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Conserved domains on  [gi|1720404492|ref|XP_030108596|]
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ATPase family gene 2 protein homolog A isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CDC48 super family cl36852
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
322-834 0e+00

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


The actual alignment was detected with superfamily member TIGR01243:

Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 651.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 322 FYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTM 401
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 402 IARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMD 481
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 482 GIGSEGsegRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGA 561
Cdd:TIGR01243 308 GLKGRG---RVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 562 DLKALCNEAGLHALRRVLRKQPNLPDSK-----VAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKL 636
Cdd:TIGR01243 384 DLAALAKEAAMAALRRFIREGKINFEAEeipaeVLKELKVTMKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQ 463
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 637 KLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKAR 716
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 717 AVAPSIIFFDELDALAVERGSSSGAgNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLP 796
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPP 622
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1720404492 797 DAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:TIGR01243 623 DEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGAD 660
CDC48_N super family cl21693
Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel ...
63-131 1.62e-04

Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases pfam00004 is a substrate 185-residue recognition domain.


The actual alignment was detected with superfamily member smart01073:

Pssm-ID: 451359 [Multi-domain]  Cd Length: 82  Bit Score: 41.06  E-value: 1.62e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720404492   63 NSLVHLGLNTMKSANICIGRPVLLTsldGKQEVY-TAWP-VAGFPGGKVGLSEMAQKNVGVRAGETIQVQP 131
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT---GKRRTVaIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
322-834 0e+00

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 651.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 322 FYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTM 401
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 402 IARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMD 481
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 482 GIGSEGsegRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGA 561
Cdd:TIGR01243 308 GLKGRG---RVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 562 DLKALCNEAGLHALRRVLRKQPNLPDSK-----VAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKL 636
Cdd:TIGR01243 384 DLAALAKEAAMAALRRFIREGKINFEAEeipaeVLKELKVTMKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQ 463
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 637 KLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKAR 716
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 717 AVAPSIIFFDELDALAVERGSSSGAgNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLP 796
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPP 622
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1720404492 797 DAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:TIGR01243 623 DEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGAD 660
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
568-834 7.75e-109

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 336.59  E-value: 7.75e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 568 NEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVaidvPNVSWSDIGGLENIKLKLKQAVEWPLK 647
Cdd:COG1222    24 RLGVELALLLQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAES----PDVTFDDIGGLDEQIEEIREAVELPLK 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 648 HPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDE 727
Cdd:COG1222   100 NPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDE 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 728 LDALAVERGSSSGAGNVaDRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNL 807
Cdd:COG1222   180 IDAIAARRTDDGTSGEV-QRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKI 258
                         250       260
                  ....*....|....*....|....*..
gi 1720404492 808 QFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:COG1222   259 HLRDMPLADDVDLDKLAKLTEGFSGAD 285
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
634-793 1.12e-102

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 314.22  E-value: 1.12e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 634 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 713
Cdd:cd19511     1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 714 KARAVAPSIIFFDELDALAVERGSSSGaGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 793
Cdd:cd19511    81 KARQAAPCIIFFDEIDSLAPRRGQSDS-SGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIYV 159
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
586-834 9.20e-89

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 286.34  E-value: 9.20e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 586 PDSKVAgmvkitLN-------DFLQGMNDIRPSAMrEVaIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQ 658
Cdd:PRK03992   92 PGARVA------LNqqslaivEVLPSEKDPRVQAM-EV-IESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIE 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 659 PPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVER--G 736
Cdd:PRK03992  164 PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdS 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 737 SSSGAGNVaDRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISN 816
Cdd:PRK03992  244 GTSGDREV-QRTLMQLLAEMDGFDPRGNVKIIAATNRIDILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMNLAD 322
                         250
                  ....*....|....*...
gi 1720404492 817 EVDLDELVLQTDTYSGAE 834
Cdd:PRK03992  323 DVDLEELAELTEGASGAD 340
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
663-795 1.11e-52

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 179.33  E-value: 1.11e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 663 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSgaG 742
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGG--D 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720404492 743 NVADRVLAQLLTEMDGIEQLK-NVTVLAATNRPDRIDKALMrpGRIDRIIYVPL 795
Cdd:pfam00004  79 SESRRVVNQLLTELDGFTSSNsKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
659-797 3.77e-18

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 82.04  E-value: 3.77e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492  659 PPKGVLLYGPPGCSKTMIAKALANESGLN---FLAIKGPELM--------------NKYVGESERAVREIFRKARAVAPS 721
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILeevldqllliivggKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404492  722 IIFFDELDALAVERGSssgagnvADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPgRIDRIIYVPLPD 797
Cdd:smart00382  81 VLILDEITSLLDAEQE-------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
CDC48_N smart01073
Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...
63-131 1.62e-04

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases is a substrate 185-residue recognition domain.


Pssm-ID: 215012 [Multi-domain]  Cd Length: 82  Bit Score: 41.06  E-value: 1.62e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720404492   63 NSLVHLGLNTMKSANICIGRPVLLTsldGKQEVY-TAWP-VAGFPGGKVGLSEMAQKNVGVRAGETIQVQP 131
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT---GKRRTVaIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
322-834 0e+00

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 651.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 322 FYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTM 401
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 402 IARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMD 481
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 482 GIGSEGsegRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGA 561
Cdd:TIGR01243 308 GLKGRG---RVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 562 DLKALCNEAGLHALRRVLRKQPNLPDSK-----VAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKL 636
Cdd:TIGR01243 384 DLAALAKEAAMAALRRFIREGKINFEAEeipaeVLKELKVTMKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQ 463
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 637 KLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKAR 716
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 717 AVAPSIIFFDELDALAVERGSSSGAgNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLP 796
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPP 622
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1720404492 797 DAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:TIGR01243 623 DEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGAD 660
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
568-834 7.75e-109

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 336.59  E-value: 7.75e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 568 NEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVaidvPNVSWSDIGGLENIKLKLKQAVEWPLK 647
Cdd:COG1222    24 RLGVELALLLQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAES----PDVTFDDIGGLDEQIEEIREAVELPLK 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 648 HPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDE 727
Cdd:COG1222   100 NPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDE 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 728 LDALAVERGSSSGAGNVaDRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNL 807
Cdd:COG1222   180 IDAIAARRTDDGTSGEV-QRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKI 258
                         250       260
                  ....*....|....*....|....*..
gi 1720404492 808 QFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:COG1222   259 HLRDMPLADDVDLDKLAKLTEGFSGAD 285
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
634-793 1.12e-102

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 314.22  E-value: 1.12e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 634 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 713
Cdd:cd19511     1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 714 KARAVAPSIIFFDELDALAVERGSSSGaGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 793
Cdd:cd19511    81 KARQAAPCIIFFDEIDSLAPRRGQSDS-SGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIYV 159
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
344-617 5.43e-97

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 305.78  E-value: 5.43e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 344 DSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 423
Cdd:COG1222    70 AESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELV 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 424 SKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVE-KRVVASLLTLMDGIGSEGSegrVLVLGATNRPQ 502
Cdd:COG1222   150 SKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEvQRTVNQLLAELDGFESRGD---VLIIAATNRPD 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 503 ALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRvlrkq 582
Cdd:COG1222   227 LLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRDMP-LADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE----- 300
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1720404492 583 pnlpdskvaGMVKITLNDFLQGMNDIRPSAMREVA 617
Cdd:COG1222   301 ---------GRDTVTMEDLEKAIEKVKKKTETATN 326
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
586-834 9.20e-89

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 286.34  E-value: 9.20e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 586 PDSKVAgmvkitLN-------DFLQGMNDIRPSAMrEVaIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQ 658
Cdd:PRK03992   92 PGARVA------LNqqslaivEVLPSEKDPRVQAM-EV-IESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIE 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 659 PPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVER--G 736
Cdd:PRK03992  164 PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdS 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 737 SSSGAGNVaDRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISN 816
Cdd:PRK03992  244 GTSGDREV-QRTLMQLLAEMDGFDPRGNVKIIAATNRIDILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMNLAD 322
                         250
                  ....*....|....*...
gi 1720404492 817 EVDLDELVLQTDTYSGAE 834
Cdd:PRK03992  323 DVDLEELAELTEGASGAD 340
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
486-834 1.75e-88

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 286.04  E-value: 1.75e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 486 EGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKA 565
Cdd:COG0464    19 DDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGELL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 566 LCNEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPsaMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWP 645
Cdd:COG0464    99 LLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGG--LEEELLELREAILDDLGGLEEVKEELRELVALP 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 646 LKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFF 725
Cdd:COG0464   177 LKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFI 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 726 DELDALAVERGSSSGAgnVADRVLAQLLTEMDGIEqlKNVTVLAATNRPDRIDKALMRpgRIDRIIYVPLPDAATRREIL 805
Cdd:COG0464   257 DEADALAGKRGEVGDG--VGRRVVNTLLTEMEELR--SDVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIF 330
                         330       340
                  ....*....|....*....|....*....
gi 1720404492 806 NLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:COG0464   331 RIHLRKRPLDEDVDLEELAEATEGLSGAD 359
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
354-520 1.67e-87

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 274.55  E-value: 1.67e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 433
Cdd:cd19503     2 IGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 434 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALDAALRRPGR 513
Cdd:cd19503    82 LREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGM---SSRGKVVVIAATNRPDAIDPALRRPGR 158

                  ....*..
gi 1720404492 514 FDKEIEI 520
Cdd:cd19503   159 FDREVEI 165
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
354-521 1.02e-83

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 264.68  E-value: 1.02e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 433
Cdd:cd19519     2 IGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 434 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALDAALRRPGR 513
Cdd:cd19519    82 LRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGL---KQRAHVIVMAATNRPNSIDPALRRFGR 158

                  ....*...
gi 1720404492 514 FDKEIEIG 521
Cdd:cd19519   159 FDREIDIG 166
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
634-793 3.93e-79

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 252.03  E-value: 3.93e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 634 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 713
Cdd:cd19529     1 VKQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 714 KARAVAPSIIFFDELDALAVERGSSSGAGnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 793
Cdd:cd19529    81 KARQVAPCVIFFDEIDSIAPRRGTTGDSG-VTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
596-834 3.41e-78

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 257.42  E-value: 3.41e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 596 ITLNDFLQGMNDIRPSAMrEVaIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTM 675
Cdd:TIGR01242  94 LTIVDVLPTSKDPLVKGM-EV-EERPNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYGPPGTGKTL 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 676 IAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGN-VADRVLAQLLT 754
Cdd:TIGR01242 172 LAKAVAHETNATFIRVVGSELVRKYIGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRTDSGTSGDrEVQRTLMQLLA 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 755 EMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:TIGR01242 252 ELDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRIIEVPLPDFEGRLEILKIHTRKMKLAEDVDLEAIAKMTEGASGAD 331
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
351-576 4.56e-78

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 258.30  E-value: 4.56e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 351 YDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGET 430
Cdd:COG0464   156 LDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGET 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 431 EARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgsegsEGRVLVLGATNRPQALDAALRR 510
Cdd:COG0464   236 EKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEEL-----RSDVVVIAATNRPDLLDPALLR 310
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404492 511 pgRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALR 576
Cdd:COG0464   311 --RFDEIIFFPLPDAEERLEIFRIHLRKRP-LDEDVDLEELAEATEGLSGADIRNVVRRAALQALR 373
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
634-793 1.64e-74

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 240.10  E-value: 1.64e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 634 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 713
Cdd:cd19528     1 VKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 714 KARAVAPSIIFFDELDALAVERGSSSG-AGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIY 792
Cdd:cd19528    81 KARAAAPCVLFFDELDSIAKARGGNIGdAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLIY 160

                  .
gi 1720404492 793 V 793
Cdd:cd19528   161 I 161
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
627-793 2.07e-73

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 237.19  E-value: 2.07e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 627 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 706
Cdd:cd19503     1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 707 AVREIFRKARAVAPSIIFFDELDALAVERGSSSGAgnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGR 786
Cdd:cd19503    81 NLREIFEEARSHAPSIIFIDEIDALAPKREEDQRE--VERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPGR 158

                  ....*..
gi 1720404492 787 IDRIIYV 793
Cdd:cd19503   159 FDREVEI 165
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
348-609 9.73e-72

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 240.89  E-value: 9.73e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 348 KVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 427
Cdd:PRK03992  127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 428 GETeARL-RQIFAEATLRHPSIIFIDELDALCPKR----EGAQSEVEkRVVASLLTLMDGIgseGSEGRVLVLGATNRPQ 502
Cdd:PRK03992  207 GEG-ARLvRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAEMDGF---DPRGNVKIIAATNRID 281
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 503 ALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVpHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRvLRKQ 582
Cdd:PRK03992  282 ILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKM-NLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD-DRTE 359
                         250       260
                  ....*....|....*....|....*..
gi 1720404492 583 pnlpdskvagmvkITLNDFLQGMNDIR 609
Cdd:PRK03992  360 -------------VTMEDFLKAIEKVM 373
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
619-834 9.24e-71

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 238.51  E-value: 9.24e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 619 DVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMN 698
Cdd:PTZ00454  138 EKPDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQ 217
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 699 KYVGESERAVREIFRKARAVAPSIIFFDELDALAVER-GSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRI 777
Cdd:PTZ00454  218 KYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTL 297
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720404492 778 DKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:PTZ00454  298 DPALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKMNLSEEVDLEDFVSRPEKISAAD 354
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
624-793 1.07e-70

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 229.92  E-value: 1.07e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 624 SWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGE 703
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 704 SERAVREIFRKARAVAPSIIFFDELDALAVER-GSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALM 782
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRfDSGTGGDREVQRTMLELLNQLDGFDPRGNIKVIMATNRPDILDPALL 160
                         170
                  ....*....|.
gi 1720404492 783 RPGRIDRIIYV 793
Cdd:cd19502   161 RPGRFDRKIEF 171
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
631-793 1.96e-68

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 223.52  E-value: 1.96e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 631 LENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRE 710
Cdd:cd19530     1 LDHVREELTMSILRPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 711 IFRKARAVAPSIIFFDELDALAVERGssSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRI 790
Cdd:cd19530    81 VFQRARASAPCVIFFDEVDALVPKRG--DGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKT 158

                  ...
gi 1720404492 791 IYV 793
Cdd:cd19530   159 LYV 161
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
349-615 1.66e-67

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 238.65  E-value: 1.66e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 349 VTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 428
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 429 ETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSE-VEKRVVASLLTLMDGIgSEGSEgrVLVLGATNRPQALDAA 507
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTsVTDRIVNQLLTEMDGI-QELSN--VVVIAATNRPDILDPA 606
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 508 LRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRVLRKQPN--- 584
Cdd:TIGR01243 607 LLRPGRFDRLILVPPPDEEARKEIFKIHTRSMP-LAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAKekl 685
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1720404492 585 -LPDSKVAGMVKITLNDFLQGMNDIRPSAMRE 615
Cdd:TIGR01243 686 eVGEEEFLKDLKVEMRHFLEALKKVKPSVSKE 717
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
627-794 5.01e-67

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 220.00  E-value: 5.01e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 627 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 706
Cdd:cd19519     1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 707 AVREIFRKARAVAPSIIFFDELDALAVERGSSSgaGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGR 786
Cdd:cd19519    81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTH--GEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGR 158

                  ....*...
gi 1720404492 787 IDRIIYVP 794
Cdd:cd19519   159 FDREIDIG 166
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
621-834 3.09e-66

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 227.73  E-value: 3.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 621 PNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKY 700
Cdd:PTZ00361  178 PLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKY 257
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 701 VGESERAVREIFRKARAVAPSIIFFDELDALAVER-GSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDK 779
Cdd:PTZ00361  258 LGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRyDATSGGEKEIQRTMLELLNQLDGFDSRGDVKVIMATNRIESLDP 337
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720404492 780 ALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:PTZ00361  338 ALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIMAKDELSGAD 392
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
342-608 1.62e-65

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 223.14  E-value: 1.62e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 342 EQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPE 421
Cdd:TIGR01242 112 EVEERPNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSE 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 422 IISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQSEVEkRVVASLLTLMDGIGSEGSegrVLVLGA 497
Cdd:TIGR01242 192 LVRKYIGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAELDGFDPRGN---VKVIAA 267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 498 TNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILqKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRR 577
Cdd:TIGR01242 268 TNRPDILDPALLRPGRFDRIIEVPLPDFEGRLEIL-KIHTRKMKLAEDVDLEAIAKMTEGASGADLKAICTEAGMFAIRE 346
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1720404492 578 vlrkqpnlpdskvaGMVKITLNDFLQGMNDI 608
Cdd:TIGR01242 347 --------------ERDYVTMDDFIKAVEKV 363
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
619-805 3.37e-65

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 226.90  E-value: 3.37e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 619 DVPNVSWSDIGGL-ENIKLkLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALAN-------ESGLN--- 687
Cdd:TIGR03689 175 EVPDVTYADIGGLgSQIEQ-IRDAVELPFLHPELYREYGLKPPKGVLLYGPPGCGKTLIAKAVANslaarigAEGGGksy 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 688 FLAIKGPELMNKYVGESERAVREIFRKARAVA----PSIIFFDELDALAVERGS--SSgagNVADRVLAQLLTEMDGIEQ 761
Cdd:TIGR03689 254 FLNIKGPELLNKYVGETERQIRLIFQRAREKAsegrPVIVFFDEMDSLFRTRGSgvSS---DVETTVVPQLLAEIDGVES 330
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1720404492 762 LKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIL 805
Cdd:TIGR03689 331 LDNVIVIGASNREDMIDPAILRPGRLDVKIRIERPDAEAAADIF 374
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
634-792 6.15e-65

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 214.21  E-value: 6.15e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 634 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 713
Cdd:cd19526     1 VKKALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720404492 714 KARAVAPSIIFFDELDALAVERGSSSGAgnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIY 792
Cdd:cd19526    81 RAQSAKPCILFFDEFDSIAPKRGHDSTG--VTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
601-837 5.27e-64

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 222.93  E-value: 5.27e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 601 FLQGMNDIRPSAM-------REVAIDVPNVSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSK 673
Cdd:TIGR01241  23 FRRQMQGGGGRAFsfgkskaKLLNEEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGK 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 674 TMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGN-VADRVLAQL 752
Cdd:TIGR01241 102 TLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGNdEREQTLNQL 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 753 LTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSG 832
Cdd:TIGR01241 182 LVEMDGFGTNTGVIVIAATNRPDVLDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKKLAPDVDLKAVARRTPGFSG 261

                  ....*
gi 1720404492 833 AESDN 837
Cdd:TIGR01241 262 ADLAN 266
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
623-793 7.68e-64

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 211.71  E-value: 7.68e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 623 VSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVG 702
Cdd:cd19501     1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 703 ESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGN-VADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKAL 781
Cdd:cd19501    80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHdEREQTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPAL 159
                         170
                  ....*....|..
gi 1720404492 782 MRPGRIDRIIYV 793
Cdd:cd19501   160 LRPGRFDRQVYV 171
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
354-518 1.28e-63

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 211.11  E-value: 1.28e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 433
Cdd:cd19518     2 IGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 434 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEG-RVLVLGATNRPQALDAALRRPG 512
Cdd:cd19518    82 IRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELNNEKTAGgPVLVIGATNRPDSLDPALRRAG 161

                  ....*.
gi 1720404492 513 RFDKEI 518
Cdd:cd19518   162 RFDREI 167
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
634-793 3.80e-63

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 209.06  E-value: 3.80e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 634 IKLKLKQAVEWPLKHPKSFnRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 713
Cdd:cd19481     1 LKASLREAVEAPRRGSRLR-RYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 714 KARAVAPSIIFFDELDALAVERGSSSGAGnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 793
Cdd:cd19481    80 RARRLAPCILFIDEIDAIGRKRDSSGESG-ELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIEF 158
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
362-518 1.31e-58

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 196.74  E-value: 1.31e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 362 KAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEA 441
Cdd:cd19511     3 RELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKA 82
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720404492 442 TLRHPSIIFIDELDALCPKREGAQS-EVEKRVVASLLTLMDGIgsEGSEGrVLVLGATNRPQALDAALRRPGRFDKEI 518
Cdd:cd19511    83 RQAAPCIIFFDEIDSLAPRRGQSDSsGVTDRVVSQLLTELDGI--ESLKG-VVVIAATNRPDMIDPALLRPGRLDKLI 157
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
350-520 2.42e-58

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 196.40  E-value: 2.42e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 350 TYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGE 429
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 430 TEARLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQSEVEkRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALD 505
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFdsgtGGDREVQ-RTMLELLNQLDGF---DPRGNIKVIMATNRPDILD 156
                         170
                  ....*....|....*
gi 1720404492 506 AALRRPGRFDKEIEI 520
Cdd:cd19502   157 PALLRPGRFDRKIEF 171
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
352-570 3.10e-58

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 198.95  E-value: 3.10e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 352 DMIGGlNSQLKAIREIIElPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETE 431
Cdd:COG1223     3 DVVGQ-EEAKKKLKLIIK-ELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 432 ARLRQIFAEATlRHPSIIFIDELDALCpKREGAQSEV-E-KRVVASLLTLMDGIGSEgsegrVLVLGATNRPQALDAALR 509
Cdd:COG1223    81 RNLRKLFDFAR-RAPCVIFFDEFDAIA-KDRGDQNDVgEvKRVVNALLQELDGLPSG-----SVVIAATNHPELLDSALW 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720404492 510 RpgRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEA 570
Cdd:COG1223   154 R--RFDEVIEFPLPDKEERKEILELNLKKFP-LPFELDLKKLAKKLEGLSGADIEKVLKTA 211
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
621-834 3.11e-58

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 209.12  E-value: 3.11e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 621 PNVSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKY 700
Cdd:COG0465   137 PKVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMF 215
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 701 VG--ESeRaVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGNvaD---RVLAQLLTEMDGIEQLKNVTVLAATNRPD 775
Cdd:COG0465   216 VGvgAS-R-VRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGH--DereQTLNQLLVEMDGFEGNEGVIVIAATNRPD 291
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720404492 776 RIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:COG0465   292 VLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARKKPLAPDVDLEVIARRTPGFSGAD 350
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
360-520 1.58e-57

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 193.65  E-value: 1.58e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 360 QLKAIREIIELPLKQPELFKsYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFA 439
Cdd:cd19481     1 LKASLREAVEAPRRGSRLRR-YGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 440 EATLRHPSIIFIDELDALCPKREG-AQSEVEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALDAALRRPGRFDKEI 518
Cdd:cd19481    80 RARRLAPCILFIDEIDAIGRKRDSsGESGELRRVLNQLLTELDGV---NSRSKVLVIAATNRPDLLDPALLRPGRFDEVI 156

                  ..
gi 1720404492 519 EI 520
Cdd:cd19481   157 EF 158
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
634-793 9.60e-56

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 188.88  E-value: 9.60e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 634 IKLKLKQAVEWPLKHPKSFNRmGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 713
Cdd:cd19527     1 VKKEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 714 KARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQ-LKNVTVLAATNRPDRIDKALMRPGRIDRIIY 792
Cdd:cd19527    80 KARDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSsGQDVFVIGATNRPDLLDPALLRPGRFDKLLY 159

                  .
gi 1720404492 793 V 793
Cdd:cd19527   160 L 160
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
625-834 9.06e-55

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 189.71  E-value: 9.06e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 625 WSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGES 704
Cdd:COG1223     1 LDDVVGQEEAKKKLKLIIKE-LRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGET 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 705 ERAVREIFRKARAvAPSIIFFDELDALAVERGSSSGAGNVAdRVLAQLLTEMDGIEQlkNVTVLAATNRPDRIDKALMRp 784
Cdd:COG1223    80 ARNLRKLFDFARR-APCVIFFDEFDAIAKDRGDQNDVGEVK-RVVNALLQELDGLPS--GSVVIAATNHPELLDSALWR- 154
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720404492 785 gRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:COG1223   155 -RFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLEGLSGAD 203
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
364-520 1.80e-54

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 185.39  E-value: 1.80e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 364 IREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATL 443
Cdd:cd19529     5 LKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKARQ 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720404492 444 RHPSIIFIDELDALCPKR-EGAQSEVEKRVVASLLTLMDGIGSEGSegrVLVLGATNRPQALDAALRRPGRFDKEIEI 520
Cdd:cd19529    85 VAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGLEEMNG---VVVIAATNRPDIIDPALLRAGRFDRLIYI 159
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
349-577 3.46e-54

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 193.06  E-value: 3.46e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 349 VTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 428
Cdd:PTZ00454  142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLG 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 429 ETEARLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQSEVEkRVVASLLTLMDGIGSEGSegrVLVLGATNRPQAL 504
Cdd:PTZ00454  222 EGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdaqTGADREVQ-RILLELLNQMDGFDQTTN---VKVIMATNRADTL 297
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720404492 505 DAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVpHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRR 577
Cdd:PTZ00454  298 DPALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKM-NLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRK 369
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
354-520 1.11e-53

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 183.32  E-value: 1.11e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAIREIIELPLKQPELFKsyGIPA-PRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 432
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPDLFP--GLRGpPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 433 RLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEgSEGRVLVLGATNRPQALDAALRRpg 512
Cdd:cd19509    79 IVRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNK-PEDRVLVLGATNRPWELDEAFLR-- 155

                  ....*...
gi 1720404492 513 RFDKEIEI 520
Cdd:cd19509   156 RFEKRIYI 163
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
350-576 1.07e-52

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 189.98  E-value: 1.07e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 350 TYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGE 429
Cdd:PTZ00361  181 SYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGD 260
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 430 TEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEK---RVVASLLTLMDGIGSEGSegrVLVLGATNRPQALDA 506
Cdd:PTZ00361  261 GPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKeiqRTMLELLNQLDGFDSRGD---VKVIMATNRIESLDP 337
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 507 ALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVpHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALR 576
Cdd:PTZ00361  338 ALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKM-TLAEDVDLEEFIMAKDELSGADIKAICTEAGLLALR 406
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
663-795 1.11e-52

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 179.33  E-value: 1.11e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 663 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSgaG 742
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGG--D 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720404492 743 NVADRVLAQLLTEMDGIEQLK-NVTVLAATNRPDRIDKALMrpGRIDRIIYVPL 795
Cdd:pfam00004  79 SESRRVVNQLLTELDGFTSSNsKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
ftsH CHL00176
cell division protein; Validated
623-834 4.04e-52

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 192.96  E-value: 4.04e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 623 VSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVG 702
Cdd:CHL00176  180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 703 ESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGN-VADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKAL 781
Cdd:CHL00176  259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAGIGGGNdEREQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAAL 338
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720404492 782 MRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 834
Cdd:CHL00176  339 LRPGRFDRQITVSLPDREGRLDILKVHARNKKLSPDVSLELIARRTPGFSGAD 391
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
354-517 3.11e-51

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 176.93  E-value: 3.11e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVI-----NGPEIISKFYG 428
Cdd:cd19517     2 IGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKGGQKVsffmrKGADCLSKWVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 429 ETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALDAAL 508
Cdd:cd19517    82 EAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGL---DNRGQVVVIGATNRPDALDPAL 158

                  ....*....
gi 1720404492 509 RRPGRFDKE 517
Cdd:cd19517   159 RRPGRFDRE 167
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
344-577 4.59e-51

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 186.72  E-value: 4.59e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 344 DSQFKVTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 423
Cdd:TIGR01241  47 EEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 424 SKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQSEVEkRVVASLLTLMDGIGseGSEGrVLVLGATN 499
Cdd:TIGR01241 126 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGaglgGGNDERE-QTLNQLLVEMDGFG--TNTG-VIVIAATN 201
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720404492 500 RPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRR 577
Cdd:TIGR01241 202 RPDVLDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKK-LAPDVDLKAVARRTPGFSGADLANLLNEAALLAARK 278
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
389-521 6.41e-51

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 174.32  E-value: 6.41e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEV 468
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720404492 469 EKRVVASLLTLMDGIgsEGSEGRVLVLGATNRPQALDAALRrpGRFDKEIEIG 521
Cdd:pfam00004  81 SRRVVNQLLTELDGF--TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
628-793 7.89e-51

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 175.62  E-value: 7.89e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 628 IGGLENIKLKLKQAVEWPLKHPKSFnRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERA 707
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPDLF-PGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 708 VREIFRKARAVAPSIIFFDELDALAVERGSSSGAGNVadRVLAQLLTEMDGIEQLKN--VTVLAATNRPDRIDKALMRpg 785
Cdd:cd19509    80 VRALFALARELQPSIIFIDEIDSLLSERGSGEHEASR--RVKTEFLVQMDGVLNKPEdrVLVLGATNRPWELDEAFLR-- 155

                  ....*...
gi 1720404492 786 RIDRIIYV 793
Cdd:cd19509   156 RFEKRIYI 163
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
361-516 2.68e-49

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 171.13  E-value: 2.68e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 361 LKAIREIIEL----PLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQ 436
Cdd:cd19530     1 LDHVREELTMsilrPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 437 IFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgsegsEGR--VLVLGATNRPQALDAALRRPGRF 514
Cdd:cd19530    81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGL-----EERsnVFVIAATNRPDIIDPAMLRPGRL 155

                  ..
gi 1720404492 515 DK 516
Cdd:cd19530   156 DK 157
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
627-791 3.62e-49

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 171.05  E-value: 3.62e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 627 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 706
Cdd:cd19518     1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 707 AVREIFRKARAVAPSIIFFDELDALAVERGSSSgaGNVADRVLAQLLTEMDGIEQLKN----VTVLAATNRPDRIDKALM 782
Cdd:cd19518    81 KIRELFDQAISNAPCIVFIDEIDAITPKRESAQ--REMERRIVSQLLTCMDELNNEKTaggpVLVIGATNRPDSLDPALR 158

                  ....*....
gi 1720404492 783 RPGRIDRII 791
Cdd:cd19518   159 RAGRFDREI 167
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
611-837 8.23e-49

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 183.70  E-value: 8.23e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 611 SAMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLA 690
Cdd:PRK10733  137 SKARMLTEDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFT 215
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 691 IKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAG-NVADRVLAQLLTEMDGIEQLKNVTVLA 769
Cdd:PRK10733  216 ISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGhDEREQTLNQMLVEMDGFEGNEGIIVIA 295
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720404492 770 ATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAESDN 837
Cdd:PRK10733  296 ATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLAN 363
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
627-792 2.33e-47

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 166.15  E-value: 2.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 627 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESG-----LNFLAIKGPELMNKYV 701
Cdd:cd19517     1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSkggqkVSFFMRKGADCLSKWV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 702 GESERAVREIFRKARAVAPSIIFFDELDALAVERgsSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKAL 781
Cdd:cd19517    81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVR--SSKQEQIHASIVSTLLALMDGLDNRGQVVVIGATNRPDALDPAL 158
                         170
                  ....*....|.
gi 1720404492 782 MRPGRIDRIIY 792
Cdd:cd19517   159 RRPGRFDREFY 169
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
364-520 4.68e-46

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 161.91  E-value: 4.68e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 364 IREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATL 443
Cdd:cd19528     5 LQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 444 RHPSIIFIDELDALCPKREGA---QSEVEKRVVASLLTLMDGIGSEGSegrVLVLGATNRPQALDAALRRPGRFDKEIEI 520
Cdd:cd19528    85 AAPCVLFFDELDSIAKARGGNigdAGGAADRVINQILTEMDGMNTKKN---VFIIGATNRPDIIDPAILRPGRLDQLIYI 161
ftsH CHL00176
cell division protein; Validated
349-577 3.09e-45

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 172.93  E-value: 3.09e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 349 VTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 428
Cdd:CHL00176  180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 429 ETEARLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQSEVEKrVVASLLTLMDGIgsEGSEGrVLVLGATNRPQAL 504
Cdd:CHL00176  259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRgagiGGGNDEREQ-TLNQLLTEMDGF--KGNKG-VIVIAATNRVDIL 334
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720404492 505 DAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRR 577
Cdd:CHL00176  335 DAALLRPGRFDRQITVSLPDREGRLDILKVHARNKK-LSPDVSLELIARRTPGFSGADLANLLNEAAILTARR 406
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
349-520 3.78e-45

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 159.71  E-value: 3.78e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 349 VTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 428
Cdd:cd19501     1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 429 ETEARLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQSEVEkRVVASLLTLMDGIGSegSEGrVLVLGATNRPQAL 504
Cdd:cd19501    80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGaglgGGHDERE-QTLNQLLVEMDGFES--NTG-VIVIAATNRPDVL 155
                         170
                  ....*....|....*.
gi 1720404492 505 DAALRRPGRFDKEIEI 520
Cdd:cd19501   156 DPALLRPGRFDRQVYV 171
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
362-519 6.23e-45

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 158.75  E-value: 6.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 362 KAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEA 441
Cdd:cd19526     3 KALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRA 82
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720404492 442 TLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgsEGSEGrVLVLGATNRPQALDAALRRPGRFDKEIE 519
Cdd:cd19526    83 QSAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGV--EGLDG-VYVLAATSRPDLIDPALLRPGRLDKLVY 157
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
348-577 6.76e-45

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 170.99  E-value: 6.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 348 KVTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGayvsV----INGPEII 423
Cdd:COG0465   138 KVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAG----VpffsISGSDFV 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 424 SKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKReGA--------------QsevekrvvasLLTLMDGIgsEGSE 489
Cdd:COG0465   213 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQR-GAglggghdereqtlnQ----------LLVEMDGF--EGNE 279
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 490 GrVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNE 569
Cdd:COG0465   280 G-VIVIAATNRPDVLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARKKP-LAPDVDLEVIARRTPGFSGADLANLVNE 357

                  ....*...
gi 1720404492 570 AGLHALRR 577
Cdd:COG0465   358 AALLAARR 365
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
344-576 1.45e-44

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 170.99  E-value: 1.45e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 344 DSQFKVTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 423
Cdd:PRK10733  144 EDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFV 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 424 SKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKRE---GAQSEVEKRVVASLLTLMDGIgsEGSEGrVLVLGATNR 500
Cdd:PRK10733  223 EMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGaglGGGHDEREQTLNQMLVEMDGF--EGNEG-IIVIAATNR 299
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404492 501 PQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALR 576
Cdd:PRK10733  300 PDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVP-LAPDIDAAIIARGTPGFSGADLANLVNEAALFAAR 374
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
348-520 7.11e-44

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 156.18  E-value: 7.11e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 348 KVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPApRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 427
Cdd:cd19521     3 NVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPW-SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 428 GETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEgSEGrVLVLGATNRPQALDAA 507
Cdd:cd19521    82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGND-SQG-VLVLGATNIPWQLDSA 159
                         170
                  ....*....|...
gi 1720404492 508 LRRpgRFDKEIEI 520
Cdd:cd19521   160 IRR--RFEKRIYI 170
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
349-520 5.46e-43

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 154.38  E-value: 5.46e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 349 VTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPaPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 428
Cdd:cd19525    19 INWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGP-PKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 429 ETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSeGSEGRVLVLGATNRPQALDAAL 508
Cdd:cd19525    98 EGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATT-SSEDRILVVGATNRPQEIDEAA 176
                         170
                  ....*....|..
gi 1720404492 509 RRpgRFDKEIEI 520
Cdd:cd19525   177 RR--RLVKRLYI 186
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
627-783 7.36e-43

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 153.35  E-value: 7.36e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 627 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGI-QPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESE 705
Cdd:cd19520     1 DIGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 706 RAVREIFRKARAVAPSIIFFDELDALAVERgsSSGAGNVADRVLAQLLTEMDGI--EQLKNVTVLAATNRPDRIDKALMR 783
Cdd:cd19520    81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR--SSTDHEATAMMKAEFMSLWDGLstDGNCRVIVMGATNRPQDLDEAILR 158
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
362-516 8.18e-43

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 153.05  E-value: 8.18e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 362 KAIREIIELPLKQPELFKSyGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEA 441
Cdd:cd19527     3 KEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720404492 442 TLRHPSIIFIDELDALCPKR--EGAQSEVEKRVVASLLTLMDGIGSEGSEgrVLVLGATNRPQALDAALRRPGRFDK 516
Cdd:cd19527    82 RDAKPCVIFFDELDSLAPSRgnSGDSGGVMDRVVSQLLAELDGMSSSGQD--VFVIGATNRPDLLDPALLRPGRFDK 156
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
627-793 3.09e-42

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 151.68  E-value: 3.09e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 627 DIGGLENIKLKLKQAVEWPLKHPKSFNrmGIQPP-KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESE 705
Cdd:cd19522     1 DIADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 706 RAVREIFRKARAVAPSIIFFDELDALAVERGSSSgAGNVADRVLAQLLTEMDGI-------EQLKNVTVLAATNRPDRID 778
Cdd:cd19522    79 KLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSE-EHEASRRVKSELLVQMDGVggasendDPSKMVMVLAATNFPWDID 157
                         170
                  ....*....|....*
gi 1720404492 779 KALMRpgRIDRIIYV 793
Cdd:cd19522   158 EALRR--RLEKRIYI 170
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
621-793 7.00e-42

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 150.78  E-value: 7.00e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 621 PNVSWSDIGGLENIKLKLKQAVEWPLKHPKSF--NRmgiQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMN 698
Cdd:cd19521     2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFtgNR---KPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 699 KYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGssSGAGNVADRVLAQLLTEMDGI-EQLKNVTVLAATNRPDRI 777
Cdd:cd19521    79 KWMGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRG--EGESEASRRIKTELLVQMNGVgNDSQGVLVLGATNIPWQL 156
                         170
                  ....*....|....*.
gi 1720404492 778 DKALMRpgRIDRIIYV 793
Cdd:cd19521   157 DSAIRR--RFEKRIYI 170
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
354-514 5.64e-41

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 147.96  E-value: 5.64e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAIREIIELPLKQPELFKSYGI-PAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 432
Cdd:cd19520     2 IGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 433 RLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEgRVLVLGATNRPQALDAALRR-- 510
Cdd:cd19520    82 LVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNC-RVIVMGATNRPQDLDEAILRrm 160

                  ....
gi 1720404492 511 PGRF 514
Cdd:cd19520   161 PKRF 164
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
649-788 1.26e-40

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 147.25  E-value: 1.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 649 PKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANE-SGLNFLAIKGPELMNKYVGESERAVREIFRKA----RAVAPS-- 721
Cdd:cd19504    24 PEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMlNAREPKIVNGPEILNKYVGESEANIRKLFADAeeeqRRLGANsg 103
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720404492 722 --IIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRID 788
Cdd:cd19504   104 lhIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRKDLIDEALLRPGRLE 172
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
613-793 2.34e-40

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 147.06  E-value: 2.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 613 MREVAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNrmGIQ-PPKGVLLYGPPGCSKTMIAKALANESGLNFLAI 691
Cdd:cd19525     9 MSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFT--GLRgPPKGILLFGPPGTGKTLIGKCIASQSGATFFSI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 692 KGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGnvADRVLAQLLTEMDGIEQLKN--VTVLA 769
Cdd:cd19525    87 SASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHES--SRRIKTEFLVQLDGATTSSEdrILVVG 164
                         170       180
                  ....*....|....*....|....
gi 1720404492 770 ATNRPDRIDKALMRpgRIDRIIYV 793
Cdd:cd19525   165 ATNRPQEIDEAARR--RLVKRLYI 186
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
354-520 1.62e-39

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 143.97  E-value: 1.62e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAIREIIELPLKQPELFKsyGIPAP-RGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 432
Cdd:cd19522     2 IADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 433 RLRQIFAEATLRHPSIIFIDELDALCPKR-EGAQSEVEKRVVASLLTLMDGIG----SEGSEGRVLVLGATNRPQALDAA 507
Cdd:cd19522    80 LVRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGVGgaseNDDPSKMVMVLAATNFPWDIDEA 159
                         170
                  ....*....|...
gi 1720404492 508 LRRpgRFDKEIEI 520
Cdd:cd19522   160 LRR--RLEKRIYI 170
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
354-510 1.76e-39

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 143.45  E-value: 1.76e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAIREIIELPLKQPELFKSYGIPaPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 433
Cdd:cd19524     2 IAGQDLAKQALQEMVILPSLRPELFTGLRAP-ARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720404492 434 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEgRVLVLGATNRPQALD-AALRR 510
Cdd:cd19524    81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDD-RVLVMGATNRPQELDdAVLRR 157
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
354-520 1.52e-36

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 135.70  E-value: 1.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAI-REIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAY-VSVINGPEIISKFYGETE 431
Cdd:cd19504     2 IGGLDKEFSDIfRRAFASRVFPPEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMLNARePKIVNGPEILNKYVGESE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 432 ARLRQIFAEATLRHPS--------IIFIDELDALCPKR--EGAQSEVEKRVVASLLTLMDGIGSEGSegrVLVLGATNRP 501
Cdd:cd19504    82 ANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQRgsMAGSTGVHDTVVNQLLSKIDGVEQLNN---ILVIGMTNRK 158
                         170
                  ....*....|....*....
gi 1720404492 502 QALDAALRRPGRFDKEIEI 520
Cdd:cd19504   159 DLIDEALLRPGRLEVQMEI 177
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
627-793 9.70e-35

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 129.97  E-value: 9.70e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 627 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGiQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 706
Cdd:cd19524     1 DIAGQDLAKQALQEMVILPSLRPELFTGLR-APARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 707 AVREIFRKARAVAPSIIFFDELDALAVERgsSSGAGNVADRVLAQLLTEMDGIEQLKN--VTVLAATNRPDRIDKALMRp 784
Cdd:cd19524    80 LVRALFAVARELQPSIIFIDEVDSLLSER--SEGEHEASRRLKTEFLIEFDGVQSNGDdrVLVMGATNRPQELDDAVLR- 156

                  ....*....
gi 1720404492 785 gRIDRIIYV 793
Cdd:cd19524   157 -RFTKRVYV 164
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
627-793 1.22e-32

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 124.02  E-value: 1.22e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 627 DIGGLENIKlklkqavEWPLKHPKSFN----RMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVG 702
Cdd:cd19507     1 DVGGLDNLK-------DWLKKRKAAFSkqasAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVG 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 703 ESERAVREIFRKARAVAPSIIFFDELDAlAVERGSSSGAGNVADRVLAQLLTEMDgiEQLKNVTVLAATNRPDRIDKALM 782
Cdd:cd19507    74 ESESRLRQMIQTAEAIAPCVLWIDEIEK-GFSNADSKGDSGTSSRVLGTFLTWLQ--EKKKPVFVVATANNVQSLPPELL 150
                         170
                  ....*....|.
gi 1720404492 783 RPGRIDRIIYV 793
Cdd:cd19507   151 RKGRFDEIFFV 161
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
629-795 1.35e-28

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 111.85  E-value: 1.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 629 GGLENIKLKLKQAVEWPlkhpksfnrmgiqPPKGVLLYGPPGCSKTMIAKALANES---GLNFLAIKGPELMNKYVGESE 705
Cdd:cd00009     1 VGQEEAIEALREALELP-------------PPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAEL 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 706 R---AVREIFRKARAVAPSIIFFDELDALAVErgsssgagnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALM 782
Cdd:cd00009    68 FghfLVRLLFELAEKAKPGVLFIDEIDSLSRG---------AQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRA 138
                         170
                  ....*....|...
gi 1720404492 783 RPGRIDRIIYVPL 795
Cdd:cd00009   139 LYDRLDIRIVIPL 151
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
354-520 4.40e-28

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 111.13  E-value: 4.40e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNSQLKAIREIIELPLKQPELFKSYGIPaPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 433
Cdd:cd19523     2 IAGLGALKAAIKEEVLWPLLRPDAFSGLLRL-PRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 434 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVeKRVVASLLTLMDGIGSEGSEGrVLVLGATNRPQALDAALRRpgR 513
Cdd:cd19523    81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPV-GRLQVELLAQLDGVLGSGEDG-VLVVCTTSKPEEIDESLRR--Y 156

                  ....*..
gi 1720404492 514 FDKEIEI 520
Cdd:cd19523   157 FSKRLLV 163
ycf46 CHL00195
Ycf46; Provisional
621-834 4.46e-28

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 118.97  E-value: 4.46e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 621 PNVSWSDIGGLENIKLKLKqavewplKHPKSFNRM----GIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL 696
Cdd:CHL00195  223 VNEKISDIGGLDNLKDWLK-------KRSTSFSKQasnyGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKL 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 697 MNKYVGESERAVREIFRKARAVAPSIIFFDELDAlAVERGSSSGAGNVADRVLAQLLTEMDgiEQLKNVTVLAATNRPDR 776
Cdd:CHL00195  296 FGGIVGESESRMRQMIRIAEALSPCILWIDEIDK-AFSNSESKGDSGTTNRVLATFITWLS--EKKSPVFVVATANNIDL 372
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720404492 777 IDKALMRPGRIDRIIYVPLPDAATRREIlnLQFHSMPIS----NEVDLDELVLQTDTYSGAE 834
Cdd:CHL00195  373 LPLEILRKGRFDEIFFLDLPSLEEREKI--FKIHLQKFRpkswKKYDIKKLSKLSNKFSGAE 432
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
627-783 3.22e-26

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 105.74  E-value: 3.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 627 DIGGLENIKLKLKQAVEWPLKHPKSFNRMgIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 706
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGL-LRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEK 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720404492 707 AVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGNvadRVLAQLLTEMDGI--EQLKNVTVLAATNRPDRIDKALMR 783
Cdd:cd19523    80 ILQASFLAARCRQPSVLFISDLDALLSSQDDEASPVG---RLQVELLAQLDGVlgSGEDGVLVVCTTSKPEEIDESLRR 155
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
355-521 7.35e-25

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 101.45  E-value: 7.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 355 GGLNSQLKAIREIIELPlkqpelfksygipAPRGLLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISKFYGETE 431
Cdd:cd00009     1 VGQEEAIEALREALELP-------------PPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAEL 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 432 AR---LRQIFAEATLRHPSIIFIDELDALcpkREGAQSEVekrvvasLLTLMDGIGSEGSEGRVLVLGATNRPQALDAAL 508
Cdd:cd00009    68 FGhflVRLLFELAEKAKPGVLFIDEIDSL---SRGAQNAL-------LRVLETLNDLRIDRENVRVIGATNRPLLGDLDR 137
                         170
                  ....*....|...
gi 1720404492 509 RRPGRFDKEIEIG 521
Cdd:cd00009   138 ALYDRLDIRIVIP 150
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
354-515 2.09e-22

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 94.74  E-value: 2.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 354 IGGLNsQLKAIREIIELPLKQPElfKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 433
Cdd:cd19507     2 VGGLD-NLKDWLKKRKAAFSKQA--SAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESR 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 434 LRQIFAEATLRHPSIIFIDELD-ALCPKREGAQSEVEKRVVASLLTLMdgigSEGSEgRVLVLGATNRPQALDAALRRPG 512
Cdd:cd19507    79 LRQMIQTAEAIAPCVLWIDEIEkGFSNADSKGDSGTSSRVLGTFLTWL----QEKKK-PVFVVATANNVQSLPPELLRKG 153

                  ...
gi 1720404492 513 RFD 515
Cdd:cd19507   154 RFD 156
ycf46 CHL00195
Ycf46; Provisional
348-574 8.34e-20

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 93.55  E-value: 8.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 348 KVTYDMIGGLNSqLKAIREiielplKQPELF----KSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 423
Cdd:CHL00195  224 NEKISDIGGLDN-LKDWLK------KRSTSFskqaSNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLF 296
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 424 SKFYGETEARLRQI--FAEATlrHPSIIFIDELD-ALCPKREGAQSEVEKRVVASLLTLMdgigsegSEGR--VLVLGAT 498
Cdd:CHL00195  297 GGIVGESESRMRQMirIAEAL--SPCILWIDEIDkAFSNSESKGDSGTTNRVLATFITWL-------SEKKspVFVVATA 367
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720404492 499 NRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRV-PHLLTKAELLRLANNAHGYVGADLKALCNEAGLHA 574
Cdd:CHL00195  368 NNIDLLPLEILRKGRFDEIFFLDLPSLEEREKIFKIHLQKFrPKSWKKYDIKKLSKLSNKFSGAEIEQSIIEAMYIA 444
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
364-520 1.85e-19

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 85.87  E-value: 1.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 364 IREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfyGETEARLRQIFAEATL 443
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEV-----VLTDDRLNHLLNTAPK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 444 RhpSIIFIDELDALCPKREGAQSEVEK-----RVVAS-LLTLMDGIGSegSEGRVLVLgATNRPQALDAALRRPGRFDKE 517
Cdd:cd19510    76 Q--SIILLEDIDAAFESREHNKKNPSAygglsRVTFSgLLNALDGVAS--SEERIVFM-TTNHIERLDPALIRPGRVDMK 150

                  ...
gi 1720404492 518 IEI 520
Cdd:cd19510   151 IYM 153
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
659-797 3.77e-18

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 82.04  E-value: 3.77e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492  659 PPKGVLLYGPPGCSKTMIAKALANESGLN---FLAIKGPELM--------------NKYVGESERAVREIFRKARAVAPS 721
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILeevldqllliivggKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404492  722 IIFFDELDALAVERGSssgagnvADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPgRIDRIIYVPLPD 797
Cdd:smart00382  81 VLILDEITSLLDAEQE-------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
638-793 8.39e-18

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 81.24  E-value: 8.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 638 LKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFlaikgpelmnkYVGESERAVREIFRKAR- 716
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDI-----------CDLNLSEVVLTDDRLNHl 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 717 -AVAP--SIIFFDELDALAVER---GSSSGAGNVADRV-LAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDR 789
Cdd:cd19510    70 lNTAPkqSIILLEDIDAAFESRehnKKNPSAYGGLSRVtFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDM 149

                  ....
gi 1720404492 790 IIYV 793
Cdd:cd19510   150 KIYM 153
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
386-524 5.80e-16

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 75.87  E-value: 5.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492  386 PRGLLLYGPPGTGKTMIARAVANEVGAY---VSVINGPEI--------------ISKFYGETEARLRQIFAEATLRHPSI 448
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPDV 81
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404492  449 IFIDELDALCPKREGAQSEVEKRVVASLLTLmdgigsegSEGRVLVLGATNRPQALDAALRRPgRFDKEIEIGIPN 524
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLLK--------SEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
663-793 1.67e-12

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 67.09  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 663 VLLYGPPGCSKTMIAKALANESGLN---------FLAIKGPELMNKYVGESERAVREIFRKARAVA--PSIIFF---DEL 728
Cdd:cd19508    55 VLLHGPPGTGKTSLCKALAQKLSIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFQKIQELIddKDALVFvliDEV 134
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720404492 729 DALAVERGSSSGAGNVAD--RVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMrpGRIDRIIYV 793
Cdd:cd19508   135 ESLAAARSASSSGTEPSDaiRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAFV--DRADIKQYI 199
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
387-519 1.71e-12

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 65.63  E-value: 1.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 387 RGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEiISKFYGETEARLRQIFAEA-TLRHPSIIFIDELDALCPKRegAQ 465
Cdd:cd19512    23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAIHKVFDWAnTSRRGLLLFVDEADAFLRKR--ST 99
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720404492 466 SEVEKRVVASLLTLMDGIGsEGSEGRVLVLgATNRPQALDAALRrpGRFDKEIE 519
Cdd:cd19512   100 EKISEDLRAALNAFLYRTG-EQSNKFMLVL-ASNQPEQFDWAIN--DRIDEMVE 149
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
360-519 7.29e-11

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 65.64  E-value: 7.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 360 QLKAIREIIELPLKQPElfksYGIPAP---RGLLLYGPPGTGKTMIARAVANEVgAYVSVINGPEI--------ISKFYG 428
Cdd:TIGR03922 287 QVAALKSSTAMALARAE----RGLPVAqtsNHMLFAGPPGTGKTTIARVVAKIY-CGLGVLRKPLVrevsradlIGQYIG 361
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 429 ETEARLRQIFAEATLRhpsIIFIDELDALCPKREGAQSEVEKRVVASLLTLMdgigsEGSEGRVLVLGATNRpQALDAAL 508
Cdd:TIGR03922 362 ESEAKTNEIIDSALGG---VLFLDEAYTLVETGYGQKDPFGLEAIDTLLARM-----ENDRDRLVVIGAGYR-KDLDKFL 432
                         170
                  ....*....|....*
gi 1720404492 509 R-RPG---RFDKEIE 519
Cdd:TIGR03922 433 EvNEGlrsRFTRVIE 447
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
661-791 2.82e-10

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 59.46  E-value: 2.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 661 KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL--MNKyvgESERAVREIFRKARAVAPSIIFF-DELDALAVERgS 737
Cdd:cd19512    23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR---EGVTAIHKVFDWANTSRRGLLLFvDEADAFLRKR-S 98
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720404492 738 SSGAGNVADRVLAQLLTEMDgiEQLKNVTVLAATNRPDRIDKALMrpGRIDRII 791
Cdd:cd19512    99 TEKISEDLRAALNAFLYRTG--EQSNKFMLVLASNQPEQFDWAIN--DRIDEMV 148
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
387-508 6.89e-10

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 59.38  E-value: 6.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 387 RGLLLYGPPGTGKTMIARAVANEVGAYVSV---------INGPEIISKFYGETEARLRQIF---AEATLRHPSIIF--ID 452
Cdd:cd19508    53 RLVLLHGPPGTGKTSLCKALAQKLSIRLSSryrygqlieINSHSLFSKWFSESGKLVTKMFqkiQELIDDKDALVFvlID 132
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 453 ELDALCPKREGAQSEVEK----RVVASLLTLMDGIGSEGSegrVLVLGATNRPQALDAAL 508
Cdd:cd19508   133 EVESLAAARSASSSGTEPsdaiRVVNAVLTQIDRIKRYHN---NVILLTSNLLEKIDVAF 189
44 PHA02544
clamp loader, small subunit; Provisional
362-538 1.86e-09

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 60.00  E-value: 1.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 362 KAIREIIeLPLKQPELFKSY----GIPAprgLLLYGP-PGTGKTMIARAVANEVGAYVSVINGPEIISKFygeTEARLRQ 436
Cdd:PHA02544   18 STIDECI-LPAADKETFKSIvkkgRIPN---MLLHSPsPGTGKTTVAKALCNEVGAEVLFVNGSDCRIDF---VRNRLTR 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 437 IFAEATLR-HPSIIFIDELDalcpkREGAqSEVEKrvvaSLLTLMdgigsEGSEGRVLVLGATNRPQALDAALRrpGRFD 515
Cdd:PHA02544   91 FASTVSLTgGGKVIIIDEFD-----RLGL-ADAQR----HLRSFM-----EAYSKNCSFIITANNKNGIIEPLR--SRCR 153
                         170       180
                  ....*....|....*....|...
gi 1720404492 516 kEIEIGIPNAQDRLDILQKLLRR 538
Cdd:PHA02544  154 -VIDFGVPTKEEQIEMMKQMIVR 175
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
389-459 2.14e-09

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 60.48  E-value: 2.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGAYVSVINGpeIISKFygeteARLRQIFAEATLRHPS----IIFIDEL--------DA 456
Cdd:PRK13342   39 MILWGPPGTGKTTLARIIAGATDAPFEALSA--VTSGV-----KDLREVIEEARQRRSAgrrtILFIDEIhrfnkaqqDA 111

                  ...
gi 1720404492 457 LCP 459
Cdd:PRK13342  112 LLP 114
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
547-581 5.42e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 52.54  E-value: 5.42e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1720404492 547 ELLRLANNAHGYVGADLKALCNEAGLHALRRVLRK 581
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
654-793 6.84e-09

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 55.84  E-value: 6.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 654 RMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAI--------------KGPELMNKYVGESERAVREIFRKARAVA 719
Cdd:cd19505     6 RLGLSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRIslnkllynkpdfgnDDWIDGMLILKESLHRLNLQFELAKAMS 85
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720404492 720 PSIIFFDELDALAVERGSSSGAGNvADRVLAQLLTEM-DGIEQ--LKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 793
Cdd:cd19505    86 PCIIWIPNIHELNVNRSTQNLEED-PKLLLGLLLNYLsRDFEKssTRNILVIASTHIPQKVDPALIAPNRLDTCINI 161
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
389-473 1.69e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 57.76  E-value: 1.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGAYVSVINGpeIISkfygeTEARLRQIFAEATLRH----PSIIFIDEL--------DA 456
Cdd:COG2256    52 MILWGPPGTGKTTLARLIANATDAEFVALSA--VTS-----GVKDIREVIEEARERRaygrRTILFVDEIhrfnkaqqDA 124
                          90
                  ....*....|....*..
gi 1720404492 457 LCPkregaqsEVEKRVV 473
Cdd:COG2256   125 LLP-------HVEDGTI 134
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
384-505 2.81e-08

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 54.07  E-value: 2.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 384 PAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGET--EARLRQIFAEATLRHPSIIFIDELDAL---- 457
Cdd:cd19506    24 PLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTfykk 103
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1720404492 458 CPKREGAQSevEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALD 505
Cdd:cd19506   104 VPKTEKQLD--PKRLKKDLPKILKSL---KPEDRVLIVGTTSRPFEAD 146
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
389-552 1.07e-07

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 54.40  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGAYVSVIN-----------GPEIISKFYGETEARLRQIFAeatlrhpSIIFIDELDal 457
Cdd:COG0714    34 LLLEGVPGVGKTTLAKALARALGLPFIRIQftpdllpsdilGTYIYDQQTGEFEFRPGPLFA-------NVLLADEIN-- 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 458 cpkRegAQSEVEkrvvASLLTLMDgigsegsEGRVLVLGAT----NRPQAL---------------DAALRrpgRFDKEI 518
Cdd:COG0714   105 ---R--APPKTQ----SALLEAME-------ERQVTIPGGTyklpEPFLVIatqnpieqegtyplpEAQLD---RFLLKL 165
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720404492 519 EIGIPNAQDRLDILQKLLRR----VPHLLTKAELLRLA 552
Cdd:COG0714   166 YIGYPDAEEEREILRRHTGRhlaeVEPVLSPEELLALQ 203
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
382-520 2.89e-07

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 50.84  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 382 GIPAPRGLLLYGPPGTGKTMIARAVANEvgAYVSVI---------NGPEIISK-------FYGETEARLRQIFAEATLRH 445
Cdd:cd19505     8 GLSPSKGILLIGSIETGRSYLIKSLAAN--SYVPLIrislnkllyNKPDFGNDdwidgmlILKESLHRLNLQFELAKAMS 85
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404492 446 PSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGR-VLVLGATNRPQALDAALRRPGRFDKEIEI 520
Cdd:cd19505    86 PCIIWIPNIHELNVNRSTQNLEEDPKLLLGLLLNYLSRDFEKSSTRnILVIASTHIPQKVDPALIAPNRLDTCINI 161
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
389-462 1.05e-06

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 51.53  E-value: 1.05e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygeteARLRQIFAEATLRHP-SIIFIDELDALCPKRE 462
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIANEMGVNLKITSGPAL---------EKPGDLAAILTNLEEgDVLFIDEIHRLSPAVE 98
PRK13341 PRK13341
AAA family ATPase;
389-459 1.37e-06

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 51.98  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGAYVSVINgpeiiSKFYGETEarLRQIFAEATLRHP-----SIIFIDEL--------D 455
Cdd:PRK13341   55 LILYGPPGVGKTTLARIIANHTRAHFSSLN-----AVLAGVKD--LRAEVDRAKERLErhgkrTILFIDEVhrfnkaqqD 127

                  ....
gi 1720404492 456 ALCP 459
Cdd:PRK13341  128 ALLP 131
PRK04195 PRK04195
replication factor C large subunit; Provisional
658-731 1.52e-06

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 51.46  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 658 QPPKGVLLYGPPGCSKTMIAKALANESGLNFLaikgpEL----------MNKYVGESERaVREIFRKARavapSIIFFDE 727
Cdd:PRK04195   37 KPKKALLLYGPPGVGKTSLAHALANDYGWEVI-----ELnasdqrtadvIERVAGEAAT-SGSLFGARR----KLILLDE 106

                  ....
gi 1720404492 728 LDAL 731
Cdd:PRK04195  107 VDGI 110
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
663-736 1.91e-06

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 51.21  E-value: 1.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 663 VLLYGPPGCSKTMIAKALANESGLNFLAIkgpelmnkyvgeseRAV-------REIFRKARAVA----PSIIFFDEL--- 728
Cdd:COG2256    52 MILWGPPGTGKTTLARLIANATDAEFVAL--------------SAVtsgvkdiREVIEEARERRaygrRTILFVDEIhrf 117
                          90
                  ....*....|....*
gi 1720404492 729 -----DAL--AVERG 736
Cdd:COG2256   118 nkaqqDALlpHVEDG 132
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
663-736 1.92e-06

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 51.24  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 663 VLLYGPPGCSKTMIAKALANESGLNFLAIKGpelmnkyVGESERAVREIFRKARAVAPS----IIFFDEL--------DA 730
Cdd:PRK13342   39 MILWGPPGTGKTTLARIIAGATDAPFEALSA-------VTSGVKDLREVIEEARQRRSAgrrtILFIDEIhrfnkaqqDA 111

                  ....*...
gi 1720404492 731 L--AVERG 736
Cdd:PRK13342  112 LlpHVEDG 119
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
388-514 2.32e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 47.67  E-value: 2.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 388 GLLLYGPPGTGKTMIARAVA----NEVGAYVSvingpeiISKFYgeTEARLRQIFAEATL-------------RHPSIIF 450
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAaalsNRPVFYVQ-------LTRDT--TEEDLFGRRNIDPGgaswvdgplvraaREGEIAV 71
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720404492 451 IDELDalcpkregaqsEVEKRVVASLLTL--------MDGIGSEGSEG-RVLVLGATNRPQA----LDAALRRpgRF 514
Cdd:pfam07728  72 LDEIN-----------RANPDVLNSLLSLlderrlllPDGGELVKAAPdGFRLIATMNPLDRglneLSPALRS--RF 135
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
355-441 2.54e-06

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 50.39  E-value: 2.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 355 GGLNSQLKAiREIIELPLkqpELFKSYGIpAPRGLLLYGPPGTGKTMIARAVANEVGAYV--SVINGPEIISKFYGETEA 432
Cdd:pfam06068  24 GGLVGQEKA-REAAGVIV---EMIKEGKI-AGRAVLIAGPPGTGKTALAIAISKELGEDTpfTSISGSEVYSLEMKKTEA 98

                  ....*....
gi 1720404492 433 rLRQIFAEA 441
Cdd:pfam06068  99 -LTQAFRKA 106
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
385-437 4.06e-06

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 50.35  E-value: 4.06e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404492 385 APRGLLLYGPPGTGKTMIARAVANEVGA---YVSvINGPEIISKFYGETEARLRQI 437
Cdd:COG1224    63 AGKGILIVGPPGTGKTALAVAIARELGEdtpFVA-ISGSEIYSAELKKTEFLMQAL 117
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
663-823 6.60e-06

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 48.63  E-value: 6.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 663 VLLYGPPGCSKTMIAKALANESGLNFLAIKG-PELM-NKYVGES---ERAVREIFRKaRAVAPSIIFFDELDalaveRgs 737
Cdd:COG0714    34 LLLEGVPGVGKTTLAKALARALGLPFIRIQFtPDLLpSDILGTYiydQQTGEFEFRP-GPLFANVLLADEIN-----R-- 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 738 ssgagnvAD-RVLAQLLTEMDgiEqlKNVT-------------VLAATNRPDRI----------DKALMRpgridriIYV 793
Cdd:COG0714   106 -------APpKTQSALLEAME--E--RQVTipggtyklpepflVIATQNPIEQEgtyplpeaqlDRFLLK-------LYI 167
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1720404492 794 PLPDAATRREILNLQ--FHSMPISNEVDLDEL 823
Cdd:COG0714   168 GYPDAEEEREILRRHtgRHLAEVEPVLSPEEL 199
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
660-740 1.22e-05

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 46.60  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 660 PKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMN-KYVGeseRAVREIFRKaraVAPSIIFFDELDALAVERGSS 738
Cdd:cd19498    46 PKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEvGYVG---RDVESIIRD---LVEGIVFIDEIDKIAKRGGSS 119

                  ..
gi 1720404492 739 SG 740
Cdd:cd19498   120 GP 121
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
389-453 1.34e-05

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 48.20  E-value: 1.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygETEARLRQIFaeATLRHPSIIFIDE 453
Cdd:PRK00080   54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL------EKPGDLAAIL--TNLEEGDVLFIDE 110
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
389-453 1.63e-05

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 45.95  E-value: 1.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygeteARLRQIFAEAT-LRHPSIIFIDE 453
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAI---------ERPGDLAAILTnLEPGDVLFIDE 92
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
662-783 2.38e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 44.98  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 662 GVLLYGPPGCSKTMIAKALANE-SGLNFLAIKGPELMNK---------YVGESERAVREIFRKARavAPSIIFFDEldal 731
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAAlSNRPVFYVQLTRDTTEedlfgrrniDPGGASWVDGPLVRAAR--EGEIAVLDE---- 74
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720404492 732 aVERGSSSgagnVADRVLAQL----LTEMDGIEQLK----NVTVLAATNRPDR----IDKALMR 783
Cdd:pfam07728  75 -INRANPD----VLNSLLSLLderrLLLPDGGELVKaapdGFRLIATMNPLDRglneLSPALRS 133
PRK08116 PRK08116
hypothetical protein; Validated
333-425 3.88e-05

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 46.17  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 333 LRKICTNSKEQ-DSQFKvTYDMIGGLNSQLKAIREIielpLKQPELFKSYGIpaprGLLLYGPPGTGKTMIARAVANEV- 410
Cdd:PRK08116   69 LKSNSLLDEKFrNSTFE-NFLFDKGSEKAYKIARKY----VKKFEEMKKENV----GLLLWGSVGTGKTYLAACIANELi 139
                          90
                  ....*....|....*..
gi 1720404492 411 --GAYVSVINGPEIISK 425
Cdd:PRK08116  140 ekGVPVIFVNFPQLLNR 156
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
376-495 7.09e-05

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 44.03  E-value: 7.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 376 ELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISkFYGETEARLRQIFAEATLRHPSIIFID 452
Cdd:pfam13191  14 DALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALerdGGYFLRGKCDENLP-YSPLLEALTREGLLRQLLDELESSLLE 92
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720404492 453 ELDALCPKREGAQSEVEKRVVASLLTLMDGI---GSEGSEGRVLVL 495
Cdd:pfam13191  93 AWRAALLEALAPVPELPGDLAERLLDLLLRLldlLARGERPLVLVL 138
PRK04195 PRK04195
replication factor C large subunit; Provisional
358-411 7.14e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 46.07  E-value: 7.14e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720404492 358 NSQLKAIREIIELPLKqpelfksyGIPaPRGLLLYGPPGTGKTMIARAVANEVG 411
Cdd:PRK04195   20 EKAKEQLREWIESWLK--------GKP-KKALLLYGPPGVGKTSLAHALANDYG 64
CDC48_N smart01073
Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...
63-131 1.62e-04

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases is a substrate 185-residue recognition domain.


Pssm-ID: 215012 [Multi-domain]  Cd Length: 82  Bit Score: 41.06  E-value: 1.62e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720404492   63 NSLVHLGLNTMKSANICIGRPVLLTsldGKQEVY-TAWP-VAGFPGGKVGLSEMAQKNVGVRAGETIQVQP 131
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT---GKRRTVaIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
654-792 2.35e-04

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 42.93  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 654 RMGIQPPK---GVLLY-GPPGCSKTMIAKALA---NESGLNFLAIKGPELMNK------------YVGESERAVreIFRK 714
Cdd:cd19499    31 RAGLSDPNrpiGSFLFlGPTGVGKTELAKALAellFGDEDNLIRIDMSEYMEKhsvsrligappgYVGYTEGGQ--LTEA 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 715 ARAVAPSIIFFDEldalaVERGSSsgagNVADRVLAQL----LTEMDGIE-QLKNVTVLAATN--RPDRIdkalmrpGRI 787
Cdd:cd19499   109 VRRKPYSVVLLDE-----IEKAHP----DVQNLLLQVLddgrLTDSHGRTvDFKNTIIIMTSNhfRPEFL-------NRI 172

                  ....*
gi 1720404492 788 DRIIY 792
Cdd:cd19499   173 DEIVV 177
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
383-465 2.49e-04

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 43.62  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 383 IPAPRGLLLYGPPGTGKTMIARAVANE-VGAYVSV--INGPEIISKFY-GETEARLRQIFaeATLRHPSIIFIDELDALC 458
Cdd:COG1484    96 IERGENLILLGPPGTGKTHLAIALGHEaCRAGYRVrfTTAPDLVNELKeARADGRLERLL--KRLAKVDLLILDELGYLP 173

                  ....*..
gi 1720404492 459 PKREGAQ 465
Cdd:COG1484   174 LDAEGAE 180
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
663-696 2.60e-04

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 42.10  E-value: 2.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720404492 663 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL 696
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAI 69
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
358-505 2.74e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 44.07  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 358 NSQLKAIREIIElPLKQPELfksygipaPRGLLLYGPPGTGKTMIARAVANEVG------------AYV---------SV 416
Cdd:COG1474    32 EEEIEELASALR-PALRGER--------PSNVLIYGPTGTGKTAVAKYVLEELEeeaeergvdvrvVYVncrqastryRV 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 417 INgpEIISKFYGETE--------ARLRQIFAEATLRH--PSIIFIDELDALcPKREGaqseveKRVVASLLTLMDGIgse 486
Cdd:COG1474   103 LS--RILEELGSGEDipstglstDELFDRLYEALDERdgVLVVVLDEIDYL-VDDEG------DDLLYQLLRANEEL--- 170
                         170
                  ....*....|....*....
gi 1720404492 487 gSEGRVLVLGATNRPQALD 505
Cdd:COG1474   171 -EGARVGVIGISNDLEFLE 188
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
389-422 3.50e-04

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 43.53  E-value: 3.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEI 422
Cdd:COG2255    57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGPAI 90
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
386-482 3.54e-04

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 42.37  E-value: 3.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 386 PRGLLLYGPPGTGKTMIARAVANEVGA-YVSVingpeIISKFygeTEARLRQIFAEATLRH--PSIIFIDELDALCPKRE 462
Cdd:cd19498    46 PKNILMIGPTGVGKTEIARRLAKLAGApFIKV-----EATKF---TEVGYVGRDVESIIRDlvEGIVFIDEIDKIAKRGG 117
                          90       100
                  ....*....|....*....|.
gi 1720404492 463 GAQSEVEKR-VVASLLTLMDG 482
Cdd:cd19498   118 SSGPDVSREgVQRDLLPIVEG 138
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
661-727 5.16e-04

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 41.36  E-value: 5.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720404492 661 KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGES--ERAVREIFRKARAVAPSIIFFDE 727
Cdd:cd19506    27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGD 95
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
385-557 6.91e-04

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 43.22  E-value: 6.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 385 APRGLLLYGPPGTGKTMIARAVANEVGAY-------VSV---------ING--PEIISKFYGETEARLRQIFAEATL--R 444
Cdd:COG1401   220 TKKNVILAGPPGTGKTYLARRLAEALGGEdngriefVQFhpswsyedfLLGyrPSLDEGKYEPTPGIFLRFCLKAEKnpD 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 445 HPSIIFIDELDalcpkRegaqSEVEKrVVASLLTLMD---------------GIGSEGSEGR-VLVLGATN---RPQAL- 504
Cdd:COG1401   300 KPYVLIIDEIN-----R----ANVEK-YFGELLSLLEsdkrgeelsielpysGEGEEFSIPPnLYIIGTMNtddRSLALs 369
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720404492 505 DAALRRpgRFD------KEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHG 557
Cdd:COG1401   370 DKALRR--RFTfefldpDLDKLSNEEVVDLLEELNEILEKRDFQIGHRALLLLDGLLSG 426
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
661-715 7.90e-04

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 42.65  E-value: 7.90e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720404492 661 KGVLLYGPPGCSKTMIAKALANESGLN--FLAIKGPELMNKYVGESErAVREIFRKA 715
Cdd:COG1224    65 KGILIVGPPGTGKTALAVAIARELGEDtpFVAISGSEIYSAELKKTE-FLMQALRKA 120
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
386-587 1.10e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 41.88  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 386 PRGLLLYGPPGTGKTMIARAVANEVG-----------------------AYVSVINgPEIISKFYGETEAR-LRQIFAEA 441
Cdd:COG0470    18 PHALLLHGPPGIGKTTLALALARDLLcenpeggkacgqchsrlmaagnhPDLLELN-PEEKSDQIGIDQIReLGEFLSLT 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 442 TLRHPS-IIFIDELDALcpkREGAQSevekrvvaSLLTLMDgigsEGSEGRVLVLgATNRPQALDAALR---RPgrfdke 517
Cdd:COG0470    97 PLEGGRkVVIIDEADAM---NEAAAN--------ALLKTLE----EPPKNTPFIL-IANDPSRLLPTIRsrcQV------ 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 518 IEIGIPNAQDRLDILQKllrrvpHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRVLRKQPNLPD 587
Cdd:COG0470   155 IRFRPPSEEEALAWLRE------EGVDEDALEAILRLAGGDPRAAINLLQALAGRKELLEDLAALLSRDR 218
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
389-484 1.18e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 39.41  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 389 LLLYGPPGTGKTMIARAVAN---EVGAYVSVINGPEIIskfygetearLRQIFAEATLRHPSIIFIDELDALCPKREGAQ 465
Cdd:cd01120     1 ILITGPPGSGKTTLLLQFAEqalLSDEPVIFISFLDTI----------LEAIEDLIEEKKLDIIIIDSLSSLARASQGDR 70
                          90
                  ....*....|....*....
gi 1720404492 466 SEVEKRVVASLLTLMDGIG 484
Cdd:cd01120    71 SSELLEDLAKLLRAARNTG 89
DEXXQc_Helz-like cd18038
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ...
357-407 1.22e-03

DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350796 [Multi-domain]  Cd Length: 229  Bit Score: 41.45  E-value: 1.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720404492 357 LNS-QLKAIREIIELPLKqpelfksygiPAPrgLLLYGPPGTGKTM-IARAVA 407
Cdd:cd18038     2 LNDeQKLAVRNIVTGTSR----------PPP--YIIFGPPGTGKTVtLVEAIL 42
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
660-729 1.47e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 40.26  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 660 PKGV-LLYGPPGCSKTMIAKALANESGL---NFLAIKGPELMNK------------YVGESERAVreIFRKARAVAPSII 723
Cdd:pfam07724   2 PIGSfLFLGPTGVGKTELAKALAELLFGderALIRIDMSEYMEEhsvsrligappgYVGYEEGGQ--LTEAVRRKPYSIV 79

                  ....*.
gi 1720404492 724 FFDELD 729
Cdd:pfam07724  80 LIDEIE 85
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
389-404 1.55e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 41.95  E-value: 1.55e-03
                          10
                  ....*....|....*.
gi 1720404492 389 LLLYGPPGTGKTMIAR 404
Cdd:COG0606   214 LLMIGPPGSGKTMLAR 229
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
390-700 1.62e-03

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 42.13  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 390 LLYGPPGTGKTMIARAVANEV--GAYVSVINGPEIIS----------KFYGETEARLRQIFAEATLRHPSIIFIDELDAL 457
Cdd:PRK11034  211 LLVGESGVGKTAIAEGLAWRIvqGDVPEVMADCTIYSldigsllagtKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTI 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 458 CpkreGAQSEVEKRVVASLLtlmdgIGSEGSEGRVLVLGATNRPQ-----ALDAALRRpgRFDKeIEIGIPNAQDRLDIL 532
Cdd:PRK11034  291 I----GAGAASGGQVDAANL-----IKPLLSSGKIRVIGSTTYQEfsnifEKDRALAR--RFQK-IDITEPSIEETVQII 358
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 533 QKllrrvphLLTKAEllrlannAHGYVGADLKALCNEAGLHALRRVLRkqpNLPDSKV-----AG----MVKITLNDFLQ 603
Cdd:PRK11034  359 NG-------LKPKYE-------AHHDVRYTAKAVRAAVELAVKYINDR---HLPDKAIdvideAGararLMPVSKRKKTV 421
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 604 GMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLK-------QAVEwPLKHPKSFNRMGI----QPPKGVLLYGPPGCS 672
Cdd:PRK11034  422 NVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKmlvfgqdKAIE-ALTEAIKMSRAGLghehKPVGSFLFAGPTGVG 500
                         330       340
                  ....*....|....*....|....*...
gi 1720404492 673 KTMIAKALANESGLNFLAIKGPELMNKY 700
Cdd:PRK11034  501 KTEVTVQLSKALGIELLRFDMSEYMERH 528
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
663-696 1.79e-03

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 41.27  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720404492 663 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL 696
Cdd:PRK00080   54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL 87
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
390-459 2.12e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 39.87  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 390 LLYGPPGTGKTMIARAVANEVGAY---VSVINGPE-----IISKFYGETEARLRQ----IFAEATLRHP-SIIFIDELDA 456
Cdd:pfam07724   7 LFLGPTGVGKTELAKALAELLFGDeraLIRIDMSEymeehSVSRLIGAPPGYVGYeeggQLTEAVRRKPySIVLIDEIEK 86

                  ...
gi 1720404492 457 LCP 459
Cdd:pfam07724  87 AHP 89
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
389-405 2.16e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 40.21  E-value: 2.16e-03
                          10
                  ....*....|....*..
gi 1720404492 389 LLLYGPPGTGKTMIARA 405
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKR 41
AAA_22 pfam13401
AAA domain;
389-457 2.23e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.86  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 389 LLLYGPPGTGKTMIARAVANEVGA------YVSVING-------PEIISKF-----YGETEARLRQIFAEA--TLRHPSI 448
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQLPEvrdsvvFVDLPSGtspkdllRALLRALglplsGRLSKEELLAALQQLllALAVAVV 87

                  ....*....
gi 1720404492 449 IFIDELDAL 457
Cdd:pfam13401  88 LIIDEAQHL 96
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
657-735 4.08e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 39.76  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720404492 657 IQPPKGVLLYGPPGCSKTMIAKALANE---SGLNFLAIKGPELMNK-YVGESERAVREIFRKARAVAPSIIffDELDALA 732
Cdd:COG1484    96 IERGENLILLGPPGTGKTHLAIALGHEacrAGYRVRFTTAPDLVNElKEARADGRLERLLKRLAKVDLLIL--DELGYLP 173

                  ...
gi 1720404492 733 VER 735
Cdd:COG1484   174 LDA 176
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
382-423 5.83e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 39.13  E-value: 5.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1720404492 382 GIPAPRGLLLYGPPGTGKT------MIARAVANEVGAYVSVINGPEII 423
Cdd:COG0467    16 GLPRGSSTLLSGPPGTGKTtlalqfLAEGLRRGEKGLYVSFEESPEQL 63
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
663-694 8.81e-03

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 39.29  E-value: 8.81e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1720404492 663 VLLYGPPGCSKTMIAKALANESGLNFLAIKGP 694
Cdd:COG2255    57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGP 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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