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Conserved domains on  [gi|1720375948|ref|XP_030103300|]
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synaptic vesicle glycoprotein 2C isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
synapt_SV2 super family cl31090
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 22-307 0e+00

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


The actual alignment was detected with superfamily member TIGR01299:

Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 571.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  22 IW---TYRYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQIHTGMEYENGRFLGVKFKSVTFKDSVFK 98
Cdd:TIGR01299 453 VWftlSFGYYGLSVWFPDMIKHLQADDYAALTKNFPGDKVAHFSFNFTLENQIHRGGEYDNDKFIGLKFKSVSFEDSLFE 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  99 SCTFDDVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQITFD-DDYSAYWIYFVNFLGTLAVLPGN 177
Cdd:TIGR01299 533 ECTFDDVTSSNTFFKNCTFIDTLFENTDFEEYKFIDSEFQNCSFLHNKEGCPIDFDgDDEGAYMIYFVNFLGTLAVLPGN 612

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 178 IVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNAL 257
Cdd:TIGR01299 613 IVSALLMDKIGRLRMLAGSMVLSCISCFFLSFGNSESAMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAFGFLNAL 692

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720375948 258 CKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQVLM 307
Cdd:TIGR01299 693 CKAAAVLGILIFGSFVGITKAAPILFASAALACGGLLALKLPDTRGQVLM 742
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 22-307 0e+00

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 571.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  22 IW---TYRYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQIHTGMEYENGRFLGVKFKSVTFKDSVFK 98
Cdd:TIGR01299 453 VWftlSFGYYGLSVWFPDMIKHLQADDYAALTKNFPGDKVAHFSFNFTLENQIHRGGEYDNDKFIGLKFKSVSFEDSLFE 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  99 SCTFDDVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQITFD-DDYSAYWIYFVNFLGTLAVLPGN 177
Cdd:TIGR01299 533 ECTFDDVTSSNTFFKNCTFIDTLFENTDFEEYKFIDSEFQNCSFLHNKEGCPIDFDgDDEGAYMIYFVNFLGTLAVLPGN 612

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 178 IVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNAL 257
Cdd:TIGR01299 613 IVSALLMDKIGRLRMLAGSMVLSCISCFFLSFGNSESAMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAFGFLNAL 692

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720375948 258 CKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQVLM 307
Cdd:TIGR01299 693 CKAAAVLGILIFGSFVGITKAAPILFASAALACGGLLALKLPDTRGQVLM 742
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 24-302 5.42e-154

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 439.35  E-value: 5.42e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  24 TYRYYGLSVWFPDVIKHLQsdeyalltrnvqkdkyanfsinftmenqihtgmeyengrflgvkFKSVTFKDSVFKSCTFD 103
Cdd:cd17440   245 SFGYYGLSVWFPDVIKHLQ--------------------------------------------FKSVTFEDSLFKSCFFE 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 104 DVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALL 183
Cdd:cd17440   281 DVTSVNTYFRNCTFIETVFYNTDLEDYKFIDSDFINCTFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALL 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 184 MDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAV 263
Cdd:cd17440   361 MDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAV 440

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1720375948 264 LGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTR 302
Cdd:cd17440   441 LGNLIFGSLVGITKAIPILLASTVLVCGGLVGLRLPDTR 479
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
157-302 4.21e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 68.74  E-value: 4.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 157 YSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRL--TMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSL 234
Cdd:COG2271   213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 235 DVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSIT--KAIPILLASTVLVCGGLVGLRLPDTR 302
Cdd:COG2271   293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATgyQAAFLLLAALALLAALLALLLLRETR 362
MFS_1 pfam07690
Major Facilitator Superfamily;
161-304 1.81e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.73  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 161 WIYFVNFLGTLAvlpGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLyNGLTISA-WNSLDVVTV 239
Cdd:pfam07690  36 LLLTLFSLGYAL---AQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVL-QGLGAGAlFPAALALIA 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720375948 240 ELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQ 304
Cdd:pfam07690 112 DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 176-298 3.78e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.95  E-value: 3.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 176 GNIVSALLMDRIGRLTMLGGsmVLSGISCFFLWFGTSESMMiGMLC--LYNGLTISAWNS-LDVVTVELYPTDRRATGFG 252
Cdd:PRK11551  271 GSLLIGALMDRLRPRRVVLL--IYAGILASLAALAAAPSFA-GMLLagFAAGLFVVGGQSvLYALAPLFYPTQVRGTGVG 347

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1720375948 253 FLNALCKAAAVLGNLIFGSLVSITKAIPILLAST--VLVCGGLVGLRL 298
Cdd:PRK11551  348 AAVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASipVILVAALAALLL 395
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 22-307 0e+00

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 571.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  22 IW---TYRYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQIHTGMEYENGRFLGVKFKSVTFKDSVFK 98
Cdd:TIGR01299 453 VWftlSFGYYGLSVWFPDMIKHLQADDYAALTKNFPGDKVAHFSFNFTLENQIHRGGEYDNDKFIGLKFKSVSFEDSLFE 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  99 SCTFDDVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQITFD-DDYSAYWIYFVNFLGTLAVLPGN 177
Cdd:TIGR01299 533 ECTFDDVTSSNTFFKNCTFIDTLFENTDFEEYKFIDSEFQNCSFLHNKEGCPIDFDgDDEGAYMIYFVNFLGTLAVLPGN 612

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 178 IVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNAL 257
Cdd:TIGR01299 613 IVSALLMDKIGRLRMLAGSMVLSCISCFFLSFGNSESAMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAFGFLNAL 692

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720375948 258 CKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQVLM 307
Cdd:TIGR01299 693 CKAAAVLGILIFGSFVGITKAAPILFASAALACGGLLALKLPDTRGQVLM 742
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 24-302 5.42e-154

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 439.35  E-value: 5.42e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  24 TYRYYGLSVWFPDVIKHLQsdeyalltrnvqkdkyanfsinftmenqihtgmeyengrflgvkFKSVTFKDSVFKSCTFD 103
Cdd:cd17440   245 SFGYYGLSVWFPDVIKHLQ--------------------------------------------FKSVTFEDSLFKSCFFE 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 104 DVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALL 183
Cdd:cd17440   281 DVTSVNTYFRNCTFIETVFYNTDLEDYKFIDSDFINCTFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALL 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 184 MDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAV 263
Cdd:cd17440   361 MDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAV 440

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1720375948 264 LGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTR 302
Cdd:cd17440   441 LGNLIFGSLVGITKAIPILLASTVLVCGGLVGLRLPDTR 479
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 24-302 1.42e-132

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 384.92  E-value: 1.42e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  24 TYRYYGLSVWFPDVIKHLQsdeyalltrnvqkdkyanfsinftmenqihtgmeyengrflgvkfksvtFKDSVFKSCTFD 103
Cdd:cd17363   245 SFSYYGLTVWFPDMIKYLQ-------------------------------------------------FEDSLFEECYFE 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 104 DVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALL 183
Cdd:cd17363   276 DVTSTNTFFENCTFINTVFYNTDLFEYKFIDSRFLNSTFFLKEKCGCHLNDDEENAYLIYLVSFLGSLSVLPGNIVSALL 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 184 MDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAV 263
Cdd:cd17363   356 MDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIGLQCLFCGVSIAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAI 435

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1720375948 264 LGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTR 302
Cdd:cd17363   436 LGNSIFGSFVGITKVIPILLASAALVCGGLLALKLPETR 474
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 24-302 3.38e-103

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 310.04  E-value: 3.38e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  24 TYRYYGLSVWFPDVIKHLQsdeyalltrnvqkdkyanfsinftmenqihtgmeyengrflgvkfKSVTFKDSVFKSCTFD 103
Cdd:cd17439   245 SFSYYGLTVWFPDMIKHLQ---------------------------------------------KSVVFEDSLFEECYFE 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 104 DVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALL 183
Cdd:cd17439   280 DITSSNTFFKNCTFISTLFYNTDLFEYKFINSKLINSTFLHNKEGCLLDFSDENNAYMIYFVSFLGTLAVLPGNIVSALL 359

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 184 MDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAV 263
Cdd:cd17439   360 MDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAV 439

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1720375948 264 LGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTR 302
Cdd:cd17439   440 LGISIFTSFVGITKAVPILLASAALAAGSSLALKLPETR 478
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 24-302 1.80e-99

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 300.69  E-value: 1.80e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948  24 TYRYYGLSVWFPDVIKHLQsdeyalltrnvqkdkyanfsinftmenqihtgmeyengrflgvkfKSVTFKDSVFKSCTFD 103
Cdd:cd17438   245 AFSYYGLTVWFPDMIRYLQ---------------------------------------------KHVTFEDSLFDECYFE 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 104 DVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDySAYWIYFVNFLGTLAVLPGNIVSALL 183
Cdd:cd17438   280 DVTSTDTYFKNCTIESTIFYNTDLYEHKFIDCRFINSTFLEQKEGCHMDFEED-NDFLIYLVSFLGSLSVLPGNIISALL 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 184 MDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAV 263
Cdd:cd17438   359 MDKIGRIKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAI 438

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1720375948 264 LGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTR 302
Cdd:cd17438   439 LGNSIFASFVGITKVIPILLASTALVGGGLISLRLPETR 477
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 151-296 6.01e-23

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 96.90  E-value: 6.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 151 ITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISC--FFLWFGTSESMMIGMLCLYNGLTI 228
Cdd:cd17316   204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAlpLFYLLSGSPTLLLLLLFILSFFVG 283

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 229 SAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVS--ITKAIPILLASTVLVCGGLVGL 296
Cdd:cd17316   284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAstGGTGVPALILALLAIVALIVAL 353
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 164-299 1.63e-14

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 72.61  E-value: 1.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 164 FVNFLGTLAV-LPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWF--GTSESMMIGMLCLYNGLTISAWNSLDVVTVE 240
Cdd:cd17317   194 YLNFFLSGLVeIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALlpDDENTLALTLALVGKFAISAAFSVIYLYTAE 273

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720375948 241 LYPTDRRATGFGFLNALCKAAAVLGNLIFgSLVSITKAIPILLASTVLVCGGLVGLRLP 299
Cdd:cd17317   274 LYPTVVRNTGVGLCSTVARVGAILAPFIV-LLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
157-302 4.21e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 68.74  E-value: 4.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 157 YSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRL--TMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSL 234
Cdd:COG2271   213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 235 DVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSIT--KAIPILLASTVLVCGGLVGLRLPDTR 302
Cdd:COG2271   293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATgyQAAFLLLAALALLAALLALLLLRETR 362
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 162-306 2.38e-12

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 66.96  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 162 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSE--SMMIGMLCLYNGLTISAWNSLDVVTV 239
Cdd:TIGR00898 357 IYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDlyFLRTALAVLGKFGITSAFQMVYLYTA 436

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720375948 240 ELYPTDRRATGFGflnaLCKAAAVLGNlIFGSLVSITKAI----PILLASTVLVCGGLVGLRLPDTRTQVL 306
Cdd:TIGR00898 437 ELYPTVVRNLGVG----VCSTMARVGS-IISPFLVYLGEKwlflPLVLFGGLALLAGILTLFLPETKGVPL 502
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 162-299 1.72e-10

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 60.77  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 162 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSE--SMMIGMLCLYNGLTISAWNSLDVVTV 239
Cdd:cd17374   203 VFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEmqTLRTVLAVLGKGSSAAAFTISYVYTA 282

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 240 ELYPTDRRATGFGFLNALCKAAAVLGNLIFgSLVSITKAIPILLASTVLVCGGLVGLRLP 299
Cdd:cd17374   283 ELFPTVLRQTGMGLNSMFARIGGILAPLIM-LLGVYSPLLPMIIYGVLPILAGLLALLLP 341
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 167-293 2.38e-10

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 60.63  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 167 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDR 246
Cdd:cd17372   236 FIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAV 315

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1720375948 247 RATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGL 293
Cdd:cd17372   316 RALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIALLLFSVVCLVSAI 362
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 162-296 6.51e-10

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 59.29  E-value: 6.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 162 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISC---FFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVT 238
Cdd:cd17378   203 IYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCllcFVLSIGGTTSLQIALELVGFFGAAGAFNLLYIYT 282

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720375948 239 VELYPTDRRATGFGFLNalckAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGL 296
Cdd:cd17378   283 VELFPTCVRNAALGMLR----QALVVGGIFAPFIVSLGRKNAALSFGVFGVAILLLGL 336
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 158-299 3.13e-09

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 57.12  E-value: 3.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 158 SAYWIYFVNFLGTLAVLPGNIvsaLLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVV 237
Cdd:cd17442   237 SDYQTMIISTLGEIALNPLNI---LGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGLTIFLFMLRALVSANFNTVYIY 313

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720375948 238 TVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLP 299
Cdd:cd17442   314 TAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASVLGALCLFSSVCIVCAISAFTLP 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
157-257 3.49e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.91  E-value: 3.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 157 YSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDV 236
Cdd:COG2814   240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA 319

                          90       100
                  ....*....|....*....|.
gi 1720375948 237 VTVELYPTDRRATGFGFLNAL 257
Cdd:COG2814   320 LVAELAPPEARGRASGLYNSA 340
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
158-276 1.51e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 55.29  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 158 SAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWF-GTSESMMIGMLCLYNGLTISAWNSL-- 234
Cdd:COG2211   262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlGPGNLWLLLVLAALAGIGLGAILVLpw 341

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1720375948 235 ----DVVTVELYPTDRRATG--FGFLNALCKAAAVLGNLIFGSLVSIT 276
Cdd:COG2211   342 amlaDVVDYDEWKTGRRREGlyFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_1 pfam07690
Major Facilitator Superfamily;
161-304 1.81e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.73  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 161 WIYFVNFLGTLAvlpGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLyNGLTISA-WNSLDVVTV 239
Cdd:pfam07690  36 LLLTLFSLGYAL---AQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVL-QGLGAGAlFPAALALIA 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720375948 240 ELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQ 304
Cdd:pfam07690 112 DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 158-296 2.26e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.74  E-value: 2.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 158 SAYWIYFVNFLGTLavlPGNIVSALLMDR-IGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDV 236
Cdd:cd06174   240 VAGLLLSLFGLAGA---LGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 237 VTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLastvLVCGGLVGL 296
Cdd:cd06174   317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF----LVLAVLLLL 372
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 176-294 5.28e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 53.36  E-value: 5.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 176 GNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGL-TISAWNSLDVVTVELYPTDRRATGFGFL 254
Cdd:cd17365   222 GSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGAcVNGAQVGLYALAARFYPTEVRATGVGWA 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1720375948 255 NALCKAAAVLGNLIFGSLVSITKAIP---ILLASTVLVCGGLV 294
Cdd:cd17365   302 LGVGRLGAILGPLLGGLLLAAGLGPEsvfLALAIPAALGALAV 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
150-304 7.80e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.05  E-value: 7.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 150 QITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYnGLTIS 229
Cdd:COG2814    35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQ-GLGAG 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720375948 230 AWNSL-DVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSIT--KAIPILLASTVLVCGGLVGLRLPDTRTQ 304
Cdd:COG2814   114 ALFPAaLALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgwRWVFLVNAVLALLALLLLLRLLPESRPA 191
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 156-272 2.31e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 51.39  E-value: 2.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 156 DYSAYWIYFVNFLGTLAVLPG-----NIVSAL-------LMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLY 223
Cdd:cd17370   218 SFAFLILRAQELGLSAALIPLlyalfNLVYALaaypagrLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILW 297

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720375948 224 nGLTISAWNSL-DVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSL 272
Cdd:cd17370   298 -GLYMGAQESIeRAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL 346
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 161-299 2.36e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.66  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 161 WIYFVNFLGTLAvlpGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVE 240
Cdd:cd06174    35 LLFALFSLGYAL---LQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAD 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720375948 241 LYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKA---IPILLASTVLVCGGLVGLRLP 299
Cdd:cd06174   112 LFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAALALLAAILLLLVV 173
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
164-304 2.52e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.42  E-value: 2.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 164 FVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWF--GTSESMMIGMLCLynGLTISAWNSLDVVTV-E 240
Cdd:COG2223   245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALalGSLWLFLVLFLLL--GLALGGGNGAVFALVpD 322

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720375948 241 LYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAI-PILLASTVLVCGGLVGLRLPDTRTQ 304
Cdd:COG2223   323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYtAAFLVFAVLALVALVLTLLLYRRPR 387
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
161-274 3.45e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.02  E-value: 3.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 161 WIYFVNFLGTLAvlpGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLyNGLTISA-WNSLDVVTV 239
Cdd:COG2271    49 LLASAFFLGYAL---GQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFL-LGLGEAGfFPAALKLIA 124

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720375948 240 ELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVS 274
Cdd:COG2271   125 EWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 150-273 4.83e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 50.82  E-value: 4.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 150 QITFDDDYSAYWIYFVNFLGTLavlpGNIVSALLMDRIGRLTMLGGSMvLSGISCFFLWFG-TSESMMIGMLCLYNGLTI 228
Cdd:TIGR00895 279 ELGFSLSLAATGGALFNFGGVI----GSIIFGWLADRLGPRVTALLLL-LGAVFAVLVGSTlFSPTLLLLLGAIAGFFVN 353

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720375948 229 SAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLV 273
Cdd:TIGR00895 354 GGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
167-298 7.10e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.26  E-value: 7.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 167 FLGTLAVLPGNIVSALLMDRIG-RLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLynGLTISAWNSLD-VVTVELYPT 244
Cdd:COG2807   257 SLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL--GLGQGGLFPLAlTLIGLRART 334

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720375948 245 DRRAT-------GFGFLnalckaAAVLGNLIFGSLVSITK--AIPILLASTVLVCGGLVGLRL 298
Cdd:COG2807   335 PAEAAalsgmaqSVGYL------LAALGPLLVGALHDATGswTAALLLLAALAVLMLVAGLLA 391
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 175-304 8.78e-07

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 49.77  E-value: 8.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 175 PGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESM---MIGMLCLYNGLTISAWNSLdvvTVELYPTDRRATGF 251
Cdd:COG2270   289 LGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAfwiLGLLIGLVMGGIQALSRSL---LARLIPPGREAEFF 365

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720375948 252 GFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVL--VCGGLVGLRLPDTRTQ 304
Cdd:COG2270   366 GLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVffVIGLVLLLRVKVPRGR 420
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 156-298 1.00e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.50  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 156 DYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLD 235
Cdd:cd17325   231 GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL 310

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720375948 236 VVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLV-SITKAIPILLASTVLVCGGLVGLRL 298
Cdd:cd17325   311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAALLLLAAVLFLLL 374
MFS_1 pfam07690
Major Facilitator Superfamily;
156-265 1.21e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.34  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 156 DYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGR---LTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWN 232
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRrrrLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1720375948 233 SLDVVTVELYPTDRRATGFGFLNALCKAAAVLG 265
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 158-304 1.91e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.73  E-value: 1.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 158 SAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVV 237
Cdd:cd17325    29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMAL 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720375948 238 TVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSIT--KAIPILLASTVLVCGGLVGLRLPDTRTQ 304
Cdd:cd17325   109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALgyRAPFLVCAALALLALVLALLLLPEPRPP 177
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 162-299 3.41e-06

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 47.73  E-value: 3.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 162 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFgTSESMM---IGMLCLYN-GLTIsAWNSLDVV 237
Cdd:cd17379   201 LYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAF-IPPDLHwlkTTIACVGRlGITM-AFEIVCLV 278

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720375948 238 TVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTV-LVCGGLVgLRLP 299
Cdd:cd17379   279 NTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYRLAEIWLELPLIVFGVLaLVAGGLV-LLLP 340
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 162-299 3.59e-06

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 47.80  E-value: 3.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 162 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSE--SMMIGMLCLYNGLTISAWNSLDVVTV 239
Cdd:cd17447   203 VYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEftVVRTVIAVLGKGFSEAAFTTVFLYTS 282

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 240 ELYPTDRRATGFGFLNALCKAAAVLGNLIFgSLVSITKAIPILLASTVLVCGGLVGLRLP 299
Cdd:cd17447   283 ELYPTVLRQNGMGYTSFIARLGGSLAPLVI-LLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
76-146 8.28e-06

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 43.03  E-value: 8.28e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720375948  76 EYENGRFLGVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLHNK 146
Cdd:pfam13599   2 DFTRCSFEGCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNAQFSGCNLKNSNFSDVK 72
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 161-298 3.08e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.91  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 161 WIYFVNFLGTLAvlpGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYnGLTISAWN-SLDVVTV 239
Cdd:cd06173   248 LLLAAFGVGALL---GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLL-GLAGGLFNvPLNTLLQ 323

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 240 ELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKA-IPILLASTVLVCGGLVGLRL 298
Cdd:cd06173   324 LRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLsAVFLLAGALLLLAALLLLLL 383
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
159-296 3.19e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.84  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 159 AYWIYFVNFLGTLAVLpgnIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLY---NGLTISAWNSLd 235
Cdd:COG0738    45 AGLLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLglgLGLLDVAANPY- 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720375948 236 VVTVElypTDRRATGFGFLNALCKAAAVLGNLIFGSLvsITKAIPILLASTVLVCGGLVGL 296
Cdd:COG0738   121 VAALG---PETAASRLNLLHAFFSLGALLGPLLGGLL--ILLGLSLSWHLPYLILAVLLLL 176
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 162-302 3.45e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.99  E-value: 3.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 162 IYFVNFLGTLAvlpgnivSALLMDRIGRLTMLGGSMVLSGISC---FFLWFGTSESMMIGMLCLYngLTISAWNSLDVVT 238
Cdd:cd17371   254 TILGGFLGYLA-------GGFLADRIGRRNNFALFALGSAISIllyFFLPLSPTLILILGFPLGF--FASGPFSGMGAYL 324

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720375948 239 VELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLV-SITKAIPILLASTVLVCGGLVGLRLPDTR 302
Cdd:cd17371   325 TELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLAtSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 176-298 3.78e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.95  E-value: 3.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 176 GNIVSALLMDRIGRLTMLGGsmVLSGISCFFLWFGTSESMMiGMLC--LYNGLTISAWNS-LDVVTVELYPTDRRATGFG 252
Cdd:PRK11551  271 GSLLIGALMDRLRPRRVVLL--IYAGILASLAALAAAPSFA-GMLLagFAAGLFVVGGQSvLYALAPLFYPTQVRGTGVG 347

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1720375948 253 FLNALCKAAAVLGNLIFGSLVSITKAIPILLAST--VLVCGGLVGLRL 298
Cdd:PRK11551  348 AAVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASipVILVAALAALLL 395
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 153-299 4.35e-05

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 44.47  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 153 FDDDYSAYWIYFVNFLGTLavlpGNIVSALLMDR--IGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYnGLTISA 230
Cdd:cd17352   215 IDESDAAFLLSIIGISDIV----GRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLF-GFCSGS 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720375948 231 WNSL-DVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITK--AIPILLASTVLVCGGLVGLRLP 299
Cdd:cd17352   290 YSSLtPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGdyDAAFYFCGACLLLSGVLLFLLP 361
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 168-299 6.22e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 44.18  E-value: 6.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 168 LGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTV-ELYPTDR 246
Cdd:cd17355   253 LIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAaRYFGARS 332

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720375948 247 RATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLP 299
Cdd:cd17355   333 YGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 167-299 6.35e-05

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 43.97  E-value: 6.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 167 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSE-SMMIGMLCLYNGLTIS-AWNSLDVVTVELYPT 244
Cdd:cd17375   208 FLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDyEVLTIVLSMTGKFAIAiAFGLIYLYTAELYPT 287

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720375948 245 DRRATGFGFLNALCKAAAVLGNLIFgSLVSITKAIPILLASTVLVCGGLVGLRLP 299
Cdd:cd17375   288 IVRSLAVGSGSMMCRVGSVVAPFCV-YLSDVWIFLPQLLVGIMAFLSGILTLMLP 341
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
90-151 6.56e-05

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 40.72  E-value: 6.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720375948  90 VTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFDNTDFEPYKFIDSEFQNCSFLH-NKTGCQI 151
Cdd:pfam13599   1 ADFTRCSFEGCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNaQFSGCNL 63
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 169-298 7.52e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 43.71  E-value: 7.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 169 GTLAVLP------GNIVSALLMDRI---GRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTV 239
Cdd:cd17319   218 GLLAAIPflagaiGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPA 297

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720375948 240 ELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITK--AIPILLASTVLVCGGLVGLRL 298
Cdd:cd17319   298 DLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsyTAAFLFLAAVALLAALLVLLL 358
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 167-286 1.42e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 42.90  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 167 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCF--FLWFGTSES--MMIGMLCLYN---GLTISAWNSLdvvTV 239
Cdd:cd17369   271 LIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFpfFWLLDTGSTwlIVLAAVVVLGvlhGMMYGPQAAF---LA 347

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1720375948 240 ELYPTDRRATGFGFlnalckaAAVLGNLIFGSLVSITKAipILLAST 286
Cdd:cd17369   348 ELFPTRVRYTGASL-------GYQLGAILGGGFAPLIAT--ALVAAT 385
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 170-299 1.96e-04

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 42.49  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 170 TLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRAT 249
Cdd:cd17441   243 TLSEFPGLLVTLWIIDRFGRKKTMALCFFVFSFCTLLLFSCVGRFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRAL 322

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720375948 250 GFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLP 299
Cdd:cd17441   323 GLGTCSGMARVGALITPFIAQVMLESSVYLTLSVYSGCCLLAAIASCFLP 372
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 162-302 2.28e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 42.28  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 162 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSES---------MMIGMLCLYNGLTISAwn 232
Cdd:cd17367   261 ATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTdspytafalVLVGLVFLSGYTSINA-- 338

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720375948 233 sldVVTVELYPTDRRATGFGFLNALckAAAVLGN---LIFGSLVSITKAIPILLASTVLVC-GGLVGLRLPDTR 302
Cdd:cd17367   339 ---VVKAELFPTHVRALGVGLPYAL--AVAIFGGtapYVALWLKSIGHEWVFFWYVAGLIAiSLVVYLRMPETR 407
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 142-276 2.67e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 42.23  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 142 FLHNKTGCQITfdddySAYWIYFVNFLGTLAvlpGNIVSALLMDRIG---RLTMLGGSMVLSGISCFFLWFGTSESMM-- 216
Cdd:cd17475   224 FLHDHLGLSVV-----AAGALLAVAQLGGAL---GRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLLSPGTPLwl 295

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720375948 217 IGMLCLYNGLTISAWNSLDVVTV-ELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSIT 276
Cdd:cd17475   296 LVLLLILLGLFAIGWNGLYLTLVaESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAT 356
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 168-307 4.10e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 41.34  E-value: 4.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 168 LGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLyNGLTISA-WNSLDVVTVELYPTDR 246
Cdd:COG0477    57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARAL-QGIGAGGlMPGALALIAELFPARE 135

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720375948 247 RATGFGFLNALCKAAAVLGNLIFGSLVSITK-AIPILLASTVLVCGGLVGLRLPDTRTQVLM 307
Cdd:COG0477   136 RGRALGLWGAAIGLGLALGPLLGGLLVAALGwRWIFLINAPLGLLALVLRLRLPESRGLLLA 197
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 164-275 4.63e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 41.49  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 164 FVNFLGTLAVLPGNIVSALLMDRIGR--LTMLGGSMV---LSGISCFFLWFGTSEsmmIGMLCLYnGLTISAWN-----S 233
Cdd:cd17364   244 GQLIIALAGTVPGYWFTVFLIDRIGRkkIQMMGFFGMtifLLILAGPYDHWKIST---IGFFVLY-GLTFFFSNfgpntT 319

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720375948 234 LDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSI 275
Cdd:cd17364   320 TFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQN 361
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 154-248 5.85e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 41.03  E-value: 5.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 154 DDDYSAYWIYFVNFLGtlaVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCL----YNGLTIS 229
Cdd:cd17317    22 DRDWLVALVQTIFFLG---VLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLvgvtSAGIFTV 98

                          90
                  ....*....|....*....
gi 1720375948 230 AWnsldVVTVELYPTDRRA 248
Cdd:cd17317    99 GF----VLGMEIVGPKYRS 113
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 158-298 8.77e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 8.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 158 SAYWIYFVNFlgTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVV 237
Cdd:cd17489   227 SNAGLFFTVY--AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQAL 304

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720375948 238 TVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITK-AIPILLASTVLVCGGLVGLRL 298
Cdd:cd17489   305 AVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGyRAMFLLAAVVVLLALVLYIFL 366
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 183-297 9.60e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.29  E-value: 9.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 183 LMDRIGRLTMLGGSMVLSGISCFFLWFGTSESM-MIGMLCLYNGLTIsAWNSLDVVTVELYPTDRRATGFGFLNALCKAA 261
Cdd:cd17329   259 LVERFRLRKILMIGILLFAIGFAVLAFANTLAVlILAMIVLTLGEML-VFPAVQTLVAALAPPDKRGSYMGFYALAWGLG 337

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1720375948 262 AVLGNLIFGSLVS---ITKAIPILLASTVLVCGGLVGLR 297
Cdd:cd17329   338 RAIGPLVGGLLLDllgPGLPWLILAALGLIAAALLLGLQ 376
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 164-299 1.03e-03

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 40.14  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 164 FVN-FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFF-------LWFGTSESMMIGMLCLyngltISAWNSLD 235
Cdd:cd17376   205 YLNcFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFiqlvptdLQVLATALVMLGKFGI-----TAAFSMVY 279

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720375948 236 VVTVELYPTDRRATGFGflnaLCKAAAVLGNLI---FGSLVSITKAIPILLASTVLVCGGLVGLRLP 299
Cdd:cd17376   280 VYTAELYPTVVRNMGVG----VCSTASRIGSIIspyFVYLGAYDRYLPYILMGSLTVLIGILTLFLP 342
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 158-298 1.99e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 158 SAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGIScfFLWFGTSES-----MMIGMLCLYNGLTISAwn 232
Cdd:cd17329    33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG--FALLGFAHSpwlfaIALVLTGFGGGLFEPA-- 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720375948 233 sLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRL 298
Cdd:cd17329   109 -SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFL 173
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 153-291 2.78e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 38.79  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 153 FDDDYSAYW----IYFVNFLGTlavlpgnIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYN-GLT 227
Cdd:cd17360   219 FKDNQNAIWlsliVAGTNFIFT-------IVGMYLIDKFGRRKLLLISLFGVIVALVVLAVWLALVGLILYLAFFApGMG 291

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720375948 228 ISAWnsldVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLV-SITKAIPILLASTVLVCG 291
Cdd:cd17360   292 PVPW----TVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTqAIGPYGTFLLFAGLAVLG 352
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 157-298 3.14e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 38.71  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 157 YSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFL------WFGTSESMMIGMLCLY--NGLTI 228
Cdd:cd17320   234 LSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLllaallGGLSLWPLVAPLFLIFfgFGLIF 313

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 229 SAWNSLdvvTVELYPtDRRATGFGFLNALCKAAAVLGNLIFGSLVSITkAIPILLASTVLVCGGLVGLRL 298
Cdd:cd17320   314 PNATSL---ALEPFP-HVAGTASALLGFLQFLIGALAGALVGLLPNGT-ALPMGLLILVLGLLALLLLIL 378
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 167-265 4.35e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 38.51  E-value: 4.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 167 FLGTLAVLPGNIVSAL----LMDRIGRLTMLGGSMVLSGISCF--FLWFGTSES-----MMIGMLCLYNGLTISAwnsLD 235
Cdd:cd17368   261 FLVTLLAGVANFIWAPlggaLSDRIGRRPVLLVITLAALVTLYpvFAWLTAAPSfgrllLVLLVLSFFFGMYGGA---MV 337

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720375948 236 VVTVELYPTDRRATGFGFLNALckAAAVLG 265
Cdd:cd17368   338 VALVELFPVRVRSTGFSLVYAL--AVAIFG 365
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 178-294 4.99e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 38.30  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 178 IVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLyNGLTISAWNSLDVVTV-ELYPtDR--RATGFgFL 254
Cdd:cd17471   253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLL-NAIFIGITAGLGISYFqDLMP-GQpgLATTL-YS 329

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1720375948 255 NALcKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLV 294
Cdd:cd17471   330 NAS-RIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 183-302 7.05e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 37.56  E-value: 7.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 183 LMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIgMLCLYNGLTISAWNSLDVVTV-ELYPTDRRATGFGFLNALCKAA 261
Cdd:cd17320    57 LSDRFGRRPVLLAGLLLFILASLLCALASSIEQLL-IARFLQGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMILAIA 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720375948 262 AVLGNLIfGSLVSIT---KAIPILLASTVLVCGGLVGLRLPDTR 302
Cdd:cd17320   136 PALAPLL-GGLLLLFfgwRAIFVFLALLGLLLLLLVLLFLPETL 178
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
161-298 8.27e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 37.55  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375948 161 WIYFVNFL-GTLAVLPGNIvsalLMDRIGRLTMLGGSMVLSGISCFFLWFGTS-ESMMIGMLCLYNGLTISAWNSLDVVt 238
Cdd:COG2223    44 LLFAIPVLvGALLRIPLGF----LVDRFGPRRVLLIGLLLLGIGLLLLALAVSyWLLLLLGLLLGIGGGGSFAVGIALV- 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720375948 239 VELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLV-SITKAIPILLASTVLVCGGLVGLRL 298
Cdd:COG2223   119 SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVAVLAWLF 179
Pentapeptide_3 pfam13576
Pentapeptide repeats (9 copies);
87-141 8.88e-03

Pentapeptide repeats (9 copies);


Pssm-ID: 433322 [Multi-domain]  Cd Length: 48  Bit Score: 33.75  E-value: 8.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720375948  87 FKSVTFKDSV-FKSCTFDDVTSvntyFKNCTFIDTLFDNTDFEPykfiDSEFQNCS 141
Cdd:pfam13576   1 FSGATFTGAAdFSGATFSGDAS----FSNATFGDADFSGATFTG----DADFSGAT 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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