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Conserved domains on  [gi|1720361101|ref|XP_030100891|]
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probable methyltransferase-like protein 25 isoform X4 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
4-268 5.82e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam13679:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 138  Bit Score: 68.75  E-value: 5.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361101   4 KKSHEVQAMSELI----CSIADYCGLKQIIDVGSGKGYLSSFLS-LKYGLNVYGIDSSNTNTHGAKERNRKLKkhwslyh 78
Cdd:pfam13679   1 KKLHQVEHLAEFIapllKELLDENGPITIVDHGAGKGYLGFILYyLKYGVRVYGIDTRAELVEKANALAQKLG------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361101  79 phsradangwaserprelkvpkgveckgdaesvqrsrlgnpdlsatdglpdfsgsaisvirkqqknvlaqpaeeenlyfe 158
Cdd:pfam13679     --------------------------------------------------------------------------------
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361101 159 dafslidflpvdaieptssqvqnteksglrkerrntaskardssiYSPLTSFITADSQLHDIIEDLEDCLMV-GLHTCGD 237
Cdd:pfam13679  74 ---------------------------------------------FNKRMSFLEGTIAGSTPVELPDRVDVVtALHACDT 108
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1720361101 238 LAPSTLRIFTSKaEVKAVCSVGCCYHLLSEE 268
Cdd:pfam13679 109 ATDDALRFALAK-QARAIVLVPCCYHELAEQ 138
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
4-268 5.82e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 68.75  E-value: 5.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361101   4 KKSHEVQAMSELI----CSIADYCGLKQIIDVGSGKGYLSSFLS-LKYGLNVYGIDSSNTNTHGAKERNRKLKkhwslyh 78
Cdd:pfam13679   1 KKLHQVEHLAEFIapllKELLDENGPITIVDHGAGKGYLGFILYyLKYGVRVYGIDTRAELVEKANALAQKLG------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361101  79 phsradangwaserprelkvpkgveckgdaesvqrsrlgnpdlsatdglpdfsgsaisvirkqqknvlaqpaeeenlyfe 158
Cdd:pfam13679     --------------------------------------------------------------------------------
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361101 159 dafslidflpvdaieptssqvqnteksglrkerrntaskardssiYSPLTSFITADSQLHDIIEDLEDCLMV-GLHTCGD 237
Cdd:pfam13679  74 ---------------------------------------------FNKRMSFLEGTIAGSTPVELPDRVDVVtALHACDT 108
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1720361101 238 LAPSTLRIFTSKaEVKAVCSVGCCYHLLSEE 268
Cdd:pfam13679 109 ATDDALRFALAK-QARAIVLVPCCYHELAEQ 138
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
26-74 1.07e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 39.23  E-value: 1.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720361101  26 KQIIDVGSGKGYLSSFLSlKYGLNVYGIDSSNTNTHGAKERNRKLKKHW 74
Cdd:COG2227    26 GRVLDVGCGTGRLALALA-RRGADVTGVDISPEALEIARERAAELNVDF 73
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
4-268 5.82e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 68.75  E-value: 5.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361101   4 KKSHEVQAMSELI----CSIADYCGLKQIIDVGSGKGYLSSFLS-LKYGLNVYGIDSSNTNTHGAKERNRKLKkhwslyh 78
Cdd:pfam13679   1 KKLHQVEHLAEFIapllKELLDENGPITIVDHGAGKGYLGFILYyLKYGVRVYGIDTRAELVEKANALAQKLG------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361101  79 phsradangwaserprelkvpkgveckgdaesvqrsrlgnpdlsatdglpdfsgsaisvirkqqknvlaqpaeeenlyfe 158
Cdd:pfam13679     --------------------------------------------------------------------------------
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361101 159 dafslidflpvdaieptssqvqnteksglrkerrntaskardssiYSPLTSFITADSQLHDIIEDLEDCLMV-GLHTCGD 237
Cdd:pfam13679  74 ---------------------------------------------FNKRMSFLEGTIAGSTPVELPDRVDVVtALHACDT 108
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1720361101 238 LAPSTLRIFTSKaEVKAVCSVGCCYHLLSEE 268
Cdd:pfam13679 109 ATDDALRFALAK-QARAIVLVPCCYHELAEQ 138
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
28-85 9.44e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 38.31  E-value: 9.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720361101  28 IIDVGSGKGYLSSFLSLKYGLNVYGIDSSNTNTHGAKERNRKLKKHWSLYHphsrADA 85
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQ----GDA 54
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
26-74 1.07e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 39.23  E-value: 1.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720361101  26 KQIIDVGSGKGYLSSFLSlKYGLNVYGIDSSNTNTHGAKERNRKLKKHW 74
Cdd:COG2227    26 GRVLDVGCGTGRLALALA-RRGADVTGVDISPEALEIARERAAELNVDF 73
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
19-69 2.07e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.76  E-value: 2.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720361101  19 IADYCGLKQ---IIDVGSGKGYLSSFLSLKYGLNVYGIDSSNTNTHGAKERNRK 69
Cdd:COG2230    43 ILRKLGLKPgmrVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAE 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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