NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720403497|ref|XP_030108361|]
View 

semaphorin-6C isoform X12 [Mus musculus]

Protein Classification

semaphorin( domain architecture ID 10336503)

semaphorin, containing Sema and PSI domains, is a regulatory molecule that functions in the development of the nervous system and in axonal guidance; may lack the Ig domain typically present in semaphorins

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Sema super family cl15693
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
1-371 0e+00

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


The actual alignment was detected with superfamily member cd11268:

Pssm-ID: 472829 [Multi-domain]  Cd Length: 465  Bit Score: 704.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 80
Cdd:cd11268    95 VCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  81 VYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGP 160
Cdd:cd11268   175 VQALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQALTGP 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 161 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAASFSSSQ 240
Cdd:cd11268   255 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGGAALFSSSR 334
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 241 DLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSEPI 320
Cdd:cd11268   335 DLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLPPGGRSGGPEPI 414
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720403497 321 VLEEIDAYSHARCSGKRSPRAARRIIGLELDTEGHRLFVAFPGCIVYLSLS 371
Cdd:cd11268   415 LLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLS 465
PHA03247 super family cl33720
large tegument protein UL36; Provisional
567-809 7.51e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 7.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  567 TTFLPPPDGGSPPELACLPTPETTPELPVKHLRASGGPwewnqnGNNASEGPGRPPRGCSGAGGPAPRVLVRPPPpgcpg 646
Cdd:PHA03247  2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP------ALPAAPAPPAVPAGPATPGGPARPARPPTTA----- 2764
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  647 qavevttleellrylhGPQPPRKGSEPLASAPFTSRPPASEPgASLFVDSSPMPRDGVPPlRLDVPPEGKRAAPSGRPAL 726
Cdd:PHA03247  2765 ----------------GPPAPAPPAAPAAGPPRRLTRPAVAS-LSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAG 2826
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  727 SAPAPRLGVGGSRRLPFPTHRAPPGLLTRVPSGGPARYSGGPGRHLLYLGRPEGHRGRSLKRVDVKSPLS--PKPPLASP 804
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTEsfALPPDQPE 2906

                   ....*
gi 1720403497  805 PQPAP 809
Cdd:PHA03247  2907 RPPQP 2911
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
372-393 7.80e-04

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 38.07  E-value: 7.80e-04
                          10        20
                  ....*....|....*....|..
gi 1720403497 372 RCARHGACQrSCLASLDPYCGW 393
Cdd:pfam01437   1 RCSQYTSCS-SCLAARDPYCGW 21
 
Name Accession Description Interval E-value
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
1-371 0e+00

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 704.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 80
Cdd:cd11268    95 VCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  81 VYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGP 160
Cdd:cd11268   175 VQALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQALTGP 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 161 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAASFSSSQ 240
Cdd:cd11268   255 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGGAALFSSSR 334
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 241 DLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSEPI 320
Cdd:cd11268   335 DLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLPPGGRSGGPEPI 414
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720403497 321 VLEEIDAYSHARCSGKRSPRAARRIIGLELDTEGHRLFVAFPGCIVYLSLS 371
Cdd:cd11268   415 LLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLS 465
Sema smart00630
semaphorin domain;
38-325 2.06e-111

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 345.12  E-value: 2.06e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   38 GSLYSATAADFQASDAVVYRSLGPQP-------PLRSAKYDSKWLREPHFVYALEHGEHVYFFFREVSVEDARLGRVQFS 110
Cdd:smart00630  92 GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvSLRTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDNCGKAVHS 171
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  111 RVARVCKRDMGGsPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLT-GPVNLHGRSALFGVFTTQTNSIPGSAVCAFY 189
Cdd:smart00630 172 RVARVCKNDVGG-PRSLDKKWTSFLKARLECSVPGEDPFYFNELQAAFlLPPGSESDDVLYGVFSTSSNPIPGSAVCAFS 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  190 LDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGaaasfSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLL 269
Cdd:smart00630 251 LSDINAVFNGPFKECETSTSQWLPYSRGKVPYPRPGTCPNKP-----PSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLF 325
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720403497  270 TLT-SRALLTQVAVDGMAGPHrNTTVLFLGSNDGTVLKVLPPGGQSlGSEPIVLEEI 325
Cdd:smart00630 326 VKTdSNYLLTSIAVDRVATDG-NYTVLFLGTSDGRILKVVLSESSS-SSESVVLEEI 380
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
154-330 7.32e-50

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 173.23  E-value: 7.32e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 154 LQS---LTGPVNLHGRSALFGVFTTQT-NSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVsEDKVPSPRPGSCag 229
Cdd:pfam01403   1 LQDvfvLKPGAGDALDTVLYGVFTTQWsNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPY-TGKVPYPRPGTC-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 230 vgaaASFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLTlTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLP 309
Cdd:pfam01403  78 ----INDPLRLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLV-RTGVRLTSIAVDRVQALDGNYTVLFLGTDDGRLHKVVL 152
                         170       180
                  ....*....|....*....|.
gi 1720403497 310 PGGQslgsEPIVLEEIDAYSH 330
Cdd:pfam01403 153 VGSE----ESHIIEEIQVFPE 169
PHA03247 PHA03247
large tegument protein UL36; Provisional
567-809 7.51e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 7.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  567 TTFLPPPDGGSPPELACLPTPETTPELPVKHLRASGGPwewnqnGNNASEGPGRPPRGCSGAGGPAPRVLVRPPPpgcpg 646
Cdd:PHA03247  2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP------ALPAAPAPPAVPAGPATPGGPARPARPPTTA----- 2764
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  647 qavevttleellrylhGPQPPRKGSEPLASAPFTSRPPASEPgASLFVDSSPMPRDGVPPlRLDVPPEGKRAAPSGRPAL 726
Cdd:PHA03247  2765 ----------------GPPAPAPPAAPAAGPPRRLTRPAVAS-LSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAG 2826
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  727 SAPAPRLGVGGSRRLPFPTHRAPPGLLTRVPSGGPARYSGGPGRHLLYLGRPEGHRGRSLKRVDVKSPLS--PKPPLASP 804
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTEsfALPPDQPE 2906

                   ....*
gi 1720403497  805 PQPAP 809
Cdd:PHA03247  2907 RPPQP 2911
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
372-393 7.80e-04

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 38.07  E-value: 7.80e-04
                          10        20
                  ....*....|....*....|..
gi 1720403497 372 RCARHGACQrSCLASLDPYCGW 393
Cdd:pfam01437   1 RCSQYTSCS-SCLAARDPYCGW 21
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
372-393 4.47e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 35.98  E-value: 4.47e-03
                           10        20
                   ....*....|....*....|..
gi 1720403497  372 RCARHGACQrSCLASLDPYCGW 393
Cdd:smart00423   1 RCSKYTSCS-ECLLARDPYCAW 21
 
Name Accession Description Interval E-value
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
1-371 0e+00

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 704.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 80
Cdd:cd11268    95 VCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  81 VYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGP 160
Cdd:cd11268   175 VQALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQALTGP 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 161 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAASFSSSQ 240
Cdd:cd11268   255 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGGAALFSSSR 334
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 241 DLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSEPI 320
Cdd:cd11268   335 DLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLPPGGRSGGPEPI 414
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720403497 321 VLEEIDAYSHARCSGKRSPRAARRIIGLELDTEGHRLFVAFPGCIVYLSLS 371
Cdd:cd11268   415 LLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLS 465
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
1-371 0e+00

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 698.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 80
Cdd:cd11242    96 VCRNYRIDTLEQDGEEISGMARCPFDAKQANVALFADGKLYSATVTDFLASDAVIYRSLGDSPTLRTVKYDSKWLKEPHF 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  81 VYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGP 160
Cdd:cd11242   176 VHAVEYGDYVYFFFREIAVEYNTLGKVVFSRVARVCKNDMGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFDVLQAVTDV 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 161 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAASFSSSQ 240
Cdd:cd11242   256 IRINGRPVVLGVFTTQYNSIPGSAVCAFDMDDIEKVFEGRFKEQKSPDSAWTPVPEDRVPKPRPGCCAGSGSAEKYKTSN 335
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 241 DLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTS-RALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSEP 319
Cdd:cd11242   336 DFPDDTLNFIKTHPLMDEAVPSIINRPWFTRTMvRYRLTQIAVDNAAGPYQNYTVVFLGSEAGTVLKFLARIGPSGSNGS 415
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720403497 320 IVLEEIDAYSHARCSGKRspRAARRIIGLELDTEGHRLFVAFPGCIVYLSLS 371
Cdd:cd11242   416 VFLEEIDVYNPAKCSYDG--EEDRRIIGLELDRASHALFVAFSGCVIRVPLS 465
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
1-371 6.70e-174

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 509.19  E-value: 6.70e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 80
Cdd:cd11269    96 MCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHF 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  81 VYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGP 160
Cdd:cd11269   176 LHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDI 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 161 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAASFSSSQ 240
Cdd:cd11269   256 IEINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSI 335
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 241 DLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTS-RALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSEP 319
Cdd:cd11269   336 DFPDETLSFIKSHPLMDSAVPSIIEEPWFTKTRvRYRLTAIAVDHAAGPHQNYTVIFVGSEAGVVLKILAKTSPFSLNDS 415
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720403497 320 IVLEEIDAYSHARCSGkrSPRAARRIIGLELDTEGHRLFVAFPGCIVYLSLS 371
Cdd:cd11269   416 VLLEEIEAYNHAKCSA--ENEEDRRVISLQLDRDHHALFVAFSSCVVRIPLS 465
Sema_6E cd11270
The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed ...
1-371 2.67e-168

The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed predominantly in the nervous system during embryogenesis. It binds Plexin A1 and might utilize it as a receptor to repel axons of specific types during development. Sema6E acts as a repellent to dorsal root ganglion axons as well as sympathetic axons. Sema6E is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200531 [Multi-domain]  Cd Length: 462  Bit Score: 494.63  E-value: 2.67e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPP-LRSAKYDSKWLREPH 79
Cdd:cd11270    93 TCRNYKMSSLEQDGEEVIGQARCPFESRQSNVGLFAGGDFYSATMTDFLASDAVIYRSLGESSPvLRTVKYDSKWLREPH 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  80 FVYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTG 159
Cdd:cd11270   173 FLHAIEYGNYVYFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGSPRVLERYWTSFLKARLNCSVPGDSFFYFDVLQSLTN 252
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 160 PVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAASFSSS 239
Cdd:cd11270   253 VMQINHRPAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEQRNSESAWTPVPDEAVPKPRPGSCAGDGPAAGYKSS 332
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 240 QDLPDDVLLFIKAHPLLDPAVPPATHQPLLT-LTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSE 318
Cdd:cd11270   333 TNFPDETLTFIKSYPLMDEAVPSVNNRPCFTrTTSRFKLTQIAVDTAAGPYKNYTVVFLGSENGHVLKVLASMHPNSSYS 412
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720403497 319 PIVLEEIDAYSHARCSGKRSPraaRRIIGLELDTEGHRLFVAFPGCIVYLSLS 371
Cdd:cd11270   413 TQVLEDIDVYNPNKCNVRGED---RRILGLELDKDHHALFVAFTGCVIRVPLS 462
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
1-371 1.52e-156

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 464.69  E-value: 1.52e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 80
Cdd:cd11267    96 VCANYSIDTLEPVGDNISGMARCPYDPKHANVALFADGMLFTATVTDFLAIDAVIYRSLGDSPALRTVKHDSKWFKEPYF 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  81 VYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGP 160
Cdd:cd11267   176 VHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVSDI 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 161 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGaaASFSSSQ 240
Cdd:cd11267   256 LNLGGRPVVLAVFSTPTNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEELVPRPRPGCCAAPG--MRYNSSS 333
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 241 DLPDDVLLFIKAHPLLDPAVPPATHQPLLTLT-SRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVL---PPGGQSLG 316
Cdd:cd11267   334 TLPDEVLNFVKTHPLMDEAVPSLGHAPWIVRTmTRYQLTHMVVDTEAGPHGNHTVVFLGSTRGTVLKFLiipNASSSEIS 413
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720403497 317 SEPIVLEEIDAYSHARCsGKRSPRaARRIIGLELDTEGHRLFVAFPGCIVYLSLS 371
Cdd:cd11267   414 NQSVFLEELETYNPERC-GWDSPQ-AQKLLSLELDKGSGGLLLAFPSCVVRVPVA 466
Sema_6A cd11266
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, ...
2-370 7.20e-147

The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, Sema6A-plexin A2 signaling modulates granule cell migration by controlling centrosome positioning. Besides plexin A2, plexin A4 is also found to be a receptor of Sema6A. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. It is required for the clustering of boundary cap cells at the PNS/CNS interface and thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site, it organizes the segregation of dorsal roots. Sema6A may also be involved in axonal pathfinding processes in the periinfarct and homotopic contralateral cortex. Sema6A is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200527 [Multi-domain]  Cd Length: 466  Bit Score: 439.85  E-value: 7.20e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   2 CRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFV 81
Cdd:cd11266    97 CRNYKMDTLEFFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFV 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  82 YALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGPV 161
Cdd:cd11266   177 QAVDYGDYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVI 256
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 162 NLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAASFSSSQD 241
Cdd:cd11266   257 HINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLEKYATSNE 336
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 242 LPDDVLLFIKAHPLLDPAVPPATHQPLLTLTS-RALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQS-LGSEP 319
Cdd:cd11266   337 FPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMvRYRLTKIAVDNAAGPYQNHTVVFLGSEKGIILKFLARTGNSgFLNDS 416
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720403497 320 IVLEEIDAYSHARCSgkRSPRAARRIIGLELDTEGHRLFVAFPGCIVYLSL 370
Cdd:cd11266   417 LFLEEMNVYNSEKCS--YDGVEDKRIMGMQLDKASSALYVAFSTCVIKVPL 465
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
2-370 2.07e-121

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 372.90  E-value: 2.07e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   2 CRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFV 81
Cdd:cd11235    86 CRNYNVETFELVGKEESGRGKCPYDPDHNSTALFADGELYSGTSADFLGTDPVIYRTLGHNPPLRTEYHDSKWLNEPQFV 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  82 YALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTG-P 160
Cdd:cd11235   166 GAFDIGDYVYFFFREIAVEYINCGKAVYSRVARVCKNDQGGS-RSLEKKWTTFLKARLNCSVPGEFPFYFNELQDVFDlP 244
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 161 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCagvgaaasFSSSQ 240
Cdd:cd11235   245 SPSNKEKIFYAVFTTPYNSIPGSAVCAYSLSDIEAVFNGPFKEQHSSNSAWLPVPDERVPEPRPGTC--------VDDSS 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 241 DLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRAL-LTQVAVDGM-AGPHRNTTVLFLGSNDGTVLKVLPPGGQSLgSE 318
Cdd:cd11235   317 PLPDDTLNFIKSHPLMDEAVTPILNRPLFIKTDVNYrFTKIAVDRVqAKLGQTYDVLFVGTDRGIILKVVSLPEQGL-QA 395
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720403497 319 PIVLEEIDAYsharcsgkrspRAARRIIGLELDTEGHRLFVAFPGCIVYLSL 370
Cdd:cd11235   396 SNILEEMPVG-----------PPPEPIQTMQLSRKRRSLYVGSETGVLQVPL 436
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
1-373 1.44e-115

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 358.18  E-value: 1.44e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGE-ELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSlgpqpPLRSAKYDSKWLREPH 79
Cdd:cd11237    87 LCREYTVKDGGYRVErEFDGQGLCPYDPKHNSTAVYADGQLYSATVADFSGADPLIYRE-----PLRTERYDLKQLNAPN 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  80 FVYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRhWTSFLKLRLNCSVPGDSTFYFDVLQSLTG 159
Cdd:cd11237   162 FVSSFAYGDYVYFFFRETAVEYINCGKAIYSRVARVCKNDKGGPHPFRDR-WTSFLKARLNCSVPGEYPFYFNEIQSTSD 240
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 160 PVN--LHGRSA--LFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAgvgaaas 235
Cdd:cd11237   241 IVEggYGGKSAklIYGVFTTPVNSISGSAVCAFSLQDILEVFDGSFKEQQDINSNWLPVPSNKVPEPRPGQCV------- 313
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 236 fSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTS-RALLTQVAVD----GMAGphRNTTVLFLGSNDGTVLKVLPP 310
Cdd:cd11237   314 -NDSRTLPDVTVNFIKSHPLMDEAVPSFFGRPILVRTSlQYRFTQIAVDpqvkALDG--KYYDVLFIGTDDGKVLKAVNI 390
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720403497 311 GG--QSLGSEPIVLEEIDAYSHArcsgkrsprAARRIIGLELDTEGHRLFVAFPGCIVYLSLSRC 373
Cdd:cd11237   391 ASadTVDKVSPVVIEETQVFPRG---------VPIRNLLIVRGKDDGRLVVVSDDEIVSIPLHRC 446
Sema smart00630
semaphorin domain;
38-325 2.06e-111

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 345.12  E-value: 2.06e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   38 GSLYSATAADFQASDAVVYRSLGPQP-------PLRSAKYDSKWLREPHFVYALEHGEHVYFFFREVSVEDARLGRVQFS 110
Cdd:smart00630  92 GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvSLRTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDNCGKAVHS 171
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  111 RVARVCKRDMGGsPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLT-GPVNLHGRSALFGVFTTQTNSIPGSAVCAFY 189
Cdd:smart00630 172 RVARVCKNDVGG-PRSLDKKWTSFLKARLECSVPGEDPFYFNELQAAFlLPPGSESDDVLYGVFSTSSNPIPGSAVCAFS 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  190 LDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGaaasfSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLL 269
Cdd:smart00630 251 LSDINAVFNGPFKECETSTSQWLPYSRGKVPYPRPGTCPNKP-----PSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLF 325
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720403497  270 TLT-SRALLTQVAVDGMAGPHrNTTVLFLGSNDGTVLKVLPPGGQSlGSEPIVLEEI 325
Cdd:smart00630 326 VKTdSNYLLTSIAVDRVATDG-NYTVLFLGTSDGRILKVVLSESSS-SSESVVLEEI 380
Sema_3 cd11239
The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins ...
7-373 8.04e-89

The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200500 [Multi-domain]  Cd Length: 471  Bit Score: 288.87  E-value: 8.04e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   7 ITSLQQEGEElSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFV--YAL 84
Cdd:cd11239   108 IFKLDDSSLE-SGRGKCPFDPNQPFASVLIDGELYSGTAIDFMGRDAAIFRSLGHRHYIRTEQYDSRWLNEPKFVgaYLI 186
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  85 EHGEH-----VYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPG-DST-FYFDVLQSL 157
Cdd:cd11239   187 PDSDNpdddkVYFFFREKAVEAEGSGKAIYSRVGRICKNDVGGQ-RSLVNKWSTFLKARLVCSVPGpDGIdTYFDELEDV 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 158 tgpVNLHGRSA----LFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVsEDKVPSPRPGSCAGVGAA 233
Cdd:cd11239   266 ---FLLPTRDPknplIYGVFTTSSNVFKGSAVCVYSMADIRAAFNGPFAHKEGPNYQWVEY-QGKVPYPRPGTCPSKTYG 341
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 234 ASFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRAL-LTQVAVDGMAGPHRNTTVLFLGSNDGTVLKV--LPP 310
Cdd:cd11239   342 PLYKSTKDFPDDVISFARSHPLMYNPVYPLHGRPLLIRTNVPYrLTQIAVDRVEAEDGQYDVLFIGTDSGTVLKVvsLPK 421
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720403497 311 GGQSLgsEPIVLEEIDAYSHarcsgkRSPraarrIIGLELDTEGHRLFVAFPGCIVYLSLSRC 373
Cdd:cd11239   422 ENWEM--EEVILEELQVFKH------PSP-----ITSMEISSKRQQLYVGSAEGVVQLPLHRC 471
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
18-307 8.11e-85

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 277.38  E-value: 8.11e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  18 SGQARCPFDATQSTVAIFAEG-------SLYSATAADFQASDAVVYRslgpqPPL------------RSAKYDSKWLREP 78
Cdd:cd11238   111 NGIGKCPYDPDDNSTAVWVEWgnpgdlpALYSGTRTEFTKANTVIYR-----PPLynntkgrhesfmRTLKYDSKWLDEP 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  79 HFVYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGspRALDRH-WTSFLKLRLNCSVPGDSTFYFDVLQSL 157
Cdd:cd11238   186 NFVGSFDIGDYVYFFFRETAVEYINCGKVVYSRVARVCKKDTGG--KNVLRQnWTTFLKARLNCSISGEFPFYFNEIQSV 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 158 TgPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGF-EGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGvgaaasf 236
Cdd:cd11238   264 Y-KVPGRDDTLFYATFTTSENGFTGSAVCVFTLSDINAAFdTGKFKEQASSSSAWLPVLSSEVPEPRPGTCVN------- 335
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720403497 237 sSSQDLPDDVLLFIKAHPLLDPAVppATHQPLLTLtSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKV 307
Cdd:cd11238   336 -DSATLSDTVLHFARTHPLMDDAV--SHGPPLLYL-RDVVFTHLVVDKLRIDDQEYVVFYAGSNDGKVYKI 402
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
13-325 3.75e-83

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 273.13  E-value: 3.75e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  13 EGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSaKYDSKWLREPHFVYA--------- 83
Cdd:cd11240   107 SIKFEDGKGRCPFDPAQRYTAIMVDGELYSATVNNFLGSEPVISRNHSEGNVLKT-ENTLRWLNEPAFVGSahiresids 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  84 -LEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPgDSTFYFDVLQSLtgpVN 162
Cdd:cd11240   186 pDGDDDKIYFFFTETAVEYDFYEKVTVSRVARVCKGDLGGQ-RTLQKKWTTFLKAQLVCSQP-DSGLPFNVLRDV---FV 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 163 LHGRSA----LFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSeDKVPSPRPGSCA-GVGAAASFS 237
Cdd:cd11240   261 LSPDSWdatiFYGVFTSQWNVSGLSAVCAYSLEDIKKVFSGKYKEFNRETSKWSRYT-GPVPDPRPGACItNSARSQGIT 339
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 238 SSQDLPDDVLLFIKAHPLLDPAVPPaTHQPLLtLTSRALLTQVAVDGMAGPHRNT-TVLFLGSNDGTVLKVLppggqSLG 316
Cdd:cd11240   340 SSLNLPDNVLTFVKDHPLMDEQVHP-INRPLL-VKSGVNYTRIAVHRVQALDGQTyTVLFLGTEDGFLHKAV-----SLD 412

                  ....*....
gi 1720403497 317 SEPIVLEEI 325
Cdd:cd11240   413 GGMHIIEEI 421
Sema_3B cd11250
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is ...
19-373 4.86e-74

The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is coexpressed with semaphorin 3F and both proteins are candidate tumor suppressors. Both Sema3B and Sema3F show high levels of expression in normal tissues and low-grade tumors but are down-regulated in highly metastatic tumors in the lung, melanoma cells, bladder carcinoma cells and prostate carcinoma. They are upregulated by estrogen and inhibit cell motility and invasiveness through decreased FAK phosphorylation and inhibition of MMP-2 and MMP-9 expression. Two receptor families, the neuropilins (NP) and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3B is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200511 [Multi-domain]  Cd Length: 471  Bit Score: 249.44  E-value: 4.86e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  19 GQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVYAL-------EHGEHVY 91
Cdd:cd11250   119 GKGKSPYDPRHTAASVLVGDELYSGVATDLMGRDFTIFRSLGQRPSLRTEQHDSRWLNEPKFVKVFwipesenPDDDKIY 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  92 FFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGD--STFYFDVLQSL-TGPVNLHGRSA 168
Cdd:cd11250   199 FFFRETAVEAAGLGKQSYSRIGQICRNDMGGQ-RSLVNKWTTFLKARLVCSVPGNegGDTHFDELRDVfLLQTRDKRNPL 277
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 169 LFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVsEDKVPSPRPGSCAGvGAAASFSSSQDLPDDVLL 248
Cdd:cd11250   278 IYAVFSTSSSVFQGSAVCVYTMNDVRRAFLGPFAHKEGPNYQWVSY-QGKVPYPRPGMCPS-KTFGSFESTKDFPDDVIQ 355
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 249 FIKAHPLLDPAVPPATHQPLLTLTSRAL-LTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLP-PGGQSLGSEPIVLEEID 326
Cdd:cd11250   356 FARNHPLMFNPVLPLGGRPLFLRTGIPYtFTQIAVDRVAAADGHYDVMFIGTDVGSVLKVISvPKGSWPSNEELLLEELH 435
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1720403497 327 AYSHArcsgkrSPraarrIIGLELDTEGHRLFVAFPGCIVYLSLSRC 373
Cdd:cd11250   436 VFKDS------SP-----ITSMQISSKRQQLYVGSRSGVSQLPLHRC 471
Sema_3F cd11254
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is ...
18-373 9.44e-74

The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200515 [Multi-domain]  Cd Length: 470  Bit Score: 248.58  E-value: 9.44e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  18 SGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVYAL---EHGEH----V 90
Cdd:cd11254   118 SGKGKCPYDPKQDSVSALINGELYAGVYIDFMGTDAAIFRTMGKQPAMRTDQYNSRWLNDPAFVHAHlipDSSEKnddkL 197
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  91 YFFFREVSVEdARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTF--YFDVLQSL-TGPVNLHGRS 167
Cdd:cd11254   198 YFFFREKSLE-APQSPAVLSRIGRVCLNDDGGH-CCLVNKWSTFLKARLVCSVPGADGIetHFDELRDVfIQPTQDTKNP 275
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 168 ALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSeDKVPSPRPGSCAGVGAAASFSSSQDLPDDVL 247
Cdd:cd11254   276 VIYAVFSTSGSVFKGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPYT-GKIPYPRPGTCPGGTFTPSMKSTKDYPDEVI 354
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 248 LFIKAHPLLDPAVPPATHQPLLTLTSRAL-LTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSEPIVLEEID 326
Cdd:cd11254   355 NFMRTHPLMYNAVYPVHRRPLVVRTNVNYrFTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDLETEELTLEEVE 434
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1720403497 327 AYsharcsgkRSPRAARRiigLELDTEGHRLFVAFPGCIVYLSLSRC 373
Cdd:cd11254   435 VF--------KVPAPIKT---MKISSKRQQLYVSSAVGVTHLSLHRC 470
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
1-338 1.24e-72

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 244.55  E-value: 1.24e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGEELSGQARCPFDATQ-STVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPH 79
Cdd:cd11263    90 ICTNRTLNNLTEIHDQISGMARCPYSPQHnSTALLTSSGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPN 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  80 FVYALEHGEHVYFFFREVSVEDaRLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQsltG 159
Cdd:cd11263   170 FVSSYDIGNFTYFFFRENAVEH-DCGKTVFSRAARVCKNDIGGR-FLLEDTWTTFMKARLNCSRPGEIPFYYNELQ---S 244
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 160 PVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPvsedkVPSPRPG-SCAGVGAAASFSS 238
Cdd:cd11263   245 TFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLP-----YPNPNPNfQCGTMDQGLYVNL 319
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 239 SQDLPDDVLLFIKAHPLLDPAVPPATHqplltLTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSe 318
Cdd:cd11263   320 TERNLQDAQKFILMHEVVQPVTPVPYF-----MEDNSRFSHVAVDVVQGKDMLFHIIYLATDYGTIKKVLAPLNQSSSS- 393
                         330       340
                  ....*....|....*....|
gi 1720403497 319 pIVLEEIDAYSHARCSGKRS 338
Cdd:cd11263   394 -CLLEEIELFPKRQREPIRS 412
Sema_5 cd11241
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ...
2-338 2.34e-72

The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200502 [Multi-domain]  Cd Length: 438  Bit Score: 243.61  E-value: 2.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   2 CRSYGITSLQQEGEELSGQARCPFD-ATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHF 80
Cdd:cd11241    91 CTIRKLSNLTQILDTISGVARCPYSpAHNSTALISASGELYAGTVYDFSGRDPAIYRSLGGKPPLRTAQYNSKWLNEPNF 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  81 VYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQsltGP 160
Cdd:cd11241   171 VGSYEIGNHTYFFFRENAVEHQDCGKTVYSRIARVCKNDIGGR-FLLEDTWTTFMKARLNCSLPGEFPFYYNEIQ---GT 246
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 161 VNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPvsedkVPSPRPGSCAgvGAAASFSSSQ 240
Cdd:cd11241   247 FYLPETDLIYAVFTTNVNGIAGSAICAFNLSAINQAFNGPFKYQENNGSAWLP-----TPNPHPNFQC--TTSIDRGQPA 319
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 241 DLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSrALLTQVAVDGMAGP-HRNTTVLFLGSNDGTVLKVLPPGGQslgSEP 319
Cdd:cd11241   320 NTTERDLQDAQKYQLMAEVVQPVTKIPLVTMDD-VRFSKLAVDVVQGRgTQLVHIFYVGTDYGTILKMYQPHRS---QKS 395
                         330
                  ....*....|....*....
gi 1720403497 320 IVLEEIDAYSHARCSGKRS 338
Cdd:cd11241   396 CTLEEIKILPAMKGEPITS 414
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
1-346 9.96e-72

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 242.20  E-value: 9.96e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   1 MCRSYGITSLQQEGEELSGQARCPFDATQ-STVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPH 79
Cdd:cd11264    90 VCTSRQVGNLSKVIERINGVARCPYDPRHnSTAVITSRGELYAATVIDFSGRDPAIYRSLGSVPPLRTAQYNSKWLNEPN 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  80 FVYALEHGEHVYFFFREVSVEDaRLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSltg 159
Cdd:cd11264   170 FIAAYDIGLFTYFFFRENAVEH-DCGKTVYSRVARVCKNDIGGR-FLLEDTWTTFMKARLNCSRPGEIPFYYNELQS--- 244
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 160 PVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPvsedkVPSPRPG-SCagvGAAASFSS 238
Cdd:cd11264   245 TFYLPEQDLIYGVFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQENPRSAWLP-----TANPIPNfQC---GTLSDDSP 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 239 SQDLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSrALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSe 318
Cdd:cd11264   317 NENLTERSLQDAQRLFLMNDVVQPVTVDPLVTQDS-VRFSKLVVDIVQGKDTLYHVMYIGTEYGTILKALSTTNRSLRS- 394
                         330       340
                  ....*....|....*....|....*...
gi 1720403497 319 pIVLEEIdaysHARCSGKRSPRAARRII 346
Cdd:cd11264   395 -CYLEEM----QILPPGQREPIRSLQIL 417
Sema_3D cd11252
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted ...
18-373 2.79e-70

The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted semaphorin expressed during the development of the nervous system. In zebrafish, Sema3D is expressed in the ventral tectum. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200513 [Multi-domain]  Cd Length: 474  Bit Score: 239.43  E-value: 2.79e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  18 SGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPP---LRSAKYDSKWLREPHFVYAL-------EHG 87
Cdd:cd11252   118 SGRLKCPFDPQQPFASVMTDEYLYAGTASDFLGKDTTFTRSLGPTPDhhyIRTDISEHYWLNGAKFIGTFpipdtynPDD 197
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  88 EHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGD--STFYFDVLQSL-TGPVNLH 164
Cdd:cd11252   198 DKIYFFFREASQDGSTSDKSVLSRVGRVCKNDVGGQ-RSLINKWTTFLKARLVCSIPGPdgADTHFDELQDIfLLPTRDE 276
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 165 GRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVsEDKVPSPRPGSCAGVGAAASFSSSQDLPD 244
Cdd:cd11252   277 RNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESPDHRWVQY-EGRIPYPRPGTCPSKTYDPLIKSTKDFPD 355
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 245 DVLLFIKAHPLLDPAVPPATHQPLLT-LTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGSEPIVLE 323
Cdd:cd11252   356 EVISFIKRHPLMYKSVYPLTGGPVFTrINVDYRLTQIVVDHVAAEDGQYDVMFLGTDIGTVLKVVSITKEKWTMEEVVLE 435
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720403497 324 EIDAYSHArcsgkrSPraarrIIGLELDTEGHRLFVAFPGCIVYLSLSRC 373
Cdd:cd11252   436 ELQIFKHP------SP-----ILNMELSLKQQQLYIGSRDGLVQLSLHRC 474
Sema_5C cd11265
The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, ...
15-327 3.01e-70

The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, Sema5C was identified as an early development gene, which is expressed in stage 2 embryos with a striped pattern emerging at later stages. Sema5c may play a role in odor-guided behavior and in tumorigenesis. Sema5C belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200526 [Multi-domain]  Cd Length: 433  Bit Score: 237.76  E-value: 3.01e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  15 EELSGQARCPFDATQSTVAIFAE-GSLYSATAADFQASDAVVYRSLGP--QPPLRSAKYDSKWLREPHFVYALEHGEHVY 91
Cdd:cd11265   104 EWDSGVAKCPYSPHANITALLSSsGQLFVGSPTDFSGSDSAIYRTLGTsnKSFLRTKQYNSKWLNEPQFVGSFETGNFVY 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  92 FFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTgpvNLHGRSALFG 171
Cdd:cd11265   184 FLFRESAVEYMNCGKVIYSRIARVCKNDVGGGTMLLKDNWTTFLKARLNCSLPGEYPFYFDEIQGMT---YLPDEGILYA 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 172 VFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWtpvseDKVPSPRPGScagVGAAASFSSSQdlpddvLLFIK 251
Cdd:cd11265   261 TFTTPENSIAGSAVCAFNLSSINAAFDGPFKHQESSGAAW-----ERVNVNHRDH---FNQCSSSSSSH------LLESS 326
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720403497 252 AHPLLDPAVPPATHQPLLTLTSRaLLTQVAVDGMA-GPHRNTTVLFLGSNDGTVLK--VLPPggqslGSEPIVLEEIDA 327
Cdd:cd11265   327 RYQLMDEAVQPITLEPLHHAKLE-RFSHIAVDVIPtKIHQSVHVLYVATTGGLIKKisVLPR-----TQETCLVEIWQP 399
Sema_3A cd11249
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been ...
18-373 2.32e-69

The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been reported to inhibit the growth of certain experimental tumors and to regulate endothelial cell migration and apoptosis in vitro, as well as arteriogenesis in the muscle, skin vessel permeability, and tumor angiogenesis in vivo. The function of Sema3A is mediated through receptors neuropilin-1 (NP1) and plexins, although little is known about the requirement of specific plexins in its receptor complex. It is known however that Plexin-A4 is the receptor for Sema3A in the Toll-like receptor- and sepsis-induced cytokine storm during immune response. Sema3A is a member of the Class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200510 [Multi-domain]  Cd Length: 493  Bit Score: 237.21  E-value: 2.32e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  18 SGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVYAL-------EHGEHV 90
Cdd:cd11249   139 NGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHlipesdnPEDDKI 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  91 YFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTF--YFDVLQSL-----TGPVNl 163
Cdd:cd11249   219 YFFFRENAIDGEHTGKATHARIGQLCKNDFGGH-RSLVNKWTTFLKARLICSVPGPNGIdtHFDELQDVflmnsKDPKN- 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 164 hgrSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVsEDKVPSPRPGSCAGvGAAASFSSSQDLP 243
Cdd:cd11249   297 ---PIVYAVFTTSSNIFKGSAVCMYSMTDIRRVFLGPYAHRDGPNYQWVPF-QGRVPYPRPGTCPS-KTFGGFDSTKDLP 371
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 244 DDVLLFIKAHPLLDPAVPPATHQPLLTLTS-RALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLP-PGGQSLGSEPIV 321
Cdd:cd11249   372 DDVITFARSHPAMYNPVFPINNRPIIIKTDvDYQFTQIVVDRVEAEDGQYDVMFIGTDMGTVLKVVSiPKETWHDLEEVL 451
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720403497 322 LEEIDAYsharcsgkRSPRAarrIIGLELDTEGHRLFVAFPGCIVYLSLSRC 373
Cdd:cd11249   452 LEEMTVF--------REPTA---ISAMELSTKQQQLYIGSAIGVSQLPLHRC 492
Sema_3E cd11253
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted ...
18-373 8.21e-62

The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. It is also highly expressed in metastatic cancer cells. Sema3E signaling, through its high affinity functional receptor Plexin D1, drives cancer cell invasiveness and metastatic spreading. Sema3E is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200514 [Multi-domain]  Cd Length: 471  Bit Score: 215.87  E-value: 8.21e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  18 SGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFV--YALEHGE-----HV 90
Cdd:cd11253   117 RGRGRCPFDPNSSFISTLIGGELFVGLYSDYWGRDAAIFRTMNHLAHIRTEHDDERLLKEPKFVgsYMIPDNEdpddnKV 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  91 YFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTF--YFDVLQSL-TGPVNLHGRS 167
Cdd:cd11253   197 YFFFTEKALEAEGGNHAIYTRVGRVCANDQGGQ-RMLVNKWSTFLKTRLICSVPGPNGIdtHFDELEDVfLLRTRDNKNP 275
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 168 ALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTpVSEDKVPSPRPGSCAGVGAAASFSSSQDLPDDVL 247
Cdd:cd11253   276 EIFGLFSTTSNIFKGYAICVYHMASIRAAFNGPFAHKEGPEYHWS-VYEGKVPYPRPGSCASKVNGGHYGTTKDYPDEAL 354
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 248 LFIKAHPLLDPAVPPATHQPLLTLTS-RALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGQSLGS-EPIVLEEI 325
Cdd:cd11253   355 RFARSHPLMYQAVKPVHKRPILVKTDgKYNLKQIAVDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQETETmEEVILEEL 434
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1720403497 326 DAYsharcsgkrspRAARRIIGLELDTEGHRLFVAFPGCIVYLSLSRC 373
Cdd:cd11253   435 QVF-----------KVPVPIISMEISSKRQQLYIGSESGVAQIRFHQC 471
Sema_3C cd11251
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted ...
18-373 1.47e-61

The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted semaphorin expressed in and adjacent to cardiac neural crest cells, and causes impaired migration of neural crest cells to the developing cardiac outflow tract, resulting in the interruption of the aortic arch and persistent truncus arteriosus. It has been proposed that Sema3C acts as a guidance molecule, regulating migration of neural crest cells that express semaphorin receptors such as plexin A2. Sema3C may also participate in tumor progression. The cleavage of Sema3C induced by ADAMTS1 promotes the migration of breast cancer cells. Sema3C is a member of the class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200512 [Multi-domain]  Cd Length: 470  Bit Score: 215.14  E-value: 1.47e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  18 SGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVYA--LEHGEH-----V 90
Cdd:cd11251   117 SGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPIFVDAhlIPDGTDpndakL 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  91 YFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGD--STFYFDVLQSLTGPVNLHGRSA 168
Cdd:cd11251   197 YFFLKERLTDNSGSTKQIHSMIARVCPNDTGGQ-RSLVNKWTTFLKARLVCSVMDEdgTETHFDELEDVFLLETDNPRTT 275
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 169 L-FGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVsEDKVPSPRPGSCAGVGAAASFSSSQDLPDDVL 247
Cdd:cd11251   276 LvYGIFTTSSSVFKGSAVCVYHMSDIQTVFNGPFAHKEGPNHQLIAY-QGRIPYPRPGTCPGGAFTPNMQSTKEFPDDVV 354
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 248 LFIKAHPLLDPAVPPATHQPLLTLTSRAL-LTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLP-PGGQSLgSEPIVLEEI 325
Cdd:cd11251   355 TFIRNHPLMFNPIYPIGRRPLLVRTGTDYkYTKIAVDRVNAADGRYHVLFLGTDKGTVQKVVVlPTNGSL-SGELILEEL 433
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1720403497 326 DAYSharcsgKRSPraarrIIGLELDTEGHRLFVAFPGCIVYLSLSRC 373
Cdd:cd11251   434 EVFK------NHAP-----ITNMKISSKKQQLYVSSEEGISQVSLHRC 470
Sema_4B cd11257
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in ...
19-371 1.05e-60

The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in T and B cells, is an immune semaphorin. It functions as a negative regulatory of basophils through T cell-basophil contacts and it significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. In addition, T cell-derived Sema4B suppresses basophil-mediated Th2 skewing and humoral memory responses. Sema4B may be also involved in lung cancer cell mobility by inducing the degradation of CLCP1 (CUB, LCCL-homology, coagulation factor V/VIII homology domains protein). Sema4B is characterized by a PDZ-binding motif at the carboxy-terminus, which mediates interaction with the post-synaptic density protein PSD-95/SAP90, which is thought to play a central role during synaptogenesis and in the structure and function of post-synaptic specializations of excitatory synapses. Sema4B belongs to class 4 transmembrane semaphorin family proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200518 [Multi-domain]  Cd Length: 464  Bit Score: 212.80  E-value: 1.05e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  19 GQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKyDSKWLREPHFV----------YALEHGE 88
Cdd:cd11257   120 GKGRCPFDPEYKSTAIMVDGELYTGTVSNFQGNDPIIYRSLGSGTPLKTEN-SLNWLQDPAFVgsayiqeslpKLVGDDD 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  89 HVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDStFYFDVLQSL--TGPVNLHGR 166
Cdd:cd11257   199 KIYFFFSETGKEFDFFENTIVSRIARVCKGDEGGE-RVLQKRWTTFLKAQLLCSLPDDG-FPFNVLQDVfvLTPSPEDWK 276
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 167 SALF-GVFTTQTN--SIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEdKVPSPRPGSCAGVGAAA-SFSSSQDL 242
Cdd:cd11257   277 DTLFyGVFTSQWHkgTAGSSAVCVFTMDQVQRAFNGLYKEVNRETQQWYTYTH-PVPEPRPGACITNSARErKINSSLHM 355
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 243 PDDVLLFIKAHPLLDPAVppaTHQPLLtLTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLppggqSLGSEPIVL 322
Cdd:cd11257   356 PDRVLNFVKDHFLMDGQV---RSQPLL-LQPQVRYTQIAVHRVKGLHKTYDVLFLGTDDGRLHKAV-----SVGPMVHII 426
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1720403497 323 EEIDAYSharcsgkrSPRAARRIiglELDTEGHRLFVAFPGCIVYLSLS 371
Cdd:cd11257   427 EELQIFS--------EGQPVQNL---LLDTHKGLLYASSHSGVVQVPVA 464
Sema_4E cd11260
The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed ...
4-325 2.19e-60

The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed in the epithelial cells that line the pharyngeal arches in zebrafish. It may act as a guidance molecule to restrict the branchiomotor axons to the mesenchymal cells. Gain-of-function and loss-of-function studies demonstrate that Sema4E is essential for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and is sufficient for guidance of gill motor axons. Sema4E guides facial motor axons by a repulsive action. Sema4E belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200521 [Multi-domain]  Cd Length: 456  Bit Score: 211.69  E-value: 2.19e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   4 SYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSlgpQPPLRSAKYDSKWLREPHFVY- 82
Cdd:cd11260    98 SYDDGQLTLEGKQEDGKGKCPFDPFQRYSSVMVDQDLYSATSMNFLGSEPVIMRS---SPITIRTEFKSSWLNEPNFIYm 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  83 -ALEHGEH--------VYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTFYfdV 153
Cdd:cd11260   175 aAVPESEDspegdddkIYLFFSETAVEYDFYNKLVVSRVARVCKGDLGGQ-RTLQKKWTSFLKARLDCSVPEPSLPY--V 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 154 LQSLTGPVNLHGRSALF-GVFTTQTNSIPGSAVCAFYLDDIERGF-EGKFKEQRSLDGA---WTPVSEDkVPSPRPGSCA 228
Cdd:cd11260   252 IQDVFHVCHQDWRKCVFyAVFTSQSDSSQSSAVCAYNVTDISNVFsRGKFKTPVAVETSfvkWVMYSGE-LPVPRPGACI 330
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 229 GVGA-AASFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLtLTSRALLTQVAVDGMAGPHRNT-TVLFLGSNDGTVLK 306
Cdd:cd11260   331 NNAArTSGIKKSLNLPDKTLQFVKDKPLMDQAVHPITGKPLL-VKRGALFTRIVVDMVTAADGQSyPVMFIGTANGYVLK 409
                         330
                  ....*....|....*....
gi 1720403497 307 VLPPGGqslgsEPIVLEEI 325
Cdd:cd11260   410 AVNYDG-----EMHIIEEV 423
Sema_3G cd11255
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is ...
18-373 3.71e-59

The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is identified as a primarily endothelial cell- expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively. It is mainly expressed in the lung and kidney, and a little in the brain. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200516 [Multi-domain]  Cd Length: 474  Bit Score: 208.61  E-value: 3.71e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  18 SGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSaKYDSKWLREPHFVYAL-------EHGEHV 90
Cdd:cd11255   117 SGRGRCPHEPKRPFASTFTGGELYTGLTADFLGRDSVIFRGFGTRSPLRT-ETDQRLLHEPRFVAAHlipdnadRDNDKV 195
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  91 YFFFREVSVE-DARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTF--YFDVLQSLTGPVNLHGRS 167
Cdd:cd11255   196 YFFFTERATEtAEDDDGAIHSRVGRLCANDAGGQ-RVLVNKWSTFIKARLVCSVPGPHGIqtHFDQLEDVFLLRTKDGKS 274
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 168 -ALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVsEDKVPSPRPGSCAGVGAAA---SFSSSQDLP 243
Cdd:cd11255   275 pEIYALFSTISNVFQGFAVCVYSMADIWEVFNGPFAHKDGPDHQWGPY-EGKVPYPRPGVCPSKITAQpgrAFRSTKDYP 353
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 244 DDVLLFIKAHPLLDPAVPPATHQPLLTLTSRAL-LTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPG-GQSLGSEPIV 321
Cdd:cd11255   354 DEVLQFARAHPLMWRPVYPSHRRPVLVKTGLPYrLTQIVVDRVEAEDGYYDVMFIGTDSGSVLKVIVLQkGNSAAGEEVT 433
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720403497 322 LEEIDAYsharcsgkrspRAARRIIGLELDTEGHRLFVAFPGCIVYLSLSRC 373
Cdd:cd11255   434 LEELQVF-----------KVPTPITEMEISVKRQMLYVGSRTGVAQVPLHRC 474
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
2-330 6.23e-59

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 208.17  E-value: 6.23e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   2 CRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLgPQPPLRSaKYDSKWLREPHFV 81
Cdd:cd11259   105 CDYLNLTSFRLLGKNEDGKGRCPFDPAQSYTSVMVDGELYSGTSYNFLGSEPIISRNS-SQSPLRT-EYAIPWLNEPSFV 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  82 YA--------LEHGE--HVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPgDSTFYF 151
Cdd:cd11259   183 FAdviradpdSPDGEddKIYFFFTEVSVEYEFVGKLLIPRIARVCKGDQGGL-RTLQKKWTSFLKARLICSIP-DKNLVF 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 152 DVLQ--------SLTGPVnlhgrsaLFGVFTTQTNSIPGSAVCAFYLDDIERGF-EGKFKEQRSLDGAWTPVSE--DKVP 220
Cdd:cd11259   261 NVVNdvfilkspTLKEPV-------IYGVFTPQLNNVGLSAVCAYNLSTVEEVFsKGKYMQSATVEQSHTKWVRynGEVP 333
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 221 SPRPGSCAGVGA-AASFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLtLTSRALLTQVAVDGMAGPHRNT-TVLFLG 298
Cdd:cd11259   334 KPRPGACINNEArAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRL-IKKDVNYTQIVVDRVQALDGTIyDVMFIS 412
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1720403497 299 SNDGTVLKVLppggqSLGSEPIVLEEIDAYSH 330
Cdd:cd11259   413 TDRGALHKAI-----SLENEVHIIEETQLFPD 439
Sema_4G cd11262
The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and ...
3-328 2.68e-58

The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex. Sema4G and Sema4C proteins specifically bind to Plexin B2 expressed in the cerebellar granule cells. Sema4G and Sema4C are involved in neural tube closure and cerebellar granule cell development through Plexin B2.Sema4G belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200523 [Multi-domain]  Cd Length: 457  Bit Score: 205.77  E-value: 2.68e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   3 RSYGITSLQQEGEElsgqaRCPFDATQSTVAIFAEGSLYSATAADFQaSDAVVYRSLgPQPPLRSAKYDSKWLREPHFVY 82
Cdd:cd11262   102 ERFTLSSQFEEGKE-----KCPYDPAKGYTGLIVDGQLYTASQYEFR-SFPDIRRNS-PQPTLRTEEAPTRWLNDADFVG 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  83 A----------LEHGEHVYFFFREVSVEDARL---GRVqfSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPgDSTF 149
Cdd:cd11262   175 SvlvresmnssVGDDDKIYFFFTERSQEETAYfsqSRV--ARVARVCKGDRGGK-KTLQRKWTSFLKARLVCYIP-EYEF 250
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 150 YFDVLQSLTGpvnLHGR----SALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVsEDKVPSPRPG 225
Cdd:cd11262   251 LFNVLRSVFV---LWGStpqdTVFYGIFGLEWKNVKASAICRYSLSDIQTAFEGPYMEYQDSSSKWSRY-TGKVPEPRPG 326
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 226 SCAGVGA-AASFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLtLTSRALLTQVAVDGMAGPHRNT-TVLFLGSNDGT 303
Cdd:cd11262   327 SCITDEHrSQGINSSQDLPDNVLDFVRRHPLMAEQVLPVEGRPLL-FKRNVIYTKIAVQTVRGLDGRVyDVLFLGTDEGW 405
                         330       340
                  ....*....|....*....|....*
gi 1720403497 304 VLKVLppggqSLGSEPIVLEEIDAY 328
Cdd:cd11262   406 LHKAV-----VIGSAVHIIEELQVF 425
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
19-325 6.90e-56

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 199.26  E-value: 6.90e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  19 GQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSaKYDSKWLREPHFVYAL--------EHG--E 88
Cdd:cd11258   114 GKGKCPYDPAKGHTGLIVDGELYSATLNNFLGTEPVILRNLGQHYSMKT-EYLAFWLNEPHFVGSAfvpesvgsFTGddD 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  89 HVYFFFREVSVE-DARLGRVqFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPgDSTFYFDVLQSL-TGPVNLHGR 166
Cdd:cd11258   193 KIYFFFSERAVEyDCDSEQV-VARVARVCKGDLGGA-RTLQKKWTTFLKARLLCSIP-EWQLYFNQLKAVfTLEGASWRN 269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 167 SALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSeDKVPSPRPGSCA-GVGAAASFSSSQDLPDD 245
Cdd:cd11258   270 TTFFAVFQARWGDMDVSAVCEYQLGEIQQVFEGPYKEYSEQAQKWGRYT-DPVPSPRPGSCInNWHRDHGYTSSLELPDN 348
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 246 VLLFIKAHPLLDPAVPPATHQPLLTLTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLppggqSLGSEPIVLEEI 325
Cdd:cd11258   349 TLNFVKKHPLMEDRVKPRLGRPLLVPCNSNFTHVVWTRVLGLDGETYSVLFIGTLDGWLIKAV-----SLGSWVHMIEEL 423
Sema_4F cd11261
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in ...
2-313 1.06e-53

The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in heterotypic cell-cell contacts and controls cell proliferation and suppresses tumorigenesis. In neurofibromatosis type 1 (NF1) patients, reduced Sema4F level disrupts Schwann cell/axonal interactions. Experiments using a yeast two-hybrid system show that the extreme C-terminus of Sema4F interacts with the PDZ domains of post-synaptic density protein SAP90/PSD-95, indicating possible functional involvement of Semas4F at glutamatergic synapses. Recent work also suggests a role for Sema4F in the injury response of intramedullary axotomized motoneuron. Sema4F belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulator molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200522 [Multi-domain]  Cd Length: 460  Bit Score: 193.18  E-value: 1.06e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   2 CRSYGITSLQQEGEELSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFV 81
Cdd:cd11261    98 CGVIDVSSFQQVERLESGRGKCPFEPAQRSAAIMAGGVLYAATVKNFLGTEPIISRAVGRAEEWIRTETLPSWLNAPAFV 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  82 YAL-----EHGE-----HVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDSTfYF 151
Cdd:cd11261   178 AAVflspaEWGDedgddEIYFFFTETAREYDSYERIKVPRVARVCAGDLGGR-KTLQQRWTTFLKADLLCPGPEHGR-AS 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 152 DVLQSLTG--PVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSC-A 228
Cdd:cd11261   256 SILQDVTTlrPLPGAGTPIFYGIFSSQWEGASISAVCAFRPQDIRRVMNGPFREFKHDCNRGLPVMDSDVPQPRPGECiT 335
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 229 GVGAAASFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRALLTQVA--VDGMAGPHRNttVLFLGSNDGTVLK 306
Cdd:cd11261   336 NNMKLLGFGSSLSLPDRVLTFVRDHPLMDRPVFPADGHPLLVTTDTAYLRVAAhrVTSLSGKEYD--VLYLGTEDGHLHR 413

                  ....*..
gi 1720403497 307 VLPPGGQ 313
Cdd:cd11261   414 AVRIGAQ 420
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
2-366 4.35e-53

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 189.72  E-value: 4.35e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497   2 CRSYGITSLQQEGEE--LSGQARCPFDATQSTVAIFAEGSLYSATAADF-QASDAVVYRSLGPQPPLRSAKYDSKWLREP 78
Cdd:cd09295    91 CGSYRLDVLVELGKVrwPSGRPRCPIDNKHSNMGVNVDSKLYSATDHDFkDGDRPALSRRSSNVHYLRIVVDSSTGLDEI 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  79 HFVYALEHG---EHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPgDSTFYFDVLQ 155
Cdd:cd09295   171 TFVYAFVSGdddDEVYFFFRQEPVEYLKKGMVYVPRIARVCKLDVGGC-HRLKKKLTSFLKADLNCSRP-QSGFAFNLLQ 248
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 156 SLTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFegkfkeqrsldgawtpvsedkvpsprpgscagvgaaas 235
Cdd:cd09295   249 DATGDTKNLIQDVKFAIFSSCLNKSVESAVCAYLFTDINNVF-------------------------------------- 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 236 fsssqdlpddvllfikahpllDPAVPPATHQPLLTLTS-RALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLPPGGqS 314
Cdd:cd09295   291 ---------------------DDPVEAINNRPLYAHQNqRSRLTSIAVDATKQKSVGYQVVFLGLKLGSLGKALAFFF-L 348
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720403497 315 LGSEpiVLEEIDAYsharcsgkrspRAARRIIGLELDTEGHRLFVAFPGCIV 366
Cdd:cd09295   349 YKGH--IIEEWKVF-----------KDSSRITNLDLSRPPLYLYVGSESGVL 387
Sema_4A cd11256
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed ...
17-365 3.96e-51

The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed in immune cells and is thus termed an "immune semaphorin". It plays critical roles in T cell-DC interactions in the immune response. It has been reported to enhance activation and differentiation of T cells in vitro and generation of antigen-specific T cells in vivo. The function of Sema4A in the immune response implicates its role in infectious and noninfectious diseases. Sema4A exerts its function through three receptors, namely Plexin B, Plexin D1, and Tim-2. Sema4A belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. TThe Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200517 [Multi-domain]  Cd Length: 447  Bit Score: 185.50  E-value: 3.96e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  17 LSGQARCPFDATQSTVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYdSKWLR-EPHFVYAL--EHGEHVYFF 93
Cdd:cd11256   117 MDGKGQSPFDPQHNYTAILVDGELYTGTMNNFRGNEPIIFRNLGTKVSLKTDGF-LRWLNaDAVFVASFnpQGDSKVYFF 195
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  94 FREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPGDstFYFDVLQ-SLTGPVNLHGRSALFGV 172
Cdd:cd11256   196 FEETAREFDFFEKLTVARVARVCKNDVGGE-KLLQKKWTTFLKAQLTCSQQGH--FPFNVIHhVALLNQPDPNNSVFYAV 272
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 173 FTT--QTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTpVSEDKVPSPRPGSCAGvGAAAsfsssqdlpDDVLLFI 250
Cdd:cd11256   273 FTSqwQLGGRRSSAVCAYKLNDIEKVFNGKYKELNKESSRWT-RYMGPVSDPRPGSCSG-GKSS---------DKALNFM 341
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 251 KAHPLLDPAVPPATHQPLLtLTSRALLTQVAVDGMAGPH-RNTTVLFLGSNDGTVLKVLPPGgqslGSEPIVLEEIDAYS 329
Cdd:cd11256   342 KDHFLMDEVVLPGAGRPLL-VKSNVQYTRIAVDSVQGVSgHNYTVMFLGTDKGFLHKAVLMG----GSESHIIEEIELLT 416
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1720403497 330 --HARCSGKRSPraarriigleldTEGhRLFVAFPGCI 365
Cdd:cd11256   417 ppEPVENLLLAA------------NEG-VVYIGYSAGV 441
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
154-330 7.32e-50

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 173.23  E-value: 7.32e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 154 LQS---LTGPVNLHGRSALFGVFTTQT-NSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVsEDKVPSPRPGSCag 229
Cdd:pfam01403   1 LQDvfvLKPGAGDALDTVLYGVFTTQWsNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPY-TGKVPYPRPGTC-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 230 vgaaASFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLTlTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLP 309
Cdd:pfam01403  78 ----INDPLRLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLV-RTGVRLTSIAVDRVQALDGNYTVLFLGTDDGRLHKVVL 152
                         170       180
                  ....*....|....*....|.
gi 1720403497 310 PGGQslgsEPIVLEEIDAYSH 330
Cdd:pfam01403 153 VGSE----ESHIIEEIQVFPE 169
Sema_7A cd11243
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); ...
24-359 1.68e-34

The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); Sema7A plays regulatory roles in both immune and nervous systems. Unlike other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Sema7A also plays a critical role in the negative regulation of T cell activation and function. Sema7A is a membrane-anchored member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200504 [Multi-domain]  Cd Length: 414  Bit Score: 136.90  E-value: 1.68e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  24 PFDATQSTVAIFAEGSLYSATAAdfQASDAVVYRSLGPQPPLRSAkyDSkWLREPHFVYAL------EHGEHVYFFFREV 97
Cdd:cd11243   102 PFLPDENSLVLIEGNNVYSTISG--KKGNIPRFRRYGGKKELYTS--DT-VMQKPQFVKATllpedeQYQDKIYYFFRED 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  98 SVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTfYFDVLQS-LTGPVNLHGRSALFGVFTTQ 176
Cdd:cd11243   177 NEDKGPEAEPNISRVARLCKEDQGGTSSLSTSKWSTFLKARLVCGDPATPM-NFNRLQDvFLLPKEEWREAVVYGVFSNT 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 177 TNSipgSAVCAFYLDDIERGFegkfkEQRSLDGAWTPvsedkVPSPRPGSCagvgaaasFSSSQDLPDDVLLFIKAHPLL 256
Cdd:cd11243   256 WGS---SAVCSYSLGDIDKVF-----RTSSLKGYSGS-----LPNPRPGTC--------VPPEQTHPSETFSFADEHPEL 314
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 257 DPAVPPATHQPLLTLTSRALLTQVAVDGMAGPHRNT-TVLFLGSNDGTVLKVLPPGGQSlgsepIVLEEIDAYsharcsg 335
Cdd:cd11243   315 DDRIEPDEPRKLPVFQNKDHYQKVVVDEVRASDGVSyDVLYLATDKGKIHKVVESKGQT-----HNIMEIQPF------- 382
                         330       340
                  ....*....|....*....|....
gi 1720403497 336 krspRAARRIIGLELDTEGHRLFV 359
Cdd:cd11243   383 ----KEQEPIQSMILDAERSHLYV 402
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
68-307 3.13e-13

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 72.89  E-value: 3.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  68 AKYDSKWLREphFVYALEHGEHVYFFFREVSVEDARlgrvQFSRVARVCKRDmggspraldRHWTSFLKLRLNCSVPGDS 147
Cdd:cd11276   182 SAYVSRYTQQ--FRYAFEDNNYVYFLFNQQLGHPDK----NRTLIARLCEND---------HHYYSYTEMDLNCRDGANA 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 148 ---------TFYFDVLQSLTGPVNLHGRsALFGVFTTQTNSIPGSAVCAFYLDDIERGFEgkfkeqRSLDGAWTPVSEDK 218
Cdd:cd11276   247 ynkcqaayvSTPGKELAQNYGNSILSDK-VLFAVFSRDEKDSGESALCMFPLKSINAKME------ANREACYTGTIDDR 319
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 219 --VPSP----RPGSCAGVGAAASFS---SSQDLPddvllfikaHPLLDPAvPPATHQPLLTlTSRALLTQVAVdgmaGPH 289
Cdd:cd11276   320 dvFYKPfhsqKDIICGSHQQKNSKSfpcGSEHLP---------YPLGSRD-ELALTAPVLQ-RGGLNLTAVTV----AVE 384
                         250
                  ....*....|....*...
gi 1720403497 290 RNTTVLFLGSNDGTVLKV 307
Cdd:cd11276   385 NGHTVAFLGTSDGRILKV 402
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
79-311 9.65e-12

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 68.03  E-value: 9.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  79 HFVYALEHGEHVYFFFrevSVEDARLGRVQFSRVARVCKRdmggspralDRHWTSFLKLRLNCSVPGDSTfyFDVLQSL- 157
Cdd:cd11245   185 DFVYAFADNGYIYFLF---SRRPGTADSTKRTYISRLCEN---------DHHYYSYVELPLNCTVNQENT--YNLVQAAy 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 158 --TGPVNLHGRsALFGVFTTQTNSIPG----SAVCAFYLDDIERGFEgkfkeqRSLDGAWTP--VSEDKVPSprpgscag 229
Cdd:cd11245   251 laKPGKVLNGK-VLFGVFSADEASTAApdgrSALCMYPLSSVDARFE------RTRESCYTGegLEDDKPET-------- 315
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 230 vgAAASFSSSQD---LPDDVLlfiKAHPLLDPAVPP--ATHQPLLT---LTSRALLTQVAVDGMAGpHrntTVLFLGSND 301
Cdd:cd11245   316 --AYIEYNVKSIcktLPDKNV---KAYPCGAEHTPSplASRYPLAAkpiLTRNDMLTAVAVAVENG-H---TIAFLGDSG 386
                         250
                  ....*....|.
gi 1720403497 302 GTVLKV-LPPG 311
Cdd:cd11245   387 GQLHKVyLDPN 397
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
79-308 1.39e-11

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 67.36  E-value: 1.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  79 HFVYALEHGEHVYFFFREVSVEDARLGRVqfSRVARVCKRDmggspraldRHWTSFLKLRLNCSVpGDSTFY-------- 150
Cdd:cd11236   184 KYVYGFSSGGFSYFVTVQRKSVDDESPYI--SRLVRVCQSD---------SNYYSYTEVPLQCTG-GDGTNYnllqaayv 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 151 ----FDVLQSLTGPVNLHgrsALFGVFTTQTNS--IPG--SAVCAFYLDDIERgfegKFKEQrsldgawTPVSedkvpsp 222
Cdd:cd11236   252 gkagSDLARSLGISTDDD---VLFGVFSKSKGPsaEPSskSALCVFSMKDIEA----AFNDN-------CPLG------- 310
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 223 rpgscagvgaaasfsssqdlpddvllfikahplldpAVPPATHQPLLtltSRALLTQVAVDGmagpHRNTTVLFLGSNDG 302
Cdd:cd11236   311 ------------------------------------GGVPITTSAVL---SDSLLTSVAVTT----TRNHTVAFLGTSDG 347

                  ....*.
gi 1720403497 303 TVLKVL 308
Cdd:cd11236   348 QLKKVV 353
PHA03247 PHA03247
large tegument protein UL36; Provisional
567-809 7.51e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 7.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  567 TTFLPPPDGGSPPELACLPTPETTPELPVKHLRASGGPwewnqnGNNASEGPGRPPRGCSGAGGPAPRVLVRPPPpgcpg 646
Cdd:PHA03247  2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP------ALPAAPAPPAVPAGPATPGGPARPARPPTTA----- 2764
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  647 qavevttleellrylhGPQPPRKGSEPLASAPFTSRPPASEPgASLFVDSSPMPRDGVPPlRLDVPPEGKRAAPSGRPAL 726
Cdd:PHA03247  2765 ----------------GPPAPAPPAAPAAGPPRRLTRPAVAS-LSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAG 2826
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  727 SAPAPRLGVGGSRRLPFPTHRAPPGLLTRVPSGGPARYSGGPGRHLLYLGRPEGHRGRSLKRVDVKSPLS--PKPPLASP 804
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTEsfALPPDQPE 2906

                   ....*
gi 1720403497  805 PQPAP 809
Cdd:PHA03247  2907 RPPQP 2911
PHA03247 PHA03247
large tegument protein UL36; Provisional
571-814 1.79e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  571 PPPDGGSPPELACLPTPETTpELPVKHLRASGGPwewNQNGNNASEGPGRPPRGCSGAGGPAPRVLVRPPPPGcPGQAVE 650
Cdd:PHA03247  2617 LPPDTHAPDPPPPSPSPAAN-EPDPHPPPTVPPP---ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR-RAARPT 2691
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  651 VTTLEELLRylhgPQPPRKGSEPlASAPFTSRPPASEPGASLFVDSSPMPRDGVPPLRLDVP-------PEGKRAAPSGR 723
Cdd:PHA03247  2692 VGSLTSLAD----PPPPPPTPEP-APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPatpggpaRPARPPTTAGP 2766
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  724 PALSAPAPRLGvGGSRRLPFPThrappglltrVPSGGPARYSGGPGRHLLYLGRPEGHRGRSLKRVDVKSPLSPKPPLAS 803
Cdd:PHA03247  2767 PAPAPPAAPAA-GPPRRLTRPA----------VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835
                          250
                   ....*....|.
gi 1720403497  804 PPQPAPHGGHF 814
Cdd:PHA03247  2836 PTAPPPPPGPP 2846
PHA03378 PHA03378
EBNA-3B; Provisional
585-812 2.83e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 585 PTPETTPELPVK--HLRASGGPWEWNQngnnasegPGRPPRGCSGAGGPAPRVLVRPPPPGCPGQAVEVTTLEELLRYLH 662
Cdd:PHA03378  600 PHPSQTPEPPTTqsHIPETSAPRQWPM--------PLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGH 671
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 663 GPQPPR----KGSEPLASAPFTSRPPASEPGaslfvdssPMPRDGVPPLRLDVPpegkRAAPSgrpalSAPAPRLGVGGS 738
Cdd:PHA03378  672 IPYQPSptgaNTMLPIQWAPGTMQPPPRAPT--------PMRPPAAPPGRAQRP----AAATG-----RARPPAAAPGRA 734
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720403497 739 RRLPFPTHRAPPglltrvPSGGPARY---SGGPGRhllyLGRPEGHRGRSLKRVDVKSPLSP--KPPLASPPQPAPHGG 812
Cdd:PHA03378  735 RPPAAAPGRARP------PAAAPGRArppAAAPGR----ARPPAAAPGAPTPQPPPQAPPAPqqRPRGAPTPQPPPQAG 803
PHA03247 PHA03247
large tegument protein UL36; Provisional
529-769 3.96e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 3.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  529 PGLPRPlSLRSLARLHGGGPEPPPPPKDGDAAQTPQLYTTFLPPPDGGSPPELACLPTPETTPELPVKHLRASGGPWEwn 608
Cdd:PHA03247  2781 RRLTRP-AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA-- 2857
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  609 QNGNNASEGPGRPPrgcsgAGGPAPRVLVRPPPPGCPGQAVEVTTLeellrylhgPQPPrkgsEPLASAPFTSRPPASEP 688
Cdd:PHA03247  2858 PGGDVRRRPPSRSP-----AAKPAAPARPPVRRLARPAVSRSTESF---------ALPP----DQPERPPQPQAPPPPQP 2919
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  689 GASLFVDSSPMPRDGVPPLRLDVPPEGKRAAPSGRPALSAPAPRLGVGGSRRLPFPTHRAP---PGLLTRVPSGGPARYS 765
Cdd:PHA03247  2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqpaPSREAPASSTPPLTGH 2999

                   ....
gi 1720403497  766 GGPG 769
Cdd:PHA03247  3000 SLSR 3003
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
79-320 5.40e-04

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 43.26  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  79 HFVYALEHGEHVYFFFREvsvEDARLGRVQFSRVARVCkrdMGgspralDRHWTSFLKLRLNCSvpgdstfyfdVLQSLT 158
Cdd:cd11277   187 SYVGAFAHNGYVYFLFRR---RGARAQAEYRTYVARVC---LG------DTNLYSYVEVPLVCQ----------GGYNLA 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 159 GPVNLH-GRSALFGVFTTQTNSIP----GSAVCAFYLDDIERGFEGKFK-----EQRSLDGAWTPVSEDKVPSprpgSCA 228
Cdd:cd11277   245 QAAYLApGQGTLFVVFAAGQGSTPtptdQTALCAYPLVELDSAMERARRlcytaGGGGPNGKEEATIEYGVTS----RCV 320
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 229 GVgaaasfssSQDLPDdvllfikAHPLLDPAVP-------PATHQPLLTLTSRalLTQVAVDGMAGphrnTTVLFLGSND 301
Cdd:cd11277   321 NL--------PKDSPE-------SYPCGDEHTPspiasrqPLEAEPLLTLTPP--LTAVAALQEDG----HTIAFLGDTQ 379
                         250       260
                  ....*....|....*....|.
gi 1720403497 302 GTVLKVL--PPGGQSLGSEPI 320
Cdd:cd11277   380 GQLHKVFlnGSAGQVYSSQPV 400
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
372-393 7.80e-04

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 38.07  E-value: 7.80e-04
                          10        20
                  ....*....|....*....|..
gi 1720403497 372 RCARHGACQrSCLASLDPYCGW 393
Cdd:pfam01437   1 RCSQYTSCS-SCLAARDPYCGW 21
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
79-312 9.29e-04

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 42.64  E-value: 9.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  79 HFVYALEHGEHVYFFF--REVSVEDarlgRVQFSRVARVCKRdmggspralDRHWTSFLKLRLNCSVPGDStfyFDVLQS 156
Cdd:cd11275   197 HFIKAFTYGSSVYFLFyrRDLKSQS----REYKTYISRICLD---------DSHYYSYVELPLLCQSKANT---YSLLQA 260
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 157 ----------LTGPVNLHGrSALFGVFTTQTNSIPG----SAVCAFYLDDIERGFEGK-----FKEQRSLDGAWTPVSED 217
Cdd:cd11275   261 ayvtqpgerlAQGQLDTDG-EVLFAAFSAWQASSGKlseeSALCAYPMDEVDRLTNWTrdvcyTRDGKAEDGTEVAYIEY 339
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 218 KVPSprpgSCAgvgaaasfsssqDLPDDVLlfiKAHPLLDPAVP-------PATHQPLLTLTSrALLTQVAVDGMAGphr 290
Cdd:cd11275   340 DVSS----NCV------------QLPADTL---DAYPCGSDHTPspmasrvPLEATPLLEWTE-IRLTAVAVNVEDG--- 396
                         250       260
                  ....*....|....*....|...
gi 1720403497 291 nTTVLFLGSNDGTVLKV-LPPGG 312
Cdd:cd11275   397 -HTIAFLGDSRGRLHKVyLGAGG 418
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
593-793 1.49e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.97  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 593 LPVKHLRASGGpwewnqngnnasegpGRPPRGCSGAGGPAPrvlvrppppGCpgqavevttleellrylHGPQPPRKGSE 672
Cdd:PRK14959  366 MPVESLRPSGG---------------GASAPSGSAAEGPAS---------GG-----------------AATIPTPGTQG 404
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497 673 PLASAPFTSRPPASEPGASLFVDSSPMPR---DGVPP--LRLDVPPEGKRAAPSGRPALSAPAPRLGVGGSRrlpfPTHR 747
Cdd:PRK14959  405 PQGTAPAAGMTPSSAAPATPAPSAAPSPRvpwDDAPPapPRSGIPPRPAPRMPEASPVPGAPDSVASASDAP----PTLG 480
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720403497 748 APPGLLTRVPSG-----GPARY----SGGPGRHLLYLGRPEGHRGRSLKRVDVKS 793
Cdd:PRK14959  481 DPSDTAEHTPSGprtwdGFLEFcqgrNGQGGRLATVLRQATPEHADGRLRLATMS 535
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
572-815 2.04e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  572 PPDGGSPPELAclPTPETTPELPVKHLRASGGPWEWNQNGNNASEGPGRPPRGCSGAGGPAprvlvrppppgcpgqavEV 651
Cdd:PHA03307    71 PPPGPGTEAPA--NESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPS-----------------PA 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  652 TTLEELLRYLHGPQPPRKGSEPLASAPFTS--RPPASEPGASLFVDSSPMPRDGVPPLRLDVPPEGKRAAPSGRPA---- 725
Cdd:PHA03307   132 PDLSEMLRPVGSPGPPPAASPPAAGASPAAvaSDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPrrss 211
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  726 -LSAPAPRLGVGGSRRLPFPTHRAPPGLLTRVPSG---GP----ARYSGGPGRHLLYLGRPEGHRGRSLKRVDVKSPLSP 797
Cdd:PHA03307   212 pISASASSPAPAPGRSAADDAGASSSDSSSSESSGcgwGPenecPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP 291
                          250
                   ....*....|....*...
gi 1720403497  798 KPPLASPPQPAPHGGHFN 815
Cdd:PHA03307   292 RERSPSPSPSSPGSGPAP 309
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
372-393 4.47e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 35.98  E-value: 4.47e-03
                           10        20
                   ....*....|....*....|..
gi 1720403497  372 RCARHGACQrSCLASLDPYCGW 393
Cdd:smart00423   1 RCSKYTSCS-ECLLARDPYCAW 21
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
571-808 6.59e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 6.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  571 PPPDGGSPPELACLPTPETTPELPVKHLRASGGPWEWNQNGNNASEGPGRPPRGCSGAGGPAPRVLVRPPPPGCPGQ-AV 649
Cdd:PHA03307   112 SSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSpPA 191
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  650 EVTTLEELLRYLHGPQPPRKGSEPLASAPFTSRPPASEPGASlfvdSSPMPRDGVPPLRLDVPPEGKRAAPSGRPALSAP 729
Cdd:PHA03307   192 EPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAG----ASSSDSSSSESSGCGWGPENECPLPRPAPITLPT 267
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403497  730 APRLGVGGSRRLPFPTHRAPPGLL-----TRVPSGGPARYSGGPGRHLLYLGRPE------------------GHRGRSL 786
Cdd:PHA03307   268 RIWEASGWNGPSSRPGPASSSSSPrerspSPSPSSPGSGPAPSSPRASSSSSSSRessssstssssessrgaaVSPGPSP 347
                          250       260
                   ....*....|....*....|..
gi 1720403497  787 KRVdvKSPLSPKPPLASPPQPA 808
Cdd:PHA03307   348 SRS--PSPSRPPPPADPSSPRK 367
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH