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Conserved domains on  [gi|1720415248|ref|XP_030110767|]
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protein tweety homolog 3 isoform X4 [Mus musculus]

Protein Classification

tweety family protein( domain architecture ID 10522668)

tweety family protein may function as a large-conductance Ca(2+)-activated chloride channel that plays a role in Ca(2+) signal transduction

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tweety pfam04906
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ...
80-452 0e+00

Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.


:

Pssm-ID: 461475  Cd Length: 429  Bit Score: 565.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248  80 FYSFWLCCRRRKTDEHLDADCCCTAWCVIITTLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAAA 159
Cdd:pfam04906  56 VYLICLCCCRRKEDERPPADCCCVTWSVVIATLVCCAAIGVGFYGNSETNDGVYQLTYSLRHANHTVSGIDDLVSDTTES 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 160 LNRTAEPNLQSLERQLAGRQEPLRAVQRLQTLLGTLLGYTAAIPFWRNPGVSLEVLAEQVDLYDWYRWLGYLGLLLLDVI 239
Cdd:pfam04906 136 LNETLEQHLTRLEEIFAKRTDYLQAVRFLQRQLANLIQQLAGLPFWKGAELSLTALAEQVDFYEWYRWLGYLLLLLLDLV 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 240 ICLLVLVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDTFVTKMVEEHsvLSGDILQYYLACSPR 319
Cdd:pfam04906 216 ICLVTLLGLARQSKCLLIGMCVCGLLALVISWASLGLELATAVGTSDFCVDPDDYVVNQTGEE--LSSDILQYYLNCSQS 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 320 ATNPFQQKLSGSHKALVEMQDVVAELLRNVPREHPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDYVQALTGFCY 399
Cdd:pfam04906 294 LTNPFQQRLTESQRALVEMQDQVQGLLRFAVPLFPTAQKDLLGIQGLLNSTERNLHQLTALLDCRSLHKDYLQALRGLCY 373
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720415248 400 DGVEGLIYLALFSFVTALMFSSIVCSIPHTW---QQKRGPDDDGEEETAPGPRQAH 452
Cdd:pfam04906 374 DGLEGLLYLLLFSLLTALAFSSIVCSDPHAWiyfQKRDRDYDDIDEEDPFNPQEAR 429
 
Name Accession Description Interval E-value
Tweety pfam04906
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ...
80-452 0e+00

Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.


Pssm-ID: 461475  Cd Length: 429  Bit Score: 565.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248  80 FYSFWLCCRRRKTDEHLDADCCCTAWCVIITTLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAAA 159
Cdd:pfam04906  56 VYLICLCCCRRKEDERPPADCCCVTWSVVIATLVCCAAIGVGFYGNSETNDGVYQLTYSLRHANHTVSGIDDLVSDTTES 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 160 LNRTAEPNLQSLERQLAGRQEPLRAVQRLQTLLGTLLGYTAAIPFWRNPGVSLEVLAEQVDLYDWYRWLGYLGLLLLDVI 239
Cdd:pfam04906 136 LNETLEQHLTRLEEIFAKRTDYLQAVRFLQRQLANLIQQLAGLPFWKGAELSLTALAEQVDFYEWYRWLGYLLLLLLDLV 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 240 ICLLVLVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDTFVTKMVEEHsvLSGDILQYYLACSPR 319
Cdd:pfam04906 216 ICLVTLLGLARQSKCLLIGMCVCGLLALVISWASLGLELATAVGTSDFCVDPDDYVVNQTGEE--LSSDILQYYLNCSQS 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 320 ATNPFQQKLSGSHKALVEMQDVVAELLRNVPREHPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDYVQALTGFCY 399
Cdd:pfam04906 294 LTNPFQQRLTESQRALVEMQDQVQGLLRFAVPLFPTAQKDLLGIQGLLNSTERNLHQLTALLDCRSLHKDYLQALRGLCY 373
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720415248 400 DGVEGLIYLALFSFVTALMFSSIVCSIPHTW---QQKRGPDDDGEEETAPGPRQAH 452
Cdd:pfam04906 374 DGLEGLLYLLLFSLLTALAFSSIVCSDPHAWiyfQKRDRDYDDIDEEDPFNPQEAR 429
Tweety_N cd07912
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ...
80-438 2.20e-171

N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins.


Pssm-ID: 143653  Cd Length: 418  Bit Score: 489.15  E-value: 2.20e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248  80 FYSFWLCCRRRKTDEHLDADCCCTAWCVIITTLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAAA 159
Cdd:cd07912    59 VYLITRCCDRKPTEERPRHSICCLKWSLVIATLLCCAAIGVGLYGNDETHDGVVQLTYSLRNANHTVAGIDNQTSDTEAS 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 160 LNRTAEPNLQSLERQLAGRQ---EPLRAVQRLQTLLGTLLGYTAAIPFWRNPGVSLEVLAEQVDLYDWYRWLGYLGLLLL 236
Cdd:cd07912   139 LNVTVEPQLTNLEDIFDARVnktDYLQIVQGLQQMATNAAQQLTGIPFWSLVGVSLTKLADQVSLYESYRWLAYLGLLSL 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 237 DVIICLLVLVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDTFVTKMVEehSVLSGDILQYYLAC 316
Cdd:cd07912   219 LLVICLVLLVGLARHSRCLLIVFSVCGLFALIISWLSLGLYLASAVALSDFCVDPDDYVRNQTP--SGLSSDILQYYLTC 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 317 SPRATNPFQQKLSGSHKALVEMQDVVAELLRNVPREHPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDYVQALTG 396
Cdd:cd07912   297 EPSTTNPFQQRLTESQRALTNMQSQVQGLLREAVFEFPTAEDNLLSLQGDLNSTEINLHQLTALLDCRGLHKDYVEALRG 376
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1720415248 397 FCYDGVEGLIYLALFSFVTALMFSSIVCSIPHTWQQKRGPDD 438
Cdd:cd07912   377 LCYDGLEGLLYLLLFSLLAALLFTILVCVDSHTWIYIRKRDD 418
 
Name Accession Description Interval E-value
Tweety pfam04906
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ...
80-452 0e+00

Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.


Pssm-ID: 461475  Cd Length: 429  Bit Score: 565.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248  80 FYSFWLCCRRRKTDEHLDADCCCTAWCVIITTLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAAA 159
Cdd:pfam04906  56 VYLICLCCCRRKEDERPPADCCCVTWSVVIATLVCCAAIGVGFYGNSETNDGVYQLTYSLRHANHTVSGIDDLVSDTTES 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 160 LNRTAEPNLQSLERQLAGRQEPLRAVQRLQTLLGTLLGYTAAIPFWRNPGVSLEVLAEQVDLYDWYRWLGYLGLLLLDVI 239
Cdd:pfam04906 136 LNETLEQHLTRLEEIFAKRTDYLQAVRFLQRQLANLIQQLAGLPFWKGAELSLTALAEQVDFYEWYRWLGYLLLLLLDLV 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 240 ICLLVLVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDTFVTKMVEEHsvLSGDILQYYLACSPR 319
Cdd:pfam04906 216 ICLVTLLGLARQSKCLLIGMCVCGLLALVISWASLGLELATAVGTSDFCVDPDDYVVNQTGEE--LSSDILQYYLNCSQS 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 320 ATNPFQQKLSGSHKALVEMQDVVAELLRNVPREHPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDYVQALTGFCY 399
Cdd:pfam04906 294 LTNPFQQRLTESQRALVEMQDQVQGLLRFAVPLFPTAQKDLLGIQGLLNSTERNLHQLTALLDCRSLHKDYLQALRGLCY 373
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720415248 400 DGVEGLIYLALFSFVTALMFSSIVCSIPHTW---QQKRGPDDDGEEETAPGPRQAH 452
Cdd:pfam04906 374 DGLEGLLYLLLFSLLTALAFSSIVCSDPHAWiyfQKRDRDYDDIDEEDPFNPQEAR 429
Tweety_N cd07912
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ...
80-438 2.20e-171

N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins.


Pssm-ID: 143653  Cd Length: 418  Bit Score: 489.15  E-value: 2.20e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248  80 FYSFWLCCRRRKTDEHLDADCCCTAWCVIITTLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAAA 159
Cdd:cd07912    59 VYLITRCCDRKPTEERPRHSICCLKWSLVIATLLCCAAIGVGLYGNDETHDGVVQLTYSLRNANHTVAGIDNQTSDTEAS 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 160 LNRTAEPNLQSLERQLAGRQ---EPLRAVQRLQTLLGTLLGYTAAIPFWRNPGVSLEVLAEQVDLYDWYRWLGYLGLLLL 236
Cdd:cd07912   139 LNVTVEPQLTNLEDIFDARVnktDYLQIVQGLQQMATNAAQQLTGIPFWSLVGVSLTKLADQVSLYESYRWLAYLGLLSL 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 237 DVIICLLVLVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDTFVTKMVEehSVLSGDILQYYLAC 316
Cdd:cd07912   219 LLVICLVLLVGLARHSRCLLIVFSVCGLFALIISWLSLGLYLASAVALSDFCVDPDDYVRNQTP--SGLSSDILQYYLTC 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720415248 317 SPRATNPFQQKLSGSHKALVEMQDVVAELLRNVPREHPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDYVQALTG 396
Cdd:cd07912   297 EPSTTNPFQQRLTESQRALTNMQSQVQGLLREAVFEFPTAEDNLLSLQGDLNSTEINLHQLTALLDCRGLHKDYVEALRG 376
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1720415248 397 FCYDGVEGLIYLALFSFVTALMFSSIVCSIPHTWQQKRGPDD 438
Cdd:cd07912   377 LCYDGLEGLLYLLLFSLLAALLFTILVCVDSHTWIYIRKRDD 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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