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Conserved domains on  [gi|1720389941|ref|XP_030105614|]
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zinc finger protein 51 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
42-82 1.78e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.78e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720389941  42 LLTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSV 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-749 4.09e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 327 SCPECGREFHQLSHLRKHYRLHTGEKPYKCN--ECDRSFTHYASLRWHQKTHTPE-IHYECKECGKSFIELSHLKRHYRI 403
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpSDLNSKSLPLSNSKASSSSLSSSS 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 404 HTGEKPYKCEICDKSFTTTttlktHQKIHTGEKPYKCRECDKSFIHSSHlrrhqnvhtgerpyrcKECDKSFHESATLRE 483
Cdd:COG5048   115 SNSNDNNLLSSHSLPPSSR-----DPQLPDLLSISNLRNNPLPGNNSSS----------------VNTPQSNSLHPPLPA 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 484 HEKSHTGEKtykcrecdksftqrAYLRNHHNRVHTGERPYECKECGKSFTTCSTLRIHQTIHTGKKPYKCIECGKSFTNN 563
Cdd:COG5048   174 NSLSKDPSS--------------NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 564 SYLRTHQKVHSGEKPYRCKECDKSFTSCSTLKAHQNIHTGE-------KPYKCIECDKSFTQVSHLRTHQR--VHTGE-- 632
Cdd:COG5048   240 LLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEsl 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 633 RPFRCTE--CDKSFIRSSHLREHQKIHSGEKPYKC--RDCDISFSQISNLRRHQKLH-----TGEKPYKCM--ECDKSFT 701
Cdd:COG5048   320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFK 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720389941 702 HNSNFRTHQRVHTGEKP--YRCAECDKSFTRCSYLRAHQKIHTGEKPYKC 749
Cdd:COG5048   400 RDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.16e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 284 ALKSHQKLHTGEKPYKCKECDKSFAH 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.17e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 256 HLKIHQRRHTGEKPYKCKECEKSFVQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
42-82 1.78e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.78e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720389941  42 LLTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSV 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
43-83 3.88e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 3.88e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720389941   43 LTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSVE 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
43-81 3.43e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 3.43e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720389941  43 LTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVS 81
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-749 4.09e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 327 SCPECGREFHQLSHLRKHYRLHTGEKPYKCN--ECDRSFTHYASLRWHQKTHTPE-IHYECKECGKSFIELSHLKRHYRI 403
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpSDLNSKSLPLSNSKASSSSLSSSS 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 404 HTGEKPYKCEICDKSFTTTttlktHQKIHTGEKPYKCRECDKSFIHSSHlrrhqnvhtgerpyrcKECDKSFHESATLRE 483
Cdd:COG5048   115 SNSNDNNLLSSHSLPPSSR-----DPQLPDLLSISNLRNNPLPGNNSSS----------------VNTPQSNSLHPPLPA 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 484 HEKSHTGEKtykcrecdksftqrAYLRNHHNRVHTGERPYECKECGKSFTTCSTLRIHQTIHTGKKPYKCIECGKSFTNN 563
Cdd:COG5048   174 NSLSKDPSS--------------NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 564 SYLRTHQKVHSGEKPYRCKECDKSFTSCSTLKAHQNIHTGE-------KPYKCIECDKSFTQVSHLRTHQR--VHTGE-- 632
Cdd:COG5048   240 LLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEsl 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 633 RPFRCTE--CDKSFIRSSHLREHQKIHSGEKPYKC--RDCDISFSQISNLRRHQKLH-----TGEKPYKCM--ECDKSFT 701
Cdd:COG5048   320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFK 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720389941 702 HNSNFRTHQRVHTGEKP--YRCAECDKSFTRCSYLRAHQKIHTGEKPYKC 749
Cdd:COG5048   400 RDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
677-702 2.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 677 NLRRHQKLHTGEKPYKCMECDKSFTH 702
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 284 ALKSHQKLHTGEKPYKCKECDKSFAH 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 256 HLKIHQRRHTGEKPYKCKECEKSFVQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
239-318 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 239 EKPYKCSV--CDKSFTQCTHLKIHqRRHtgekpykcKECEKSFVQLSALKSHQKLHTGEKPYKCKECDKSFAHYPNFRTH 316
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417

                  ..
gi 1720389941 317 QK 318
Cdd:COG5189   418 RK 419
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
42-82 1.78e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.78e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720389941  42 LLTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSV 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
43-83 3.88e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 3.88e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1720389941   43 LTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSVE 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
43-81 3.43e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 3.43e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720389941  43 LTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVS 81
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-749 4.09e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 327 SCPECGREFHQLSHLRKHYRLHTGEKPYKCN--ECDRSFTHYASLRWHQKTHTPE-IHYECKECGKSFIELSHLKRHYRI 403
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpSDLNSKSLPLSNSKASSSSLSSSS 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 404 HTGEKPYKCEICDKSFTTTttlktHQKIHTGEKPYKCRECDKSFIHSSHlrrhqnvhtgerpyrcKECDKSFHESATLRE 483
Cdd:COG5048   115 SNSNDNNLLSSHSLPPSSR-----DPQLPDLLSISNLRNNPLPGNNSSS----------------VNTPQSNSLHPPLPA 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 484 HEKSHTGEKtykcrecdksftqrAYLRNHHNRVHTGERPYECKECGKSFTTCSTLRIHQTIHTGKKPYKCIECGKSFTNN 563
Cdd:COG5048   174 NSLSKDPSS--------------NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 564 SYLRTHQKVHSGEKPYRCKECDKSFTSCSTLKAHQNIHTGE-------KPYKCIECDKSFTQVSHLRTHQR--VHTGE-- 632
Cdd:COG5048   240 LLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEsl 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 633 RPFRCTE--CDKSFIRSSHLREHQKIHSGEKPYKC--RDCDISFSQISNLRRHQKLH-----TGEKPYKCM--ECDKSFT 701
Cdd:COG5048   320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFK 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720389941 702 HNSNFRTHQRVHTGEKP--YRCAECDKSFTRCSYLRAHQKIHTGEKPYKC 749
Cdd:COG5048   400 RDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
196-616 9.95e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 9.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 196 FSSAYSLMQPTAYIKEKPHQCGKCGKCFNTSSSLTVHHRIHTKEKPYKCSV--CDKSFTQCTHLKIHQRRHTGEKPYkck 273
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 274 ECEKSFVQLSALKSHQKL----HTGEKPYKCKECDKSFAHYPNFRTHQKIHTSEEHCSCPECGREFHQ-LSHLRKHYRLH 348
Cdd:COG5048    93 LNSKSLPLSNSKASSSSLssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLP 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 349 TGEKPYKCNECDRSFTHyaslrwHQKTHTPEIHYECKECGKSFIELSHLKRHYRIHTgEKPYKCEICDKSFTTTTTLKTH 428
Cdd:COG5048   173 ANSLSKDPSSNLSLLIS------SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSP 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 429 QKIHTGEKPYKCRECDKSFIHSSHLRRHQNVHTGER-------PYRCKECDKSFHESATLREHEKS--HTGE--KTYKCR 497
Cdd:COG5048   246 SSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCP 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 498 E--CDKSFTQRAYLRNHHnRVHTGERPYECK--ECGKSFTTCSTLRIHQTIHTGKKPYKCIE-------CGKSFTNNSYL 566
Cdd:COG5048   326 YslCGKLFSRNDALKRHI-LLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNL 404
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720389941 567 RTHQKVHSGEKP--YRCKECDKSFTSCSTLKAHQNIHTGEKPYKCIECDKSF 616
Cdd:COG5048   405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-570 1.35e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 132 FRCCNNEDVSVDSSNQNRYKSTHTGEEP--CESKDCEKSLTLCSDISQDQRLYNAKQHR---QEVYDDYFSSAYSLMQPT 206
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPsqCSYSGCDKSFSRPLELSRHLRTHHNNPSDlnsKSLPLSNSKASSSSLSSS 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 207 AYIKEKPHQCGKCGKCFNTSSSLTVHHRIHTKEKPYKCSVCDKSFTQCTH--LKIHQRRHTGEKPYKCKEceksfvqlSA 284
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnSLHPPLPANSLSKDPSSN--------LS 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 285 LKSHQKLHTGEKPYKCKECDKSFAHYPNFRTHQKIHTSEEHCSCPECGREFHQLSHLRKHYRLHTGEKPYKCNECDRSFT 364
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 365 HYASLRWHQKTHTPE-------IHYECKECGKSFIELSHLKRHYR--IHTGE--KPYKC--EICDKSFTTTTTLKTHQKI 431
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 432 HTGEKPYKC--RECDKSFIHSSHLRRHQNVHtgerpyrckecdkSFHESATLREHEKSHTGektykcreCDKSFTQRAYL 509
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-------------QYKDLKNDKKSETLSNS--------CIRNFKRDSNL 404
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720389941 510 RNhHNRVHTGERPYECK--ECGKSFTTCSTLRIHQTIHTGKKPYKCIECGKSFTNNSYLRTHQ 570
Cdd:COG5048   405 SL-HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
464-774 2.21e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 464 RPYRCKECDKSFHESATLREHEKSHTGEKTYKCR--ECDKSFTQRAYLRNHHNRVHTGERPYECKECGKSFTTCSTLRIH 541
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 542 QTIHTGKKPYKCieCGKSFTNNSYLRTHQKVHSGEKpYRCKECDKSFTSCSTLKAHQNIHtgeKPYKCIECDKSFTQVSH 621
Cdd:COG5048   112 SSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISN-LRNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNLS 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 622 LRTHQRVHTGERPFRCTECDKSFIRSSHLREHQKIHSGEKPYKCRDCDISFSQISNLRRHQKLHtgeKPYKCMECDKSFT 701
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDSSSSASESPR 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 702 HNSNFRTHQR---------VHTG-EKPYRCAECDKSFTRCSYLRAHQ--KIHTGE--KPYKCME--YDKPNTQDSNLKRH 765
Cdd:COG5048   263 SSLPTASSQSsspnesdssSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                  ....*....
gi 1720389941 766 QRVHTGVKH 774
Cdd:COG5048   343 ILLHTSISP 351
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
406-489 2.06e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 406 GEKPYKCEI--CDKSFTTTTTLKTHQKI-HTGEKPYKCRECDKsfihsshlrrHQNVHTGERPYRCKECDKSFHESATLR 482
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415

                  ....*..
gi 1720389941 483 EHEKSHT 489
Cdd:COG5189   416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
677-702 2.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 677 NLRRHQKLHTGEKPYKCMECDKSFTH 702
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
350-430 5.66e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 350 GEKPYKCN--ECDRSFTHYASLRWHQKthtpEIHyeckeCGKSFIELSHLKRHYRIHTGEKPYKCEICDKSFTTTTTLKT 427
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML----HGH-----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                  ...
gi 1720389941 428 HQK 430
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-419 6.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.97e-04
                          10        20
                  ....*....|....*....|....
gi 1720389941 396 HLKRHYRIHTGEKPYKCEICDKSF 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 284 ALKSHQKLHTGEKPYKCKECDKSFAH 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 256 HLKIHQRRHTGEKPYKCKECEKSFVQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
239-318 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 239 EKPYKCSV--CDKSFTQCTHLKIHqRRHtgekpykcKECEKSFVQLSALKSHQKLHTGEKPYKCKECDKSFAHYPNFRTH 316
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417

                  ..
gi 1720389941 317 QK 318
Cdd:COG5189   418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-449 1.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|....*
gi 1720389941 425 LKTHQKIHTGEKPYKCRECDKSFIH 449
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 3.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 340 HLRKHYRLHTGEKPYKCNECDRSFTH 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
621-646 3.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 621 HLRTHQRVHTGERPFRCTECDKSFIR 646
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
705-730 3.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 705 NFRTHQRVHTGEKPYRCAECDKSFTR 730
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-590 4.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389941 565 YLRTHQKVHSGEKPYRCKECDKSFTS 590
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
490-574 5.01e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 5.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 490 GEKTYKCR--ECDKSFTQRAYLRNH----HNRVHTGERPYECKecgksfttcstlriHQTIHTGKKPYKCIECGKSFTNN 563
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHmlhgHQNQKLHENPSPEK--------------MNIFSAKDKPYRCEVCDKRYKNL 411
                          90
                  ....*....|.
gi 1720389941 564 SYLRTHQKvHS 574
Cdd:COG5189   412 NGLKYHRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
547-625 5.18e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389941 547 GKKPYKC--IECGKSFTNNSYLRTHQKvHSgekpyrckECDKSFTSCSTLKAHQNIHTGEKPYKCIECDKSFTQVSHLRT 624
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                  .
gi 1720389941 625 H 625
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-475 5.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.48e-03
                          10        20
                  ....*....|....*....|....
gi 1720389941 452 HLRRHQNVHTGERPYRCKECDKSF 475
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-505 5.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.76e-03
                          10        20
                  ....*....|....*....|....*
gi 1720389941 481 LREHEKSHTGEKTYKCRECDKSFTQ 505
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
594-618 6.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.61e-03
                          10        20
                  ....*....|....*....|....*
gi 1720389941 594 LKAHQNIHTGEKPYKCIECDKSFTQ 618
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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