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Conserved domains on  [gi|1720419110|ref|XP_030111524|]
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MICOS complex subunit Mic60 isoform X4 [Mus musculus]

Protein Classification

MICOS complex subunit MIC60( domain architecture ID 12101363)

MICOS complex subunit MIC60 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-696 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


:

Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 587.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 123 LPVAQSQKTKGDTPASAG-DTLSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVTLQTITAQNAAV 201
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSsEVAEEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESATAVAKEAKDDAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 202 QAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITA 281
Cdd:pfam09731 157 QAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 282 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMtGKLSTDDLNSLIAHAHRR 361
Cdd:pfam09731 217 APETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKED-NLLSNDDLNSLIAHAHRE 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 362 IDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQA 437
Cdd:pfam09731 296 IDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQA 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 438 AAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 517
Cdd:pfam09731 375 EAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQ 443

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 518 QLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAM 597
Cdd:pfam09731 444 QLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSL 523

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 598 IDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKE 677
Cdd:pfam09731 524 IDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKE 599

                         650
                  ....*....|....*....
gi 1720419110 678 ARMTLETKQIVEILTAYAS 696
Cdd:pfam09731 600 ARRRLEVQQALELLQAEAA 618
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-696 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 587.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 123 LPVAQSQKTKGDTPASAG-DTLSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVTLQTITAQNAAV 201
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSsEVAEEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESATAVAKEAKDDAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 202 QAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITA 281
Cdd:pfam09731 157 QAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 282 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMtGKLSTDDLNSLIAHAHRR 361
Cdd:pfam09731 217 APETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKED-NLLSNDDLNSLIAHAHRE 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 362 IDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQA 437
Cdd:pfam09731 296 IDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQA 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 438 AAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 517
Cdd:pfam09731 375 EAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQ 443

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 518 QLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAM 597
Cdd:pfam09731 444 QLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSL 523

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 598 IDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKE 677
Cdd:pfam09731 524 IDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKE 599

                         650
                  ....*....|....*....
gi 1720419110 678 ARMTLETKQIVEILTAYAS 696
Cdd:pfam09731 600 ARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 227-527 7.54e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 7.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 227 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 306
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 307 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmtgklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK 386
Cdd:COG1196   304 -------IARLEERRRELEERLEEL----------------EEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 387 HKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 461
Cdd:COG1196   361 AEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720419110 462 GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 527
Cdd:COG1196   438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
PTZ00121 PTZ00121
MAEBL; Provisional
 196-519 4.25e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 4.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  196 AQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEA----------ADALLKAKEELEK---M 260
Cdd:PTZ00121  1344 AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKkaEEKKKADEAkkkaeedkkkADELKKAAAAKKKadeA 1423

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  261 KTIIEDAKKREIAGAtphiTAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDdfRKELDSITPditpgwK 340
Cdd:PTZ00121  1424 KKKAEEKKKADEAKK----KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEE--AKKADEAKK------K 1491

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  341 GMTGKLSTDDLNSlIAHAHRRIDQLNRELAQQKATEKQHIElalEKHKLEEKRTFDSaVAKALEHHRSE--IQAEQDRKV 418
Cdd:PTZ00121  1492 AEEAKKKADEAKK-AAEAKKKADEAKKAEEAKKADEAKKAE---EAKKADEAKKAEE-KKKADELKKAEelKKAEEKKKA 1566

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  419 EEVRDAMENEMRTQLRRQAAAHTDHLR--DVLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARL 496
Cdd:PTZ00121  1567 EEAKKAEEDKNMALRKAEEAKKAEEARieEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1720419110  497 RGIEQ-----------AVQSHAVAEEEARKAHQL 519
Cdd:PTZ00121  1647 KKAEElkkaeeenkikAAEEAKKAEEDKKKAEEA 1680
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 172-505 3.70e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  172 TTALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRK 241
Cdd:TIGR02168  624 GVLVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEK 698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  242 AVDEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 321
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  322 DDFRKELDSITPDITpgwkgmTGKLSTDDLNSLIAHAHRRIDQLNRELAQQK-----------ATEKQHIELALEK---- 386
Cdd:TIGR02168  778 AEAEAEIEELEAQIE------QLKEELKALREALDELRAELTLLNEEAANLRerleslerriaATERRLEDLEEQIeels 851

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  387 -------HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKV 450
Cdd:TIGR02168  852 edieslaAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LEL 929

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720419110  451 QEQELKYEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 505
Cdd:TIGR02168  930 RLEGLEVRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-696 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 587.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 123 LPVAQSQKTKGDTPASAG-DTLSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVTLQTITAQNAAV 201
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSsEVAEEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESATAVAKEAKDDAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 202 QAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITA 281
Cdd:pfam09731 157 QAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 282 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMtGKLSTDDLNSLIAHAHRR 361
Cdd:pfam09731 217 APETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKED-NLLSNDDLNSLIAHAHRE 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 362 IDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQA 437
Cdd:pfam09731 296 IDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQA 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 438 AAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 517
Cdd:pfam09731 375 EAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQ 443

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 518 QLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAM 597
Cdd:pfam09731 444 QLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSL 523

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 598 IDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKE 677
Cdd:pfam09731 524 IDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKE 599

                         650
                  ....*....|....*....
gi 1720419110 678 ARMTLETKQIVEILTAYAS 696
Cdd:pfam09731 600 ARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 227-527 7.54e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 7.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 227 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 306
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 307 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmtgklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK 386
Cdd:COG1196   304 -------IARLEERRRELEERLEEL----------------EEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 387 HKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 461
Cdd:COG1196   361 AEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720419110 462 GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 527
Cdd:COG1196   438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
PTZ00121 PTZ00121
MAEBL; Provisional
 196-519 4.25e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 4.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  196 AQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEA----------ADALLKAKEELEK---M 260
Cdd:PTZ00121  1344 AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKkaEEKKKADEAkkkaeedkkkADELKKAAAAKKKadeA 1423

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  261 KTIIEDAKKREIAGAtphiTAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDdfRKELDSITPditpgwK 340
Cdd:PTZ00121  1424 KKKAEEKKKADEAKK----KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEE--AKKADEAKK------K 1491

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  341 GMTGKLSTDDLNSlIAHAHRRIDQLNRELAQQKATEKQHIElalEKHKLEEKRTFDSaVAKALEHHRSE--IQAEQDRKV 418
Cdd:PTZ00121  1492 AEEAKKKADEAKK-AAEAKKKADEAKKAEEAKKADEAKKAE---EAKKADEAKKAEE-KKKADELKKAEelKKAEEKKKA 1566

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  419 EEVRDAMENEMRTQLRRQAAAHTDHLR--DVLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARL 496
Cdd:PTZ00121  1567 EEAKKAEEDKNMALRKAEEAKKAEEARieEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1720419110  497 RGIEQ-----------AVQSHAVAEEEARKAHQL 519
Cdd:PTZ00121  1647 KKAEElkkaeeenkikAAEEAKKAEEDKKKAEEA 1680
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
227-450 2.69e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.07  E-value: 2.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  227 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKR----EIAGATPHITAAEGRLHNmiVDLDNVVKKVQA 302
Cdd:COG4913    692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRleaaEDLARLELRALLEERFAA--ALGDAVERELRE 769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  303 A------QSEAKVVSQYHELV--------------------VQARDDFRKELDSITPDITPG----WKGMTGKLSTDDLN 352
Cdd:COG4913    770 NleeridALRARLNRAEEELEramrafnrewpaetadldadLESLPEYLALLDRLEEDGLPEyeerFKELLNENSIEFVA 849

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  353 SL-------IAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAM 425
Cdd:COG4913    850 DLlsklrraIREIKERIDPLNDSLKRIPFGPGRYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAALKRLI 929

                          250       260
                   ....*....|....*....|....*.
gi 1720419110  426 EnemrtQLRRQAAAHTDH-LRDVLKV 450
Cdd:COG4913    930 E-----RLRSEEEESDRRwRARVLDV 950
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 172-505 3.70e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  172 TTALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRK 241
Cdd:TIGR02168  624 GVLVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEK 698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  242 AVDEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 321
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  322 DDFRKELDSITPDITpgwkgmTGKLSTDDLNSLIAHAHRRIDQLNRELAQQK-----------ATEKQHIELALEK---- 386
Cdd:TIGR02168  778 AEAEAEIEELEAQIE------QLKEELKALREALDELRAELTLLNEEAANLRerleslerriaATERRLEDLEEQIeels 851

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  387 -------HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKV 450
Cdd:TIGR02168  852 edieslaAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LEL 929

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720419110  451 QEQELKYEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 505
Cdd:TIGR02168  930 RLEGLEVRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 399-518 3.48e-05

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 44.27  E-value: 3.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 399 VAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAhtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRS 478
Cdd:pfam15346  24 VEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREA---------ELEEERRKEEEERKKREELERILEENNRKI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1720419110 479 QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 518
Cdd:pfam15346  95 EEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQ 134
PTZ00121 PTZ00121
MAEBL; Provisional
 211-519 1.54e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 1.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  211 LKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAGAtphitaaegrlhn 288
Cdd:PTZ00121  1283 LKKAEEKKKADEAKKAEEKKKADEAKKkaEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAK------------- 1349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  289 mivdldnvvKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITpditpgwKGMTGKLSTDDLNSLIAHAHRRIDQLNRE 368
Cdd:PTZ00121  1350 ---------AEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAK-------KKAEEKKKADEAKKKAEEDKKKADELKKA 1413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  369 LAQQKATEKQhielaleKHKLEEKRTFDSAVAKAlehhrseiqaEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 448
Cdd:PTZ00121  1414 AAAKKKADEA-------KKKAEEKKKADEAKKKA----------EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAK 1476

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720419110  449 KVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSftldintayARLRGIEQAVQS-HAVAEEEARKAHQL 519
Cdd:PTZ00121  1477 KKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKA---------DEAKKAEEAKKAdEAKKAEEAKKADEA 1539
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 349-517 1.90e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 1.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  349 DDLNSLIAHAHRRIDQLNREL--AQQKATEKQ-HIELALEKH-----KLEEKRTFDSAVAKALEHHRSEIQ------AEQ 414
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELsdASRKIGEIEkEIEQLEQEEeklkeRLEELEEDLSSLEQEIENVKSELKeleariEEL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  415 DRKVEEVRDAMEN-----------EMRTQLRRQAAAHTDhLRDVLKVQEQEL-KYEFEQGLSEKLSEQELEFRRRSQEQM 482
Cdd:TIGR02169  771 EEDLHKLEEALNDlearlshsripEIQAELSKLEEEVSR-IEARLREIEQKLnRLTLEKEYLEKEIQELQEQRIDLKEQI 849

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1720419110  483 DSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 517
Cdd:TIGR02169  850 KSIEKEIENLNGKKEELEEELEELEAALRDLESRL 884
PTZ00121 PTZ00121
MAEBL; Provisional
 196-519 1.90e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 1.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  196 AQNAAVQAVKAHsNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEK---MKTIIEDAKKREI 272
Cdd:PTZ00121  1449 AKKKAEEAKKAE-EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadeAKKAEEAKKADEA 1527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  273 AGATPHITAAEGRLHNMIVDLDNV-----------VKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKG 341
Cdd:PTZ00121  1528 KKAEEAKKADEAKKAEEKKKADELkkaeelkkaeeKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKM 1607

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  342 MTGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEiqaEQDRKVEEV 421
Cdd:PTZ00121  1608 KAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE----ENKIKAAEEAKKAE---EDKKKAEEA 1680

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  422 RDAMENEMrtqlrrqaaahtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSftldintAYARLRGIEQ 501
Cdd:PTZ00121  1681 KKAEEDEK-------------------KAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA-------EEENKIKAEE 1734

                          330
                   ....*....|....*...
gi 1720419110  502 AVQShavAEEEARKAHQL 519
Cdd:PTZ00121  1735 AKKE---AEEDKKKAEEA 1749
COG4223 COG4223
Uncharacterized conserved protein [Function unknown];
463-697 5.98e-04

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443367 [Multi-domain]  Cd Length: 259  Bit Score: 42.34  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 463 LSEKLSEQELEFRRRSQEQMDsftLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSaemptiPL 542
Cdd:COG4223    39 LEARLAALRAALAAAREAVAA---AAAAALEARLAALEAKAAAPEAEAAAAARAAALALAAAALRAAVERGQ------PF 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 543 GSAVEAIRVNCSDNEFTQALTAAippesLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLlfppk 622
Cdd:COG4223   110 AAELAALEALAPDAPALAALAAF-----AATGVPTLAALRAEFPAAARAALAAARAPEADASWLDRLLAFARSLV----- 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720419110 623 QLKPPAElyPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASA 697
Cdd:COG4223   180 TVRRVGP--VEGDDPDAILARAEAALAAGDLAGALAELEALPEAAQAAAAPWIAKAEARLAADAALQALAAQALA 252
PTZ00121 PTZ00121
MAEBL; Provisional
 360-536 6.29e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 6.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  360 RRIDQLNR-ELAQQKATEKQHIElalEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQaa 438
Cdd:PTZ00121  1224 KKAEAVKKaEEAKKDAEEAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKA-- 1298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  439 ahtdhlRDVLKVQEQELKYEfEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARlRGIEQAVQSHAVAEEEARKAHQ 518
Cdd:PTZ00121  1299 ------EEKKKADEAKKKAE-EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEAEAAEEKAEAAE 1370

                          170
                   ....*....|....*...
gi 1720419110  519 LWLSVEALKYSMKTSSAE 536
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAE 1388
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
356-499 8.51e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 8.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  356 AHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMR----- 430
Cdd:COG4913    647 REALQRLAEYSWDEIDVASAEREIAELEAELERLDA----SSDDLAALEEQLEELEAELEELEEELDELKGEIGRlekel 722

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  431 TQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSE-KLSEQELEFRRRSQEQMDSFTLDINTAYARLRGI 499
Cdd:COG4913    723 EQAEEELDELQDRLEAAEDLARLELRALLEERFAAaLGDAVERELRENLEERIDALRARLNRAEEELERA 792
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 170-470 1.23e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.13  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  170 SETTALAKSLEDAlNRTSSVTLQTITAQnaAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADA 249
Cdd:pfam12128  664 SEKDKKNKALAER-KDSANERLNSLEAQ--LKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAA 740

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  250 L-LKAKEELEKMKTiiedAKKREIAGATPHitaaEGRLHNMIVDLDNVVKKV-QAAQSEAKVVSQ---YHELVVQARDDF 324
Cdd:pfam12128  741 RrSGAKAELKALET----WYKRDLASLGVD----PDVIAKLKREIRTLERKIeRIAVRRQEVLRYfdwYQETWLQRRPRL 812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  325 RKELDSITPDITPgwkgmtgklSTDDLNSLIAHAHRRIDQLNRELaqqKATEKQHIELALEKHKLeekRTFDSAVAKALE 404
Cdd:pfam12128  813 ATQLSNIERAISE---------LQQQLARLIADTKLRRAKLEMER---KASEKQQVRLSENLRGL---RCEMSKLATLKE 877

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  405 HHRSE----IQAEQDRKVEEVRDAMENEMrtqlrRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQ 470
Cdd:pfam12128  878 DANSEqaqgSIGERLAQLEDLKLKRDYLS-----ESVKKYVEHFKNVIADHSGSGLAETWESLREEDHYQ 942
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 368-540 1.31e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 368 ELAQQKATEKQHIELALEKHKLEEKRtfdsavaKALEHHRSeiQAEQDRKVEEVRDAMENEMRTqlRRQAAAHTDHLRDV 447
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERKR-------KKLELEKE--KRDRKRAEEQRRKILEKELEE--RKQAMIEEERKRKL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 448 LKVQEQELK---YEFEQ---GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRgiEQAVQSHAVAEEEARKAHQLWL 521
Cdd:pfam17380 518 LEKEMEERQkaiYEEERrreAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMER--EREMMRQIVESEKARAEYEATT 595

                         170       180
                  ....*....|....*....|.
gi 1720419110 522 SVEALK--YSMKTSSAEMPTI 540
Cdd:pfam17380 596 PITTIKpiYRPRISEYQPPDV 616
PTZ00121 PTZ00121
MAEBL; Provisional
 196-485 1.63e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  196 AQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALK-ERRKAVDEAADALLKAK-EELEKMktiiEDAKKREIA 273
Cdd:PTZ00121  1488 AKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKaEEAKKADEAKKAEEKKKaDELKKA----EELKKAEEK 1563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  274 GATPHITAAEGRlHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPgwKGMTGKLSTDDLNS 353
Cdd:PTZ00121  1564 KKAEEAKKAEED-KNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELK--KAEEEKKKVEQLKK 1640

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  354 LIAHAHRRIDQLNRELAQQKATEKQHIELALE-KHKLEEKRTFDSAVAKALEHHRSEiqAEQDRKVEEVRDAMENEMRT- 431
Cdd:PTZ00121  1641 KEAEEKKKAEELKKAEEENKIKAAEEAKKAEEdKKKAEEAKKAEEDEKKAAEALKKE--AEEAKKAEELKKKEAEEKKKa 1718

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  432 -QLRRQAAAHTDHLRDVLKVQEQ------ELKYE----------------------------FEQGLSEKLSEQELEFRR 476
Cdd:PTZ00121  1719 eELKKAEEENKIKAEEAKKEAEEdkkkaeEAKKDeeekkkiahlkkeeekkaeeirkekeavIEEELDEEDEKRRMEVDK 1798


                   ....*....
gi 1720419110  477 RSQEQMDSF 485
Cdd:PTZ00121  1799 KIKDIFDNF 1807
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 363-481 2.89e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 41.11  E-value: 2.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110  363 DQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHtd 442
Cdd:TIGR00618  256 LKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAH-- 333

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1720419110  443 hlrdvlkvQEQELKYEFEQGLSEKLSEQELEFRRRSQEQ 481
Cdd:TIGR00618  334 --------VKQQSSIEEQRRLLQTLHSQEIHIRDAHEVA 364
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 325-480 3.26e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.18  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 325 RKELDSITPDITPGWKGMTGKLSTDDLNslIAHAHRRIDQLNRELaqqKATEKQHIELALEKHKLEEKRTFDSAVAKALE 404
Cdd:pfam15905 165 RNKLEAKMKEVMAKQEGMEGKLQVTQKN--LEHSKGKVAQLEEKL---VSTEKEKIEEKSETEKLLEYITELSCVSEQVE 239

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720419110 405 HHRSEIQaeqdrKVEEVRDAMENEMRTqLRRQAAAHTDHLRDVLKVQEQELKyEFEQGLSEKLSEQELEFRRRSQE 480
Cdd:pfam15905 240 KYKLDIA-----QLEELLKEKNDEIES-LKQSLEEKEQELSKQIKDLNEKCK-LLESEKEELLREYEEKEQTLNAE 308
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 232-421 9.36e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 38.37  E-value: 9.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 232 VEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAkKREIAgatphitaaegRLHNMIVDLDNVVKKVQAAQSEAKVVS 311
Cdd:COG1579    22 LEHRLKELPAELAELEDELAALEARLEAAKTELEDL-EKEIK-----------RLELEIEEVEARIKKYEEQLGNVRNNK 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419110 312 QYHELvvqarddfRKELDSITPDItpgwkgmtgklstDDLNSLIAHAHRRIDQLNRELAQQKAtekqhiELALEKHKLEE 391
Cdd:COG1579    90 EYEAL--------QKEIESLKRRI-------------SDLEDEILELMERIEELEEELAELEA------ELAELEAELEE 142

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1720419110 392 KRT-FDSAVAKaLEHHRSEIQAEQDRKVEEV 421
Cdd:COG1579   143 KKAeLDEELAE-LEAELEELEAEREELAAKI 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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