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Conserved domains on  [gi|1720414826|ref|XP_030110670|]
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transmembrane protein 248 isoform X1 [Mus musculus]

Protein Classification

TMEM219 domain-containing protein( domain architecture ID 10633099)

TMEM219 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TMEM219 pfam14940
Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this ...
10-256 1.18e-108

Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention.


:

Pssm-ID: 464388  Cd Length: 236  Bit Score: 315.57  E-value: 1.18e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414826  10 LKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTM 89
Cdd:pfam14940   1 LKSFAVSRPPLVVFFVCLLAFAIAFLSLGYYIKVHDIKNPDITKDWNTFLLSFAELDFCVSSNETLKHVLEDTSPPESTH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414826  90 TV-GQARSSTqppqsleesgpINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPAAWNA 168
Cdd:pfam14940  81 VVsTTLSASL-----------INISVPIHLTLDPSDLFVGYSPNVTHLSATVSGSQLGLKGAAAKEEVNITFTLPAAWSS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414826 169 DDCALHGHCEQAVFTACMTLTAAPGVFPVTVQPPHCIPDTYSNATLWYKIFTTARDANTKYAQDYNpfWCYKGAIGKVYH 248
Cdd:pfam14940 150 SDVCTGKHCEQVVFLTCVTFTAPAHVFPTTRQPPGCNPETVNVSTSVSPYRTTAVQSPRQYSPEYS--WCSKGVLVKFYH 227

                  ....*...
gi 1720414826 249 ALNPKLTV 256
Cdd:pfam14940 228 KLDPKLTV 235
 
Name Accession Description Interval E-value
TMEM219 pfam14940
Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this ...
10-256 1.18e-108

Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention.


Pssm-ID: 464388  Cd Length: 236  Bit Score: 315.57  E-value: 1.18e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414826  10 LKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTM 89
Cdd:pfam14940   1 LKSFAVSRPPLVVFFVCLLAFAIAFLSLGYYIKVHDIKNPDITKDWNTFLLSFAELDFCVSSNETLKHVLEDTSPPESTH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414826  90 TV-GQARSSTqppqsleesgpINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPAAWNA 168
Cdd:pfam14940  81 VVsTTLSASL-----------INISVPIHLTLDPSDLFVGYSPNVTHLSATVSGSQLGLKGAAAKEEVNITFTLPAAWSS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414826 169 DDCALHGHCEQAVFTACMTLTAAPGVFPVTVQPPHCIPDTYSNATLWYKIFTTARDANTKYAQDYNpfWCYKGAIGKVYH 248
Cdd:pfam14940 150 SDVCTGKHCEQVVFLTCVTFTAPAHVFPTTRQPPGCNPETVNVSTSVSPYRTTAVQSPRQYSPEYS--WCSKGVLVKFYH 227

                  ....*...
gi 1720414826 249 ALNPKLTV 256
Cdd:pfam14940 228 KLDPKLTV 235
 
Name Accession Description Interval E-value
TMEM219 pfam14940
Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this ...
10-256 1.18e-108

Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention.


Pssm-ID: 464388  Cd Length: 236  Bit Score: 315.57  E-value: 1.18e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414826  10 LKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTM 89
Cdd:pfam14940   1 LKSFAVSRPPLVVFFVCLLAFAIAFLSLGYYIKVHDIKNPDITKDWNTFLLSFAELDFCVSSNETLKHVLEDTSPPESTH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414826  90 TV-GQARSSTqppqsleesgpINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPAAWNA 168
Cdd:pfam14940  81 VVsTTLSASL-----------INISVPIHLTLDPSDLFVGYSPNVTHLSATVSGSQLGLKGAAAKEEVNITFTLPAAWSS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414826 169 DDCALHGHCEQAVFTACMTLTAAPGVFPVTVQPPHCIPDTYSNATLWYKIFTTARDANTKYAQDYNpfWCYKGAIGKVYH 248
Cdd:pfam14940 150 SDVCTGKHCEQVVFLTCVTFTAPAHVFPTTRQPPGCNPETVNVSTSVSPYRTTAVQSPRQYSPEYS--WCSKGVLVKFYH 227

                  ....*...
gi 1720414826 249 ALNPKLTV 256
Cdd:pfam14940 228 KLDPKLTV 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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