPLAKVYGS 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 339 LVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLvSGT 418
Cdd:cd17423   298 LLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLL-LGS 376

                  ....*
gi 1720360825 419 YLLIG 423
Cdd:cd17423   377 LILLT 381
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
20-420 6.95e-74

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 237.34  E-value: 6.95e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17422     1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17422    81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17422   161 LVVGALQLNIVVCGALLR------------------------------------------VLKEPGFICYALFGLFATLG 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRpRIQYLFSSAIIFtGICHLLCPLATTYSAL 339
Cdd:cd17422   199 FFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIR-KIYIELICVILL-CVVLLLFPFAYGFWSL 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 340 VVYVVFFGLGFGSISSLLFECLM--DIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSG 417
Cdd:cd17422   277 LVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGA 356

                  ...
gi 1720360825 418 TYL 420
Cdd:cd17422   357 VFL 359
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
20-416 2.52e-54

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 186.18  E-value: 2.52e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17421     1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLStLAPFNQYLFNNYGWKGSF 179
Cdd:cd17421    81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFA-LAPFTQLLLDEYDWQGAL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRPVgpspntkkskskvgsrhdstlkkaskvstaqkvnrflDFSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17421   160 LIFGGIMLNLVASGMLLRPI-------------------------------------DFSLLKDPFFCIYTWSFVFSQLA 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRpriQYLFSSA-IIFTGICHLLCPLATTYSA 338
Cdd:cd17421   203 YFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIK---KYHYHKAyLILCGVTNLLAPLATTYPL 279
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720360825 339 LVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVS 416
Cdd:cd17421   280 LMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLS 357
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
20-420 3.29e-54

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 185.78  E-value: 3.29e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17424     1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17424    81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17424   161 LILGGFVLNLCVCGALMR------------------------------------------FLLMPDFLVLAVSVLFLAYG 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17424   199 CSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLL 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17424   279 VPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLL 358

                  .
gi 1720360825 420 L 420
Cdd:cd17424   359 L 359
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
20-420 3.39e-41

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 151.91  E-value: 3.39e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNT-----TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGG 94
Cdd:cd17420     1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  95 LLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYG 174
Cdd:cd17420    81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 175 WKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKASKVstaqkvnrfLDFSLFMHRGFLIYLSGNV 254
Cdd:cd17420   161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHSRINLFLRKI---------FNVEIFKRKRYVIWALGIP 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 255 ILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIqYLFSSAIIFTGICHLLCPLAT 334
Cdd:cd17420   232 LALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQVLSFVSIGLMSMMIPLCN 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 335 TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVL 414
Cdd:cd17420   311 SFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPL 390

                  ....*.
gi 1720360825 415 VSGTYL 420
Cdd:cd17420   391 IGSSLL 396
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
20-422 6.83e-35

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 133.80  E-value: 6.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17429     1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17429    81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17429   161 FIQGAVSLNLCVCGALMR------------------------------------------LFTNKVFVAFIFWALFAYCS 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAF-LLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIftGICHLLCPLATTYS- 337
Cdd:cd17429   199 FVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTL--GVCILILPLMHTYTg 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 338 -ALVVYVVFFGLGFGSISSLLFEclmDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVS 416
Cdd:cd17429   277 lAIVCALIGFSSGYFSLMPVVTE---DLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVG 353

                  ....*.
gi 1720360825 417 GTYLLI 422
Cdd:cd17429   354 IICLLL 359
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
20-420 4.45e-33

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 129.53  E-value: 4.45e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSS-----QIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGG 94
Cdd:cd17464     1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDaqmrfKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  95 LLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYG 174
Cdd:cd17464    81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 175 WKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKskvgsrhdstlKKASKVSTaqkVNRFLDFSLFMHRGFLIYLSGNV 254
Cdd:cd17464   161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGK-----------KRKFKCPP---LKKIFNFNIWKSTGYRIWAFGIP 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 255 ILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIqYLFSSAIIFTGICHLLCPLAT 334
Cdd:cd17464   227 AALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKV-YLQVSSFFFIGLMSMMIPLCH 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 335 TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVL 414
Cdd:cd17464   306 VFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPI 385

                  ....*.
gi 1720360825 415 VSGTYL 420
Cdd:cd17464   386 IGGIIL 391
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
20-422 1.17e-30

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 121.85  E-value: 1.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17428     1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17428    81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17428   161 LIVGALALNLLACGSLMR------------------------------------------LFKNRVFSALFIAILLFDIG 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHIGVDDYNSAF-LLSVMAFIDMFARPSVGLIANTSLIRPriQYLFSSAIIFTGICHLLCPLATTYSA 338
Cdd:cd17428   199 AFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS--LYLYVLTLIGMGAALLAIPFAKSYLT 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 339 LVVYVVFFGLGFGSISSLLFeCLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGT 418
Cdd:cd17428   277 LAVLSAILGFLSGNWSIFPY-VTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGF 355

                  ....
gi 1720360825 419 YLLI 422
Cdd:cd17428   356 LLLL 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
21-416 6.74e-29

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 117.67  E-value: 6.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  21 WVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIG 100
Cdd:COG2223     4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 101 MILASYSNSvIELYLTVGFIGGLGLAFNLQPALTIIGKYFY-RRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:COG2223    84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLhscVAGCLMRPVGPSPNTKKSKSKVGSRHDStlkkaskvstaqkvnrfldFSLFMHRGFLIYLSGNVILFLG 259
Cdd:COG2223   163 LILGILLL---VVAVLAWLFLRDPPAGAAAAAKASLRDQ-------------------LEALRDPRFWLLSLLYFGTFGS 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAK-HIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtslirpRIQYLFSSAIIFTGICHLLCPLATTYSA 338
Cdd:COG2223   221 FIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSD------RIGGRRVLLIVFALMALGLLLLALALGS 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 339 LVVYVVFF---GLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLV 415
Cdd:COG2223   295 LWLFLVLFlllGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV 374

                  .
gi 1720360825 416 S 416
Cdd:COG2223   375 A 375
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
17-417 1.79e-27

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 113.04  E-value: 1.79e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  17 GGWGWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLL 96
Cdd:COG2271     5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  97 CCIGMILASYSNSVIELYLTVgFIGGLGLAFNLQPALTIIGKYFY-RRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGW 175
Cdd:COG2271    85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 176 KGSFLILGGIFLhscVAGCLMrpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfslfmhrgFLIYLSGNVI 255
Cdd:COG2271   164 RAAFLILGLPGL---LLALLR-------------------------------------------------FWLLALAYFL 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 256 LFLGIFAPIIFLAQYAKHI-GVDDYNSAFLLSVMAFIDMFARPSVGLIANtsLIRPRIQYLFSSAIIFTGICHLLCPLAT 334
Cdd:COG2271   192 VYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD--RLGRRRKLVLAIGLLLAALALLLLALLP 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 335 TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIASGTVVL 414
Cdd:COG2271   270 SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALAL 348

                  ...
gi 1720360825 415 VSG 417
Cdd:COG2271   349 LAA 351
MFS_1 pfam07690
Major Facilitator Superfamily;
22-389 4.71e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 108.66  E-value: 4.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  22 VVVCASFISIGFSYAFPkavtVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGM 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGP----ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 102 ILASYSNSVIELYLtVGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFL 180
Cdd:pfam07690  77 LLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 181 ILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSrhdstlkkaskvstaqkvnRFLDFSLFMHRGFLIYLSGNVILFLGI 260
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLS-------------------LIVAWKALLRDPVLWLLLALLLFGFAF 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 261 FAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIqYLFSSAIIFTGICHLLCPLATTYSALV 340
Cdd:pfam07690 217 FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL-LLALLLLILAALGLLLLSLTLSSLWLL 295
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1720360825 341 VYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGP 389
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
20-421 1.73e-24

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 104.66  E-value: 1.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17355     1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPA-LTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGS 178
Cdd:cd17355    81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 179 FLILGGIFLHSCVAGCLMRPVGPSPntkkskskvgsrhdstLKKASKVSTAQKVNRFLDFSLFMHRGFLIYLSGNVILFL 258
Cdd:cd17355   161 LLVLALLALLVLVPVLLLLRRRPAD----------------LALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGF 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 259 GIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGichLLCPLATTYSA 338
Cdd:cd17355   225 AVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLA---LLLLLPFPPLA 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 339 LVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGT 418
Cdd:cd17355   302 LLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381

                  ...
gi 1720360825 419 YLL 421
Cdd:cd17355   382 LVL 384
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-380 6.61e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 102.36  E-value: 6.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  14 PPDGGWGWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVG 93
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  94 GLLCCIGMILASYSNSVIELYLtVGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNN 172
Cdd:COG2814    82 LLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 173 YGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVgsrhdstlkkaskvstaqkvnrfldFSLFMHRGFLIYLSG 252
Cdd:COG2814   161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-------------------------RELLRRPRLLLLLLL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 253 NVILFLGIFAPIIFLAQYAKHI-GVDDYNSAFLLSVMAFIDMFARPSVGLIANtsliRPRIQYLFSSAIIFTGICHLLCP 331
Cdd:COG2814   216 AFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLAD----RFGRRRLLLIGLLLLALGLLLLA 291
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1720360825 332 LATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIV 380
Cdd:COG2814   292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
5-420 5.77e-23

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 100.72  E-value: 5.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825   5 PSAPLPQPLPPDGGWGWVVVCASFISIGFSYAFPkAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNY 84
Cdd:COG2807     2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAIT-SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  85 GSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGFIG-GLGLAFNLQPALtiIGKYFYRRRPLANGCAMAGSPVFLSTLA 163
Cdd:COG2807    81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGaGIAVGNVLLPGL--IKRWFPDRVGLMTGLYTAAMGLGAALAA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 164 PFNQYLFNNYGWKGSFLILGGIflhSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKAskvstaqkvnRFLDFSLFMh 243
Cdd:COG2807   159 GLTVPLAAALGWRGALAVWALL---ALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSP----------LAWLLTLFF- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 244 rgfliylSGNVILFLGIFApiiFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtSLIRPRIQYLFSSAIIFT 323
Cdd:COG2807   225 -------GLQSLLYYAVVA---WLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD-RLGDRRPLLLLLGLLGLA 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 324 GICHLLcpLATTySALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAvgLTTIVECCPVL---FGPPLAGKLLDITG 400
Cdd:COG2807   294 GLLGLL--LAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAA--LSGMAQSVGYLlaaLGPLLVGALHDATG 368
                         410       420
                  ....*....|....*....|...
gi 1720360825 401 EYK---YLYIASGTVVLVSGTYL 420
Cdd:COG2807   369 SWTaalLLLAALAVLMLVAGLLA 391
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
19-417 1.38e-21

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 96.53  E-value: 1.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  19 WGWVVVCasfISIGFSYAFpkavTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCC 98
Cdd:cd17353     7 LGAVLMH---LILGYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  99 IGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANG---CAMAGSPVFLStlaPFNQYLFNNYGW 175
Cdd:cd17353    80 LGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGiviAGFGLGSLIFS---PLIAYLINTVGV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 176 KGSFLILGGIFL-HSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKASKVSTAQKvnrfldfslfmhRGFLIYLSgnv 254
Cdd:cd17353   157 PTTFLILGIIFLiIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTP------------TFWLLWLM--- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 255 iLFLGIFAPIIFLAQYA----KHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtsliRPRIQYLFSSAIIFTGICHLLC 330
Cdd:cd17353   222 -FFLNATAGLMLIGQAKpigqEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSD----KIGRKNTLSIAFLIQGVAMFLL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 331 PLAT-TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGkLLDITGEYKYLYIAS 409
Cdd:cd17353   297 PFIGsVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIA 375

                  ....*...
gi 1720360825 410 GTVVLVSG 417
Cdd:cd17353   376 AALSLVAL 383
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
20-421 2.45e-20

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 92.55  E-value: 2.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQ-----IAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGG 94
Cdd:cd17465     1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQavqfkTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  95 LLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYG 174
Cdd:cd17465    81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 175 WKGSFLILGGIFLHSCVAGclmrpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfLDFSLFMHRGFLIYLSGNV 254
Cdd:cd17465   161 LAHTFQVLSLFMFIQIFLS------------------------------------------LTYKVFRRKTYRIWAFGIA 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 255 ILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtSLIRPRIQYLFSSAIIFTGICHLLCPLAT 334
Cdd:cd17465   199 TAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGD-LIPGLKKIYLQVASFLLLGIMSMMIPLCQ 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 335 TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVL 414
Cdd:cd17465   278 VFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPI 357

                  ....*..
gi 1720360825 415 VSGTYLL 421
Cdd:cd17465   358 IGGTVLF 364
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
20-423 4.16e-20

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 92.09  E-value: 4.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17314     1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17314    81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLHSCVAGCLMRPVGPSPNTKKSkskvgsrhdstlkkaskvstaQKVNRFLDFSLFMHRGFLIYLSGNVIL--F 257
Cdd:cd17314   161 TILGILAAIVLSVVSLLGFKEPPDNQARL---------------------HVQKKKTQTMGEIFRDKVFWILFIAIFlvL 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 258 LGIFAPIIFLAQYAKHIGVDDYN-SAFLLSVMAFIDMFARPSVGLIANTsLIRPRIQYLFSSAIIFTGICHLLCPLATTY 336
Cdd:cd17314   220 IGGFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVADF-FGGRLSTLSILLTILGLGLCAFLFLLKMTP 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 337 SALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVS 416
Cdd:cd17314   299 VGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLA 378

                  ....*..
gi 1720360825 417 GTYLLIG 423
Cdd:cd17314   379 SAILLAV 385
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
24-421 6.41e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 85.17  E-value: 6.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  24 VCASFISIGFSYAfpkAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMIL 103
Cdd:cd06174     1 LLLGFFLTGLARG---LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 104 ASYSNSVIELYLTvGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLF--NNYGWKGSFL 180
Cdd:cd06174    78 FAFAPSFWLLLLG-RFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 181 ILGGIFLHSCVAGCLMRPvgpspntkkskskvgSRHDSTLKKASKVSTAQKVNRFldFSLFMHRGFLIYLSGNVILFLGI 260
Cdd:cd06174   157 IAAALALLAAILLLLVVP---------------DPPESARAKNEEASSKSVLKLL--KRVLKNPGLWLLLLAIFLVNLAY 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 261 FAPIIFLAQYAK-HIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFssaIIFTGICHLLCPLATTYSAL 339
Cdd:cd06174   220 YSFSTLLPLFLLdLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG---LLLMALGLALLLLAPSLLLL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd06174   297 LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376

                  ..
gi 1720360825 420 LL 421
Cdd:cd06174   377 LL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
55-423 8.37e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 75.69  E-value: 8.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  55 TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTVgFIGGLGLAFNLQPALT 134
Cdd:cd17325    29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 135 IIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVG 213
Cdd:cd17325   108 LIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 214 SRHDstlkkaskvstaqkvnrfldFSLFMHRGFLIYLSGNVILFLGIFAPII-FLAQYAKH-IGVDDYNSAFLLSVMAFI 291
Cdd:cd17325   188 LRSG--------------------LRLLLRDRRLLALFLAIFVLAFAFGALEpFLPLYAAElGGLSPAQIGLLFGAQGLA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 292 DMFARPSVGLIANTsliRPRIQYLFSSAIIfTGICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFS 371
Cdd:cd17325   248 SALSQPPAGKLSDR---IGRKPLILIGLLL-SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRG 323
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720360825 372 SAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIASGTVVLVSGTYLLIG 423
Cdd:cd17325   324 TAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLL 374
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
75-416 1.59e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 68.77  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  75 PISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIeLYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRpLANGCAMAG 154
Cdd:cd17489    49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYG 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 155 SPVFLSTL--APFNQYLFNNYGWKGSFLILGGIFLHSCVAgCLMRPVGPSPNTKKSKSKVGSRHDSTLKKAskvstaqkv 232
Cdd:cd17489   127 LATTLAMAlgPALGLFLYQHLGFAVLFIVAAVLALLALLL-VFLVKDPPPVAAEEAEAGTRAFRRLVEKKV--------- 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 233 nrfLDFSLFMhrgFLIYLSGNVILFlgifapiiFLAQYAKHIGVDdyNSAFLLSVMAFIDMFARPSVGLIANTslIRPRI 312
Cdd:cd17489   197 ---LPPALIL---FLASIAYGAIST--------FLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDR--KGPKT 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 313 QYLFSSAIIFTGICHLLcpLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLA 392
Cdd:cd17489   259 VIIPGLLLLALGLLLLS--FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLL 336
                         330       340
                  ....*....|....*....|....
gi 1720360825 393 GKLLDITGeYKYLYIASGTVVLVS 416
Cdd:cd17489   337 GLVAELFG-YRAMFLLAAVVVLLA 359
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
22-400 2.13e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 68.34  E-value: 2.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  22 VVVCASFISIGFSYAfpkAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGM 101
Cdd:COG0738    11 IAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 102 ILASYSNSVIeLYLTVGFIGGLGLAF---NLQPALTIIGKYFYRRR-PLANGCAMAGS---PVFLSTLAPFNqylfNNYG 174
Cdd:COG0738    88 LLFALAPSYP-LLLLALFLLGLGLGLldvAANPYVAALGPETAASRlNLLHAFFSLGAllgPLLGGLLILLG----LSLS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 175 WKGSFLILGGIFLhsCVAGCLMRpvGPSPNTKKSKSKVGSRHDSTlkkaskvstaqkvnrfldFSLFMHRGFLIYLsgnV 254
Cdd:COG0738   163 WHLPYLILAVLLL--LLALLFLR--SKLPEIEEEEEEAAGSAASL------------------KSLLKNPRLLLGG---L 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 255 ILFLGIFA---PIIFLAQYAKHI-GVDDYNSAFLLSVMAFIDMFARPSVGLIANtsLIRPRIQYLFSSAIIFTGIchLLC 330
Cdd:COG0738   218 AIFLYVGAegaIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLK--RFGPVRLLRLSALLAAVGL--LLA 293
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 331 PLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRfSSAVGLTTIVECCPVLFGPPLAGKLLDITG 400
Cdd:COG0738   294 LLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFG 362
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
45-414 1.90e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 62.20  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  45 FKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELyLTVGFIGGLG 124
Cdd:cd17474    22 LPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 125 LAFNLQPALTIIGKYF---YRRRPL-----ANGCAMAGSPVFLSTLApfnqylfnNYGWKGSFLILGGIFLHSCVAgcLM 196
Cdd:cd17474   101 AAGLGPLALTLIGDLFeggERAKAMglyeaALGLGIAVGPLLGGLLA--------AISWRYPFFLLAALIPVAFLA--IL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 197 RPVGPSPNTKKSKSKVGSRHdstlkkaskvstaqkvnrflDFSLFMHRGFLIYLSGNVILFLGIFAPIIFLAQYAKHigv 276
Cdd:cd17474   171 FLLPEPKEKAKSSSATKLRD--------------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLEL--- 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 277 DDYNSAFLLSVMAFIdmfarPSVGLIANTSLIRPRIQYLFSS------AIIFTGICHLLCPLATTYSALVVYVVFFGLGF 350
Cdd:cd17474   228 LYGISPIIIGLLFAG-----WSVLLALGSLFVGRLLKKRFGArrilviGLLLYALSLLLLGFVPSLALLLIAIVLFGLGL 302
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720360825 351 GSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVL 414
Cdd:cd17474   303 GLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
47-369 1.35e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 59.87  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  47 DIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFIGGLGLA 126
Cdd:cd17324    24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-FALLLLARALAGLAHG 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 127 FNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLILGGIFLhsCVAGCLMRPVGPSPNT 205
Cdd:cd17324   103 GFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLLPSLPPK 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 206 KKSKSKVGSRHDSTLKKAskvstaqkvnrfldfslfmhRGFLIYLSGnVILFLGIFAPIIFLAQYAKHI-GVDDYNSAFL 284
Cdd:cd17324   181 KPGSLGLLSSLLLLLRNP--------------------RLRLAYLIT-FLLFGGFFALYTYLAPFLTDVpGFSSSAIIGL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 285 LSVMAFIDMFARPSVGLIANTSLIRPriqyLFSSAIIFTGICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDI 364
Cdd:cd17324   240 LLLFGVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315

                  ....*
gi 1720360825 365 VGATR 369
Cdd:cd17324   316 APEAR 320
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
48-416 2.61e-09

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 58.79  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  48 IQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFIGGLGLAf 127
Cdd:cd17475    22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS-YPVLLVLLFLVGAGYG- 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 128 NLQPALT--IIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNT 205
Cdd:cd17475   100 SVQPGGGraIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASA 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 206 KKSkskvgsrhdstlKKASKVSTAQKVNRFLDFslfmhrgFLIYLSGnVILFLGIFAPIIFLAQYAK-HIGVDDYNSAFL 284
Cdd:cd17475   180 ATE------------SASTLLRSLKEVLRNRDV-------WLIAIAG-ALLVAPQFALLTFLLLFLHdHLGLSVVAAGAL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 285 LSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTG--ICHLLCPLATTYSALVVYVVFFGL---GFGSISSLLfe 359
Cdd:cd17475   240 LAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAalLVLSLLSPGTPLWLLVLLLILLGLfaiGWNGLYLTL-- 317
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720360825 360 cLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVS 416
Cdd:cd17475   318 -VAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLA 373
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
40-351 5.07e-09

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 57.97  E-value: 5.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  40 AVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELyLTVGF 119
Cdd:cd17503    14 IVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL-IIFRI 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 120 IGGLGLAFNLQPALTIIGKYFYRRRpLANGCAMAGSPVFLS-TLAP-FNQYLFNNYGWKGSFLILGGIflhsCVAGCLMR 197
Cdd:cd17503    93 LQGFGGGVLIPLAQTILLRIYPPEK-RGAAMGLVGLVILLApAIGPtLGGWLTDNLSWRWIFYINLPI----GILALLLA 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 198 PvgpspntkkskskvgsrhdstlkkaskvstaqkvnrFLDFSLFMHRGFLIYLSGNVILFLGIFAPIIFLAQYAKHI-GV 276
Cdd:cd17503   168 P------------------------------------LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVlGY 211
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720360825 277 DDYNSAFLLSVMAFIDMFARPSVGLIANTslIRPRIqYLFSSAIIFTGICHLLCPLATTYSALVVYVVFFGLGFG 351
Cdd:cd17503   212 SAFESGLVLAPGGLASAILSPLVGRLLDK--FGPRL-LLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLG 283
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
19-187 1.08e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 56.36  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  19 WGWVVVCASFISIGFSYAfpkAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCC 98
Cdd:COG0477    14 RALLALALGTFLEGLDFT---IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  99 IGMILASYSNSVIELYLTVgFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKG 177
Cdd:COG0477    91 LASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
                         170
                  ....*....|
gi 1720360825 178 SFLILGGIFL 187
Cdd:COG0477   170 IFLINAPLGL 179
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
244-422 2.09e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.75  E-value: 2.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 244 RGFLIYLSGNVILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtslIRPRIQYLFSSAIIFT 323
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD---RFGRRRVLLLGLLLFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 324 gICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGeYK 403
Cdd:COG2814    87 -LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WR 164
                         170
                  ....*....|....*....
gi 1720360825 404 YLYIASGTVVLVSGTYLLI 422
Cdd:COG2814   165 WVFLVNAVLALLALLLLLR 183
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
52-186 3.10e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 55.44  E-value: 3.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  52 FNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELyLTVGFIGGLGLAFNLQP 131
Cdd:TIGR00895  47 WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQL-LILRFLAGLGLGGLMPN 125
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720360825 132 ALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLIlGGIF 186
Cdd:TIGR00895 126 LNALVSEYApKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV-GGIA 180
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
60-400 3.94e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.21  E-value: 3.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  60 AWISSIMLAVMYAGG---PISSVLVNNYGSR-----PVVIVGGLLCCIGMILA----SYSNSVIELYLTVGFIG-GLGLA 126
Cdd:COG2211    46 ALVGLILLVARLWDAitdPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLftapDLSPTGKLIYALVTYLLlGLAYT 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 127 FNLQPALTIIGKYF--YRRRPLANG----CAMAGSPVFLSTLAPFNQYLFNN--YGWKGSFLILGGIFLHSCVAGCLMRP 198
Cdd:COG2211   126 LVNIPYSALGAELTpdYEERTRLSSwrfaFAGLGGLLASVLPPPLVAAFGGDaaLGYRLTALIFAVLGLLAFLLTFFGTK 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 199 VGPSPNTKKSKSKVGSRhdstlkkaskvstaqkvnrfldfSLFMHRGFLIYLSGNVILFLGIFAPIIFLAQYAKH-IGVD 277
Cdd:COG2211   206 ERPVPEEEKVSLKESLK-----------------------ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLS 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 278 DYNSAFLLSVMAFIDMFARPSVGLIANtslirpRI--QYLFSSAIIFTGICHLLCPLA--TTYSALVVYVVFFGLGFGSI 353
Cdd:COG2211   263 AALVGLLLALYFLAALLGAPLWPRLAK------RFgkKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAI 336
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720360825 354 SSLLFECLMDIV-------GATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITG 400
Cdd:COG2211   337 LVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
74-422 9.54e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.03  E-value: 9.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  74 GPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFIGGLGLAFNLQPALTIIGKYF---YRRRPLA-NG 149
Cdd:cd17473    52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS-LYALLASRALLGIGVAGIMTLATALIGDYFegeERAKMLGlQS 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 150 CAMAGSPVFLSTLAPFnqylFNNYGWKGSFLI-LGGIFLHSCVAGCLmrpvgpsPNTKKSKSKVGSRHDSTLKKASKVST 228
Cdd:cd17473   131 AAMSLGGVVFLLLGGA----LAEIGWRAPFLVyLLALPVLILVLLFL-------PEPARKSKSAASPGAATAAALPWKRV 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 229 aqkvnrfldfslfmhrgFLIYLSGnVILFLGIFAPIIFLAQYAKHIGVDDYNSA-FLLSVMAFIDMFARPSVGLIANtsl 307
Cdd:cd17473   200 -----------------LPIYFLA-FLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKR--- 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 308 iRPRIQYLFSSAIIFTGICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVeccpVLF 387
Cdd:cd17473   259 -RLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA----FFL 333
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1720360825 388 G----PPLAGKLLDITGEYKYLYIASGTVVLVSGTYLLI 422
Cdd:cd17473   334 GqflsPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
250-416 1.35e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.29  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 250 LSGNVILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTslIRPRIQYLFSSAIifTGICHLL 329
Cdd:cd17489     2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLI--FALATLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 330 CPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIAS 409
Cdd:cd17489    78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVA 156

                  ....*..
gi 1720360825 410 GTVVLVS 416
Cdd:cd17489   157 AVLALLA 163
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
24-421 2.31e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 49.63  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  24 VCASFISIGFSYAFpkaVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMIL 103
Cdd:cd17333     1 LYISFFSNGLTDAL---LGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 104 ASYSNSVIeLYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRP----LANGCAMAGSPVFLSTLAPFnqyLFNNYGWKGSF 179
Cdd:cd17333    78 IFATPSIY-LFVVLMFLAGLGAGILDTGANTFVGALFEESSAtrlnVLHGFFGLGALIGPLIATSL---LTSELSWSWAY 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGGIFLhsCVAGCLMRPvgpspntkKSKSKVGSRHDSTLKKASKVSTAQKvnrfldfslfmhRGFLIYLSGNVILFLG 259
Cdd:cd17333   154 LIIGLIYL--LLAILILLT--------LFPELPSARNPQQSVGAFSASASRL------------LRNPSIILGALALFLY 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIF------LAQYAKHIGVDDynSAFLLSVMAFIDMFARPSVGLIANTslIRPRIQYLFSSAIIFTGichlLCPLA 333
Cdd:cd17333   212 VGAETAFsswvpsYLVEKKHVSDGL--AGYLLSGFWVGITIGRLLGGPISRR--IKPHTLLVLSGSGALLG----LLILL 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 334 TTYSALVVYVVFFGLGFGsiSSLLFECLMdIVGATRF----SSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIAS 409
Cdd:cd17333   284 LAPTLVVGLVATALLGLF--MAALFPTIL-SLGISNLpyakGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLIT 360
                         410
                  ....*....|..
gi 1720360825 410 GTVVLVSGTYLL 421
Cdd:cd17333   361 ILYAIIFVLALL 372
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
45-363 1.33e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 47.19  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  45 FKDIQEIFNTTSSQIAWISSIMLAVMYAG----GPISSVlvnnYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFI 120
Cdd:cd17320    22 LPAIARDLGASASAVQLTLSAYLLGFALGqllyGPLSDR----FGRRPVLLAGLLLFILASLLCALASS-IEQLLIARFL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 121 GGLGLAFNLQPALTIIGKYfYRRRPLANGCAMAGSPVFLS-TLAP-FNQYLFNNYGWKGSFLILGGIFLhSCVAGCLMRP 198
Cdd:cd17320    97 QGLGAAAGSVVARAIVRDL-YSGAELAKIFSLLMMILAIApALAPlLGGLLLLFFGWRAIFVFLALLGL-LLLLLVLLFL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 199 VGPSPNTKKSKSKVGSRHDStlkkaskvstaqkvnrfldFSLFMHRGFLIYLSGNVILFLGIF-----APIIFLAQYakH 273
Cdd:cd17320   175 PETLPEEKRKPLLSSLLRAY-------------------KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQL--G 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 274 IGVDDYNSAFLLSVMAFIDMfarpsvGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLAT-----TYSALVVYVVFFGL 348
Cdd:cd17320   234 LSPAQFGLLFALNAIALILG------SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAllgglSLWPLVAPLFLIFF 307
                         330
                  ....*....|....*
gi 1720360825 349 GFGSISSLLFECLMD 363
Cdd:cd17320   308 GFGLIFPNATSLALE 322
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
21-198 1.56e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  21 WVVVCASFISIGFSYAFpkaVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSR--PVVIVGGLLCC 98
Cdd:COG2271   183 WLLALAYFLVYFALYGF---LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  99 IGMILASYSNSVIeLYLTVGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKG 177
Cdd:COG2271   260 LALLLLALLPSPA-LAIALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
                         170       180
                  ....*....|....*....|.
gi 1720360825 178 SFLILGGIFLHSCVAGCLMRP 198
Cdd:COG2271   339 AFLLLAALALLAALLALLLLR 359
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
47-376 1.75e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.78  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  47 DIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELylTVG-FIGGLGL 125
Cdd:cd17321    21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL--IAArALQGIGA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 126 AFNLQPALTIIGKYFY-RRRPLA---NGCAMAGSPVFLSTLAPFnqyLFNNYGWKGSFLILGGIflhsCVAGclmrpvgp 201
Cdd:cd17321    99 AAIMPASLALIAATFPgERRGRAlglWGAVVGIGAALGPLLGGL---LLELFGWRWIFLINVPI----GLVA-------- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 202 spntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLGIFAPIIFLAQYAKHI-GVDDYN 280
Cdd:cd17321   164 --------------------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVlGYSPLQ 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 281 SAFLLSVMAFIDMFARPSVGLIANTslIRPRIQYLFSSAIIFTGICHL-LCPLATTYSALVVYVVFFGLGFGSISSLLFE 359
Cdd:cd17321   206 AGLALLPLALAMLVAAPLAGRLADR--FGPRLVLVAGLLLTAVGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFATPLTN 283
                         330
                  ....*....|....*..
gi 1720360825 360 CLMDIVGATRFSSAVGL 376
Cdd:cd17321   284 AALSSVPKEKAGAASGI 300
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
48-378 2.76e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.42  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  48 IQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGfIGGLGLAF 127
Cdd:cd17504    22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA-LQGIGGAV 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 128 nLQPALTIIGKYFYRRR-PLANGcAMAGSPVFLSTLA-PFNQYLFNNYGWKGSFLILGGIflhsCVAGCLMRPvgpspnt 205
Cdd:cd17504   101 -FPLAFALVREEFPPERvPVAQG-ILSATFGIGAGIGlPLGGWIVQHLGWRWIFWTAAPV----AVLLAALVP------- 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 206 kkskskvgsrhdstlkkaskvstaqkvnrFLDFSLFMHRGFLIYLSGNVILFLGIFA---PIIFLAQYAKHIGV--DDYN 280
Cdd:cd17504   168 -----------------------------LIDLRLLRRRNVLLANITALLAGFGMFMvfqLLPQLLQLPTPTGFglGITE 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 281 SAFLLSVMAFIDMFARPSVGLIAntSLIRPRIQYLFSSAIIFTGIChLLCPLATTYSALVVYVVFFGLGFGSISSLLFEC 360
Cdd:cd17504   219 AGLLLLPGALVMLIAGPLAGRLI--ARVGPRRVLLIGLVISAVGLL-LLALLHSSLWALVVALLLIGIGLGLAFASLPNI 295
                         330
                  ....*....|....*...
gi 1720360825 361 LMDIVGATRFSSAVGLTT 378
Cdd:cd17504   296 VVESVPPDRTGIATGMNT 313
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
21-422 4.15e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 45.64  E-value: 4.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  21 WVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIG 100
Cdd:cd17319     2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 101 MILASYSNSVIELYLtVGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17319    82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 180 LILGgiflhscVAGCLMRPVgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17319   161 IIEG-------LLGLLLAVL---------------------------------------WWFYLRQVWGLALGYFGINYA 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 260 IFAPIIFLAQYAKHI-GVDDYNSAFLLS---VMAFIDMFArpsVGLIANTSLIRPRIQYLFSSAiIFTGICHLLCPLATT 335
Cdd:cd17319   195 LYGLLTWLPTYLKQArGFSLKQVGLLAAipfLAGAIGMIL---GGRLSDRLLRGARRLVIIIGL-LLAAVGLLLAYLTTS 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 336 YSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLV 415
Cdd:cd17319   271 PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350

                  ....*..
gi 1720360825 416 SGTYLLI 422
Cdd:cd17319   351 AALLVLL 357
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
52-184 9.16e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 44.50  E-value: 9.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  52 FNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTvGFIGGLGLAFNLQP 131
Cdd:cd17365    29 WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL-RFLTGLGLGAAMPN 107
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720360825 132 ALTIIGKYF-YRRRPLANGCAMAGSPV---FLSTLAPFnqyLFNNYGWKGSFLILGG 184
Cdd:cd17365   108 AITLVSEYApARRRSLAVTLMFCGYPLgaaLGGFLAAA---LIPAFGWRSVFLLGGV 161
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
21-136 1.91e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.72  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  21 WVVVCASFISIGFSYAFPKAVTVFFKDIQEI-FNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17504   180 LLANITALLAGFGMFMVFQLLPQLLQLPTPTgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720360825 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTII 136
Cdd:cd17504   260 GLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV 296
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
55-186 2.09e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 43.77  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  55 TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGFIG-GLGLAFNLQPAL 133
Cdd:cd06179    30 PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGiGAGTQGLGAAVA 109
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720360825 134 T-IIGKyfyRRRPLANGCAMAGSPVFlSTLAPF-NQYLFNNY--GWKGSFLILGGIF 186
Cdd:cd06179   110 SeLVPN---KYRGLVQGVVNLVASPG-SALGPLiAGALVEANaaGWRWIFYINAIFN 162
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
21-422 3.71e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.60  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  21 WVVVCASFI-SIGFSYAFPkAVTVFFKDIQEIfntTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17329     2 WVLLIGSFLnRLGFFMVWP-FMAIYLHQQLGL---SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIEL---YLTVGFIGGLglafnLQPAL-TIIG--------KYFYRRRPLANGCAMAGSPVFLSTLApfnq 167
Cdd:cd17329    78 GFALLGFAHSPWLFaiaLVLTGFGGGL-----FEPASeAMIAdvttpenrTRAFSLLYWAINLGVAIGPLLGGLLL---- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 168 ylfnNYGWKGSFLILGGIFLhsCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKAskvstaqkvnrfldfslfmHRGFL 247
Cdd:cd17329   149 ----LYSFRLLFLAAAVLFL--LAALVLLFLLPETRPKRRAAEKTEILRGYKIVLR-------------------DRAFL 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 248 IYLSGNVILFLGIFAPIIFLAQYAKHIGVDDYNS-AFLLSVMAFIDMFARPSVGLIANtsliRPRIQYLFSSAIIFTGIC 326
Cdd:cd17329   204 LFLLASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPVARLVE----RFRLRKILMIGILLFAIG 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 327 HLLCPLATTYSALVVYVVFFGLG---FGSISSLLFECLMDIVGATRFSSAVGLTTIVEccpVLFGPPLAGKLLDITGEYK 403
Cdd:cd17329   280 FAVLAFANTLAVLILAMIVLTLGemlVFPAVQTLVAALAPPDKRGSYMGFYALAWGLG---RAIGPLVGGLLLDLLGPGL 356
                         410
                  ....*....|....*....
gi 1720360825 404 YLYIASGTVVLVSGTYLLI 422
Cdd:cd17329   357 PWLILAALGLIAAALLLGL 375
MFS_1 pfam07690
Major Facilitator Superfamily;
250-422 4.17e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.41  E-value: 4.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 250 LSGNVILFLGIFAPIIFLAQY-AKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtsLIRPRIQYLFSsaIIFTGICHL 328
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD--RFGRRRVLLIG--LLLFALGLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 329 LCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIA 408
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
                         170
                  ....*....|....
gi 1720360825 409 SGTVVLVSGTYLLI 422
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
49-187 1.14e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  49 QEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTVgFIGGLGLAFN 128
Cdd:cd17325   227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL-ALLGLGLGLV 305
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720360825 129 LQPALTIIGKYFYRRR-----PLANGC---AMAGSPVFLStlapfnqYLFNNYGWKGSFLILGGIFL 187
Cdd:cd17325   306 FPATLALLADIVPPEGrgtamGLFNTAfslGMVLGPLLGG-------FLYDAFGFATPFLAAAALLL 365
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
22-187 2.23e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 40.32  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  22 VVVCASFISIGFSYAFPKAVTVFFKD-IQEIF------NTTSSQIAWISSIMLAVMYAGG----PISSVLVNNYGSRPVV 90
Cdd:cd17357     3 IVAFGGSFQFGYNIGVVNAPQEVFKEfINDTLvdryglNLSDSELDLLWSLIVSIFFIGGaigsFISAFLANRFGRKNGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  91 IVGGLLCCIG--MILASYSNSVIELYLTVGFIGGLglafnlqpaltiigkyfyrrrplANGCAMAGSPVFLSTLAPfnqy 168
Cdd:cd17357    83 LISNALLVVSslLMFLSKSAKSPELLIFGRFLVGI-----------------------ACGLSTGFVPMYLQEISP---- 135
                         170
                  ....*....|....*....
gi 1720360825 169 lfnnYGWKGSFLILGGIFL 187
Cdd:cd17357   136 ----SELRGALGSLTQIGV 150
2_A_01_02 TIGR00880
Multidrug resistance protein;
74-183 2.26e-03

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 38.40  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  74 GPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTvGFIGGLGLAFNLQPALTIIGKYFYR-RRPLANGCAM 152
Cdd:TIGR00880  15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIA-RFLQGFGAAFALVAGAALIADIYPPeERGVALGLMS 93
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720360825 153 AGSPVFLSTLAPFNQYLFNNYGWKGSFLILG 183
Cdd:TIGR00880  94 AGIALGPLLGPPLGGVLAQFLGWRAPFLFLA 124
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
48-357 3.72e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.46  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  48 IQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFIGGLGLAF 127
Cdd:cd17478    22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN-YWLLLLLVALAGIGSAA 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 128 NLQPALTIIGKYFYRRRPLANGCAMAG-------SPVFLStlapfnqYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVG 200
Cdd:cd17478   101 FHPEGARLASQAAGGRRGLAMSIFSVGgnlgfalGPLIAA-------ALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 201 PSPNTKKSKskvgsrhdstlkKASKVSTAQKVNRFLDFSLFMhrGFLIYLSGNVIlflgifapIIFLAQYAKHIGVDDYN 280
Cdd:cd17478   174 KPEAKKAAA------------KSSARSTLKGVWRALLLLLII--VFLRSWVLSSL--------TTFLPFYLVQRGYSLVF 231
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720360825 281 SAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTgichLLCPLATTYSALVVYVVFFGLGFGSISSLL 357
Cdd:cd17478   232 AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFL----LLFLLTPGIWSYILLVLAGFLLFASFPVTV 304
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
21-185 3.78e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 39.56  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  21 WVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAvMYAGGP-ISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17312     2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLI-AYAVGKfISGFLSDRSNIRRFMSAGLLLSAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 100 GMILASYSNSVIELYLTVGFIG---GLGLAfnlqPALTIIGKYFYRRR-----PLANGCAMAGSpvFLSTLapFNQYLFN 171
Cdd:cd17312    81 ANIFMGFSTSLWFFAVLWGLNGlfqSMGWP----PCVKLLGNWFSKKErgtvyGIWSTSHNFGG--ILAPI--LAASLAS 152
                         170
                  ....*....|....
gi 1720360825 172 NYGWKGSFLILGGI 185
Cdd:cd17312   153 YYGWRAAFLVPGIV 166
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
221-422 5.48e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.13  E-value: 5.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 221 KKASKVSTAQKVNRFLDFslfMHRGFLIYLSgnvilFLGIFAPII-------FLAQYAKHIGVddynSAFLLSVMAFIDM 293
Cdd:cd17490   173 ERREKKPVLTELKELLSV---LKDKKLLFFS-----LLAILQQMItfsttfgFTPLIAKQLGA----SSFQLGLLSIIYL 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 294 FARPSVGLIANTSLIRPRIQY--LFSSAIIfTGICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFS 371
Cdd:cd17490   241 LPNALASLLSGTLFYKKLGERntIIIGFLL-LGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRS 319
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720360825 372 SAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIASGTVVLVSGTYLLI 422
Cdd:cd17490   320 TAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLA 369
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
28-187 7.38e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.71  E-value: 7.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825  28 FISIGFSYAFPKAV--TVFFKDIQEIFNTTSSQIAWISSIM-LAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILA 104
Cdd:cd17330   179 LLLVYFLIALAFAGleSVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720360825 105 SYSNSVIELYLTVGFIgGLGLAFNLQPALTIIGKYFY-RRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLILG 183
Cdd:cd17330   259 PFASSVPLLVLAAAIL-AFGTGIVFPALSALLSKSVPsKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAA 337

                  ....
gi 1720360825 184 GIFL 187
Cdd:cd17330   338 GLLL 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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