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Conserved domains on  [gi|1720370173|ref|XP_030102349|]
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reticulon-1 isoform X1 [Mus musculus]

Protein Classification

reticulon family protein( domain architecture ID 10493657)

reticulon family protein associates with the endoplasmic reticulum (ER) through a C-terminal di-lysine ER retention motif; such as mammalian RTN4/Nogo, a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
514-676 2.12e-40

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


:

Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 145.32  E-value: 2.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 514 DLLYWRDIKQTGIVFGSFLLL--LFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVqktdeGHPFKaylelEITLS 591
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGATALwlLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRP-----PPPIP-----ELELS 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 592 QEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQ 671
Cdd:pfam02453  73 EETVRELADSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDA 152

                  ....*
gi 1720370173 672 YLGLV 676
Cdd:pfam02453 153 YVEKA 157
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
184-504 1.19e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  184 DELSDEQHRVSLVTAP-VKITLTEIEPPLMTATQETIPEKQDLCLKPSPDTVPTVTVSEPeDDSPGSVTPPSSGTEPSAA 262
Cdd:PHA03307    34 DLLSGSQGQLVSDSAElAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLS-TLAPASPAREGSPTPPGPS 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  263 ESQGKGSVSEDELIAAiKEAKGLSyettESPRPVGQVADKPKTKTrsglPTIPSPLDQEASSAESGdSEIELVSEDPMAS 342
Cdd:PHA03307   113 SPDPPPPTPPPASPPP-SPAPDLS----EMLRPVGSPGPPPAASP----PAAGASPAAVASDAASS-RQAALPLSSPEET 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  343 EDALPSGyvsfghvsgpppSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQD------SPPMKPGALDA 416
Cdd:PHA03307   183 ARAPSSP------------PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGasssdsSSSESSGCGWG 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  417 IREET-------GSRATEERAPSHQGPVEPDPMLSFAPAAALQSRPEPS---SGDGASVPEPPRSQQQKPEEEAVSSSQS 486
Cdd:PHA03307   251 PENECplprpapITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSpssPGSGPAPSSPRASSSSSSSRESSSSSTS 330
                          330
                   ....*....|....*...
gi 1720370173  487 PTAtEIPGPLGSGLMPPL 504
Cdd:PHA03307   331 SSS-ESSRGAAVSPGPSP 347
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
514-676 2.12e-40

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 145.32  E-value: 2.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 514 DLLYWRDIKQTGIVFGSFLLL--LFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVqktdeGHPFKaylelEITLS 591
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGATALwlLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRP-----PPPIP-----ELELS 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 592 QEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQ 671
Cdd:pfam02453  73 EETVRELADSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDA 152

                  ....*
gi 1720370173 672 YLGLV 676
Cdd:pfam02453 153 YVEKA 157
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
184-504 1.19e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  184 DELSDEQHRVSLVTAP-VKITLTEIEPPLMTATQETIPEKQDLCLKPSPDTVPTVTVSEPeDDSPGSVTPPSSGTEPSAA 262
Cdd:PHA03307    34 DLLSGSQGQLVSDSAElAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLS-TLAPASPAREGSPTPPGPS 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  263 ESQGKGSVSEDELIAAiKEAKGLSyettESPRPVGQVADKPKTKTrsglPTIPSPLDQEASSAESGdSEIELVSEDPMAS 342
Cdd:PHA03307   113 SPDPPPPTPPPASPPP-SPAPDLS----EMLRPVGSPGPPPAASP----PAAGASPAAVASDAASS-RQAALPLSSPEET 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  343 EDALPSGyvsfghvsgpppSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQD------SPPMKPGALDA 416
Cdd:PHA03307   183 ARAPSSP------------PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGasssdsSSSESSGCGWG 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  417 IREET-------GSRATEERAPSHQGPVEPDPMLSFAPAAALQSRPEPS---SGDGASVPEPPRSQQQKPEEEAVSSSQS 486
Cdd:PHA03307   251 PENECplprpapITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSpssPGSGPAPSSPRASSSSSSSRESSSSSTS 330
                          330
                   ....*....|....*...
gi 1720370173  487 PTAtEIPGPLGSGLMPPL 504
Cdd:PHA03307   331 SSS-ESSRGAAVSPGPSP 347
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
308-505 3.46e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 308 RSGLPTIPSPLDQEASSAESGDSEIE------LVSEDPMASEDALPSGYVSFGHVSGPPPSPASPSIQYSILREEREAEL 381
Cdd:pfam03154 142 RSTSPSIPSPQDNESDSDSSAQQQILqtqppvLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 382 DSELIIESCDASSASEESPKREQDSPPMKPGALDAIREETGSRATEEraPSHQGPVEPDPM-LSFAPA-----AALQSRP 455
Cdd:pfam03154 222 QSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQ--PSLHGQMPPMPHsLQTGPShmqhpVPPQPFP 299
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720370173 456 EPSSGDGASVPEPPRSQQQKPEEEAVSSSQSPTATEIPGPLGSGLMPPLP 505
Cdd:pfam03154 300 LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAP 349
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
514-676 2.12e-40

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 145.32  E-value: 2.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 514 DLLYWRDIKQTGIVFGSFLLL--LFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVqktdeGHPFKaylelEITLS 591
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGATALwlLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRP-----PPPIP-----ELELS 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 592 QEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQ 671
Cdd:pfam02453  73 EETVRELADSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDA 152

                  ....*
gi 1720370173 672 YLGLV 676
Cdd:pfam02453 153 YVEKA 157
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
184-504 1.19e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  184 DELSDEQHRVSLVTAP-VKITLTEIEPPLMTATQETIPEKQDLCLKPSPDTVPTVTVSEPeDDSPGSVTPPSSGTEPSAA 262
Cdd:PHA03307    34 DLLSGSQGQLVSDSAElAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLS-TLAPASPAREGSPTPPGPS 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  263 ESQGKGSVSEDELIAAiKEAKGLSyettESPRPVGQVADKPKTKTrsglPTIPSPLDQEASSAESGdSEIELVSEDPMAS 342
Cdd:PHA03307   113 SPDPPPPTPPPASPPP-SPAPDLS----EMLRPVGSPGPPPAASP----PAAGASPAAVASDAASS-RQAALPLSSPEET 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  343 EDALPSGyvsfghvsgpppSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQD------SPPMKPGALDA 416
Cdd:PHA03307   183 ARAPSSP------------PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGasssdsSSSESSGCGWG 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173  417 IREET-------GSRATEERAPSHQGPVEPDPMLSFAPAAALQSRPEPS---SGDGASVPEPPRSQQQKPEEEAVSSSQS 486
Cdd:PHA03307   251 PENECplprpapITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSpssPGSGPAPSSPRASSSSSSSRESSSSSTS 330
                          330
                   ....*....|....*...
gi 1720370173  487 PTAtEIPGPLGSGLMPPL 504
Cdd:PHA03307   331 SSS-ESSRGAAVSPGPSP 347
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
308-505 3.46e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 308 RSGLPTIPSPLDQEASSAESGDSEIE------LVSEDPMASEDALPSGYVSFGHVSGPPPSPASPSIQYSILREEREAEL 381
Cdd:pfam03154 142 RSTSPSIPSPQDNESDSDSSAQQQILqtqppvLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370173 382 DSELIIESCDASSASEESPKREQDSPPMKPGALDAIREETGSRATEEraPSHQGPVEPDPM-LSFAPA-----AALQSRP 455
Cdd:pfam03154 222 QSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQ--PSLHGQMPPMPHsLQTGPShmqhpVPPQPFP 299
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720370173 456 EPSSGDGASVPEPPRSQQQKPEEEAVSSSQSPTATEIPGPLGSGLMPPLP 505
Cdd:pfam03154 300 LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAP 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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