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Conserved domains on  [gi|1907173756|ref|XP_036008266|]
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leucine-rich repeat transmembrane neuronal protein 1 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-315 5.63e-30

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.58  E-value: 5.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  49 LLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNhicsvqgDAFQKLRRVKELTLSSNQITEL 128
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 129 ANTtFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQFVPvRIFQDCRSLKFLDIGYNQLKSLArNSFAGL 208
Cdd:COG4886   129 PEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 209 FKLTELHLEHNDLIKVNFAhFPRLISLHSLCLRRNKVaivvSSLDWVW---NLEKMDLSGNEIEYMEPhvFETVPYLQTL 285
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL----TDLPELGnltNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                         250       260       270
                  ....*....|....*....|....*....|
gi 1907173756 286 QLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
Cdd:COG4886   278 DLSNNQLTDLKLKELELLLGLNSLLLLLLL 307
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-315 5.63e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.58  E-value: 5.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  49 LLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNhicsvqgDAFQKLRRVKELTLSSNQITEL 128
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 129 ANTtFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQFVPvRIFQDCRSLKFLDIGYNQLKSLArNSFAGL 208
Cdd:COG4886   129 PEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 209 FKLTELHLEHNDLIKVNFAhFPRLISLHSLCLRRNKVaivvSSLDWVW---NLEKMDLSGNEIEYMEPhvFETVPYLQTL 285
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL----TDLPELGnltNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                         250       260       270
                  ....*....|....*....|....*....|
gi 1907173756 286 QLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
Cdd:COG4886   278 DLSNNQLTDLKLKELELLLGLNSLLLLLLL 307
LRR_8 pfam13855
Leucine rich repeat;
113-173 1.65e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.65e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907173756 113 RRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-314 1.74e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.81  E-value: 1.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 112 LRRVKELTLSSNQITELANttFRPMPNLRSVDLSYNKLQALapDLFHGLRKLTTLHMRANAIQfvpvRI--FQDCRSLKF 189
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIE----KIenLENLVNLKK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 190 LDIGYNQLKSLarNSFAGLFKLTELHLEHNDLIKVNFAHF-PRLISLHSLCLRRnkvaivvssldwvwnlekMDLSGNEI 268
Cdd:cd21340    73 LYLGGNRISVV--EGLENLTNLEELHIENQRLPPGEKLTFdPRSLAALSNSLRV------------------LNISGNNI 132

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907173756 269 EYMEPhvFETVPYLQTLQLDSNRLTYIEP--RILNSWKSLTSITLAGN 314
Cdd:cd21340   133 DSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-314 1.25e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  88 LMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLH 167
Cdd:PLN00113  307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLI 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 168 MRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLI-KVNFAHFpRLISLHSLCLRRNKVA 246
Cdd:PLN00113  387 LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQMLSLARNKFF 465

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907173756 247 IVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPYLQTLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
Cdd:PLN00113  466 GGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
LRR smart00370
Leucine-rich repeats, outliers;
136-159 4.28e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 4.28e-03
                           10        20
                   ....*....|....*....|....
gi 1907173756  136 MPNLRSVDLSYNKLQALAPDLFHG 159
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-315 5.63e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.58  E-value: 5.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  49 LLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNhicsvqgDAFQKLRRVKELTLSSNQITEL 128
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 129 ANTtFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQFVPvRIFQDCRSLKFLDIGYNQLKSLArNSFAGL 208
Cdd:COG4886   129 PEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 209 FKLTELHLEHNDLIKVNFAhFPRLISLHSLCLRRNKVaivvSSLDWVW---NLEKMDLSGNEIEYMEPhvFETVPYLQTL 285
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL----TDLPELGnltNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                         250       260       270
                  ....*....|....*....|....*....|
gi 1907173756 286 QLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
Cdd:COG4886   278 DLSNNQLTDLKLKELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-311 1.46e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.42  E-value: 1.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  85 FTGLMQLTWLYLDHNHICSVqGDAFQKLRRVKELTLSSNQITELaNTTFRPMPNLRSVDLSYNKLQALaPDLFHGLRKLT 164
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLK 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 165 TLHMRANAIQFVPVRIFQdCRSLKFLDIGYNQLKSLArNSFAGLFKLTELHLEHNDLikVNFAHFPRLISLHSLCLRRNK 244
Cdd:COG4886   186 ELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQ 261

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907173756 245 VAiVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPYLQTLQLDSNRLTYIEPRILNSWKSLTSITL 311
Cdd:COG4886   262 LT-DLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327
LRR_8 pfam13855
Leucine rich repeat;
113-173 1.65e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.65e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907173756 113 RRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-314 1.74e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.81  E-value: 1.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 112 LRRVKELTLSSNQITELANttFRPMPNLRSVDLSYNKLQALapDLFHGLRKLTTLHMRANAIQfvpvRI--FQDCRSLKF 189
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIE----KIenLENLVNLKK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 190 LDIGYNQLKSLarNSFAGLFKLTELHLEHNDLIKVNFAHF-PRLISLHSLCLRRnkvaivvssldwvwnlekMDLSGNEI 268
Cdd:cd21340    73 LYLGGNRISVV--EGLENLTNLEELHIENQRLPPGEKLTFdPRSLAALSNSLRV------------------LNISGNNI 132

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907173756 269 EYMEPhvFETVPYLQTLQLDSNRLTYIEP--RILNSWKSLTSITLAGN 314
Cdd:cd21340   133 DSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
90-149 9.02e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.93  E-value: 9.02e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  90 QLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKL 149
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
161-221 1.74e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 1.74e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907173756 161 RKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-314 1.25e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  88 LMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLH 167
Cdd:PLN00113  307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLI 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 168 MRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLI-KVNFAHFpRLISLHSLCLRRNKVA 246
Cdd:PLN00113  387 LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQMLSLARNKFF 465

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907173756 247 IVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPYLQTLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
Cdd:PLN00113  466 GGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
LRR_8 pfam13855
Leucine rich repeat;
73-125 6.15e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907173756  73 RYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQI 125
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-192 1.44e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  75 NSLSELRagQFTGLMQLTWLYLDHNHICSVQGdaFQKLRRVKELTLSSNQITELANTTFRPM------PNLRSVDLSYNK 148
Cdd:cd21340    56 NQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNISGNN 131

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907173756 149 LQALAPdlFHGLRKLTTLHMRANAIQ-FVPV-RIFQDCRSLKFLDI 192
Cdd:cd21340   132 IDSLEP--LAPLRNLEQLDASNNQISdLEELlDLLSSWPSLRELDL 175
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-293 3.11e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.16  E-value: 3.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  90 QLTWLYLDHNHICSV----QGDafqklrrVKELTLSSNQITELANTtfrpMPN-LRSVDLSYNKLQALAPDLFHGLRKLT 164
Cdd:PRK15370  200 QITTLILDNNELKSLpenlQGN-------IKTLYANSNQLTSIPAT----LPDtIQEMELSINRITELPERLPSALQSLD 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 165 TLHmraNAIQFVPVRIFQDcrsLKFLDIGYNQLKSLARNSFAGlfkLTELHLEHNDLIKVNfAHFPrlISLHSLCLRRNK 244
Cdd:PRK15370  269 LFH---NKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPSG---ITHLNVQSNSLTALP-ETLP--PGLKTLEAGENA 336

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907173756 245 VAIVVSSLDwvWNLEKMDLSGNEIEYMEphvfETV-PYLQTLQLDSNRLT 293
Cdd:PRK15370  337 LTSLPASLP--PELQVLDVSKNQITVLP----ETLpPTITTLDVSRNALT 380
LRR_8 pfam13855
Leucine rich repeat;
257-315 7.71e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 7.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907173756 257 NLEKMDLSGNEIEYMEPHVFETVPYLQTLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-221 2.49e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  90 QLTWLYLDHNHICSVQGDAFQKlRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMR 169
Cdd:PLN00113  453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173756 170 ANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL 221
Cdd:PLN00113  532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-221 8.87e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 8.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  96 LDHNHICSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMP-----------------------NLRSVDLSYNKLQAL 152
Cdd:PLN00113  411 LQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPslqmlslarnkffgglpdsfgskRLENLDLSRNQFSGA 490

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907173756 153 APDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL 221
Cdd:PLN00113  491 VPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 90-221 1.49e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.48  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  90 QLTWLYLDHNHIcSVQG-----DAFQKLRRVKELTLSSNQITE-----LANTTFRPMPnLRSVDLSYNKL-----QALAP 154
Cdd:COG5238   265 TVETLYLSGNQI-GAEGaialaKALQGNTTLTSLDLSVNRIGDegaiaLAEGLQGNKT-LHTLNLAYNGIgaqgaIALAK 342

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907173756 155 DLFHGlRKLTTLHMRANAI---------QFVpvrifQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELH---LEHNDL 221
Cdd:COG5238   343 ALQEN-TTLHSLDLSDNQIgdegaialaKYL-----EGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHtliLDGNLI 415
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 86-243 2.75e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  86 TGLMQLTWLYLDHNHI----CSVQGDAFQKLRRVKELTLSSNQITE----LANTTFRPMPNLRSVDLSYNKL-----QAL 152
Cdd:COG5238   233 KGNKSLTTLDLSNNQIgdegVIALAEALKNNTTVETLYLSGNQIGAegaiALAKALQGNTTLTSLDLSVNRIgdegaIAL 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 153 APDLfHGLRKLTTLHMRANAIQFVPVRIF----QDCRSLKFLDIGYNQL-----KSLArNSFAGLFKLTELHLEHNDLIK 223
Cdd:COG5238   313 AEGL-QGNKTLHTLNLAYNGIGAQGAIALakalQENTTLHSLDLSDNQIgdegaIALA-KYLEGNTTLRELNLGKNNIGK 390

                         170       180
                  ....*....|....*....|...
gi 1907173756 224 VNFAHFPRLI---SLHSLCLRRN 243
Cdd:COG5238   391 QGAEALIDALqtnRLHTLILDGN 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-314 4.86e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  99 NHICSVQGDAFQKLRRVKELTLSSNQIT-ELANTTFRpMPNLRSVDLSYNKLQALAPDlfhglrklttlhmranaiqfvp 177
Cdd:PLN00113   55 ADVCLWQGITCNNSSRVVSIDLSGKNISgKISSAIFR-LPYIQTINLSNNQLSGPIPD---------------------- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 178 vRIFQDCRSLKFLDIGYNQLK-SLARNSfagLFKLTELHLEHNDLIkvnfAHFPRLISLHSlclrrnkvaivvssldwvw 256
Cdd:PLN00113  112 -DIFTTSSSLRYLNLSNNNFTgSIPRGS---IPNLETLDLSNNMLS----GEIPNDIGSFS------------------- 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907173756 257 NLEKMDLSGNEIEYMEPHVFETVPYLQTLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
Cdd:PLN00113  165 SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 85-268 8.15e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 8.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  85 FTGLMQLTWLYLDHNHICSVQGDAFQKLRR---VKELTLSSNQITE-----LANTTFRPMPNLRSVDLSYNKL-----QA 151
Cdd:cd00116    77 LTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLegascEA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 152 LApDLFHGLRKLTTLHMRANAIQF----VPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFK----LTELHLEHNDLIK 223
Cdd:cd00116   157 LA-KALRANRDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTD 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907173756 224 VNFAHF-----PRLISLHSLCLRRNKVAI-----VVSSLDWVWNLEKMDLSGNEI 268
Cdd:cd00116   236 AGAAALasallSPNISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
234-292 1.01e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907173756 234 SLHSLCLRRNKVaivvSSLDWVW-----NLEKMDLSGNEIEYMEPHVFETVPYLQTLQLDSNRL 292
Cdd:pfam13855   2 NLRSLDLSNNRL----TSLDDGAfkglsNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
107-210 1.82e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 107 DAFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAP-DLFHGLRKLTTLHMRANAIQFVP---VRIFQ 182
Cdd:pfam14580  58 DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDlDPLASLKKLTFLSLLRNPVTNKPhyrLYVIY 137

                          90       100
                  ....*....|....*....|....*...
gi 1907173756 183 DCRSLKFLDigYNQLKSLARNSFAGLFK 210
Cdd:pfam14580 138 KVPQLRLLD--FRKVKQKERQAAEKMFR 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-242 2.88e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  73 RYNSLSELRagQFTGLMQLTWLYLDHNHICSVqgDAFQKLRRVKELTLSSNQITELANTTFRPMPNLRsvDLSYNKLQAL 152
Cdd:COG4886   236 SNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLN--SLLLLLLLLN 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 153 APDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIKVNFAHFPRL 232
Cdd:COG4886   310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389

                         170
                  ....*....|
gi 1907173756 233 ISLHSLCLRR 242
Cdd:COG4886   390 LLLLLTTTAG 399
LRR_8 pfam13855
Leucine rich repeat;
185-245 3.67e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 3.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907173756 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIKVNFAHFPRLISLHSLCLRRNKV 245
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 94-173 1.92e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  94 LYLDHNHICSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 137-171 2.29e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907173756 137 PNLRSVDLSYNKLQALapDLFHGLRKLTTLHMRAN 171
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 75-268 2.67e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756  75 NSLSELRAGQ-FTGLMQLTWLYLDHNHI----CSVQGDAFQKLRRVKELTLSSNQ------ITELANTTFRPMPNLRSVD 143
Cdd:cd00116     8 ELLKTERATElLPKLLCLQVLRLEGNTLgeeaAKALASALRPQPSLKELCLSLNEtgriprGLQSLLQGLTKGCGLQELD 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173756 144 LSYNKLQALAPDLFHGLRKLTTL---HMRANAIQFVPVRI----FQDCR-SLKFLDIGYNQLKSLARNSFAGLF----KL 211
Cdd:cd00116    88 LSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLRLlakgLKDLPpALEKLVLGRNRLEGASCEALAKALranrDL 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907173756 212 TELHLEHNDL-------IKVNFAHFPRL--ISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEI 268
Cdd:cd00116   168 KELNLANNGIgdagiraLAEGLKANCNLevLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNL 233
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 114-149 4.05e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 4.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907173756 114 RVKELTLSSNQITELANttFRPMPNLRSVDLSYNKL 149
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
LRR smart00370
Leucine-rich repeats, outliers;
136-159 4.28e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 4.28e-03
                           10        20
                   ....*....|....*....|....
gi 1907173756  136 MPNLRSVDLSYNKLQALAPDLFHG 159
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
136-159 4.28e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 4.28e-03
                           10        20
                   ....*....|....*....|....
gi 1907173756  136 MPNLRSVDLSYNKLQALAPDLFHG 159
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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