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Conserved domains on  [gi|1720385230|ref|XP_030104664|]
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protein LMBR1L isoform X1 [Mus musculus]

Protein Classification

LMBR1 domain-containing protein( domain architecture ID 10521549)

LMBR1 domain-containing protein similar to Homo sapiens limb region 1 protein (LMBR1), a putative membrane receptor that may play a role in limb development

Gene Ontology:  GO:0007165

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LMBR1 pfam04791
LMBR1-like membrane protein; Members of this family are integral membrane proteins that are ...
24-451 1.09e-52

LMBR1-like membrane protein; Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. Lysosomal cobalamin transport escort protein LMBD1 is a lysosomal membrane chaperone required to export cobalamin from lysosome to the cytosol, allowing its conversion to cofactors. A member of this family has been shown to be a lipocalin membrane receptor.


:

Pssm-ID: 461429  Cd Length: 471  Bit Score: 184.78  E-value: 1.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230  24 ISILLFATLYILCHIFLTRFKKPAEfttvddedatVNKIALELCTFTLAVALGAVLLLPFSIIS--------NEVLLSLP 95
Cdd:pfam04791   4 IFLLLFLLLFLLSLYLLRRYGRPKD----------VPAYVKLLVFLALALSFLIVLLLPLDIAStayrqssnSNEVLLYP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230  96 RNYYIQWLNGSLIHGLWNLVFLFSNLSLVFLMPFAYFFTESEGFAGSRKGVlgRV-YETVVMLILLTLLVLGMVWVASAI 174
Cdd:pfam04791  74 CSYYWSWLPSSLLLVLWRIVYWLSFLLTWLILPFMQFYSESGDFTGKGKLK--RSlKENAIYYGLLLVIVLGLLIYLLIL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 175 vdndkaSRESLYdfWEYYLPYLYSCISFLGVLLLLVCTPLGLARM-FSVTGKLLVKPRL-------------LEDLEEQL 240
Cdd:pfam04791 152 ------PGESLL--LRSLKPFLISLANTWGLFLLIILLGYGLVELpRSLWRASNLGERLkrlyfkaaklnteKEEAEREL 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 241 NcSAFEEAALTRRICNPTSCWLPLDMEL-----------------LHRQVLALQAQRV--------LLEKRRKASAWQRN 295
Cdd:pfam04791 224 E-DLLKQVSLLSQSISSSDLRDYIETILnkvpeeitepsekslasLHKQLIRALQRRLrtedqwrkLLKKAFRLSKLTPT 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 296 LGYPLAML----CLLVLTGLSVLIVAVHIL-ELLIDEAAMPRGMQDAALGQASFSKLGSFGA-IIQVVLIFYLMVSSVVG 369
Cdd:pfam04791 303 LEYYWYCLllpyVLLILSVILALLSVIVVWsELTFFLIKPVLSLFALFIGLHASSSFGYFGIeLIEIIFILYLCLCAYSG 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 370 FYS--SPLFGSLRPrWHDTSMTQIIGNCVCLLVLSSalPVFSRTLGLTRFD------LLGDFGRFNWLGnFYIVFLYNAA 441
Cdd:pfam04791 383 LFKikVFGFYRLVP-HHQTDMNSLIFNAGLLLRLTS--PLCYNFLGLIHFDshiftqLLGHMDVLPFLG-FGFNIYFPIF 458
                         490
                  ....*....|
gi 1720385230 442 FAGLTTLCLV 451
Cdd:pfam04791 459 ILILCLATLF 468
 
Name Accession Description Interval E-value
LMBR1 pfam04791
LMBR1-like membrane protein; Members of this family are integral membrane proteins that are ...
24-451 1.09e-52

LMBR1-like membrane protein; Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. Lysosomal cobalamin transport escort protein LMBD1 is a lysosomal membrane chaperone required to export cobalamin from lysosome to the cytosol, allowing its conversion to cofactors. A member of this family has been shown to be a lipocalin membrane receptor.


Pssm-ID: 461429  Cd Length: 471  Bit Score: 184.78  E-value: 1.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230  24 ISILLFATLYILCHIFLTRFKKPAEfttvddedatVNKIALELCTFTLAVALGAVLLLPFSIIS--------NEVLLSLP 95
Cdd:pfam04791   4 IFLLLFLLLFLLSLYLLRRYGRPKD----------VPAYVKLLVFLALALSFLIVLLLPLDIAStayrqssnSNEVLLYP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230  96 RNYYIQWLNGSLIHGLWNLVFLFSNLSLVFLMPFAYFFTESEGFAGSRKGVlgRV-YETVVMLILLTLLVLGMVWVASAI 174
Cdd:pfam04791  74 CSYYWSWLPSSLLLVLWRIVYWLSFLLTWLILPFMQFYSESGDFTGKGKLK--RSlKENAIYYGLLLVIVLGLLIYLLIL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 175 vdndkaSRESLYdfWEYYLPYLYSCISFLGVLLLLVCTPLGLARM-FSVTGKLLVKPRL-------------LEDLEEQL 240
Cdd:pfam04791 152 ------PGESLL--LRSLKPFLISLANTWGLFLLIILLGYGLVELpRSLWRASNLGERLkrlyfkaaklnteKEEAEREL 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 241 NcSAFEEAALTRRICNPTSCWLPLDMEL-----------------LHRQVLALQAQRV--------LLEKRRKASAWQRN 295
Cdd:pfam04791 224 E-DLLKQVSLLSQSISSSDLRDYIETILnkvpeeitepsekslasLHKQLIRALQRRLrtedqwrkLLKKAFRLSKLTPT 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 296 LGYPLAML----CLLVLTGLSVLIVAVHIL-ELLIDEAAMPRGMQDAALGQASFSKLGSFGA-IIQVVLIFYLMVSSVVG 369
Cdd:pfam04791 303 LEYYWYCLllpyVLLILSVILALLSVIVVWsELTFFLIKPVLSLFALFIGLHASSSFGYFGIeLIEIIFILYLCLCAYSG 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 370 FYS--SPLFGSLRPrWHDTSMTQIIGNCVCLLVLSSalPVFSRTLGLTRFD------LLGDFGRFNWLGnFYIVFLYNAA 441
Cdd:pfam04791 383 LFKikVFGFYRLVP-HHQTDMNSLIFNAGLLLRLTS--PLCYNFLGLIHFDshiftqLLGHMDVLPFLG-FGFNIYFPIF 458
                         490
                  ....*....|
gi 1720385230 442 FAGLTTLCLV 451
Cdd:pfam04791 459 ILILCLATLF 468
 
Name Accession Description Interval E-value
LMBR1 pfam04791
LMBR1-like membrane protein; Members of this family are integral membrane proteins that are ...
24-451 1.09e-52

LMBR1-like membrane protein; Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. Lysosomal cobalamin transport escort protein LMBD1 is a lysosomal membrane chaperone required to export cobalamin from lysosome to the cytosol, allowing its conversion to cofactors. A member of this family has been shown to be a lipocalin membrane receptor.


Pssm-ID: 461429  Cd Length: 471  Bit Score: 184.78  E-value: 1.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230  24 ISILLFATLYILCHIFLTRFKKPAEfttvddedatVNKIALELCTFTLAVALGAVLLLPFSIIS--------NEVLLSLP 95
Cdd:pfam04791   4 IFLLLFLLLFLLSLYLLRRYGRPKD----------VPAYVKLLVFLALALSFLIVLLLPLDIAStayrqssnSNEVLLYP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230  96 RNYYIQWLNGSLIHGLWNLVFLFSNLSLVFLMPFAYFFTESEGFAGSRKGVlgRV-YETVVMLILLTLLVLGMVWVASAI 174
Cdd:pfam04791  74 CSYYWSWLPSSLLLVLWRIVYWLSFLLTWLILPFMQFYSESGDFTGKGKLK--RSlKENAIYYGLLLVIVLGLLIYLLIL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 175 vdndkaSRESLYdfWEYYLPYLYSCISFLGVLLLLVCTPLGLARM-FSVTGKLLVKPRL-------------LEDLEEQL 240
Cdd:pfam04791 152 ------PGESLL--LRSLKPFLISLANTWGLFLLIILLGYGLVELpRSLWRASNLGERLkrlyfkaaklnteKEEAEREL 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 241 NcSAFEEAALTRRICNPTSCWLPLDMEL-----------------LHRQVLALQAQRV--------LLEKRRKASAWQRN 295
Cdd:pfam04791 224 E-DLLKQVSLLSQSISSSDLRDYIETILnkvpeeitepsekslasLHKQLIRALQRRLrtedqwrkLLKKAFRLSKLTPT 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 296 LGYPLAML----CLLVLTGLSVLIVAVHIL-ELLIDEAAMPRGMQDAALGQASFSKLGSFGA-IIQVVLIFYLMVSSVVG 369
Cdd:pfam04791 303 LEYYWYCLllpyVLLILSVILALLSVIVVWsELTFFLIKPVLSLFALFIGLHASSSFGYFGIeLIEIIFILYLCLCAYSG 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720385230 370 FYS--SPLFGSLRPrWHDTSMTQIIGNCVCLLVLSSalPVFSRTLGLTRFD------LLGDFGRFNWLGnFYIVFLYNAA 441
Cdd:pfam04791 383 LFKikVFGFYRLVP-HHQTDMNSLIFNAGLLLRLTS--PLCYNFLGLIHFDshiftqLLGHMDVLPFLG-FGFNIYFPIF 458
                         490
                  ....*....|
gi 1720385230 442 FAGLTTLCLV 451
Cdd:pfam04791 459 ILILCLATLF 468
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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