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Conserved domains on  [gi|1720355220|ref|XP_030109817|]
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suppression of tumorigenicity 18 protein isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
487-720 2.24e-94

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


:

Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 299.75  E-value: 2.24e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  487 AITSPRASASKEQEKFGKVPFDYASFDAQVFGKRPLLQTGQGQKAPP--FPESKHFSNPVKFPNGLPSAGAHTQSTVRAS 564
Cdd:pfam08474    6 PTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPkgFDAKKYFCKPSSPSSSLTSSYAPSSSSSSSS 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  565 SYGHGQYSEDTHIAAAAAiLNLSTRCREATDILSNKPQSLRAKGAEIEVDENGTLDLSMKKNRIHDKSIPPTSSPTTITT 644
Cdd:pfam08474   86 SYDYTHDMEAAHMAATAI-LNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRGVTSGSVLTPLPPMS 164
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720355220  645 PssspfNASSLLVNAAFYQALSDQEGWNVPINYSKSHGKTEEEKE--KDPVNFLENLEEKKFAGEASIPSPKPKLHTR 720
Cdd:pfam08474  165 P-----QRQASLLNSRCYQALCAQDCWDLPVDYTKIKRIDEEEKEepEDLDPFQELLEERKYPGEVTIPSPKPKYPPC 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
772-800 1.36e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 73.72  E-value: 1.36e-16
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  772 KCPTPGCDGSGHVTGNYASHRSLSGCPRA 800
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
728-756 7.88e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 71.80  E-value: 7.88e-16
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  728 TCPTPGCDGSGHVTGNYASHRSVSGCPLA 756
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
416-444 5.64e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 5.64e-14
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  416 KCPTPGCTGRGHVNSNRNTHRSLSGCPIA 444
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
820-848 8.33e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.02  E-value: 8.33e-14
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  820 RCPVIGCDGQGHISGKYTSHRTASGCPLA 848
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
372-398 7.71e-13

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 63.32  E-value: 7.71e-13
                           10        20
                   ....*....|....*....|....*..
gi 1720355220  372 KCPIPGCDGTGHVTGLYPHHRSLSGCP 398
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
874-900 5.60e-11

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 57.93  E-value: 5.60e-11
                           10        20
                   ....*....|....*....|....*..
gi 1720355220  874 CPLPGCNGLGHVNNVFVTHRSLSGCPL 900
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPY 28
Atg16_CCD super family cl46300
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
928-977 2.33e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


The actual alignment was detected with superfamily member cd22887:

Pssm-ID: 480640 [Multi-domain]  Cd Length: 91  Bit Score: 41.01  E-value: 2.33e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720355220  928 DEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEEN-KLIE 977
Cdd:cd22887     24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
EnvC super family cl34844
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
895-1050 3.23e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4942:

Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 3.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  895 LSGCPLNAQAIKKVKVSEELMTIKlkatggidgdEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENK 974
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQ----------QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELA 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  975 LIEQSNESLLKELAGLSQALISSLADIQ-----LPQMGPINEQNFEAYVNTLTDMYSNLE--QDYSPECKALLESIKQAV 1047
Cdd:COG4942     80 ALEAELAELEKEIAELRAELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADL 159

                   ...
gi 1720355220 1048 KGI 1050
Cdd:COG4942    160 AEL 162
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
487-720 2.24e-94

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 299.75  E-value: 2.24e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  487 AITSPRASASKEQEKFGKVPFDYASFDAQVFGKRPLLQTGQGQKAPP--FPESKHFSNPVKFPNGLPSAGAHTQSTVRAS 564
Cdd:pfam08474    6 PTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPkgFDAKKYFCKPSSPSSSLTSSYAPSSSSSSSS 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  565 SYGHGQYSEDTHIAAAAAiLNLSTRCREATDILSNKPQSLRAKGAEIEVDENGTLDLSMKKNRIHDKSIPPTSSPTTITT 644
Cdd:pfam08474   86 SYDYTHDMEAAHMAATAI-LNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRGVTSGSVLTPLPPMS 164
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720355220  645 PssspfNASSLLVNAAFYQALSDQEGWNVPINYSKSHGKTEEEKE--KDPVNFLENLEEKKFAGEASIPSPKPKLHTR 720
Cdd:pfam08474  165 P-----QRQASLLNSRCYQALCAQDCWDLPVDYTKIKRIDEEEKEepEDLDPFQELLEERKYPGEVTIPSPKPKYPPC 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
772-800 1.36e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 73.72  E-value: 1.36e-16
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  772 KCPTPGCDGSGHVTGNYASHRSLSGCPRA 800
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
728-756 7.88e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 71.80  E-value: 7.88e-16
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  728 TCPTPGCDGSGHVTGNYASHRSVSGCPLA 756
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
416-444 5.64e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 5.64e-14
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  416 KCPTPGCTGRGHVNSNRNTHRSLSGCPIA 444
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
820-848 8.33e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.02  E-value: 8.33e-14
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  820 RCPVIGCDGQGHISGKYTSHRTASGCPLA 848
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
372-398 7.71e-13

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 63.32  E-value: 7.71e-13
                           10        20
                   ....*....|....*....|....*..
gi 1720355220  372 KCPIPGCDGTGHVTGLYPHHRSLSGCP 398
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
874-900 5.60e-11

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 57.93  E-value: 5.60e-11
                           10        20
                   ....*....|....*....|....*..
gi 1720355220  874 CPLPGCNGLGHVNNVFVTHRSLSGCPL 900
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPY 28
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
928-977 2.33e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 41.01  E-value: 2.33e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720355220  928 DEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEEN-KLIE 977
Cdd:cd22887     24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
895-1050 3.23e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 3.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  895 LSGCPLNAQAIKKVKVSEELMTIKlkatggidgdEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENK 974
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQ----------QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELA 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  975 LIEQSNESLLKELAGLSQALISSLADIQ-----LPQMGPINEQNFEAYVNTLTDMYSNLE--QDYSPECKALLESIKQAV 1047
Cdd:COG4942     80 ALEAELAELEKEIAELRAELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADL 159

                   ...
gi 1720355220 1048 KGI 1050
Cdd:COG4942    160 AEL 162
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
928-1011 3.95e-04

YlbF/YmcA family competence regulator;


Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 41.07  E-value: 3.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  928 DEEIRHLDE--EIKEL------NESNLKIEADMMKLQTQITSMESNLKTIEEE--------NKLIEQsNEsLLKELAGLS 991
Cdd:PRK13676    13 ERALRELPEykALKEAkeavkaDEEAKKLFDEFRALQLEIQQKQMTGQEITEEeqqkaqelGQKIQQ-NE-LLSKLMEAE 90
                           90       100
                   ....*....|....*....|
gi 1720355220  992 QALISSLADIQLPQMGPINE 1011
Cdd:PRK13676    91 QRLSVYINDINKIIFKPLEE 110
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
487-720 2.24e-94

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 299.75  E-value: 2.24e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  487 AITSPRASASKEQEKFGKVPFDYASFDAQVFGKRPLLQTGQGQKAPP--FPESKHFSNPVKFPNGLPSAGAHTQSTVRAS 564
Cdd:pfam08474    6 PTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPkgFDAKKYFCKPSSPSSSLTSSYAPSSSSSSSS 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  565 SYGHGQYSEDTHIAAAAAiLNLSTRCREATDILSNKPQSLRAKGAEIEVDENGTLDLSMKKNRIHDKSIPPTSSPTTITT 644
Cdd:pfam08474   86 SYDYTHDMEAAHMAATAI-LNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRGVTSGSVLTPLPPMS 164
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720355220  645 PssspfNASSLLVNAAFYQALSDQEGWNVPINYSKSHGKTEEEKE--KDPVNFLENLEEKKFAGEASIPSPKPKLHTR 720
Cdd:pfam08474  165 P-----QRQASLLNSRCYQALCAQDCWDLPVDYTKIKRIDEEEKEepEDLDPFQELLEERKYPGEVTIPSPKPKYPPC 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
772-800 1.36e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 73.72  E-value: 1.36e-16
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  772 KCPTPGCDGSGHVTGNYASHRSLSGCPRA 800
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
728-756 7.88e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 71.80  E-value: 7.88e-16
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  728 TCPTPGCDGSGHVTGNYASHRSVSGCPLA 756
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
416-444 5.64e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 5.64e-14
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  416 KCPTPGCTGRGHVNSNRNTHRSLSGCPIA 444
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
820-848 8.33e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.02  E-value: 8.33e-14
                           10        20
                   ....*....|....*....|....*....
gi 1720355220  820 RCPVIGCDGQGHISGKYTSHRTASGCPLA 848
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
372-398 7.71e-13

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 63.32  E-value: 7.71e-13
                           10        20
                   ....*....|....*....|....*..
gi 1720355220  372 KCPIPGCDGTGHVTGLYPHHRSLSGCP 398
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
874-900 5.60e-11

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 57.93  E-value: 5.60e-11
                           10        20
                   ....*....|....*....|....*..
gi 1720355220  874 CPLPGCNGLGHVNNVFVTHRSLSGCPL 900
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPY 28
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
928-977 2.33e-04

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 41.01  E-value: 2.33e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720355220  928 DEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEEN-KLIE 977
Cdd:cd22887     24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
895-1050 3.23e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 3.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  895 LSGCPLNAQAIKKVKVSEELMTIKlkatggidgdEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENK 974
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQ----------QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELA 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  975 LIEQSNESLLKELAGLSQALISSLADIQ-----LPQMGPINEQNFEAYVNTLTDMYSNLE--QDYSPECKALLESIKQAV 1047
Cdd:COG4942     80 ALEAELAELEKEIAELRAELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADL 159

                   ...
gi 1720355220 1048 KGI 1050
Cdd:COG4942    160 AEL 162
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
928-1011 3.95e-04

YlbF/YmcA family competence regulator;


Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 41.07  E-value: 3.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  928 DEEIRHLDE--EIKEL------NESNLKIEADMMKLQTQITSMESNLKTIEEE--------NKLIEQsNEsLLKELAGLS 991
Cdd:PRK13676    13 ERALRELPEykALKEAkeavkaDEEAKKLFDEFRALQLEIQQKQMTGQEITEEeqqkaqelGQKIQQ-NE-LLSKLMEAE 90
                           90       100
                   ....*....|....*....|
gi 1720355220  992 QALISSLADIQLPQMGPINE 1011
Cdd:PRK13676    91 QRLSVYINDINKIIFKPLEE 110
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
900-1005 1.35e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.20  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  900 LNAQAIKKVKVSEELMTIKLKATggiDGDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQS 979
Cdd:COG4372     89 LQAAQAELAQAQEELESLQEEAE---ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165
                           90       100
                   ....*....|....*....|....*.
gi 1720355220  980 NESLLKELAGLSQALISSLADIQLPQ 1005
Cdd:COG4372    166 LAALEQELQALSEAEAEQALDELLKE 191
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
929-1048 5.00e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 5.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355220  929 EEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQSNESLLKELAGLSQALISSLADIQLPQMGP 1008
Cdd:COG4372     66 EELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEI 145
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1720355220 1009 INEQN----FEAYVNTLTDMYSNLEQDYSPECKALLES-IKQAVK 1048
Cdd:COG4372    146 AEREEelkeLEEQLESLQEELAALEQELQALSEAEAEQaLDELLK 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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