|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
10-374 |
0e+00 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 644.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 10 SLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGTNFTLAELGICEP 89
Cdd:pfam06484 1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 90 SP-HRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDDNG 168
Cdd:pfam06484 81 SPrHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 169 RPIPPTSSSSLLPsaqlpSSHNPPP---VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 245
Cdd:pfam06484 161 PPIPPSSSSSSPV-----EQHSPPPpslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 246 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 322
Cdd:pfam06484 236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1720366050 323 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 374
Cdd:pfam06484 316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1169-1492 |
1.59e-46 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 171.17 E-value: 1.59e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1169 PVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSIL---------------ELrNSPghkYYLAVDPvTGSLYVSDTNSRR 1231
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAgtgtagfadgggaaaQF-NTP---SGVAVDA-AGNLYVADTGNHR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1232 IYRVkslsgakDLAGNSEVVAGTGEqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIIS 1309
Cdd:cd14953 100 IRKI-------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1310 TLLGsndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSL 1387
Cdd:cd14953 166 TVAG----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1388 SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNS 1467
Cdd:cd14953 233 DGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNN 298
|
330 340
....*....|....*....|....*
gi 1720366050 1468 PSSLAVAPDGTIYIADLGNIRIRAV 1492
Cdd:cd14953 299 PTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2612-2689 |
4.09e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.05 E-value: 4.09e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720366050 2612 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2689
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1453-2390 |
1.22e-30 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 132.96 E-value: 1.22e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1453 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASP---GEQELYVFNADGIHQYTVS 1529
Cdd:COG3209 105 LTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAgggASAYGLTLGGAAAGPATGV 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1530 LVTGEYLYNFTYSADNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLELGLMTYDGNTG 1609
Cdd:COG3209 185 GTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTG 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1610 LLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNS 1689
Cdd:COG3209 265 AGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGG 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1690 YQLCNNGTLRVMYANGMAVSFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLL 1769
Cdd:COG3209 345 TTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAG 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1770 SIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFA 1849
Cdd:COG3209 425 ALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDD 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1850 DGKVWSYSYLDKSMVLLLQSQRQYIF--------EYDSSDRLHAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFD 1921
Cdd:COG3209 505 TLGGTTTTTAGARGLVVTTGTTLTLGttttatlsATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGT 584
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1922 YSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKVGPLVDKQIYRF 2001
Cdd:COG3209 585 TGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTG 664
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2002 SEEGMINARFDYTYHDNSFRIASikpVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGR 2081
Cdd:COG3209 665 TGTGVTAGLTTLATGGTTVGGGT---GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTT 741
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2082 IKEVQYEMF-RSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH----- 2155
Cdd:COG3209 742 GTLTTTSTTtTTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitv 821
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2156 LLNPGNSARLMPLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVGRRASyKT 2235
Cdd:COG3209 822 GSGGGTDLQDRTYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RT 890
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2236 NLGHHlQYFYSDLHNPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTA 2315
Cdd:COG3209 891 DGGTT-TYTYDALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDP 950
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366050 2316 YGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrNVGKEPAPfNLYMFKNNNPLSN 2390
Cdd:COG3209 951 FGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVNY 1019
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1169-1492 |
7.34e-13 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 71.20 E-value: 7.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1169 PVALAVGIDGSLFVGDF--NYIRRIFP-SRNVTSILELRNSPGHKyyLAVDPvTGSLYVSDTNSRRIYRVkslsGAKDla 1245
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI----DPKT-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1246 GNSEVVAGTGEQCLPFdearcgdggkavdatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgsndltavrP 1322
Cdd:COG4257 90 GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF----------P 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1323 LSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslsklaiHSALESA 1399
Cdd:COG4257 140 LPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL-------------------PTPGAGP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1400 SAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncicysgdDAYATDAILNSPSSLAVAPDGTI 1479
Cdd:COG4257 191 RGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGVAVDGDGRV 244
|
330
....*....|...
gi 1720366050 1480 YIADLGNIRIRAV 1492
Cdd:COG4257 245 WFAESGANRIVRF 257
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2313-2390 |
9.09e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 57.12 E-value: 9.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2313 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrnvgkePA----PFNLYMFKNNNPL 2388
Cdd:TIGR03696 1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69
|
..
gi 1720366050 2389 SN 2390
Cdd:TIGR03696 70 NW 71
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
772-802 |
2.49e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 51.75 E-value: 2.49e-08
10 20 30
....*....|....*....|....*....|.
gi 1720366050 772 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 802
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1194-1490 |
2.34e-07 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 56.78 E-value: 2.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1194 SRNVTSILELrnsPGHkyyLAVDPVTGSLYVSDTNSRRIYrvkslsgAKDLAGNSEV-VAGTGEQCL---PFDearcgdg 1269
Cdd:PLN02919 560 PRLLTSPLKF---PGK---LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFE------- 619
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1270 gkavDATLMSPRGIAVD-KNGLMYFVDAT--MIRKVD-QNGIISTLLGS----NDLTAVRPLScdssmdvAQVrLEWPTD 1341
Cdd:PLN02919 620 ----DATFNRPQGLAYNaKKNLLYVADTEnhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWD 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1342 LAVNPMDNSLYVlennvilRITENHQV---SIIAGRPMHCQVPGIDYSLS-KLAIHSALESASAIAIS-HTGVLYITETD 1416
Cdd:PLN02919 688 VCFEPVNEKVYI-------AMAGQHQIweyNISDGVTRVFSGDGYERNLNgSSGTSTSFAQPSGISLSpDLKELYIADSE 760
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720366050 1417 EKKINRLrQVTTNGEIcLLAGAasdcDCKNDVNCICYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIR 1490
Cdd:PLN02919 761 SSSIRAL-DLKTGGSR-LLAGG----DPTFSDNLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
575-769 |
4.51e-07 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 53.86 E-value: 4.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 575 DCPRNCHGNGECVSGLCH--------------CFPGFLGADCAKAAC--PVLCsGNGQ----------YSKGTCQ----C 624
Cdd:pfam19232 11 DCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASCcgGVTC-GAGQtcdaktntcvYVKGYCSadhpC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 625 YSGwkgAECDVPMNQCI-DPSCG-GHGS-CIDG-----------------NCVCAAG--YKGEH-CEEV--------DCL 673
Cdd:pfam19232 90 PSG---SACDTAKNACIaQPPYGpDSGKgCVRGfgawiweldpatnsgvwRCRCANGslYNSAHeCSPLadqtlcaaENL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 674 DPTCSSHGVCVngECLCSPGWGG----LNCELARVQCPDqcsghgtylPDSGLCSCDPNWMGPDCSVDgcpDLCNGNGRC 749
Cdd:pfam19232 167 DPNALVPASSV--PAFAAYGWGNqpvlINKSTAGAAVPS---------PLAGVCPCKPGWAGGSCTED---RTCNGRGTW 232
|
250 260 270
....*....|....*....|....*....|....*
gi 1720366050 750 TlgQNSWQCVCQ---------------TGWRGPGC 769
Cdd:pfam19232 233 N--ETTGQCACNidfsghnscgddnncTSWTGPRC 265
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1604-1640 |
7.32e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 41.82 E-value: 7.32e-05
10 20 30
....*....|....*....|....*....|....*..
gi 1720366050 1604 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1640
Cdd:pfam05593 1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
671-700 |
1.24e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.39 E-value: 1.24e-03
10 20 30
....*....|....*....|....*....|....*
gi 1720366050 671 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 700
Cdd:cd00054 4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
583-693 |
2.29e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.90 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 583 NGECVSglchcfpgfLGADCAK-AACPVLCSGNGQYSKGTCQCYSGwkGAECDvpmNQCI----DP-SCGGHGSCIDGNC 656
Cdd:NF041328 29 GGACVD---------LRSDPSNcGACGVACGAGQTCVAGACGCGPG--TVACG---GACVdtasDPaHCGACGAACAPGQ 94
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1720366050 657 VCAAGYKGEHCEE--VDCldptcssHGVCVN--------GEC--LCSPG 693
Cdd:NF041328 95 VCEGGACREACSEglTRC-------GGACVDlatdplhcGACgvACDPG 136
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
10-374 |
0e+00 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 644.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 10 SLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGTNFTLAELGICEP 89
Cdd:pfam06484 1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 90 SP-HRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDDNG 168
Cdd:pfam06484 81 SPrHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 169 RPIPPTSSSSLLPsaqlpSSHNPPP---VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 245
Cdd:pfam06484 161 PPIPPSSSSSSPV-----EQHSPPPpslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 246 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 322
Cdd:pfam06484 236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1720366050 323 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 374
Cdd:pfam06484 316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1169-1492 |
1.59e-46 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 171.17 E-value: 1.59e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1169 PVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSIL---------------ELrNSPghkYYLAVDPvTGSLYVSDTNSRR 1231
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAgtgtagfadgggaaaQF-NTP---SGVAVDA-AGNLYVADTGNHR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1232 IYRVkslsgakDLAGNSEVVAGTGEqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIIS 1309
Cdd:cd14953 100 IRKI-------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1310 TLLGsndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSL 1387
Cdd:cd14953 166 TVAG----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1388 SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNS 1467
Cdd:cd14953 233 DGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNN 298
|
330 340
....*....|....*....|....*
gi 1720366050 1468 PSSLAVAPDGTIYIADLGNIRIRAV 1492
Cdd:cd14953 299 PTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1213-1493 |
2.58e-40 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 153.07 E-value: 2.58e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1213 LAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAGNSEVVAGTGEqclpfdEARCGDGGKAvdATLMSPRGIAVDKNGLMY 1292
Cdd:cd14953 28 VAVDA-AGNLYVADRGNHRIRKI-------TPDGVVTTVAGTGT------AGFADGGGAA--AQFNTPSGVAVDAAGNLY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1293 FVDAT--MIRKVDQNGIISTLLGsndlTAVRPLSCDSSMDVAQvrLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQV 1368
Cdd:cd14953 92 VADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGATAAQ--FNYPTGVAVDAAGN-LYVADtgNHRIRKITPDGVV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1369 SIIAGRPmhcqVPGidYSLSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndv 1448
Cdd:cd14953 165 TTVAGTG----GAG--YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTA------- 228
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1720366050 1449 ncicYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVS 1493
Cdd:cd14953 229 ----GFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2612-2689 |
4.09e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.05 E-value: 4.09e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720366050 2612 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2689
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1250-1493 |
7.88e-32 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 128.42 E-value: 7.88e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1250 VVAGTGeqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLL-----GSNDLTAvrp 1322
Cdd:cd14953 3 TVAGSG--------TAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAgtgtaGFADGGG--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1323 lscdssmdvAQVRLEWPTDLAVNPMDNsLYV--LENNVILRITENHQVSIIAGRPmhcqVPGidYSLSKLAIHSALESAS 1400
Cdd:cd14953 72 ---------AAAQFNTPSGVAVDAAGN-LYVadTGNHRIRKITPDGVVSTLAGTG----TAG--FSDDGGATAAQFNYPT 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1401 AIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNSPSSLAVAPDGTIY 1480
Cdd:cd14953 136 GVAVDAAGNLYVADTGN---HRIRKITPDGVVTTVAGTGGA-----------GYAGDGPATAAQFNNPTGVAVDAAGNLY 201
|
250
....*....|...
gi 1720366050 1481 IADLGNIRIRAVS 1493
Cdd:cd14953 202 VADRGNHRIRKIT 214
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1453-2390 |
1.22e-30 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 132.96 E-value: 1.22e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1453 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASP---GEQELYVFNADGIHQYTVS 1529
Cdd:COG3209 105 LTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAgggASAYGLTLGGAAAGPATGV 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1530 LVTGEYLYNFTYSADNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLELGLMTYDGNTG 1609
Cdd:COG3209 185 GTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTG 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1610 LLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNS 1689
Cdd:COG3209 265 AGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGG 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1690 YQLCNNGTLRVMYANGMAVSFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLL 1769
Cdd:COG3209 345 TTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAG 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1770 SIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFA 1849
Cdd:COG3209 425 ALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDD 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1850 DGKVWSYSYLDKSMVLLLQSQRQYIF--------EYDSSDRLHAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFD 1921
Cdd:COG3209 505 TLGGTTTTTAGARGLVVTTGTTLTLGttttatlsATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGT 584
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1922 YSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKVGPLVDKQIYRF 2001
Cdd:COG3209 585 TGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTG 664
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2002 SEEGMINARFDYTYHDNSFRIASikpVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGR 2081
Cdd:COG3209 665 TGTGVTAGLTTLATGGTTVGGGT---GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTT 741
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2082 IKEVQYEMF-RSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH----- 2155
Cdd:COG3209 742 GTLTTTSTTtTTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitv 821
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2156 LLNPGNSARLMPLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVGRRASyKT 2235
Cdd:COG3209 822 GSGGGTDLQDRTYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RT 890
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2236 NLGHHlQYFYSDLHNPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTA 2315
Cdd:COG3209 891 DGGTT-TYTYDALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDP 950
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366050 2316 YGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrNVGKEPAPfNLYMFKNNNPLSN 2390
Cdd:COG3209 951 FGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVNY 1019
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1139-1302 |
1.49e-17 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 86.43 E-value: 1.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1139 IITSIMGNGRRRSiscpSCNGLAEGNKLLAPVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSILELR------------ 1204
Cdd:cd14953 163 VVTTVAGTGGAGY----AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGtagfsgdggata 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1205 ---NSPghkYYLAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAGNSEVVAGTGeQCLPfdearcGDGGKAVDATLMSPR 1281
Cdd:cd14953 239 aqlNNP---TGVAVDA-AGNLYVADSGNHRIRKI-------TPAGVVTTVAGGG-AGFS------GDGGPATSAQFNNPT 300
|
170 180
....*....|....*....|...
gi 1720366050 1282 GIAVDKNGLMYFVDAT--MIRKV 1302
Cdd:cd14953 301 GVAVDAAGNLYVADTGnnRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1164-1490 |
1.65e-17 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 85.06 E-value: 1.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1164 NKLLAPVALAVGIDGSLFVGDFNYIR-RIFPSRN--VTSILELRNSPGHKYY---LAVDPvTGSLYVSDTNSRRIYRVks 1237
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTGNNRiQVFDPDGnfITSFGSFGSGDGQFNEpagVAVDS-DGNLYVADTGNHRIQKF-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1238 lsgakDLAGNSEVVAGTGeqclpfdearcGDGgkavDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLGSN 1315
Cdd:cd05819 82 -----DPDGNFLASFGGS-----------GDG----DGEFNGPRGIAVDSSGNIYVADTGnhRIQKFDPDGEFLTTFGSG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1316 dltavrplscdsSMDVAQvrLEWPTDLAVNPmDNSLYVLE--NNVILRITENHQVSIIAGRPmhCQVPGidyslsklaih 1393
Cdd:cd05819 142 ------------GSGPGQ--FNGPTGVAVDS-DGNIYVADtgNHRIQVFDPDGNFLTTFGST--GTGPG----------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1394 sALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndvncicysgdDAYATDAILNSPSSLAV 1473
Cdd:cd05819 194 -QFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNG-------------------NFLGSDGQFNRPSGLAV 250
|
330
....*....|....*..
gi 1720366050 1474 APDGTIYIADLGNIRIR 1490
Cdd:cd05819 251 DSDGNLYVADTGNNRIQ 267
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1213-1511 |
1.68e-17 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 85.06 E-value: 1.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1213 LAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAGNSEVVAGTGeqclpfdearcGDGgkavDATLMSPRGIAVDKNGLMY 1292
Cdd:cd05819 13 IAVDS-SGNIYVADTGNNRIQVF-------DPDGNFITSFGSF-----------GSG----DGQFNEPAGVAVDSDGNLY 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1293 FVDAT--MIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL--ENNVILRITENHQV 1368
Cdd:cd05819 70 VADTGnhRIQKFDPDGNFLASFGGSGDG--------------DGEFNGPRGIAVDSSGN-IYVAdtGNHRIQKFDPDGEF 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1369 SIIAGrpmhcqvpgidyslSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndv 1448
Cdd:cd05819 135 LTTFG--------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGN---HRIQVFDPDGNFLTTFG----------- 186
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366050 1449 ncicysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPG 1511
Cdd:cd05819 187 --------STGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQ 241
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1158-1362 |
9.79e-15 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 76.97 E-value: 9.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1158 NGLAEGNkLLAPVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSIL--------ELrNSPghkYYLAVDPvTGSLYVSDT 1227
Cdd:cd05819 94 SGDGDGE-FNGPRGIAVDSSGNIYVADTgnHRIQKFDPDGEFLTTFgsggsgpgQF-NGP---TGVAVDS-DGNIYVADT 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1228 NSRRIYRVKSlsgakdlagNSEVVAGTGEQClpfdearcgdggkAVDATLMSPRGIAVDKNGLMYFVDATM--IRKVDQN 1305
Cdd:cd05819 168 GNHRIQVFDP---------DGNFLTTFGSTG-------------TGPGQFNYPTGIAVDSDGNIYVADSGNnrVQVFDPD 225
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366050 1306 GIISTLLGSNdltavrplscdssmDVAQVRLEWPTDLAVNPmDNSLYVLE--NNVILRI 1362
Cdd:cd05819 226 GAGFGGNGNF--------------LGSDGQFNRPSGLAVDS-DGNLYVADtgNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1274-1505 |
9.88e-15 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 76.97 E-value: 9.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1274 DATLMSPRGIAVDKNGLMYFVDATM--IRKVDQNGIISTLLGSNDltavrplscdssmdVAQVRLEWPTDLAVNPmDNSL 1351
Cdd:cd05819 4 PGELNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFG--------------SGDGQFNEPAGVAVDS-DGNL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1352 YVL--ENNVILRITENHQVSIIAGRPmhcqvpGIDYSlsklaihsALESASAIAISHTGVLYITETDEkkiNRLRQVTTN 1429
Cdd:cd05819 69 YVAdtGNHRIQKFDPDGNFLASFGGS------GDGDG--------EFNGPRGIAVDSSGNIYVADTGN---HRIQKFDPD 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720366050 1430 GEICLLAGAASDCDCKndvncicysgddayatdaiLNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQY 1505
Cdd:cd05819 132 GEFLTTFGSGGSGPGQ-------------------FNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFLTTFGST 188
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1165-1423 |
4.12e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 71.97 E-value: 4.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1165 KLLAPVALAVGIDGSLFVGDFNYIR-RIFPS--RNVTSILELRNSPGHKYY---LAVDPvTGSLYVSDTNSRRIYRVksl 1238
Cdd:cd05819 53 QFNEPAGVAVDSDGNLYVADTGNHRiQKFDPdgNFLASFGGSGDGDGEFNGprgIAVDS-SGNIYVADTGNHRIQKF--- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1239 sgakDLAGNSEVVAGtgeqclpfdearcgdGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLGSNd 1316
Cdd:cd05819 129 ----DPDGEFLTTFG---------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGNFLTTFGST- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1317 ltavrplscdssmDVAQVRLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGrpmhcqvpgidyslSKLAIHS 1394
Cdd:cd05819 189 -------------GTGPGQFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG--------------NFLGSDG 240
|
250 260
....*....|....*....|....*....
gi 1720366050 1395 ALESASAIAISHTGVLYITETDEKKINRL 1423
Cdd:cd05819 241 QFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1169-1492 |
7.34e-13 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 71.20 E-value: 7.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1169 PVALAVGIDGSLFVGDF--NYIRRIFP-SRNVTSILELRNSPGHKyyLAVDPvTGSLYVSDTNSRRIYRVkslsGAKDla 1245
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI----DPKT-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1246 GNSEVVAGTGEQCLPFdearcgdggkavdatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgsndltavrP 1322
Cdd:COG4257 90 GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF----------P 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1323 LSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslsklaiHSALESA 1399
Cdd:COG4257 140 LPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL-------------------PTPGAGP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1400 SAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncicysgdDAYATDAILNSPSSLAVAPDGTI 1479
Cdd:COG4257 191 RGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGVAVDGDGRV 244
|
330
....*....|...
gi 1720366050 1480 YIADLGNIRIRAV 1492
Cdd:COG4257 245 WFAESGANRIVRF 257
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1164-1432 |
4.77e-10 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 63.11 E-value: 4.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1164 NKLLAPVALAVGIDGSLFVGD--FNYIRRIFPSRNVTSILELRNSPGHKYYLAVDPvTGSLYVSDTNSRRIYRVkslsga 1241
Cdd:COG4257 56 GGGSGPHGIAVDPDGNLWFTDngNNRIGRIDPKTGEITTFALPGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRL------ 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1242 kDLAGNsEVVAGTgeqcLPFDEARcgdggkavdatlmsPRGIAVDKNGLMYFVD--ATMIRKVD-QNGIISTLLGSNDLT 1318
Cdd:COG4257 129 -DPATG-EVTEFP----LPTGGAG--------------PYGIAVDPDGNLWVTDfgANAIGRIDpDTGTLTEYALPTPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1319 AvrplscdssmdvaqvrlewPTDLAVNPmDNSLYVLE--NNVILRITENhqvsiiagrpmhcqvpgiDYSLSKLAIHSAL 1396
Cdd:COG4257 189 G-------------------PRGLAVDP-DGNLWVADtgSGRIGRFDPK------------------TGTVTEYPLPGGG 230
|
250 260 270
....*....|....*....|....*....|....*.
gi 1720366050 1397 ESASAIAISHTGVLYITETDekkINRLRQVTTNGEI 1432
Cdd:COG4257 231 ARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTEL 263
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2313-2390 |
9.09e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 57.12 E-value: 9.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 2313 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrnvgkePA----PFNLYMFKNNNPL 2388
Cdd:TIGR03696 1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69
|
..
gi 1720366050 2389 SN 2390
Cdd:TIGR03696 70 NW 71
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1211-1522 |
6.23e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.65 E-value: 6.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1211 YYLAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAgnsevvagTGEqclpFDEARCGDGGkavdatlmSPRGIAVDKNGL 1290
Cdd:COG4257 20 RDVAVDP-DGAVWFTDQGGGRIGRL-------DPA--------TGE----FTEYPLGGGS--------GPHGIAVDPDGN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1291 MYFVDAT--MIRKVD-QNGIISTLLGSNDLTAvrplscdssmdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRIT-E 1364
Cdd:COG4257 72 LWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGNLWFtdQGGNRIGRLDpA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1365 NHQVSIIAGRPMHCQvpgidyslsklaihsalesASAIAISHTGVLYITETdekKINRLRQVTT-NGEIcllagaasdcd 1443
Cdd:COG4257 132 TGEVTEFPLPTGGAG-------------------PYGIAVDPDGNLWVTDF---GANAIGRIDPdTGTL----------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1444 ckndvncicysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSknkPVLNAFNQYeAASPGEQELY--VFNAD 1521
Cdd:COG4257 179 -------------TEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFD---PKTGTVTEY-PLPGGGARPYgvAVDGD 241
|
.
gi 1720366050 1522 G 1522
Cdd:COG4257 242 G 242
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
772-802 |
2.49e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 51.75 E-value: 2.49e-08
10 20 30
....*....|....*....|....*....|.
gi 1720366050 772 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 802
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1162-1360 |
7.25e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 56.15 E-value: 7.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1162 EGNKLLAPVALAVgIDGSLFVGDFNYIRRIFPSRNVTSILELRN---SPGHKYY---LAVDPvTGSLYVSDTNSRRIyrv 1235
Cdd:cd14963 97 DRVKLISPAGLAI-DDGKLYVSDVKKHKVIVFDLEGKLLLEFGKpgsEPGELSYpngIAVDE-DGNIYVADSGNGRI--- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1236 kslsgakdlagnsevvagtgeQCLPFDE--ARCGDGGKAVDATLMSPRGIAVDKNGLMYFVD--ATMIRKVDQNGIISTL 1311
Cdd:cd14963 172 ---------------------QVFDKNGkfIKELNGSPDGKSGFVNPRGIAVDPDGNLYVVDnlSHRVYVFDEQGKELFT 230
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1720366050 1312 LGsndltavrplscdsSMDVAQVRLEWPTDLAVNPmDNSLYV--LENNVIL 1360
Cdd:cd14963 231 FG--------------GRGKDDGQFNLPNGLFIDD-DGRLYVtdRENNRVA 266
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1213-1489 |
1.12e-07 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 55.29 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1213 LAVDPvTGSLYVSDTNSRRIYRvkslsgakdLAgnsevvAGTGEQC-LPFDEarcgdggkavdatLMSPRGIAVDKNGLM 1291
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLK---------LA------AGSTTQTvLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1292 YFVDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPMDNsLYVLE--NNVILRITenhqvs 1369
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQTVL-PFT----------GLNDPTGVAVDAAGN-VYVADtgNNRVLKLA------ 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1370 iiAGRPMHCQVPGIDyslsklaihsaLESASAIAISHTGVLYITETDEkkiNRLRQvttngeicLLAGAASdcdckndvn 1449
Cdd:cd14952 122 --AGSNTQTVLPFTG-----------LSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAGSTT--------- 168
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1720366050 1450 cicysgddayATD---AILNSPSSLAVAPDGTIYIADLGNIRI 1489
Cdd:cd14952 169 ----------QTVlpfTGLNSPSGVAVDTAGNVYVTDHGNNRV 201
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1194-1490 |
2.34e-07 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 56.78 E-value: 2.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1194 SRNVTSILELrnsPGHkyyLAVDPVTGSLYVSDTNSRRIYrvkslsgAKDLAGNSEV-VAGTGEQCL---PFDearcgdg 1269
Cdd:PLN02919 560 PRLLTSPLKF---PGK---LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFE------- 619
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1270 gkavDATLMSPRGIAVD-KNGLMYFVDAT--MIRKVD-QNGIISTLLGS----NDLTAVRPLScdssmdvAQVrLEWPTD 1341
Cdd:PLN02919 620 ----DATFNRPQGLAYNaKKNLLYVADTEnhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWD 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1342 LAVNPMDNSLYVlennvilRITENHQV---SIIAGRPMHCQVPGIDYSLS-KLAIHSALESASAIAIS-HTGVLYITETD 1416
Cdd:PLN02919 688 VCFEPVNEKVYI-------AMAGQHQIweyNISDGVTRVFSGDGYERNLNgSSGTSTSFAQPSGISLSpDLKELYIADSE 760
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720366050 1417 EKKINRLrQVTTNGEIcLLAGAasdcDCKNDVNCICYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIR 1490
Cdd:PLN02919 761 SSSIRAL-DLKTGGSR-LLAGG----DPTFSDNLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
575-769 |
4.51e-07 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 53.86 E-value: 4.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 575 DCPRNCHGNGECVSGLCH--------------CFPGFLGADCAKAAC--PVLCsGNGQ----------YSKGTCQ----C 624
Cdd:pfam19232 11 DCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASCcgGVTC-GAGQtcdaktntcvYVKGYCSadhpC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 625 YSGwkgAECDVPMNQCI-DPSCG-GHGS-CIDG-----------------NCVCAAG--YKGEH-CEEV--------DCL 673
Cdd:pfam19232 90 PSG---SACDTAKNACIaQPPYGpDSGKgCVRGfgawiweldpatnsgvwRCRCANGslYNSAHeCSPLadqtlcaaENL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 674 DPTCSSHGVCVngECLCSPGWGG----LNCELARVQCPDqcsghgtylPDSGLCSCDPNWMGPDCSVDgcpDLCNGNGRC 749
Cdd:pfam19232 167 DPNALVPASSV--PAFAAYGWGNqpvlINKSTAGAAVPS---------PLAGVCPCKPGWAGGSCTED---RTCNGRGTW 232
|
250 260 270
....*....|....*....|....*....|....*
gi 1720366050 750 TlgQNSWQCVCQ---------------TGWRGPGC 769
Cdd:pfam19232 233 N--ETTGQCACNidfsghnscgddnncTSWTGPRC 265
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1277-1556 |
9.45e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 49.96 E-value: 9.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1277 LMSPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL 1354
Cdd:cd14957 17 FNTPRGIAVDSAGNIYVADTgnNRIQVFTSSGVYSYSIGSGGTG--------------SGQFNSPYGIAVDSNGN-IYVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1355 EnnvilriTENHQVSII--AGrpmhcqvpGIDYSL-SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGE 1431
Cdd:cd14957 82 D-------TDNNRIQVFnsSG--------VYQYSIgTGGSGDGQFNGPYGIAVDSNGNIYVADTGN---HRIQVFTSSGT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1432 ICllagaasdcdckndvncicYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRavsknkpvlnafnqyeaaspg 1511
Cdd:cd14957 144 FS-------------------YSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ--------------------- 183
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1720366050 1512 eqelyVFNADGIHQYTV-SLVTGEYLYNFTYsadnDVTelIDNNGN 1556
Cdd:cd14957 184 -----VFTSSGTFQYTFgSSGSGPGQFSDPY----GIA--VDSDGN 218
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1169-1295 |
1.02e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 49.96 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1169 PVALAVGIDGSLFVGD-FNYIRRIFPSRNVT--SILELRNSPGHKYYL---AVDPvTGSLYVSDTNSRRIyRVKSLSGAK 1242
Cdd:cd14957 114 PYGIAVDSNGNIYVADtGNHRIQVFTSSGTFsySIGSGGTGPGQFNGPqgiAVDS-DGNIYVADTGNHRI-QVFTSSGTF 191
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1720366050 1243 DLAgnsevVAGTGEqclpfdearcGDGGkavdatLMSPRGIAVDKNGLMYFVD 1295
Cdd:cd14957 192 QYT-----FGSSGS----------GPGQ------FSDPYGIAVDSDGNIYVAD 223
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1454-1495 |
2.11e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 49.07 E-value: 2.11e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1720366050 1454 SGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKN 1495
Cdd:cd14953 11 GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1166-1353 |
2.17e-05 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 48.36 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1166 LLAPVALAVGIDGSLFVGDFNYIR--RIFPSRNVTSILELR--NSPGHkyyLAVDPVtGSLYVSDTNSRRIYRVKS---- 1237
Cdd:cd14952 51 LYQPQGVAVDAAGTVYVTDFGNNRvlKLAAGSTTQTVLPFTglNDPTG---VAVDAA-GNVYVADTGNNRVLKLAAgsnt 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1238 --------LSGAKDLA------------GNSEVV---AGTGEQC-LPFDEarcgdggkavdatLMSPRGIAVDKNGLMYF 1293
Cdd:cd14952 127 qtvlpftgLSNPDGVAvdgagnvyvtdtGNNRVLklaAGSTTQTvLPFTG-------------LNSPSGVAVDTAGNVYV 193
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1294 VDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPmDNSLYV 1353
Cdd:cd14952 194 TDH------GNNRVLKLAAGSTTPTVL-PFT----------GLNGPLGVAVDA-AGNVYV 235
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1604-1640 |
7.32e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 41.82 E-value: 7.32e-05
10 20 30
....*....|....*....|....*....|....*..
gi 1720366050 1604 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1640
Cdd:pfam05593 1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1169-1490 |
1.10e-04 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 46.88 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1169 PVALAVGIDGSLFVGDFNYIR-RIFPSRNV--TSILELRNSPGH---KYYLAVDPvTGSLYVSDTNSRRIyRVKSLSGAK 1242
Cdd:cd14957 20 PRGIAVDSAGNIYVADTGNNRiQVFTSSGVysYSIGSGGTGSGQfnsPYGIAVDS-NGNIYVADTDNNRI-QVFNSSGVY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1243 DLAgnsevVAGTGEQCLPFDEarcgdggkavdatlmsPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGSndltav 1320
Cdd:cd14957 98 QYS-----IGTGGSGDGQFNG----------------PYGIAVDSNGNIYVADTgnHRIQVFTSSGTFSYSIGS------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1321 rplscdSSMDVAQVRLewPTDLAVNPMDNsLYVLENNvilriteNHQVSII--AGRPmhcqvpgiDYSL-SKLAIHSALE 1397
Cdd:cd14957 151 ------GGTGPGQFNG--PQGIAVDSDGN-IYVADTG-------NHRIQVFtsSGTF--------QYTFgSSGSGPGQFS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1398 SASAIAISHTGVLYITETDEKKInrlrQVTTNgeicllagaasdcdckndvncicySGDDAYA------TDAILNSPSSL 1471
Cdd:cd14957 207 DPYGIAVDSDGNIYVADTGNHRI----QVFTS------------------------SGAYQYSigtsgsGNGQFNYPYGI 258
|
330
....*....|....*....
gi 1720366050 1472 AVAPDGTIYIADLGNIRIR 1490
Cdd:cd14957 259 AVDNDGKIYVADSNNNRIQ 277
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
580-602 |
2.99e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 2.99e-04
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1172-1325 |
9.56e-04 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 43.73 E-value: 9.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1172 LAVGIDGSLFVGDFNY------IRRIFPSRNVTSILE-LRNSPGhkyyLAVDPVTGSLYVSDTNSRRIYRVkslsgakDL 1244
Cdd:COG3386 98 GVVDPDGRLYFTDMGEylptgaLYRVDPDGSLRVLADgLTFPNG----IAFSPDGRTLYVADTGAGRIYRF-------DL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1245 AGNSEVVAGTgeqclPFDEARCGDGGkavdatlmsPRGIAVDKNGLMY--FVDATMIRKVDQNGiisTLLGSNDLTAVRP 1322
Cdd:COG3386 167 DADGTLGNRR-----VFADLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDG---ELLGRIELPERRP 229
|
...
gi 1720366050 1323 LSC 1325
Cdd:COG3386 230 TNV 232
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
645-667 |
1.08e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.08e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
671-700 |
1.24e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.39 E-value: 1.24e-03
10 20 30
....*....|....*....|....*....|....*
gi 1720366050 671 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 700
Cdd:cd00054 4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
710-734 |
1.68e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.68e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
638-668 |
1.73e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.73e-03
10 20 30
....*....|....*....|....*....|....*.
gi 1720366050 638 NQCIDPS-CGGHGSCIDG----NCVCAAGYKGEHCE 668
Cdd:cd00054 3 DECASGNpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
583-693 |
2.29e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.90 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 583 NGECVSglchcfpgfLGADCAK-AACPVLCSGNGQYSKGTCQCYSGwkGAECDvpmNQCI----DP-SCGGHGSCIDGNC 656
Cdd:NF041328 29 GGACVD---------LRSDPSNcGACGVACGAGQTCVAGACGCGPG--TVACG---GACVdtasDPaHCGACGAACAPGQ 94
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1720366050 657 VCAAGYKGEHCEE--VDCldptcssHGVCVN--------GEC--LCSPG 693
Cdd:NF041328 95 VCEGGACREACSEglTRC-------GGACVDlatdplhcGACgvACDPG 136
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1211-1415 |
3.07e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 42.19 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1211 YYLAVDPvTGSLYVSDTNSRRIYRvkslsgakdlagnsevvagtgeqclpFDEARcgdG-----GKAVDATLMSPRGIAV 1285
Cdd:cd14962 15 YGVAADG-RGRIYVADTGRGAVFV--------------------------FDLPN---GkvfviGNAGPNRFVSPIGVAI 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1286 DKNGLMYFVDAT--MIRKVDQNGIISTLLGSNDLtavrplscdssmdvaQVRlewPTDLAVNPMDNSLYVLEnnvilriT 1363
Cdd:cd14962 65 DANGNLYVSDAElgKVFVFDRDGKFLRAIGAGAL---------------FKR---PTGIAVDPAGKRLYVVD-------T 119
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1720366050 1364 ENHQVSIIAGRPMHCQVPGIDYSlsklaIHSALESASAIAISHTGVLYITET 1415
Cdd:cd14962 120 LAHKVKVFDLDGRLLFDIGKRGS-----GPGEFNLPTDLAVDRDGNLYVTDT 166
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1604-1646 |
3.82e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 37.18 E-value: 3.82e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1720366050 1604 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLH 1646
Cdd:TIGR01643 1 YDAA-GRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
736-769 |
4.03e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 4.03e-03
10 20 30
....*....|....*....|....*....|....*.
gi 1720366050 736 VDGC--PDLCNGNGRCTLGQNSWQCVCQTGWRGPGC 769
Cdd:cd00054 2 IDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| SOBP |
pfam15279 |
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ... |
185-349 |
5.61e-03 |
|
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.
Pssm-ID: 464609 [Multi-domain] Cd Length: 325 Bit Score: 41.72 E-value: 5.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 185 LPSSHNPPPVScQMPLLDSNTSHQIMDTNPDEEF----SPNSYLLRACSGPQQ---ASSSGPPNHHSQSTLRPPLPPPhn 257
Cdd:pfam15279 127 APKPHEPPSLP-PPPLPPKKGRRHRPGLHPPLGRppgsPPMSMTPRGLLGKPQqhpPPSPLPAFMEPSSMPPPFLRPP-- 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 258 htlsHHHSSANSlnrnSLTNRRSQIHAPAPAP-NDLATTPEsvqlqdswvlnsnvPLEtRHFLFKTSSGSTPLFSSSSPG 336
Cdd:pfam15279 204 ----PSIPQPNS----PLSNPMLPGIGPPPKPpRNLGPPSN--------------PMH-RPPFSPHHPPPPPTPPGPPPG 260
|
170
....*....|...
gi 1720366050 337 YPLTSGTVYTPPP 349
Cdd:pfam15279 261 LPPPPPRGFTPPF 273
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
611-628 |
6.02e-03 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 36.31 E-value: 6.02e-03
|
| EGF |
pfam00008 |
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
739-767 |
6.72e-03 |
|
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.21 E-value: 6.72e-03
10 20 30
....*....|....*....|....*....|
gi 1720366050 739 CPDL-CNGNGRCTLGQNSWQCVCQTGWRGP 767
Cdd:pfam00008 1 CAPNpCSNGGTCVDTPGGYTCICPEGYTGK 30
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1407-1492 |
8.08e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 41.02 E-value: 8.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366050 1407 TGVLYITETDEKKINRL----RQVTTngeiclLAGaasdcdckndvncicySGDDAYA-TDAILNSPSSLAVAPDGTIYI 1481
Cdd:cd14951 206 DGSVYVADTYNHKIKRVdpatGEVST------LAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLYV 263
|
90
....*....|.
gi 1720366050 1482 ADLGNIRIRAV 1492
Cdd:cd14951 264 ADTNNHRIRRL 274
|
|
| |
