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Conserved domains on  [gi|1720404459|ref|XP_030108591|]
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transcription factor SPT20 homolog isoform X8 [Mus musculus]

Protein Classification

Spt20 domain-containing protein( domain architecture ID 13778873)

Spt20 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Spt20 pfam12090
Spt20 family; This presumed domain is found in the Spt20 proteins from both human and yeast. ...
8-144 1.74e-23

Spt20 family; This presumed domain is found in the Spt20 proteins from both human and yeast. The Spt20 protein is part of the SAGA complex which is a large complex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains.


:

Pssm-ID: 463459 [Multi-domain]  Cd Length: 176  Bit Score: 98.25  E-value: 1.74e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459   8 LVVNLYPgnEGYSLMlrgkngSDSETIRLPYEE--GELLEYLDAEELPPILVDLLEKSQVnIFHCGCVIAEIRDYR---- 81
Cdd:pfam12090   7 LILHLYP--KHFRIN------NSTDEGIFPYNSemRKFLEHIERGTIPPEILELLRDFNI-KFYDGCLIVQIIDHRntpq 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459  82 ---------QSSNMKSPGYQSR-------------HILLRPTMQTLVCDVhSITSDN--HKWTQEDKLLLESQLILATAE 137
Cdd:pfam12090  78 qspkttnpqQNQQQPAPGNNNSskkkkttvkprvyRTLLRPTPQSLYADL-TSLSDTpkMRLSDEDLLELESEILLATNP 156

                  ....*..
gi 1720404459 138 PLCLDPS 144
Cdd:pfam12090 157 PLCLDPS 163
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
411-700 5.17e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459 411 TAQQASSFLKSPTPPPSCKPSLSRKSSVDLSQVSMLSPAALSPASSsqrsgtpkpsppTPTPSSVPHPPDAQNSAPSTPS 490
Cdd:pfam05109 481 TTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPA------------VTTPTPNATSPTLGKTSPTSAV 548
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459 491 ATPSPQESGFTPQPTLLTQFAQQQrALSQAMPVTTIPLSTMVTSITTGSSLSPVMADS----AGLTSVSVLSS--AGGAQ 564
Cdd:pfam05109 549 TTPTPNATSPTPAVTTPTPNATIP-TLGKTSPTSAVTTPTPNATSPTVGETSPQANTTnhtlGGTSSTPVVTSppKNATS 627
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459 565 ALKSGSNSMLGCDTGAIPPAGKSLCSGLLPSGGLVANT-LPSAVQAAPQAGipfglqntsslrpLNLLQLPGGSLIFNTQ 643
Cdd:pfam05109 628 AVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTShMPLLTSAHPTGG-------------ENITQVTPASTSTHHV 694
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720404459 644 QQQQQTQLPHFIQQPQQPA-ASGSQQPEEQGSEQGLTAQE----QALTAQQAAVINLTGVGG 700
Cdd:pfam05109 695 STSSPAPRPGTTSQASGPGnSSTSTKPGEVNVTKGTPPKNatspQAPSGQKTAVPTVTSTGG 756
 
Name Accession Description Interval E-value
Spt20 pfam12090
Spt20 family; This presumed domain is found in the Spt20 proteins from both human and yeast. ...
8-144 1.74e-23

Spt20 family; This presumed domain is found in the Spt20 proteins from both human and yeast. The Spt20 protein is part of the SAGA complex which is a large complex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains.


Pssm-ID: 463459 [Multi-domain]  Cd Length: 176  Bit Score: 98.25  E-value: 1.74e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459   8 LVVNLYPgnEGYSLMlrgkngSDSETIRLPYEE--GELLEYLDAEELPPILVDLLEKSQVnIFHCGCVIAEIRDYR---- 81
Cdd:pfam12090   7 LILHLYP--KHFRIN------NSTDEGIFPYNSemRKFLEHIERGTIPPEILELLRDFNI-KFYDGCLIVQIIDHRntpq 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459  82 ---------QSSNMKSPGYQSR-------------HILLRPTMQTLVCDVhSITSDN--HKWTQEDKLLLESQLILATAE 137
Cdd:pfam12090  78 qspkttnpqQNQQQPAPGNNNSskkkkttvkprvyRTLLRPTPQSLYADL-TSLSDTpkMRLSDEDLLELESEILLATNP 156

                  ....*..
gi 1720404459 138 PLCLDPS 144
Cdd:pfam12090 157 PLCLDPS 163
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
411-700 5.17e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459 411 TAQQASSFLKSPTPPPSCKPSLSRKSSVDLSQVSMLSPAALSPASSsqrsgtpkpsppTPTPSSVPHPPDAQNSAPSTPS 490
Cdd:pfam05109 481 TTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPA------------VTTPTPNATSPTLGKTSPTSAV 548
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459 491 ATPSPQESGFTPQPTLLTQFAQQQrALSQAMPVTTIPLSTMVTSITTGSSLSPVMADS----AGLTSVSVLSS--AGGAQ 564
Cdd:pfam05109 549 TTPTPNATSPTPAVTTPTPNATIP-TLGKTSPTSAVTTPTPNATSPTVGETSPQANTTnhtlGGTSSTPVVTSppKNATS 627
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459 565 ALKSGSNSMLGCDTGAIPPAGKSLCSGLLPSGGLVANT-LPSAVQAAPQAGipfglqntsslrpLNLLQLPGGSLIFNTQ 643
Cdd:pfam05109 628 AVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTShMPLLTSAHPTGG-------------ENITQVTPASTSTHHV 694
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720404459 644 QQQQQTQLPHFIQQPQQPA-ASGSQQPEEQGSEQGLTAQE----QALTAQQAAVINLTGVGG 700
Cdd:pfam05109 695 STSSPAPRPGTTSQASGPGnSSTSTKPGEVNVTKGTPPKNatspQAPSGQKTAVPTVTSTGG 756
 
Name Accession Description Interval E-value
Spt20 pfam12090
Spt20 family; This presumed domain is found in the Spt20 proteins from both human and yeast. ...
8-144 1.74e-23

Spt20 family; This presumed domain is found in the Spt20 proteins from both human and yeast. The Spt20 protein is part of the SAGA complex which is a large complex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains.


Pssm-ID: 463459 [Multi-domain]  Cd Length: 176  Bit Score: 98.25  E-value: 1.74e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459   8 LVVNLYPgnEGYSLMlrgkngSDSETIRLPYEE--GELLEYLDAEELPPILVDLLEKSQVnIFHCGCVIAEIRDYR---- 81
Cdd:pfam12090   7 LILHLYP--KHFRIN------NSTDEGIFPYNSemRKFLEHIERGTIPPEILELLRDFNI-KFYDGCLIVQIIDHRntpq 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459  82 ---------QSSNMKSPGYQSR-------------HILLRPTMQTLVCDVhSITSDN--HKWTQEDKLLLESQLILATAE 137
Cdd:pfam12090  78 qspkttnpqQNQQQPAPGNNNSskkkkttvkprvyRTLLRPTPQSLYADL-TSLSDTpkMRLSDEDLLELESEILLATNP 156

                  ....*..
gi 1720404459 138 PLCLDPS 144
Cdd:pfam12090 157 PLCLDPS 163
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
411-700 5.17e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459 411 TAQQASSFLKSPTPPPSCKPSLSRKSSVDLSQVSMLSPAALSPASSsqrsgtpkpsppTPTPSSVPHPPDAQNSAPSTPS 490
Cdd:pfam05109 481 TTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPA------------VTTPTPNATSPTLGKTSPTSAV 548
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459 491 ATPSPQESGFTPQPTLLTQFAQQQrALSQAMPVTTIPLSTMVTSITTGSSLSPVMADS----AGLTSVSVLSS--AGGAQ 564
Cdd:pfam05109 549 TTPTPNATSPTPAVTTPTPNATIP-TLGKTSPTSAVTTPTPNATSPTVGETSPQANTTnhtlGGTSSTPVVTSppKNATS 627
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404459 565 ALKSGSNSMLGCDTGAIPPAGKSLCSGLLPSGGLVANT-LPSAVQAAPQAGipfglqntsslrpLNLLQLPGGSLIFNTQ 643
Cdd:pfam05109 628 AVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTShMPLLTSAHPTGG-------------ENITQVTPASTSTHHV 694
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720404459 644 QQQQQTQLPHFIQQPQQPA-ASGSQQPEEQGSEQGLTAQE----QALTAQQAAVINLTGVGG 700
Cdd:pfam05109 695 STSSPAPRPGTTSQASGPGnSSTSTKPGEVNVTKGTPPKNatspQAPSGQKTAVPTVTSTGG 756
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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