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Conserved domains on  [gi|1720395874|ref|XP_030106953|]
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cartilage acidic protein 1 isoform X8 [Mus musculus]

Protein Classification

CRTAC1 family protein( domain architecture ID 10608401)

CRTAC1 family protein similar to human cartilage acidic protein 1 (CRTAC1), an extracellular matrix protein of articular cartilage and is a marker for cultured chondrocytes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UnbV_ASPIC pfam07593
ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...
 461-513 1.22e-13

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.


:

Pssm-ID: 429555  Cd Length: 66  Bit Score: 65.68  E-value: 1.22e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720395874 461 GAKVVLYTKkSGAHLRIIDGGSGYLCEMEPVAHFGLGR-DEASSVEVTWPDGKM 513
Cdd:pfam07593   1 GARVTVTTA-GGRQYREVTGGRGYLSSSDPRLHFGLGDaTTIDSLEVRWPDGKV 53
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 300-364 5.81e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 46.83  E-value: 5.81e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720395874 300 DFNRDGKVDIVYGNWNGPhRLYLQmsaHGKVRFRDIASPKFSTPSPVRTVIAADFDNDQELEVFF 364
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-RLYLN---NGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 256-310 1.11e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.98  E-value: 1.11e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720395874 256 DIFCdNENGPNFLFHNQGNGTFVDTAASAGVDDPHqhGRGVALADFNRDGKVDIV 310
Cdd:pfam13517   9 DLVV-ANDGGLRLYLNNGDGTFTFITSVSLGGGGG--GLSVAVGDLDGDGRLDLL 60
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 63-133 7.94e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 40.67  E-value: 7.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720395874  63 DVDHDGDFEIVVAGYTGPNLVLkyNRAQNRLVNIAVDERSSPyyalrdrqGNAIGVTACDIDGDGREEIYF 133
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRLYL--NNGDGTFTFITSVSLGGG--------GGGLSVAVGDLDGDGRLDLLV 61
 
Name Accession Description Interval E-value
UnbV_ASPIC pfam07593
ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...
 461-513 1.22e-13

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.


Pssm-ID: 429555  Cd Length: 66  Bit Score: 65.68  E-value: 1.22e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720395874 461 GAKVVLYTKkSGAHLRIIDGGSGYLCEMEPVAHFGLGR-DEASSVEVTWPDGKM 513
Cdd:pfam07593   1 GARVTVTTA-GGRQYREVTGGRGYLSSSDPRLHFGLGDaTTIDSLEVRWPDGKV 53
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 300-364 5.81e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 46.83  E-value: 5.81e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720395874 300 DFNRDGKVDIVYGNWNGPhRLYLQmsaHGKVRFRDIASPKFSTPSPVRTVIAADFDNDQELEVFF 364
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-RLYLN---NGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 256-310 1.11e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.98  E-value: 1.11e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720395874 256 DIFCdNENGPNFLFHNQGNGTFVDTAASAGVDDPHqhGRGVALADFNRDGKVDIV 310
Cdd:pfam13517   9 DLVV-ANDGGLRLYLNNGDGTFTFITSVSLGGGGG--GLSVAVGDLDGDGRLDLL 60
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 63-133 7.94e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 40.67  E-value: 7.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720395874  63 DVDHDGDFEIVVAGYTGPNLVLkyNRAQNRLVNIAVDERSSPyyalrdrqGNAIGVTACDIDGDGREEIYF 133
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRLYL--NNGDGTFTFITSVSLGGG--------GGGLSVAVGDLDGDGRLDLLV 61
RGL11 cd10318
Rhamnogalacturonan lyase of the polysaccharide lyase family 11; The rhamnogalacturonan lyase ...
 45-157 4.08e-03

Rhamnogalacturonan lyase of the polysaccharide lyase family 11; The rhamnogalacturonan lyase of the polysaccharide lyase family 11 (RGL11) cleaves glycoside bonds in polygalacturonan as well as RG (rhamnogalacturonan) type-I through a beta-elimination reaction. Functionally characterized members of this family, YesW and YesX from Bacillus subtilis, cleave glycoside bonds between rhamnose and galacturonic acid residues in the RG-I region of plant cell wall pectin. YesW and YesX work synergistically, with YesW cleaving the glycoside bond of the RG chain endolytically, and YesX converting the resultant oligosaccharides through an exotype reaction. This domain is sometimes found in architectures with non-catalytic carbohydrate-binding modules (CBMs). There are two types of RG lyases, which both cleave the alpha-1,4 bonds of the RG-I main chain through a beta-elimination reaction, but belong to two structurally unrelated polysaccharide lyase (PL) families, 4 and 11.


Pssm-ID: 199906 [Multi-domain]  Cd Length: 564  Bit Score: 39.94  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395874  45 PPDYDSNPTQLNYG-----VAVTDVDHDGDFEIVV------------AGYTGPNLVLKYNRAQNRL--VNIAVDERSSPY 105
Cdd:cd10318    95 KPAGGTTPDGETYTytandASVGDLDGDGEYEIVLkwdpsnskdnsqSGYTGNVYLDAYKLDGTRLwrIDLGKNIRAGAH 174

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720395874 106 YAlrdrqgnaiGVTACDIDGDGREEIYFLNTNNAFSGVAT-YTDKLFKFRNNR 157
Cdd:cd10318   175 YT---------QFMVYDLDGDGKAEVAVKTADGTKDGTGNvIGDASADYRNSS 218
 
Name Accession Description Interval E-value
UnbV_ASPIC pfam07593
ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...
 461-513 1.22e-13

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.


Pssm-ID: 429555  Cd Length: 66  Bit Score: 65.68  E-value: 1.22e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720395874 461 GAKVVLYTKkSGAHLRIIDGGSGYLCEMEPVAHFGLGR-DEASSVEVTWPDGKM 513
Cdd:pfam07593   1 GARVTVTTA-GGRQYREVTGGRGYLSSSDPRLHFGLGDaTTIDSLEVRWPDGKV 53
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 300-364 5.81e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 46.83  E-value: 5.81e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720395874 300 DFNRDGKVDIVYGNWNGPhRLYLQmsaHGKVRFRDIASPKFSTPSPVRTVIAADFDNDQELEVFF 364
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-RLYLN---NGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 256-310 1.11e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.98  E-value: 1.11e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720395874 256 DIFCdNENGPNFLFHNQGNGTFVDTAASAGVDDPHqhGRGVALADFNRDGKVDIV 310
Cdd:pfam13517   9 DLVV-ANDGGLRLYLNNGDGTFTFITSVSLGGGGG--GLSVAVGDLDGDGRLDLL 60
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 63-133 7.94e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 40.67  E-value: 7.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720395874  63 DVDHDGDFEIVVAGYTGPNLVLkyNRAQNRLVNIAVDERSSPyyalrdrqGNAIGVTACDIDGDGREEIYF 133
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRLYL--NNGDGTFTFITSVSLGGG--------GGGLSVAVGDLDGDGRLDLLV 61
RGL11 cd10318
Rhamnogalacturonan lyase of the polysaccharide lyase family 11; The rhamnogalacturonan lyase ...
 45-157 4.08e-03

Rhamnogalacturonan lyase of the polysaccharide lyase family 11; The rhamnogalacturonan lyase of the polysaccharide lyase family 11 (RGL11) cleaves glycoside bonds in polygalacturonan as well as RG (rhamnogalacturonan) type-I through a beta-elimination reaction. Functionally characterized members of this family, YesW and YesX from Bacillus subtilis, cleave glycoside bonds between rhamnose and galacturonic acid residues in the RG-I region of plant cell wall pectin. YesW and YesX work synergistically, with YesW cleaving the glycoside bond of the RG chain endolytically, and YesX converting the resultant oligosaccharides through an exotype reaction. This domain is sometimes found in architectures with non-catalytic carbohydrate-binding modules (CBMs). There are two types of RG lyases, which both cleave the alpha-1,4 bonds of the RG-I main chain through a beta-elimination reaction, but belong to two structurally unrelated polysaccharide lyase (PL) families, 4 and 11.


Pssm-ID: 199906 [Multi-domain]  Cd Length: 564  Bit Score: 39.94  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395874  45 PPDYDSNPTQLNYG-----VAVTDVDHDGDFEIVV------------AGYTGPNLVLKYNRAQNRL--VNIAVDERSSPY 105
Cdd:cd10318    95 KPAGGTTPDGETYTytandASVGDLDGDGEYEIVLkwdpsnskdnsqSGYTGNVYLDAYKLDGTRLwrIDLGKNIRAGAH 174

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720395874 106 YAlrdrqgnaiGVTACDIDGDGREEIYFLNTNNAFSGVAT-YTDKLFKFRNNR 157
Cdd:cd10318   175 YT---------QFMVYDLDGDGKAEVAVKTADGTKDGTGNvIGDASADYRNSS 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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