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Conserved domains on  [gi|1720393270|ref|XP_030106376|]
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zinc finger protein 516 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10443076)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
48-73 8.95e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 8.95e-07
                           10        20
                   ....*....|....*....|....*.
gi 1720393270   48 SLSQHMRKHTGEKPYKCPYCDHRASQ 73
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 811-1036 1.14e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  811 PPPALGGKECQPLLLSRFARTQVPGGAPGS---KGSSSPLGVTTKA----ASMPKNKESHSGGPCALWASGPDGYRQTRA 883
Cdd:PHA03247  2578 SEPAVTSRARRPDAPPQSARPRAPVDDRGDprgPAPPSPLPPDTHApdppPPSPSPAANEPDPHPPPTVPPPERPRDDPA 2657

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  884 GHGQEPP---SAAVQGPLAKPKQEGSSRLAPSPGSGSLSRSTTPTPSVITRVGAqPSANSKPVEKLGGPAVGTGFTP--- 957
Cdd:PHA03247  2658 PGRVSRPrraRRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPalp 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  958 --PNKHSAPDSLKAKFSPQPQGQPPLKGEGGSPLPPREPSVKAAQELRTLATCAAGSRGEAALQAPPGAPPTLNSAKQEP 1035
Cdd:PHA03247  2737 aaPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816


                   .
gi 1720393270 1036 A 1036
Cdd:PHA03247  2817 A 2817
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 34-56 2.40e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 2.40e-04
                           10        20
                   ....*....|....*....|...
gi 1720393270   34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 4.93e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.93e-03
                           10        20
                   ....*....|....*....|...
gi 1720393270  236 FPCEVCGQAFSQTWFLKAHMKKH 258
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
48-73 8.95e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 8.95e-07
                           10        20
                   ....*....|....*....|....*.
gi 1720393270   48 SLSQHMRKHTGEKPYKCPYCDHRASQ 73
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 811-1036 1.14e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  811 PPPALGGKECQPLLLSRFARTQVPGGAPGS---KGSSSPLGVTTKA----ASMPKNKESHSGGPCALWASGPDGYRQTRA 883
Cdd:PHA03247  2578 SEPAVTSRARRPDAPPQSARPRAPVDDRGDprgPAPPSPLPPDTHApdppPPSPSPAANEPDPHPPPTVPPPERPRDDPA 2657

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  884 GHGQEPP---SAAVQGPLAKPKQEGSSRLAPSPGSGSLSRSTTPTPSVITRVGAqPSANSKPVEKLGGPAVGTGFTP--- 957
Cdd:PHA03247  2658 PGRVSRPrraRRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPalp 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  958 --PNKHSAPDSLKAKFSPQPQGQPPLKGEGGSPLPPREPSVKAAQELRTLATCAAGSRGEAALQAPPGAPPTLNSAKQEP 1035
Cdd:PHA03247  2737 aaPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816


                   .
gi 1720393270 1036 A 1036
Cdd:PHA03247  2817 A 2817
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 34-56 2.40e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 2.40e-04
                           10        20
                   ....*....|....*....|...
gi 1720393270   34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 4.93e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.93e-03
                           10        20
                   ....*....|....*....|...
gi 1720393270  236 FPCEVCGQAFSQTWFLKAHMKKH 258
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
48-73 8.95e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 8.95e-07
                           10        20
                   ....*....|....*....|....*.
gi 1720393270   48 SLSQHMRKHTGEKPYKCPYCDHRASQ 73
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 811-1036 1.14e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  811 PPPALGGKECQPLLLSRFARTQVPGGAPGS---KGSSSPLGVTTKA----ASMPKNKESHSGGPCALWASGPDGYRQTRA 883
Cdd:PHA03247  2578 SEPAVTSRARRPDAPPQSARPRAPVDDRGDprgPAPPSPLPPDTHApdppPPSPSPAANEPDPHPPPTVPPPERPRDDPA 2657

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  884 GHGQEPP---SAAVQGPLAKPKQEGSSRLAPSPGSGSLSRSTTPTPSVITRVGAqPSANSKPVEKLGGPAVGTGFTP--- 957
Cdd:PHA03247  2658 PGRVSRPrraRRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPalp 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  958 --PNKHSAPDSLKAKFSPQPQGQPPLKGEGGSPLPPREPSVKAAQELRTLATCAAGSRGEAALQAPPGAPPTLNSAKQEP 1035
Cdd:PHA03247  2737 aaPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816


                   .
gi 1720393270 1036 A 1036
Cdd:PHA03247  2817 A 2817
PHA03247 PHA03247
large tegument protein UL36; Provisional
 812-1040 2.07e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  812 PPALGGKECQPLLLSRFARTQVPGGAPGSKGSSSPLGVTTKAASMPKNKESHSGGPCALWASGP-DGYRQTRAGHGQEPP 890
Cdd:PHA03247  2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPaDPPAAVLAPAAALPP 2820

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  891 SAAVQGPLAKPKQegSSRLAPSPGSGSLSRSTTPTPSVitrvgaqpsANSKPVEKLGGPAvgtgfTPPNKHSAPDSLKAK 970
Cdd:PHA03247  2821 AASPAGPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSV---------APGGDVRRRPPSR-----SPAAKPAAPARPPVR 2884

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720393270  971 FSPQPQGQPPLKGEGGSPL-PPREPSVKAAQELRTLATCAAGSRGEAALQAPPGAPPTLnSAKQEPAAEGQ 1040
Cdd:PHA03247  2885 RLARPAVSRSTESFALPPDqPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL-APTTDPAGAGE 2954
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
62-84 6.37e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 40.61  E-value: 6.37e-05
                           10        20
                   ....*....|....*....|...
gi 1720393270   62 YKCPYCDHRASQKGNLKIHIRSH 84
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 34-56 2.40e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 2.40e-04
                           10        20
                   ....*....|....*....|...
gi 1720393270   34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
828-1039 6.37e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 6.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  828 FARTQVPGGAPGSKGSSSPLGVTTKAASMPKNKESHSGGPCALWASGPD----GYRQTRAGHGQEPPSAAVQGPLAKPKQ 903
Cdd:PRK12323   363 FRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAaaaaARAVAAAPARRSPAPEALAAARQASAR 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  904 EGSSRLAPSPGSGSLSRSTTPTPSVITRVGAQPSANSKPVEKLGGPAVGTGFTPPNKHSAPDSLKAKFSPQPQGQPPLKG 983
Cdd:PRK12323   443 GPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWV 522

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720393270  984 EGGSPLPPREPSVKAAQELRTLATCAAGSRGEAALQ-APPGAPPTLNSAKQEPAAEG 1039
Cdd:PRK12323   523 AESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEpVVAPRPPRASASGLPDMFDG 579
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 62-84 8.35e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 8.35e-04
                           10        20
                   ....*....|....*....|...
gi 1720393270   62 YKCPYCDHRASQKGNLKIHIRSH 84
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 833-1038 1.18e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  833 VPGGAPGSKGSSSPLGVTTKAASMPKNKESHSGGPcalwASGPDGYRQTRAGHGQEPPSAAVQGPLAKPKQEGSSRLAPS 912
Cdd:PRK07764   587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAP----AAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  913 P----GSGSLSRSTTPTPSVITRVGAQPSANSKPVEKLGGPAVGTgfTPPNKHSAPDSLKAKFSPQPQGQPPLKGEGGSP 988
Cdd:PRK07764   663 SdggdGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAA--TPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720393270  989 LPPREPSVKAAQELRTLATCAAGSRGEAALQAPPGAPPTlnSAKQEPAAE 1038
Cdd:PRK07764   741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP--SEEEEMAED 788
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 873-1046 1.64e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  873 SGPDGYRQTRAGHGQEPPSAAVQGPLAKPKQEGssrlAPSPGSGSLS----RSTTPTPSVITRVGAQPSANSKPveklGG 948
Cdd:PHA03307    37 SGSQGQLVSDSAELAAVTVVAGAAACDRFEPPT----GPPPGPGTEApaneSRSTPTWSLSTLAPASPAREGSP----TP 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  949 PAVGTGFTPPnkhSAPDSLKAKFSPQPQGQPPLKGEGGSPLPPREPSVKAAQELRTLATCAAGSRG--------EAALQA 1020
Cdd:PHA03307   109 PGPSSPDPPP---PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQaalplsspEETARA 185

                          170       180
                   ....*....|....*....|....*.
gi 1720393270 1021 PPGAPPTLNSAKQEPAAEGQEKRLDI 1046
Cdd:PHA03307   186 PSSPPAEPPPSTPPAAASPRPPRRSS 211
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
835-1047 1.73e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  835 GGAPGSKGSSSPlgvttkaasmpknkeshsggPCALWASGPdgYRQTRAGHGQEPPSAAVQG-PLAKPKQEGSSRLAPSP 913
Cdd:PRK07003   365 GGAPGGGVPARV--------------------AGAVPAPGA--RAAAAVGASAVPAVTAVTGaAGAALAPKAAAAAAATR 422

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  914 GSGSLSRsttPTPSVITRVGAQPSANSKPVEKlggpavgtgftPPNKHSAPDSLKAKFSPQPQGQPPLKGEGGSPLPP-- 991
Cdd:PRK07003   423 AEAPPAA---PAPPATADRGDDAADGDAPVPA-----------KANARASADSRCDERDAQPPADSGSASAPASDAPPda 488

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720393270  992 -REPSVKAAQELRTLATCAAGSRGEAALQAP----PGAPPTLNSAKQEPAAEGQEKR-------LDIL 1047
Cdd:PRK07003   489 aFEPAPRAAAPSAATPAAVPDARAPAAASREdapaAAAPPAPEARPPTPAAAAPAARaggaaaaLDVL 556
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 810-1021 2.45e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  810 GPPPALGGKECQPLLLSRFARTQVP----GGAPGSKGSSSPLGVTTKAASMPKNKESHSGGPCALWASGPDGYRQTRAGH 885
Cdd:PRK07764   589 GPAPGAAGGEGPPAPASSGPPEEAArpaaPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  886 GQEPPSAAVQGPLAKPKQEGSSRlAPSPGSGSLSRSTTPTPSVITRVGAQPSANSKPVEKLGGPAVGTGFTPPnKHSAPD 965
Cdd:PRK07764   669 WPAKAGGAAPAAPPPAPAPAAPA-APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP-LPPEPD 746

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720393270  966 SLKAKFSPQPQGQPPLKGEGGSPLPPREPSVKAAQELRTLATcAAGSRGEAALQAP 1021
Cdd:PRK07764   747 DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAED-DAPSMDDEDRRDA 801
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 908-1041 3.98e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 3.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  908 RLAPSPGSGSLSRSTTPTPSVITRVGAQPSANSKPveklGGPAVGTGFTPPNKHSAPDSLKAKFSPQPQGQPPLKGEGGS 987
Cdd:PRK07764   587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAP----AAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720393270  988 PLPPREPSVKAAQELRTLATCAAGSRGEAALQAPPGAPPTLNSAKQEPAAEGQE 1041
Cdd:PRK07764   663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADD 716
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 4.93e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.93e-03
                           10        20
                   ....*....|....*....|...
gi 1720393270  236 FPCEVCGQAFSQTWFLKAHMKKH 258
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 34-56 5.93e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 5.93e-03
                           10        20
                   ....*....|....*....|...
gi 1720393270   34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 775-1039 7.08e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 7.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  775 WHRVSCSSVAPPWTQPSGHKSIRSNLVFLTRSGRTGPPPAlGGKECQPLLLSRFART----------QVPGGAPGS---K 841
Cdd:PHA03307   148 PAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPS-SPPAEPPPSTPPAAASprpprrsspiSASASSPAPapgR 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  842 GSSSPLGVTTKAASMPKNKESHSGGPCALWASGPDGYRQTRAGHGQEPPSAAVQGPLAKPKQEGSSRLAPSPGSG-SLSR 920
Cdd:PHA03307   227 SAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSsPGSG 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393270  921 STTPTPSVITRVGAQPSANSKPVEKLGGPAVGTGFTPPNKHS-----APDSLKAKFSPQPQGQPPLKGEGGSPLPPREPS 995
Cdd:PHA03307   307 PAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSrspspSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPT 386

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1720393270  996 VKAAQELRTLATCAAGSRGEAALQAPPGAPPTLNSAKQEPAAEG 1039
Cdd:PHA03307   387 RRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARY 430
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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