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Conserved domains on  [gi|1720405672|ref|XP_030108781|]
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F-box-like/WD repeat-containing protein TBL1XR1 isoform X2 [Mus musculus]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10553538)

WD40 domain-containing protein similar to Homo sapiens F-box-like/WD repeat-containing protein TBL1X/TBL1Y/TBL1XR1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-470 1.76e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.59  E-value: 1.76e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENstsgptQLVLRHCIREGGqdvpsnkdVTSLDWNSEGTLLATG 243
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG------ELLRTLKGHTGP--------VRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 244 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF 322
Cdd:cd00200    70 SSDKTIRLWdLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 323 -ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 401
Cdd:cd00200   150 vASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720405672 402 TGpgtnnpnanLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Cdd:cd00200   230 DG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 7-31 5.29e-07

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


:

Pssm-ID: 462501  Cd Length: 25  Bit Score: 45.77  E-value: 5.29e-07
                          10        20
                  ....*....|....*....|....*
gi 1720405672   7 EVNFLVYRYLQESGFSHSAFTFGIE 31
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-470 1.76e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.59  E-value: 1.76e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENstsgptQLVLRHCIREGGqdvpsnkdVTSLDWNSEGTLLATG 243
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG------ELLRTLKGHTGP--------VRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 244 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF 322
Cdd:cd00200    70 SSDKTIRLWdLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 323 -ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 401
Cdd:cd00200   150 vASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720405672 402 TGpgtnnpnanLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Cdd:cd00200   230 DG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
162-472 1.52e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.61  E-value: 1.52e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 162 AVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLsensTSGPTQLVLRHcireggqdvpSNKDVTSLDWNSEGTLLA 241
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTG----------HSGAVTSVAFSPDGKLLA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 242 TGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN 320
Cdd:COG2319   179 SGSDDGTVRLWdLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 321 -TFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399
Cdd:COG2319   259 rLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720405672 400 SPTGPgtnnpnanlMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQ 472
Cdd:COG2319   339 SPDGK---------TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 432-470 5.73e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 57.32  E-value: 5.73e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720405672  432 GICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
432-470 2.86e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.43  E-value: 2.86e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720405672 432 GICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 341-430 4.66e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.89  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 341 PIKTFQGHTNEVNAIKWDPT-GNLLASCSDDMTLKIWSMKQDN----------CVhdLQAHNKEIYTIKWsptgpgtnNP 409
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDesvkeikdpqCI--LKGHKKKISIIDW--------NP 135

                          90       100
                  ....*....|....*....|.
gi 1720405672 410 NANLMLASASFDSTVRLWDVD 430
Cdd:PTZ00420  136 MNYYIMCSSGFDSFVNIWDIE 156
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 7-31 5.29e-07

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 45.77  E-value: 5.29e-07
                          10        20
                  ....*....|....*....|....*
gi 1720405672   7 EVNFLVYRYLQESGFSHSAFTFGIE 31
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 3-36 5.60e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 42.81  E-value: 5.60e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720405672    3 ISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQ 36
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-470 1.76e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.59  E-value: 1.76e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENstsgptQLVLRHCIREGGqdvpsnkdVTSLDWNSEGTLLATG 243
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG------ELLRTLKGHTGP--------VRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 244 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF 322
Cdd:cd00200    70 SSDKTIRLWdLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 323 -ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 401
Cdd:cd00200   150 vASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720405672 402 TGpgtnnpnanLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Cdd:cd00200   230 DG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
162-472 1.52e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.61  E-value: 1.52e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 162 AVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLsensTSGPTQLVLRHcireggqdvpSNKDVTSLDWNSEGTLLA 241
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTG----------HSGAVTSVAFSPDGKLLA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 242 TGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN 320
Cdd:COG2319   179 SGSDDGTVRLWdLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 321 -TFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399
Cdd:COG2319   259 rLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720405672 400 SPTGPgtnnpnanlMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQ 472
Cdd:COG2319   339 SPDGK---------TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
164-472 8.08e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 238.27  E-value: 8.08e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLsenSTSGPTQLVLRHcireggqdvpsNKDVTSLDWNSEGTLLATG 243
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL---ATGLLLRTLTGH-----------TGAVRSVAFSPDGKTLASG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 244 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NT 321
Cdd:COG2319   139 SADGTVRLWdLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 322 FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 401
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720405672 402 TGPgtnnpnanlMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQ 472
Cdd:COG2319   299 DGK---------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
164-472 5.41e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 5.41e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSensTSGPTQLVLRHcireggqdvpsNKDVTSLDWNSEGTLLATG 243
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAA---AGALLATLLGH-----------TAAVLSVAFSPDGRLLASA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 244 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGeakqqfpfhsapaldvdwqsnntf 322
Cdd:COG2319    97 SADGTVRLWdLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG------------------------ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 323 ascstdmcihvcklgqdRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402
Cdd:COG2319   153 -----------------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 403 GPgtnnpnanlMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQ 472
Cdd:COG2319   216 GK---------LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 258-478 2.68e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.39  E-value: 2.68e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 258 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKL 336
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYlASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 337 GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTgpgtnnpnaNLMLA 416
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---------GTFVA 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720405672 417 SASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQCLLCLG 478
Cdd:cd00200   152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213
WD40 COG2319
WD40 repeat [General function prediction only];
237-480 1.22e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.63  E-value: 1.22e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 237 GTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVD 315
Cdd:COG2319     6 GAALAAASADLALALLAaALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 316 WQSN-NTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEI 394
Cdd:COG2319    86 FSPDgRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 395 YTIKWSPTGpgtnnpnanLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNT--- 471
Cdd:COG2319   166 TSVAFSPDG---------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLatg 236


                  ....*....
gi 1720405672 472 QCLLCLGFH 480
Cdd:COG2319   237 KLLRTLTGH 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 341-480 2.44e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 2.44e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPgtnnpnanlMLASASF 420
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT---------YLASGSS 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720405672 421 DSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNT---QCLLCLGFH 480
Cdd:cd00200    72 DKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVetgKCLTTLRGH 134
WD40 COG2319
WD40 repeat [General function prediction only];
164-297 7.83e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 7.83e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSenstSGPTQLVLRHcireggqdvpSNKDVTSLDWNSEGTLLATG 243
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTG----------HTGAVRSVAFSPDGKTLASG 348

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720405672 244 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHT 297
Cdd:COG2319   349 SDDGTVRLWdLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 432-470 5.73e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 57.32  E-value: 5.73e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720405672  432 GICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
432-470 2.86e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.43  E-value: 2.86e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720405672 432 GICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 340-377 3.23e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 3.23e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720405672  340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWS 377
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 341-430 4.66e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.89  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 341 PIKTFQGHTNEVNAIKWDPT-GNLLASCSDDMTLKIWSMKQDN----------CVhdLQAHNKEIYTIKWsptgpgtnNP 409
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDesvkeikdpqCI--LKGHKKKISIIDW--------NP 135

                          90       100
                  ....*....|....*....|.
gi 1720405672 410 NANLMLASASFDSTVRLWDVD 430
Cdd:PTZ00420  136 MNYYIMCSSGFDSFVNIWDIE 156
PTZ00420 PTZ00420
coronin; Provisional
 165-308 5.91e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.50  E-value: 5.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 165 LRGHESEVFICAWNPV-SDLLASGSGDSTARIWNLSENSTSgPTQLVLRHCIREGGQdvpsnKDVTSLDWNSEGT-LLAT 242
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDES-VKEIKDPQCILKGHK-----KKISIIDWNPMNYyIMCS 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720405672 243 GSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHS 308
Cdd:PTZ00420  144 SGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHD 209
PTZ00421 PTZ00421
coronin; Provisional
 286-468 1.29e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.29  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 286 VDKTTIIWD-AHTGEAKQQFpfhsapaLDVDWQSNNTFASCSTDMCihvCKLGQDRPIktFQGHTNEVNAIKWDPTGNL- 363
Cdd:PTZ00421   23 VTPSTALWDcSNTIACNDRF-------IAVPWQQLGSTAVLKHTDY---GKLASNPPI--LLGQEGPIIDVAFNPFDPQk 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 364 LASCSDDMTLKIWSMKQ--------DNCVHdLQAHNKEIYTIKWsptgpgtnNPNANLMLASASFDSTVRLWDVDRGICI 435
Cdd:PTZ00421   91 LFTASEDGTIMGWGIPEegltqnisDPIVH-LQGHTKKVGIVSF--------HPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1720405672 436 HTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHI 468
Cdd:PTZ00421  162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 271-482 1.53e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.49  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 271 ALKWNKKGNFILSAGVDKTTIIWDahtgeakqqfpfhsapaldvdwqsnntfascstdmCIHVCKLGQD--RPIKTFQGH 348
Cdd:PLN00181  488 AIGFDRDGEFFATAGVNKKIKIFE-----------------------------------CESIIKDGRDihYPVVELASR 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 349 TnEVNAIKWDP-TGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPgtnnpnanLMLASASFDSTVRLW 427
Cdd:PLN00181  533 S-KLSGICWNSyIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADP--------TLLASGSDDGSVKLW 603

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720405672 428 DVDRGICIHTLtKHQEPVYSVAFSPD-GRYLASGSFDKCVHIW---NTQCLLC--LGFHVT 482
Cdd:PLN00181  604 SINQGVSIGTI-KTKANICCVQFPSEsGRSLAFGSADHKVYYYdlrNPKLPLCtmIGHSKT 663
WD40 pfam00400
WD domain, G-beta repeat;
340-377 1.75e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.75e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720405672 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWS 377
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 7-31 5.29e-07

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 45.77  E-value: 5.29e-07
                          10        20
                  ....*....|....*....|....*
gi 1720405672   7 EVNFLVYRYLQESGFSHSAFTFGIE 31
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 349-478 6.31e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 6.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 349 TNEVNAIKWDPTGNLLASCSDDMTLKIW---SMKQDNcvHDLQ------AHNKEIYTIKWsptgpgtnNPNANLMLASAS 419
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFeceSIIKDG--RDIHypvvelASRSKLSGICW--------NSYIKSQVASSN 552

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 420 FDSTVRLWDVDRGICIHTLTKHQEPVYSVAF-SPDGRYLASGSFDKCVHIWNTQCLLCLG 478
Cdd:PLN00181  553 FEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIG 612
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 164-197 2.22e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720405672  164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 197
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 382-428 2.40e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.40e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1720405672  382 NCVHDLQAHNKEIYTIKWSPTGPgtnnpnanlMLASASFDSTVRLWD 428
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK---------YLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 159-322 2.49e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 159 SNKAVVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLsENSTSGPTqlvlrhcireggqdVPSNKD-VTSLDWNSE 236
Cdd:PTZ00421  115 SDPIVHLQGHTKKVGIVSFHPsAMNVLASAGADMVVNVWDV-ERGKAVEV--------------IKCHSDqITSLEWNLD 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 237 GTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFA-LKWNKKGNFILSAGVDKT----TIIWDAHTGEAkqqfPFHSap 310
Cdd:PTZ00421  180 GSLLCTTSKDKKLNIIDpRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWDTRKMAS----PYST-- 253

                         170
                  ....*....|..
gi 1720405672 311 aLDVDwQSNNTF 322
Cdd:PTZ00421  254 -VDLD-QSSALF 263
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 3-36 5.60e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 42.81  E-value: 5.60e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720405672    3 ISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQ 36
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 272-470 9.07e-06

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 46.50  E-value: 9.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 272 LKWNKKGNFIL---SAGVDKTTIIWdahTGEakqqfpfhsapaldvdwqsNNTFASCSTDMCIHVCKLGQDRPIKtfqgh 348
Cdd:pfam08662  11 LKWNKNGTYLLvltDTDVDKTGKSY---YGE-------------------TNLYLIGETGGPDCVVELDKEGPIH----- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 349 tnevnAIKWDPTGNLLASCSDDMTLKIwSM--KQDNCVHDLQAHNKEiyTIKWSPTGPgtnnpnanlMLASASFDST--- 423
Cdd:pfam08662  64 -----DVAWSPNGKEFAVIYGYMPAKV-SFfdLKGNVIHSFGEQPRN--TIFWSPFGR---------LVLLAGFGNLagd 126

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720405672 424 VRLWDVDRGICIHTlTKHQEPVYsVAFSPDGRYLASGS------FDKCVHIWN 470
Cdd:pfam08662 127 IEFWDVVNKKKIAT-AEASNATL-CEWSPDGRYFLTATtaprlrVDNGFKIWH 177
WD40 pfam00400
WD domain, G-beta repeat;
382-428 1.38e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1720405672 382 NCVHDLQAHNKEIYTIKWSPTGPgtnnpnanlMLASASFDSTVRLWD 428
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK---------LLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
164-197 1.53e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.53e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720405672 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 197
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 255-294 1.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.64e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720405672  255 DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWD 294
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 154-369 3.27e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 3.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 154 DVEIPsnkAVVLRGHESEVFICaWNP-VSDLLASGSGDSTARIWNLSENstsgptQLVLRhcIREggqdvpSNKDVTSLD 232
Cdd:PLN00181  521 DIHYP---VVELASRSKLSGIC-WNSyIKSQVASSNFEGVVQVWDVARS------QLVTE--MKE------HEKRVWSID 582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 233 WNS-EGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKW-NKKGNFILSAGVDKTTIIWDAHTgeakQQFPF---- 306
Cdd:PLN00181  583 YSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSLAFGSADHKVYYYDLRN----PKLPLctmi 658

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 307 -HSAPALDVDWQSNNTFASCSTDMCIHVCKLG------QDRPIKTFQGHTNEVNAIKWDPTGNLLASCSD 369
Cdd:PLN00181  659 gHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGSE 728
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 231-319 4.32e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 42.27  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 231 LDWNSEGTLLATGSYDG--------FARIWTKDGnlastlGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQ 302
Cdd:pfam12894   1 MSWCPTMDLIALATEDGelllhrlnWQRVWTLSP------DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVH 74

                          90
                  ....*....|....*..
gi 1720405672 303 QFPFHSAPALDVDWQSN 319
Cdd:pfam12894  75 HFSAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
256-294 9.39e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720405672 256 GNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWD 294
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 355-451 2.25e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.95  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 355 IKWDPTGNLLASCSDDMTL--------KIWSMKQDNcvhdlqaHNKEIYTIKWSPTGPgtnnpnanlMLASASFDSTVRL 426
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTLSPDK-------EDLEVTSLAWRPDGK---------LLAVGYSDGTVRL 64

                          90       100
                  ....*....|....*....|....*
gi 1720405672 427 WDVDRGICIHTLTKHQEPVYSVAFS 451
Cdd:pfam12894  65 LDAENGKIVHHFSAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-252 2.33e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.33e-04
                           10        20
                   ....*....|....*....|....*...
gi 1720405672  225 NKDVTSLDWNSEGTLLATGSYDGFARIW 252
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 351-458 3.08e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.49  E-value: 3.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672  351 EVNAIKWDPTGNLLASCSDDMTLKiwsmkqdncVHDL----------QAHNKEIYTIKWSPTG-------PGTNNPNAnl 413
Cdd:COG4946    390 RVFNPVWSPDGKKIAFTDNRGRLW---------VVDLasgkvrkvdtDGYGDGISDLAWSPDSkwlayskPGPNQLSQ-- 458

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1720405672  414 mlasasfdstVRLWDVDRGIcIHTLTKHQEPVYSVAFSPDGRYLA 458
Cdd:COG4946    459 ----------IFLYDVETGK-TVQLTDGRYDDGSPAFSPDGKYLY 492
WD40 pfam00400
WD domain, G-beta repeat;
225-252 3.58e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.58e-04
                          10        20
                  ....*....|....*....|....*...
gi 1720405672 225 NKDVTSLDWNSEGTLLATGSYDGFARIW 252
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 326-400 1.14e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 326 STDMCIHVCKL-GQdrpiKTFQG----HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS 400
Cdd:pfam12894  14 TEDGELLLHRLnWQ----RVWTLspdkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
PTZ00420 PTZ00420
coronin; Provisional
 164-294 2.21e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 164 VLRGHESEVFICAWNPVSDLLASGSG-DSTARIWNLsENSTSGpTQLVLrhcireggqdvpsNKDVTSLDWNSEGTLLaT 242
Cdd:PTZ00420  120 ILKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDI-ENEKRA-FQINM-------------PKKLSSLKWNIKGNLL-S 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720405672 243 GSYDG--FARIWTKDGNLASTLGQHKGP-----IFALKWNKKGNFILSAGVDKTTI----IWD 294
Cdd:PTZ00420  184 GTCVGkhMHIIDPRKQEIASSFHIHDGGkntknIWIDGLGGDDNYILSTGFSKNNMremkLWD 246
PTZ00421 PTZ00421
coronin; Provisional
 256-390 3.31e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405672 256 GNLAST----LGQhKGPIFALKWNKKGNFIL-SAGVDKTTIIWDAHTGEAKQQFpfhSAPALDVDWQS------------ 318
Cdd:PTZ00421   62 GKLASNppilLGQ-EGPIIDVAFNPFDPQKLfTASEDGTIMGWGIPEEGLTQNI---SDPIVHLQGHTkkvgivsfhpsa 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720405672 319 NNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAH 390
Cdd:PTZ00421  138 MNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 409-469 6.02e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 6.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720405672 409 PNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIW 469
Cdd:pfam20426  91 PSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVW 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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